Detailed information for compound 162986

Basic information

Technical information
  • TDR Targets ID: 162986
  • Name: 4-furan-3-yl-7-[[4-(4-hydroxyoxan-4-yl)pyridi n-2-yl]methoxy]naphthalene-2-carbonitrile
  • MW: 426.464 | Formula: C26H22N2O4
  • H donors: 1 H acceptors: 3 LogP: 3.32 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc2cc(OCc3nccc(c3)C3(O)CCOCC3)ccc2c(c1)c1cocc1
  • InChi: 1S/C26H22N2O4/c27-15-18-11-20-13-23(1-2-24(20)25(12-18)19-4-8-31-16-19)32-17-22-14-21(3-7-28-22)26(29)5-9-30-10-6-26/h1-4,7-8,11-14,16,29H,5-6,9-10,17H2
  • InChiKey: JWRBCMWYGFFHEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(3-furyl)-7-[[4-(4-hydroxytetrahydropyran-4-yl)-2-pyridyl]methoxy]naphthalene-2-carbonitrile
  • 4-(3-furyl)-7-[[4-(4-hydroxy-4-tetrahydropyranyl)-2-pyridyl]methoxy]-2-naphthalenecarbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0096 0.117 1
Schistosoma mansoni rab6-interacting 0.0024 0.0079 0.0233
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.008 0.092 0.0847
Schistosoma mansoni multidrug resistance protein 0.0096 0.117 0.3459
Echinococcus multilocularis ATP binding cassette sub family B 0.008 0.092 0.2719
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Entamoeba histolytica P-glyco protein 6, putative 0.0243 0.3382 1
Echinococcus granulosus multidrug resistance protein 1 0.0166 0.2227 0.6585
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0875 0.2588
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0079 0.0233
Schistosoma mansoni smdr1 0.008 0.092 0.2719
Plasmodium falciparum multidrug resistance protein 1 0.0243 0.3382 0.3329
Brugia malayi hypothetical protein 0.0024 0.0079 0.0233
Echinococcus multilocularis ATP binding cassette sub family B 0.008 0.092 0.2719
Schistosoma mansoni hypothetical protein 0.0024 0.0079 0.0233
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0096 0.117 0.3459
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0243 0.3382 1
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.008 0.092 0.5
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0243 0.3382 1
Loa Loa (eye worm) multidrug resistance-associated protein 0.002 0.0015 0.0044
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0243 0.3382 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.0096 0.117 0.3459
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0096 0.117 1
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.008 0.092 0.092
Loa Loa (eye worm) hypothetical protein 0.0243 0.3382 1
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.008 0.092 0.2719
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0243 0.3382 0.3382
Plasmodium vivax ABC transporter B family member 4, putative 0.008 0.092 0.0847
Entamoeba histolytica P-glycoprotein-2 0.0243 0.3382 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.008 0.092 0.2719
Entamoeba histolytica fatty acid elongase, putative 0.0089 0.1055 0.0718
Brugia malayi ABC transporter family protein 0.0243 0.3382 1
Trichomonas vaginalis ABC transporter, putative 0.0243 0.3382 1
Trypanosoma brucei p-glycoprotein 0.0096 0.117 1
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0682 1 1
Schistosoma mansoni rab6-interacting 0.0024 0.0079 0.0233
Plasmodium falciparum multidrug resistance protein 2 0.008 0.092 0.0847
Entamoeba histolytica ATP-binding cassette protein, putative 0.0096 0.117 0.1176
Trichomonas vaginalis ABC transporter, putative 0.0243 0.3382 1
Echinococcus granulosus acetylcholinesterase 0.011 0.1376 0.4069
Schistosoma mansoni multidrug resistance protein 0.0096 0.117 0.3459
Plasmodium falciparum ABC transporter B family member 6, putative 0.008 0.092 0.0847
Brugia malayi Doublecortin family protein 0.0024 0.0079 0.0233
Schistosoma mansoni multidrug resistance protein 0.0243 0.3382 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Plasmodium falciparum multidrug resistance-associated protein 1 0.008 0.092 0.0847
Trichomonas vaginalis taga, putative 0.0243 0.3382 1
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0096 0.117 0.1017
Plasmodium vivax multidrug resistance protein 2, putative 0.008 0.092 0.0847
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Plasmodium vivax ABC transporter B family member 5, putative 0.008 0.092 0.0847
Leishmania major pentamidine resistance protein 1 0.0096 0.117 0.1017
Trypanosoma cruzi multidrug resistance protein E, putative 0.0096 0.117 1
Loa Loa (eye worm) ABC transporter 0.008 0.092 0.2719
Giardia lamblia MRP-like ABC transporter 0.0096 0.117 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0233
Brugia malayi ABC transporter transmembrane region family protein 0.0096 0.117 0.3459
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0243 0.3382 1
Brugia malayi ABC transporter transmembrane region family protein 0.0077 0.0875 0.2588
Leishmania major ABC-thiol transporter 0.0096 0.117 0.1017
Plasmodium falciparum ABC transporter B family member 7, putative 0.008 0.092 0.0847
Schistosoma mansoni lipoxygenase 0.01 0.122 0.3608
Echinococcus multilocularis carboxylesterase 5A 0.011 0.1376 0.4069
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0079 0.0233
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0243 0.3382 1
Plasmodium vivax ABC transporter B family member 7, putative 0.008 0.092 0.0847
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.008 0.092 0.092
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1866 0.5517
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0243 0.3382 1
Entamoeba histolytica fatty acid elongase, putative 0.0089 0.1055 0.0718
Schistosoma mansoni multidrug resistance protein 0.008 0.092 0.2719
Onchocerca volvulus 0.0024 0.0079 0.0233
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0096 0.117 0.1017
Plasmodium falciparum ABC transporter B family member 3, putative 0.008 0.092 0.0847
Leishmania major p-glycoprotein e 0.0096 0.117 0.1017
Loa Loa (eye worm) hypothetical protein 0.011 0.1376 0.4069
Echinococcus granulosus multidrug resistance protein 1 0.0243 0.3382 1
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0077 0.0875 0.2588
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0096 0.117 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.011 0.1376 0.4069
Entamoeba histolytica ATP-binding cassette protein, putative 0.0096 0.117 0.1176
Giardia lamblia Multidrug resistance-associated protein 1 0.0096 0.117 1
Entamoeba histolytica fatty acid elongase, putative 0.0089 0.1055 0.0718
Echinococcus granulosus RUN 0.0024 0.0079 0.0233
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Schistosoma mansoni multidrug resistance protein 0.0077 0.0875 0.2588
Loa Loa (eye worm) hypothetical protein 0.0077 0.0875 0.2588
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.008 0.092 0.0847
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0166 0.2227 0.6585
Giardia lamblia Multidrug resistance-associated protein 1 0.0096 0.117 1
Loa Loa (eye worm) hypothetical protein 0.011 0.1376 0.4069
Echinococcus granulosus acetylcholinesterase 0.011 0.1376 0.4069
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0243 0.3382 1
Loa Loa (eye worm) acetylcholinesterase 1 0.011 0.1376 0.4069
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0096 0.117 0.1017
Entamoeba histolytica fatty acid elongase, putative 0.0089 0.1055 0.0718
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0243 0.3382 1
Echinococcus multilocularis acetylcholinesterase 0.011 0.1376 0.4069
Trypanosoma brucei multidrug resistance protein E 0.0096 0.117 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Trichomonas vaginalis ABC transporter, putative 0.0243 0.3382 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0243 0.3382 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0079 0.0233
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0096 0.117 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0093 0.1126 0.8495
Echinococcus multilocularis multidrug resistance protein 1 0.0243 0.3382 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0243 0.3382 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0243 0.3382 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0079 0.0233
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.024 0.3337 0.9869
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Schistosoma mansoni polycystin 1-related 0.0024 0.0079 0.0233
Schistosoma mansoni loxhd1 0.0024 0.0079 0.0233
Entamoeba histolytica hypothetical protein 0.0096 0.117 0.1176
Brugia malayi ABC transporter transmembrane region family protein 0.008 0.092 0.2719
Echinococcus granulosus multidrug resistance associated protein 1 0.0096 0.117 0.3459
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0243 0.3382 1
Echinococcus multilocularis multidrug resistance associated protein 1 0.0096 0.117 0.3459
Plasmodium falciparum ABC transporter B family member 4, putative 0.008 0.092 0.0847
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0243 0.3382 1
Loa Loa (eye worm) hypothetical protein 0.008 0.092 0.2719
Echinococcus multilocularis acetylcholinesterase 0.011 0.1376 0.4069
Trichomonas vaginalis abcb9, putative 0.0243 0.3382 1
Entamoeba histolytica fatty acid elongase, putative 0.0089 0.1055 0.0718
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0079 0.0233
Giardia lamblia ABC transporter, putative 0.0096 0.117 1
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0682 1 1
Brugia malayi ABC transporter family protein 0.008 0.092 0.2719
Trichomonas vaginalis ABC transporter, putative 0.0243 0.3382 1
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0682 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Brugia malayi ABC transporter 0.008 0.092 0.2719
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0096 0.117 0.1017
Brugia malayi multidrug resistance protein 3 0.0243 0.3382 1
Entamoeba histolytica P-glycoprotein-2 0.0243 0.3382 1
Entamoeba histolytica P-glycoprotein-1 0.0243 0.3382 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0243 0.3382 1
Brugia malayi Carboxylesterase family protein 0.011 0.1376 0.4069
Echinococcus granulosus carboxylesterase 5A 0.011 0.1376 0.4069
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0682 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0233
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.008 0.092 0.2719
Entamoeba histolytica multidrug resistance protein, putative 0.0096 0.117 0.1176
Echinococcus multilocularis ATP binding cassette sub family B 0.008 0.092 0.2719
Entamoeba histolytica ABC transporter, putative 0.0096 0.117 0.1176
Brugia malayi P-glycoprotein-like protein 0.008 0.092 0.2719
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.008 0.092 0.092
Brugia malayi ABC transporter family protein 0.008 0.092 0.2719
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.008 0.092 0.092
Entamoeba histolytica P-glycoprotein 5, putative 0.0243 0.3382 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0875 0.2588
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.008 0.092 0.092
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0682 1 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.1126 0.3328
Plasmodium vivax ABC transporter B family member 6, putative 0.008 0.092 0.0847
Onchocerca volvulus 0.0024 0.0079 0.0233
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0243 0.3382 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0243 0.3382 0.3329
Brugia malayi ABC transporter 0.0077 0.0875 0.2588
Echinococcus multilocularis ATP binding cassette sub family B 0.024 0.3337 0.9869
Trichomonas vaginalis abcb9, putative 0.0243 0.3382 1
Echinococcus multilocularis RUN 0.0024 0.0079 0.0233
Plasmodium vivax ABC transporter B family member 3, putative 0.008 0.092 0.0847
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1866 0.5517
Entamoeba histolytica P-glycoprotein 6, putative 0.008 0.092 0.0177
Brugia malayi ABC transporter family protein 0.008 0.092 0.2719
Schistosoma mansoni multidrug resistance protein 0.0243 0.3382 1
Schistosoma mansoni multidrug resistance protein 0.0243 0.3382 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0096 0.117 0.1176
Trichomonas vaginalis abcb9, putative 0.0243 0.3382 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.3382 1
Echinococcus granulosus multidrug resistance protein 1 0.0243 0.3382 1
Brugia malayi hypothetical protein 0.0024 0.0079 0.0233
Echinococcus multilocularis 0.008 0.092 0.2719
Brugia malayi hypothetical protein 0.008 0.092 0.2719
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0875 0.2588
Entamoeba histolytica ATP-binding cassette protein, putative 0.0096 0.117 0.1176
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0243 0.3382 1
Schistosoma mansoni multidrug resistance protein 0.0096 0.117 0.3459
Schistosoma mansoni smdr2 0.0243 0.3382 1
Leishmania major p-glycoprotein 0.0243 0.3382 1
Entamoeba histolytica P-glycoprotein 6, putative 0.008 0.092 0.0177
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0243 0.3382 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0096 0.117 0.3459
Brugia malayi multidrug resistance related protein 1 0.0096 0.117 0.3459
Loa Loa (eye worm) ABC transporter 0.008 0.092 0.2719
Loa Loa (eye worm) carboxylesterase 0.011 0.1376 0.4069
Entamoeba histolytica P-glycoprotein-2, putative 0.0243 0.3382 1
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0079 0.0233
Plasmodium falciparum ABC transporter B family member 5, putative 0.008 0.092 0.0847
Echinococcus granulosus multidrug resistance protein 1 0.0166 0.2227 0.6585
Echinococcus multilocularis ATP binding cassette sub family B 0.008 0.092 0.2719
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0096 0.117 0.1017
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.008 0.092 0.092
Schistosoma mansoni lipoxygenase 0.0142 0.1866 0.5517
Plasmodium falciparum multidrug resistance-associated protein 2 0.008 0.092 0.0847
Loa Loa (eye worm) hypothetical protein 0.024 0.3337 0.9869
Onchocerca volvulus 0.0243 0.3382 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0243 0.3382 1
Schistosoma mansoni multidrug resistance protein 0.0096 0.117 0.3459
Echinococcus granulosus multidrug resistance protein 1 0.0243 0.3382 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Echinococcus granulosus ATP binding cassette sub family B 0.008 0.092 0.2719
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0243 0.3382 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.008 0.092 0.092
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0875 0.2588
Loa Loa (eye worm) multidrug resistance protein 3 0.0243 0.3382 1
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0682 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0243 0.3382 1
Entamoeba histolytica P-glycoprotein-5 0.0243 0.3382 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.117 0.3459
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Echinococcus multilocularis multidrug resistance protein 1 0.0166 0.2227 0.6585
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.008 0.092 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.117 0.3459
Brugia malayi Carboxylesterase family protein 0.011 0.1376 0.4069
Loa Loa (eye worm) ABC transporter 0.008 0.092 0.2719
Echinococcus granulosus ATP binding cassette sub family B 0.008 0.092 0.2719
Echinococcus granulosus ATP binding cassette sub family B 0.0077 0.0875 0.2588
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0682 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0243 0.3382 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0079 0.0233

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.5 nM Compound was evaluated for production of leukotriene B4 in Ca+2 -ionophore -activated human polymorphonuclear (HPMN) leukocytes. ChEMBL. 9288168
IC50 (functional) = 3.5 nM Compound was evaluated for production of leukotriene B4 in Ca+2 -ionophore -activated human polymorphonuclear (HPMN) leukocytes. ChEMBL. 9288168
IC50 (functional) = 50 nM Compound was evaluated for production of leukotriene B4 in human whole blood (HWB) activated with ionophore A-23,187. ChEMBL. 9288168
IC50 (functional) = 50 nM Compound was evaluated for production of leukotriene B4 in human whole blood (HWB) activated with ionophore A-23,187. ChEMBL. 9288168
IC50 (functional) = 70 nM Inhibition of oxidation of arachidonic acid by human 5-Lipoxygenase using spectrophotometric assay ChEMBL. 9288168
IC50 (functional) = 70 nM Inhibition of oxidation of arachidonic acid by human 5-Lipoxygenase using spectrophotometric assay ChEMBL. 9288168

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 9288168

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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