Detailed information for compound 1627642

Basic information

Technical information
  • TDR Targets ID: 1627642
  • Name: ethyl N-[(2,5-dimethyl-1-naphthalen-1-ylpyrro l-3-yl)methylideneamino]carbamate
  • MW: 335.4 | Formula: C20H21N3O2
  • H donors: 1 H acceptors: 1 LogP: 4.39 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)N/N=C/c1cc(n(c1C)c1cccc2c1cccc2)C
  • InChi: 1S/C20H21N3O2/c1-4-25-20(24)22-21-13-17-12-14(2)23(15(17)3)19-11-7-9-16-8-5-6-10-18(16)19/h5-13H,4H2,1-3H3,(H,22,24)/b21-13+
  • InChiKey: LKDMNZNFBPXGEI-FYJGNVAPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl N-[[2,5-dimethyl-1-(1-naphthyl)pyrrol-3-yl]methyleneamino]carbamate
  • N-[[2,5-dimethyl-1-(1-naphthyl)-3-pyrrolyl]methyleneamino]carbamic acid ethyl ester
  • N-[[2,5-dimethyl-1-(1-naphthyl)pyrrol-3-yl]methyleneamino]carbamic acid ethyl ester
  • ethyl N-[(2,5-dimethyl-1-naphthalen-1-yl-pyrrol-3-yl)methylideneamino]carbamate
  • MLS000587723
  • N'-[1-(2,5-Dimethyl-1-naphthalen-1-yl-1H-pyrrol-3-yl)-meth-(E)-ylidene]-hydrazinecarboxylic acid ethyl ester
  • SMR000211803
  • STOCK2S-35070

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA binding protein 0.0076 0.0696 0.1653
Plasmodium vivax cation/H+ antiporter, putative 0.0024 0.0124 0.4796
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0696 0.0666
Loa Loa (eye worm) hypothetical protein 0.0024 0.0127 0.0096
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0024 0.0124 0.0124
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0197 0.7648
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0127 0.0434
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0197 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0696 0.0696
Echinococcus granulosus tar DNA binding protein 0.0076 0.0696 0.0681
Echinococcus granulosus lamin 0.0033 0.022 0.0205
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0258 0.0243
Entamoeba histolytica sodium/calcium exchanger protein, putative 0.0024 0.0124 0.9748
Loa Loa (eye worm) hypothetical protein 0.0024 0.0124 0.0092
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.022 0.0189
Brugia malayi hypothetical protein 0.002 0.0081 0.0062
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0127 0.0182
Toxoplasma gondii manganese resistance 1 protein, putative 0.0024 0.0124 0.4796
Loa Loa (eye worm) solute carrier family 8 0.0936 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.2082 0.2082
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0696 0.0696
Brugia malayi Pre-SET motif family protein 0.0251 0.2587 0.6548
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0127 1
Brugia malayi intermediate filament protein 0.0033 0.022 0.0423
Mycobacterium tuberculosis Probable ionic transporter integral membrane protein ChaA 0.0024 0.0124 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0258 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0127 0.5
Echinococcus multilocularis sodium calcium exchanger 0.0936 1 1
Onchocerca volvulus 0.0033 0.022 0.034
Plasmodium vivax SET domain protein, putative 0.0036 0.0258 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0197 0.0166
Loa Loa (eye worm) hypothetical protein 0.0032 0.0214 0.0183
Schistosoma mansoni hypothetical protein 0.0205 0.2082 0.2082
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0024 0.0124 0.0124
Brugia malayi Na/Ca eXchangers family member (ncx-4) 0.0024 0.0124 0.0173
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0057 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0258 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0696 0.0696
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0197 1
Brugia malayi K+-dependent Na+/Ca+ exchanger related-protein 0.0024 0.0124 0.0173
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2587 0.2564
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0696 0.0666
Echinococcus granulosus geminin 0.0205 0.2082 0.207
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0127 0.0011
Onchocerca volvulus 0.0036 0.0258 0.0473
Echinococcus granulosus sodium:potassium:calcium exchanger 0.0024 0.0124 0.0108
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0258 0.0258
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0165 0.1655 0.5394
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0127 0.0096
Schistosoma mansoni DNA helicase recq5 0.0024 0.0127 0.0127
Echinococcus multilocularis lamin 0.0033 0.022 0.0205
Echinococcus multilocularis lamin dm0 0.0033 0.022 0.0205
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0127 0.0434
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0197 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0127 0.0111
Brugia malayi hypothetical protein 0.003 0.0197 0.0364
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0127 0.0111
Brugia malayi Pre-SET motif family protein 0.0036 0.0258 0.0521
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0258 0.0258
Echinococcus multilocularis musashi 0.0033 0.022 0.0205
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0127 0.0111
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0127 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0258 0.0243
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0127 0.492
Echinococcus multilocularis sodium:potassium:calcium exchanger 0.0024 0.0124 0.0108
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0696 0.1653
Echinococcus multilocularis geminin 0.0205 0.2082 0.207
Schistosoma mansoni DNA helicase recq1 0.0024 0.0127 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0258 0.0258
Schistosoma mansoni lamin 0.0033 0.022 0.022
Echinococcus granulosus intermediate filament protein 0.0033 0.022 0.0205
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0127 0.0182
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0038 0.0022
Loa Loa (eye worm) hypothetical protein 0.0033 0.022 0.0189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0124 0.0092
Loa Loa (eye worm) RNA binding protein 0.0076 0.0696 0.0666
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0696 0.0696
Treponema pallidum hypothetical protein 0.0024 0.0124 0.5
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0127 0.0111
Onchocerca volvulus 0.0033 0.022 0.034
Loa Loa (eye worm) Na/Ca eXchangers family member 0.0024 0.0124 0.0092
Brugia malayi Sodium/calcium exchanger protein 0.0375 0.3921 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0696 0.0696
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0197 0.7648
Echinococcus granulosus sodium:potassium:calcium exchanger 6 0.0024 0.0124 0.0108
Loa Loa (eye worm) hypothetical protein 0.0024 0.0124 0.0092
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0127 0.0182
Echinococcus granulosus lamin dm0 0.0033 0.022 0.0205
Schistosoma mansoni sodium/calcium exchanger 0.0936 1 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0038 0.0022
Brugia malayi TAR-binding protein 0.0076 0.0696 0.1653
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0127 0.492
Schistosoma mansoni intermediate filament proteins 0.0033 0.022 0.022
Onchocerca volvulus 0.0286 0.2963 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0258 0.0227
Echinococcus multilocularis sodium:potassium:calcium exchanger 6 0.0024 0.0124 0.0108
Echinococcus granulosus bloom syndrome protein 0.0024 0.0127 0.0111
Schistosoma mansoni na/ca exchanger 0.0024 0.0124 0.0124
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0696 0.0681
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.022 0.0423
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2963 1
Schistosoma mansoni hypothetical protein 0.0014 0.0016 0.0016
Loa Loa (eye worm) RecQ helicase 0.0024 0.0127 0.0096
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0258 0.0243
Schistosoma mansoni hypothetical protein 0.0024 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0375 0.3921 0.3902
Loa Loa (eye worm) intermediate filament protein 0.0033 0.022 0.0189
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0127 0.0011
Leishmania major hypothetical protein, conserved 0.003 0.0197 1
Mycobacterium leprae Probable ionic transporter integral membrane protein ChaA 0.0024 0.0124 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0197 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0127 0.0111
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0197 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0006
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0165 0.1655 0.5394
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0244 0.0228
Schistosoma mansoni lamin 0.0033 0.022 0.022

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4467 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5174 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.