Detailed information for compound 1627792

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.31 | Formula: C19H14O8
  • H donors: 0 H acceptors: 4 LogP: 2.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Oc1ccc2c(c1)oc1c(c2=O)c(OC(=O)C)cc(c1)OC(=O)C
  • InChi: 1S/C19H14O8/c1-9(20)24-12-4-5-14-15(6-12)27-17-8-13(25-10(2)21)7-16(26-11(3)22)18(17)19(14)23/h4-8H,1-3H3
  • InChiKey: ADQSTMGPNSJMME-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0071 0.0145 0.0186
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1097 0.2329
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0745 0.5423 0.6903
Toxoplasma gondii acyl carrier protein ACP 0.0071 0.0145 0.0028
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0571 0.406 0.7425
Toxoplasma gondii type I fatty acid synthase 0.0108 0.0433 0.0571
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0145 0.0019
Mycobacterium ulcerans Type I modular polyketide synthase 0.0701 0.5082 0.6517
Loa Loa (eye worm) fatty acid synthase 0.0692 0.5009 0.5649
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 0.0135 0.0054
Trypanosoma brucei protein kinase, putative 0.0571 0.406 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0232 0.0302
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0113 0.0054
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0109 0.0446 0.3656
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0071 0.0145 0.0186
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.007 0.0135 0.0054
Treponema pallidum acyl carrier protein 0.0071 0.0145 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1178 0.2539
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.013 0.0043
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.0501 0.0983
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0071 0.0145 0.0019
Mycobacterium ulcerans Type I modular polyketide synthase 0.0701 0.5082 0.6517
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0145 0.0186
Schistosoma mansoni thyroid hormone receptor 0.0154 0.08 0.1739
Schistosoma mansoni hypothetical protein 0.0082 0.0232 0.0302
Mycobacterium tuberculosis Conserved protein 0.0211 0.1245 0.1453
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0071 0.0145 0.0019
Onchocerca volvulus 0.1221 0.9149 0.9635
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0571 0.406 1
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1097 0.2329
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.022 0.1315 0.1546
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0145 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0701 0.5082 0.6451
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0078 0.0198 0.0214
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0259 0.162 0.1524
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.0501 0.0983
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0143 0.071 0.1511
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0176 0.0969 0.2104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.013 0.0167
Schistosoma mansoni acyl carrier protein 0.0071 0.0145 0.008
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0216 0.1279 0.1498
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0176 0.0969 0.1242
Loa Loa (eye worm) hypothetical protein 0.1178 0.8816 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0571 0.406 1
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0176 0.0969 0.2104
Brugia malayi Methyltransferase-like protein 4 0.0211 0.1245 0.1144
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0078 0.0198 0.0214
Onchocerca volvulus Fatty acid synthase homolog 0.1264 0.949 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0571 0.406 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.0501 0.0983
Echinococcus granulosus AMP dependent ligase 0.0071 0.0145 0.008
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0176 0.0969 0.2104
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0071 0.0145 0.0186
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0701 0.5082 0.6451
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1097 0.2329
Mycobacterium ulcerans polyketide synthase 0.0745 0.5423 0.6954
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0745 0.5423 0.6903
Brugia malayi Calcitonin receptor-like protein seb-1 0.0259 0.162 0.1524
Mycobacterium ulcerans thioesterase TesA 0.0584 0.4167 0.5343
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0564 0.4009 0.5049
Schistosoma mansoni hypothetical protein 0.0082 0.0232 0.0302
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0259 0.162 0.1776
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0071 0.0145 0.0032
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.013 0.0043
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0176 0.0969 0.1584
Toxoplasma gondii type I fatty acid synthase, putative 0.0745 0.5423 1
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0284 0.1811 0.2192
Echinococcus granulosus mitogen activated protein kinase 3 0.0571 0.406 1
Trichomonas vaginalis CMGC family protein kinase 0.0571 0.406 1
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0176 0.0969 1
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.013 0.0043
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0176 0.0969 0.0865
Mycobacterium leprae Polyketide synthase Pks13 0.1048 0.7799 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0198 0.015
Loa Loa (eye worm) hypothetical protein 0.0177 0.0978 0.1042
Schistosoma mansoni hypothetical protein 0.0082 0.0232 0.0302
Leishmania major acyl carrier protein, putative 0.0071 0.0145 0.0037
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0108 0.0433 0.0394
Mycobacterium tuberculosis Polyketide synthase Pks2 0.068 0.4914 0.6238
Leishmania major hypothetical protein, conserved 0.0211 0.1245 0.2836
Mycobacterium tuberculosis Conserved hypothetical protein 0.0071 0.0145 0.0019
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0071 0.0145 0.0032
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0108 0.0433 0.0394
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0071 0.0145 0.0019
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0655 0.4721 0.5987
Brugia malayi MAP kinase sur-1 0.0571 0.406 0.3992
Schistosoma mansoni hypothetical protein 0.0143 0.071 0.1511
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0232 0.0302
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0293 0.1887 0.2081
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.1887 0.4373
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1097 0.2329
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0176 0.0969 0.1032
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.1887 0.4373
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0571 0.406 1
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.1887 0.4373
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0071 0.0145 0.0186
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0232 0.0302
Mycobacterium ulcerans polyketide synthase 0.0701 0.5082 0.6517
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0108 0.0433 0.0394
Schistosoma mansoni thyroid hormone receptor 0.0154 0.08 0.1739
Echinococcus granulosus acyl carrier protein mitochondrial 0.0071 0.0145 0.008
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0745 0.5423 0.6954
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 0.0135 0.0006
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.007 0.0135 0.0012
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0455 0.3153 0.5711
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0071 0.0145 0.0019
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0071 0.0145 0.0186
Mycobacterium leprae Probable polyketide synthase Pks1 0.0745 0.5423 0.6897
Brugia malayi AMP-binding enzyme family protein 0.0655 0.4721 0.4661
Brugia malayi AMP-binding enzyme family protein 0.0216 0.1279 0.1179
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0464 0.3222 0.4132
Schistosoma mansoni hypothetical protein 0.0177 0.0978 0.2191
Mycobacterium ulcerans polyketide synthase Pks9 0.0464 0.3222 0.4132
Trichomonas vaginalis CMGC family protein kinase 0.0571 0.406 1
Mycobacterium ulcerans acyl carrier protein 0.0071 0.0145 0.0186
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0176 0.0969 1
Echinococcus granulosus GPCR family 2 0.0082 0.0232 0.0302
Loa Loa (eye worm) acyl carrier protein 0.0071 0.0145 0.009
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0745 0.5423 0.6954
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0176 0.0969 0.2167
Onchocerca volvulus 0.0655 0.4721 0.4897
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0232 0.0121
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0116 0.0501 0.0983
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0701 0.5082 0.5026
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1178 0.2539
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0143 0.071 0.1511
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.1887 0.4373
Onchocerca volvulus 0.008 0.0214 0.0074
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0071 0.0145 0.0019
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0571 0.406 1
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.1887 0.4373
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0701 0.5082 0.6458
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0564 0.4009 0.5141
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1097 0.2329
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.068 0.4914 0.6238
Mycobacterium ulcerans acyl carrier protein 0.0071 0.0145 0.0186
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0232 0.019
Mycobacterium ulcerans polyketide synthase MbtC 0.0176 0.0969 0.1242
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0399 0.2712 0.3367
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0701 0.5082 0.6458
Echinococcus granulosus mitogen activated protein kinase 0.0571 0.406 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1048 0.7799 1
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0176 0.0969 0.1242
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0241 0.1478 0.1758
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0574 0.4082 0.5153
Schistosoma mansoni hypothetical protein 0.0082 0.0232 0.0302
Loa Loa (eye worm) hypothetical protein 0.0259 0.162 0.1776
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.0135 0.0173
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1048 0.7799 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0071 0.0145 0.0186
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.0501 0.0983
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.013 0.0167
Echinococcus multilocularis AMP dependent ligase 0.0071 0.0145 0.008
Mycobacterium tuberculosis Probable thioesterase TesA 0.0584 0.4167 0.5264
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0176 0.0969 0.2167
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0232 0.0302
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0571 0.406 0.4565
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0071 0.0145 0.0186
Mycobacterium ulcerans polyketide synthase MbtD 0.0216 0.1279 0.164
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 0.0135 0.0054
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.007 0.0135 0.0022
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0116 0.0501 0.0983
Mycobacterium ulcerans fatty acid synthase Fas 0.022 0.1315 0.1687
Onchocerca volvulus Glucosylceramidase homolog 0.0192 0.1097 0.1019
Schistosoma mansoni serine/threonine protein kinase 0.0571 0.406 1
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0171 0.0932 0.1046
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1097 0.2329
Schistosoma mansoni methyltransferase-related 0.0211 0.1245 0.2866
Echinococcus multilocularis NADH dehydrogenase 0.0071 0.0145 0.008
Mycobacterium ulcerans Type I modular polyketide synthase 0.0701 0.5082 0.6517
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0071 0.0145 0.0019
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0571 0.406 1
Mycobacterium tuberculosis Hypothetical protein 0.0211 0.1245 0.1453
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0564 0.4009 0.5141
Trichomonas vaginalis glucosylceramidase, putative 0.0293 0.1887 0.4373
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0176 0.0969 0.2167
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.013 0.0043
Trichomonas vaginalis CMGC family protein kinase 0.0571 0.406 1
Echinococcus multilocularis mitogen activated protein kinase 0.0571 0.406 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0154 0.08 0.1739
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.022 0.1315 0.1529
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0701 0.5082 0.6458
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1097 0.2329
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0176 0.0969 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0499 0.35 0.6366
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0293 0.1887 0.1794
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0108 0.0433 0.0394
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0745 0.5423 0.6897
Brugia malayi latrophilin 2 splice variant baaae 0.0177 0.0978 0.0875
Giardia lamblia Kinase, CMGC MAPK 0.0571 0.406 1
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0116 0.0501 0.0983
Toxoplasma gondii melibiase subfamily protein 0.0116 0.0501 0.0701
Echinococcus granulosus NADH dehydrogenase 0.0071 0.0145 0.008
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.0135 0.0173
Mycobacterium ulcerans thioesterase 0.0584 0.4167 0.5343
Loa Loa (eye worm) hypothetical protein 0.0393 0.2667 0.2973
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0071 0.0145 0.0019
Toxoplasma gondii aminotransferase, putative 0.0385 0.2603 0.4672
Brugia malayi Melibiase family protein 0.0078 0.0198 0.0085
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0655 0.4721 0.532
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0701 0.5082 0.6517
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0176 0.0969 0.2133
Mycobacterium ulcerans polyketide synthase Pks13 0.1048 0.7799 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0354 0.2366 0.4224
Loa Loa (eye worm) acyl carrier protein 0.0322 0.2116 0.2342
Echinococcus multilocularis GPCR, family 2 0.0082 0.0232 0.0302
Brugia malayi Phosphopantetheine attachment site family protein 0.0071 0.0145 0.0032
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0071 0.0145 0.008
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0745 0.5423 0.6897
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0108 0.0433 0.0376
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0071 0.0145 0.009
Loa Loa (eye worm) hypothetical protein 0.0108 0.0433 0.0419
Echinococcus multilocularis mitogen activated protein kinase 3 0.0571 0.406 1
Schistosoma mansoni hypothetical protein 0.0071 0.0145 0.008
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0232 0.0121
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0464 0.3222 0.402
Trichomonas vaginalis CMGC family protein kinase 0.0571 0.406 1
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0176 0.0969 1
Trichomonas vaginalis conserved hypothetical protein 0.0211 0.1245 0.2711
Loa Loa (eye worm) hypothetical protein 0.0082 0.0232 0.019
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0584 0.4167 0.5255
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0145 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0745 0.5423 0.6903
Loa Loa (eye worm) hypothetical protein 0.0108 0.0433 0.0419
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0446 0.3656
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0571 0.406 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.013 0.0167
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0504 0.3535 0.4441

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) > 100 uM Cytotoxicity against human HepG2 cells assessed as NADH level after overnight incubation by MTS assay ChEMBL. 22537683
MIC (functional) > 128 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 after 20 to 22 hrs by broth microdilution method ChEMBL. 22537683

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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