Detailed information for compound 162986

Basic information

Technical information
  • TDR Targets ID: 162986
  • Name: 4-furan-3-yl-7-[[4-(4-hydroxyoxan-4-yl)pyridi n-2-yl]methoxy]naphthalene-2-carbonitrile
  • MW: 426.464 | Formula: C26H22N2O4
  • H donors: 1 H acceptors: 3 LogP: 3.32 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc2cc(OCc3nccc(c3)C3(O)CCOCC3)ccc2c(c1)c1cocc1
  • InChi: 1S/C26H22N2O4/c27-15-18-11-20-13-23(1-2-24(20)25(12-18)19-4-8-31-16-19)32-17-22-14-21(3-7-28-22)26(29)5-9-30-10-6-26/h1-4,7-8,11-14,16,29H,5-6,9-10,17H2
  • InChiKey: JWRBCMWYGFFHEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(3-furyl)-7-[[4-(4-hydroxytetrahydropyran-4-yl)-2-pyridyl]methoxy]naphthalene-2-carbonitrile
  • 4-(3-furyl)-7-[[4-(4-hydroxy-4-tetrahydropyranyl)-2-pyridyl]methoxy]-2-naphthalenecarbonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 5-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ABC transporter B family member 6, putative 0.008 0.092 0.0847
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0875 0.2588
Echinococcus granulosus carboxylesterase 5A 0.011 0.1376 0.4069
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0682 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0243 0.3382 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0233
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.024 0.3337 0.9869
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.008 0.092 0.092
Schistosoma mansoni lipoxygenase 0.0142 0.1866 0.5517
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0243 0.3382 1
Entamoeba histolytica fatty acid elongase, putative 0.0089 0.1055 0.0718
Brugia malayi multidrug resistance related protein 1 0.0096 0.117 0.3459
Echinococcus granulosus multidrug resistance protein 1 0.0166 0.2227 0.6585
Leishmania major ABC-thiol transporter 0.0096 0.117 0.1017
Plasmodium vivax ABC transporter B family member 5, putative 0.008 0.092 0.0847
Schistosoma mansoni rab6-interacting 0.0024 0.0079 0.0233
Plasmodium vivax ABC transporter B family member 7, putative 0.008 0.092 0.0847
Loa Loa (eye worm) ABC transporter 0.008 0.092 0.2719
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.008 0.092 0.2719
Echinococcus granulosus ATP binding cassette sub family B 0.008 0.092 0.2719
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0079 0.0233
Entamoeba histolytica ATP-binding cassette protein, putative 0.0096 0.117 0.1176
Leishmania major p-glycoprotein e 0.0096 0.117 0.1017
Schistosoma mansoni hypothetical protein 0.0024 0.0079 0.0233
Schistosoma mansoni multidrug resistance protein 0.008 0.092 0.2719
Echinococcus multilocularis ATP binding cassette sub family B 0.008 0.092 0.2719
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0243 0.3382 1
Loa Loa (eye worm) multidrug resistance-associated protein 0.002 0.0015 0.0044
Plasmodium falciparum ABC transporter B family member 7, putative 0.008 0.092 0.0847
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0096 0.117 0.1017
Loa Loa (eye worm) hypothetical protein 0.011 0.1376 0.4069
Giardia lamblia Multidrug resistance-associated protein 1 0.0096 0.117 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.117 0.3459
Echinococcus granulosus acetylcholinesterase 0.011 0.1376 0.4069
Entamoeba histolytica ABC transporter, putative 0.0096 0.117 0.1176
Loa Loa (eye worm) ABC transporter 0.008 0.092 0.2719
Loa Loa (eye worm) hypothetical protein 0.0096 0.117 0.3459
Schistosoma mansoni polycystin 1-related 0.0024 0.0079 0.0233
Loa Loa (eye worm) multidrug resistance protein 3 0.0243 0.3382 1
Brugia malayi Carboxylesterase family protein 0.011 0.1376 0.4069
Schistosoma mansoni rab6-interacting 0.0024 0.0079 0.0233
Schistosoma mansoni multidrug resistance protein 0.0243 0.3382 1
Brugia malayi multidrug resistance protein 3 0.0243 0.3382 1
Echinococcus granulosus multidrug resistance protein 1 0.0243 0.3382 1
Echinococcus granulosus multidrug resistance protein 1 0.0243 0.3382 1
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0682 1 1
Echinococcus granulosus ATP binding cassette sub family B 0.008 0.092 0.2719
Schistosoma mansoni multidrug resistance protein 0.0096 0.117 0.3459
Schistosoma mansoni multidrug resistance protein 0.0243 0.3382 1
Echinococcus multilocularis ATP binding cassette sub family B 0.008 0.092 0.2719
Echinococcus multilocularis multidrug resistance associated protein 7 0.0096 0.117 0.3459
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Onchocerca volvulus 0.0024 0.0079 0.0233
Brugia malayi ABC transporter transmembrane region family protein 0.008 0.092 0.2719
Echinococcus granulosus multidrug resistance associated protein 7 0.0096 0.117 0.3459
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0243 0.3382 1
Brugia malayi hypothetical protein 0.008 0.092 0.2719
Echinococcus multilocularis ATP binding cassette sub family B 0.024 0.3337 0.9869
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Echinococcus granulosus multidrug resistance associated protein 1 0.0096 0.117 0.3459
Entamoeba histolytica multidrug resistance protein, putative 0.0096 0.117 0.1176
Loa Loa (eye worm) hypothetical protein 0.024 0.3337 0.9869
Brugia malayi ABC transporter transmembrane region family protein 0.0077 0.0875 0.2588
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0875 0.2588
Entamoeba histolytica P-glycoprotein-5 0.0243 0.3382 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0243 0.3382 1
Trichomonas vaginalis ABC transporter, putative 0.0243 0.3382 1
Loa Loa (eye worm) carboxylesterase 0.011 0.1376 0.4069
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0166 0.2227 0.6585
Brugia malayi hypothetical protein 0.0024 0.0079 0.0233
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0096 0.117 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0096 0.117 0.1017
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Echinococcus multilocularis carboxylesterase 5A 0.011 0.1376 0.4069
Onchocerca volvulus 0.0024 0.0079 0.0233
Brugia malayi ABC transporter transmembrane region family protein 0.0096 0.117 0.3459
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0243 0.3382 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Echinococcus granulosus acetylcholinesterase 0.011 0.1376 0.4069
Echinococcus multilocularis RUN 0.0024 0.0079 0.0233
Entamoeba histolytica ATP-binding cassette protein, putative 0.0096 0.117 0.1176
Schistosoma mansoni multidrug resistance protein 0.0096 0.117 0.3459
Trichomonas vaginalis taga, putative 0.0243 0.3382 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0096 0.117 0.1176
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0243 0.3382 1
Entamoeba histolytica fatty acid elongase, putative 0.0089 0.1055 0.0718
Entamoeba histolytica fatty acid elongase, putative 0.0089 0.1055 0.0718
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0243 0.3382 0.3382
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.008 0.092 0.0847
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.0077 0.0875 0.2588
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.008 0.092 0.092
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0243 0.3382 1
Plasmodium falciparum multidrug resistance-associated protein 1 0.008 0.092 0.0847
Loa Loa (eye worm) hypothetical protein 0.008 0.092 0.2719
Plasmodium falciparum ABC transporter B family member 4, putative 0.008 0.092 0.0847
Echinococcus multilocularis multidrug resistance associated protein 1 0.0096 0.117 0.3459
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0079 0.0233
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.008 0.092 0.092
Loa Loa (eye worm) hypothetical protein 0.0243 0.3382 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0079 0.0233
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0243 0.3382 1
Loa Loa (eye worm) hypothetical protein 0.011 0.1376 0.4069
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0077 0.0875 0.2588
Echinococcus granulosus ATP binding cassette sub family B 0.0077 0.0875 0.2588
Trichomonas vaginalis ABC transporter, putative 0.0243 0.3382 1
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0096 0.117 0.1017
Echinococcus multilocularis ATP binding cassette sub family B 0.008 0.092 0.2719
Echinococcus granulosus RUN 0.0024 0.0079 0.0233
Entamoeba histolytica P-glycoprotein 6, putative 0.008 0.092 0.0177
Entamoeba histolytica P-glycoprotein-2 0.0243 0.3382 1
Plasmodium falciparum multidrug resistance protein 1 0.0243 0.3382 0.3329
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0243 0.3382 1
Giardia lamblia ABC transporter, putative 0.0096 0.117 1
Brugia malayi ABC transporter family protein 0.008 0.092 0.2719
Schistosoma mansoni multidrug resistance protein 0.0243 0.3382 1
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.008 0.092 0.0847
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0243 0.3382 1
Plasmodium falciparum ABC transporter B family member 3, putative 0.008 0.092 0.0847
Brugia malayi ABC transporter 0.008 0.092 0.2719
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0243 0.3382 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.008 0.092 0.092
Trypanosoma cruzi multidrug resistance protein E, putative 0.0096 0.117 1
Plasmodium vivax ABC transporter B family member 3, putative 0.008 0.092 0.0847
Echinococcus multilocularis multidrug resistance protein 1 0.0166 0.2227 0.6585
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0079 0.0233
Entamoeba histolytica hypothetical protein 0.0096 0.117 0.1176
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0682 1 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.3382 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Entamoeba histolytica P-glycoprotein-2 0.0243 0.3382 1
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.008 0.092 0.5
Brugia malayi hypothetical protein 0.0024 0.0079 0.0233
Trichomonas vaginalis abcb9, putative 0.0243 0.3382 1
Plasmodium falciparum ABC transporter B family member 5, putative 0.008 0.092 0.0847
Entamoeba histolytica ATP-binding cassette protein, putative 0.0096 0.117 0.1176
Plasmodium vivax ABC transporter B family member 6, putative 0.008 0.092 0.0847
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Trichomonas vaginalis abcb9, putative 0.0243 0.3382 1
Entamoeba histolytica P-glycoprotein 6, putative 0.008 0.092 0.0177
Onchocerca volvulus 0.0243 0.3382 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0096 0.117 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0079 0.0233
Schistosoma mansoni multidrug resistance protein 0.0077 0.0875 0.2588
Echinococcus multilocularis acetylcholinesterase 0.011 0.1376 0.4069
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0096 0.117 0.3459
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0682 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0243 0.3382 1
Entamoeba histolytica P-glycoprotein 5, putative 0.0243 0.3382 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0079 0.0233
Echinococcus multilocularis ATP binding cassette sub family B 0.008 0.092 0.2719
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.008 0.092 0.092
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0079 0.0233
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0243 0.3382 1
Brugia malayi ABC transporter family protein 0.008 0.092 0.2719
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0079 0.0233
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0096 0.117 0.1017
Echinococcus multilocularis acetylcholinesterase 0.011 0.1376 0.4069
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Leishmania major p-glycoprotein 0.0243 0.3382 1
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.008 0.092 0.5
Plasmodium falciparum multidrug resistance-associated protein 2 0.008 0.092 0.0847
Plasmodium vivax multidrug resistance protein 2, putative 0.008 0.092 0.0847
Plasmodium vivax multidrug resistance protein 1, putative 0.0243 0.3382 0.3329
Giardia lamblia MRP-like ABC transporter 0.0096 0.117 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Echinococcus granulosus multidrug resistance protein 1 0.0166 0.2227 0.6585
Schistosoma mansoni smdr1 0.008 0.092 0.2719
Trypanosoma brucei p-glycoprotein 0.0096 0.117 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Brugia malayi P-glycoprotein-like protein 0.008 0.092 0.2719
Entamoeba histolytica fatty acid elongase, putative 0.0089 0.1055 0.0718
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.008 0.092 0.092
Entamoeba histolytica P-glycoprotein-1 0.0243 0.3382 1
Trichomonas vaginalis abcb9, putative 0.0243 0.3382 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.1126 0.3328
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0096 0.117 1
Plasmodium falciparum multidrug resistance protein 2 0.008 0.092 0.0847
Entamoeba histolytica fatty acid elongase, putative 0.0089 0.1055 0.0718
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0682 1 1
Plasmodium vivax ABC transporter B family member 4, putative 0.008 0.092 0.0847
Brugia malayi Doublecortin family protein 0.0024 0.0079 0.0233
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0682 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Brugia malayi Carboxylesterase family protein 0.011 0.1376 0.4069
Loa Loa (eye worm) hypothetical protein 0.0077 0.0875 0.2588
Schistosoma mansoni loxhd1 0.0024 0.0079 0.0233
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.008 0.092 0.2719
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0077 0.0875 0.2588
Brugia malayi ABC transporter family protein 0.0243 0.3382 1
Echinococcus multilocularis 0.008 0.092 0.2719
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0243 0.3382 1
Loa Loa (eye worm) ABC transporter 0.008 0.092 0.2719
Echinococcus multilocularis multidrug resistance protein 1 0.0243 0.3382 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0243 0.3382 1
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.008 0.092 0.092
Trichomonas vaginalis ABC transporter, putative 0.0243 0.3382 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0096 0.117 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1866 0.5517
Entamoeba histolytica P-glyco protein 6, putative 0.0243 0.3382 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.011 0.1376 0.4069
Giardia lamblia Multidrug resistance-associated protein 1 0.0093 0.1126 0.8495
Trypanosoma brucei multidrug resistance protein E 0.0096 0.117 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0243 0.3382 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1866 0.5517
Schistosoma mansoni lipoxygenase 0.01 0.122 0.3608
Schistosoma mansoni multidrug resistance protein 0.0096 0.117 0.3459
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.008 0.092 0.2719
Leishmania major pentamidine resistance protein 1 0.0096 0.117 0.1017
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0243 0.3382 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0243 0.3382 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0243 0.3382 1
Loa Loa (eye worm) acetylcholinesterase 1 0.011 0.1376 0.4069
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0243 0.3382 1
Trichomonas vaginalis ABC transporter, putative 0.0243 0.3382 1
Schistosoma mansoni multidrug resistance protein 0.0096 0.117 0.3459
Echinococcus multilocularis multidrug resistance protein 1 0.0243 0.3382 1
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0096 0.117 0.1017
Brugia malayi ABC transporter 0.0077 0.0875 0.2588
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0682 1 1
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0243 0.3382 1
Entamoeba histolytica P-glycoprotein-2, putative 0.0243 0.3382 1
Brugia malayi ABC transporter family protein 0.008 0.092 0.2719
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0243 0.3382 1
Schistosoma mansoni smdr2 0.0243 0.3382 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0096 0.117 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.5 nM Compound was evaluated for production of leukotriene B4 in Ca+2 -ionophore -activated human polymorphonuclear (HPMN) leukocytes. ChEMBL. 9288168
IC50 (functional) = 3.5 nM Compound was evaluated for production of leukotriene B4 in Ca+2 -ionophore -activated human polymorphonuclear (HPMN) leukocytes. ChEMBL. 9288168
IC50 (functional) = 50 nM Compound was evaluated for production of leukotriene B4 in human whole blood (HWB) activated with ionophore A-23,187. ChEMBL. 9288168
IC50 (functional) = 50 nM Compound was evaluated for production of leukotriene B4 in human whole blood (HWB) activated with ionophore A-23,187. ChEMBL. 9288168
IC50 (functional) = 70 nM Inhibition of oxidation of arachidonic acid by human 5-Lipoxygenase using spectrophotometric assay ChEMBL. 9288168
IC50 (functional) = 70 nM Inhibition of oxidation of arachidonic acid by human 5-Lipoxygenase using spectrophotometric assay ChEMBL. 9288168

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 9288168

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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