Detailed information for compound 1632007

Basic information

Technical information
  • TDR Targets ID: 1632007
  • Name: [4-[(Z)-2-chloro-1-[4-(2-dimethylaminoethoxy) phenyl]-2-(4-methoxyphenyl)ethenyl]phenyl] 2, 2-dimethylpropanoate hydrochloride
  • MW: 544.509 | Formula: C30H35Cl2NO4
  • H donors: 0 H acceptors: 1 LogP: 8.43 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)/C(=C(/c1ccc(cc1)OC(=O)C(C)(C)C)\c1ccc(cc1)OCCN(C)C)/Cl.Cl
  • InChi: 1S/C30H34ClNO4.ClH/c1-30(2,3)29(33)36-26-17-9-22(10-18-26)27(28(31)23-11-13-24(34-6)14-12-23)21-7-15-25(16-8-21)35-20-19-32(4)5;/h7-18H,19-20H2,1-6H3;1H/b28-27-;
  • InChiKey: JWRZOBQVDIBQCV-LXCLTORNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[(Z)-2-chloro-1-[4-(2-dimethylaminoethoxy)phenyl]-2-(4-methoxyphenyl)vinyl]phenyl] 2,2-dimethylpropanoate hydrochloride
  • 2,2-dimethylpropanoic acid [4-[(Z)-2-chloro-1-[4-(2-dimethylaminoethoxy)phenyl]-2-(4-methoxyphenyl)vinyl]phenyl] ester hydrochloride
  • 2,2-dimethylpropionic acid [4-[(Z)-2-chloro-1-[4-(2-dimethylaminoethoxy)phenyl]-2-(4-methoxyphenyl)vinyl]phenyl] ester hydrochloride
  • NSC644616

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0173 0.059 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.2128 0.7942 0.7942
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0897 0.3314 0.331
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0897 0.3314 0.331
Echinococcus multilocularis rac serine:threonine kinase 0.0026 0.0038 0.0031
Loa Loa (eye worm) AGC/AKT protein kinase 0.0036 0.0078 0.0071
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0173 0.059 0.0561
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0173 0.059 0.059
Trypanosoma cruzi cyclin, putative 0.0042 0.0099 0.0069
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0897 0.3314 0.3262
Trypanosoma cruzi cyclin, putative 0.0042 0.0099 0.0069
Trichomonas vaginalis cyclin D, putative 0.0018 0.0007 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0173 0.059 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2675 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0073 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0007 0.0007
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0173 0.059 0.0583
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2675 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0173 0.059 0.059
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0173 0.059 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.1598 0.5952 0.5952
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.3314 0.3314
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0173 0.059 0.0583
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0173 0.059 0.0583
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0583
Entamoeba histolytica PH domain containing protein kinase, putative 0.0026 0.0038 0.0031
Trypanosoma brucei target of rapamycin kinase 3, putative 0.213 0.795 0.7934
Entamoeba histolytica protein kinase, putative 0.0036 0.0078 0.0071
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.2128 0.7942 0.7942
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.1844 0.1844
Loa Loa (eye worm) phosphatidylinositol 3 0.0173 0.059 0.0583
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0506 0.1844 0.1838
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0173 0.059 0.0583
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0147 0.0493 0.0487
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0173 0.059 0.0583
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0173 0.059 0.0707
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0173 0.059 0.0561
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2675 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0173 0.059 0.059
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0173 0.059 0.0516
Leishmania major phosphatidylinositol kinase, putative 0.0173 0.059 0.0496
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0506 0.1844 0.1819
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0173 0.059 0.0561
Giardia lamblia Hypothetical protein 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.1444 0.5373 0.5373
Entamoeba histolytica hypothetical protein 0.0506 0.1844 0.1838
Entamoeba histolytica protein kinase 2, putative 0.0024 0.003 0.0023
Loa Loa (eye worm) phosphatidylinositol 3 0.0173 0.059 0.0583
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0897 0.3314 0.3262
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0034 0.007 0.0063
Entamoeba histolytica PH domain containing protein kinase, putative 0.0026 0.0038 0.0031
Brugia malayi Protein kinase domain containing protein 0.0036 0.0078 0.0071
Entamoeba histolytica hypothetical protein 0.0173 0.059 0.0583
Echinococcus multilocularis cyclin B 0.0042 0.0099 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.2128 0.7942 0.7942
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0173 0.059 0.0561
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1265 0.4698 0.4656
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2675 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0057
Trichomonas vaginalis cyclin B, putative 0.0042 0.0099 0.0099
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0173 0.059 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.3314 0.3314
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0083 0.0076
Loa Loa (eye worm) phosphatidylinositol 3 0.2675 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0173 0.059 0.0583
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0173 0.059 0.0583
Trichomonas vaginalis cyclins, putative 0.0029 0.0049 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.3314 0.3314
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.059 0.0583
Trichomonas vaginalis cyclin A, putative 0.0042 0.0099 0.0099
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0173 0.059 0.0583
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0173 0.059 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.1737 0.6471 0.6471
Trichomonas vaginalis cyclin B, putative 0.0018 0.0007 0.0007
Onchocerca volvulus 0.0173 0.059 0.4664
Trichomonas vaginalis cyclins, putative 0.0042 0.0099 0.0099
Trichomonas vaginalis cyclin B, putative 0.0042 0.0099 0.0099
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0019 0.0012
Echinococcus granulosus serine/threonine protein kinase 0.0026 0.0038 0.0031
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0506 0.1844 0.1838
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0391 0.1412 0.1406
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0173 0.059 0.059
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0099 0.0092
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0083 0.0076
Leishmania major phosphatidylinositol 4-kinase, putative 0.0173 0.059 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.1844 0.1844
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0897 0.3314 0.331
Loa Loa (eye worm) TTK protein kinase 0.0147 0.0493 0.0487
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.1444 0.5373 0.5373
Trichomonas vaginalis PIKK family atypical protein kinase 0.2128 0.7942 0.7942
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0173 0.059 0.0583
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0173 0.059 0.0707
Trichomonas vaginalis PIKK family atypical protein kinase 0.1442 0.5364 0.5364
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.059 0.0583
Trichomonas vaginalis cyclins, putative 0.0042 0.0099 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.059 0.059
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0147 0.0493 0.3744
Echinococcus granulosus serine protein kinase ATM 0.0506 0.1844 0.1838
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0173 0.059 0.0583
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0322 0.1152 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0506 0.1844 0.1779
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0173 0.059 0.0583
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0173 0.059 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1794 0.6688 0.6688
Trichomonas vaginalis conserved hypothetical protein 0.0391 0.1412 0.1412
Schistosoma mansoni fkbp-rapamycin associated protein 0.0506 0.1844 0.1838
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0173 0.059 0.0561
Entamoeba histolytica hypothetical protein 0.0173 0.059 0.0583
Loa Loa (eye worm) phosphatidylinositol kinase 0.0173 0.059 0.0583
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0583
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0391 0.1412 0.1406
Trypanosoma cruzi Protein kinase B 0.0026 0.0038 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0564 0.2061 0.2061
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 1 1
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0147 0.0493 0.0487
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0173 0.059 1
Schistosoma mansoni cyclin B 0.0042 0.0099 0.0092
Giardia lamblia Phosphatidylinositol 4-kinase 0.0173 0.059 0.0583
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0083 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0173 0.059 0.0583
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.1152 0.1145
Loa Loa (eye worm) hypothetical protein 0.0564 0.2061 0.2055
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 1 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0099 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0173 0.059 0.059
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0173 0.059 0.0583
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0173 0.059 0.0516
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0173 0.059 0.0583
Echinococcus multilocularis 0.0173 0.059 0.0583
Echinococcus granulosus nervana 2 0.0021 0.0019 0.0012
Entamoeba histolytica hypothetical protein 0.0173 0.059 0.0583
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0506 0.1844 0.1838
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.3314 0.3314
Loa Loa (eye worm) hypothetical protein 0.0173 0.059 0.0583
Loa Loa (eye worm) hypothetical protein 0.0042 0.0099 0.0092
Echinococcus multilocularis serine protein kinase ATM 0.0506 0.1844 0.1838
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2675 1 1
Trichomonas vaginalis cyclin D, putative 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0391 0.1412 0.1406
Echinococcus granulosus serine threonine protein kinase nrc 0.0024 0.003 0.0023
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0173 0.059 0.0707
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0564 0.2061 0.2708
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0073 0.0073
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0173 0.059 0.059
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0173 0.059 0.0583
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0516
Trichomonas vaginalis cyclin B, putative 0.0042 0.0099 0.0099
Trichomonas vaginalis cyclins, putative 0.0042 0.0099 0.0099
Brugia malayi p70 ribosomal S6 kinase beta 0.0034 0.007 0.0063
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0083 0.0076
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0506 0.1844 0.1819
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0897 0.3314 0.3294
Loa Loa (eye worm) hypothetical protein 0.0042 0.0099 0.0092
Loa Loa (eye worm) phosphatidylinositol 3 0.0897 0.3314 0.331
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0322 0.1152 0.1145
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0583
Echinococcus granulosus cyclin B 0.0042 0.0099 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.1442 0.5364 0.5364
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0173 0.059 0.0583
Trypanosoma cruzi cyclin 6, putative 0.0042 0.0099 0.0069
Leishmania major phosphatidylinositol kinase related protein, putative 0.0173 0.059 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.1583 0.5892 0.5892
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0173 0.059 0.0583
Entamoeba histolytica hypothetical protein 0.0173 0.059 0.0583
Echinococcus multilocularis nervana 2 0.0021 0.0019 0.0012
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0333 0.1195 0.1195
Schistosoma mansoni hypothetical protein 0.0391 0.1412 0.1406
Trichomonas vaginalis PIKK family atypical protein kinase 0.1598 0.5952 0.5952
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0173 0.059 0.0583
Entamoeba histolytica cyclin, putative 0.0042 0.0099 0.0092
Onchocerca volvulus 0.0173 0.059 0.4664
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0173 0.059 0.059
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0096 0.0089
Loa Loa (eye worm) phosphatidylinositol 3 0.0173 0.059 0.0583
Trypanosoma brucei mitotic cyclin 6 0.0042 0.0099 0.0021
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0173 0.059 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.199 0.7422 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2675 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1444 0.5373 0.5373
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.1152 0.1145
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0506 0.1844 0.1838
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0322 0.1152 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.1444 0.5373 0.5373
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Toxoplasma gondii FATC domain-containing protein 0.0506 0.1844 0.2412
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0173 0.059 0.0707
Brugia malayi FAT domain containing protein 0.0391 0.1412 0.1406
Trichomonas vaginalis PIKK family atypical protein kinase 0.2128 0.7942 0.7942
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0173 0.059 1
Trichomonas vaginalis cyclin B, putative 0.0042 0.0099 0.0099
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0173 0.059 0.0583
Mycobacterium leprae conserved hypothetical protein 0.0173 0.059 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.2284 0.8529 0.8529
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0897 0.3314 0.331
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0173 0.059 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 1 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0173 0.059 1
Leishmania major hypothetical protein, unknown function 0.0173 0.059 0.0496
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0583
Mycobacterium tuberculosis Conserved hypothetical protein 0.0173 0.059 0.5
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0024 0.003 0.0023
Giardia lamblia Kinase, AGC PKA 0.0024 0.003 0.0023
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0506 0.1844 0.1838
Echinococcus granulosus Glutaredoxin protein 5 0.0021 0.0019 0.0012
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0173 0.059 0.0583
Brugia malayi Protein kinase domain containing protein 0.0147 0.0493 0.0487
Schistosoma mansoni serine/threonine-protein kinase 0.0026 0.0038 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.1583 0.5892 0.5892
Trichomonas vaginalis PIKK family atypical protein kinase 0.0718 0.264 0.264
Echinococcus granulosus nervana 2 0.0021 0.0019 0.0012
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0583
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0173 0.059 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0021 0.0019 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0333 0.1195 0.1195
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0096 0.0089
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0322 0.1152 0.1145
Loa Loa (eye worm) hypothetical protein 0.0545 0.1991 0.1985
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0173 0.059 0.059
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0897 0.3314 0.3247
Trichomonas vaginalis cyclins, putative 0.0042 0.0099 0.0099
Echinococcus multilocularis nervana 2 0.0021 0.0019 0.0012
Giardia lamblia GTOR 0.2675 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0333 0.1195 0.1168
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0173 0.059 0.0561
Giardia lamblia G2/mitotic-specific cyclin B 0.0042 0.0099 0.0092
Trichomonas vaginalis cyclins, putative 0.0018 0.0007 0.0007
Trichomonas vaginalis cyclin B3, putative 0.0018 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.3314 0.3314
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.059 0.0583
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0173 0.059 0.0561
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1111 0.4119 0.4073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.059 0.0583
Entamoeba histolytica protein kinase, putative 0.0034 0.007 0.0063
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2675 1 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0026
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0173 0.059 0.0583
Loa Loa (eye worm) phosphatidylinositol 3 0.0173 0.059 0.0583
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0506 0.1844 0.1838
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0173 0.059 0.0583
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0173 0.059 0.0583
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0897 0.3314 0.3294
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.1152 0.1145
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0026 0.0038 0.0008
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0024 0.003 0.0402
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0173 0.059 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2675 1 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0173 0.059 0.0583
Brugia malayi Protein kinase domain containing protein 0.0322 0.1152 0.1145
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0173 0.059 0.0583
Giardia lamblia Kinase, TTK 0.0147 0.0493 0.0487
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0019 0.0012
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0173 0.059 0.0707
Schistosoma mansoni serine/threonine-protein kinase 0.0026 0.0038 0.0031
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0173 0.059 0.0583
Plasmodium vivax hypothetical protein 0.0173 0.059 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Entamoeba histolytica protein kinase rad3, putative 0.0506 0.1844 0.1838
Loa Loa (eye worm) phosphatidylinositol 3 0.0173 0.059 0.0583
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0493 0.0493
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.213 0.795 0.793
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0147 0.0493 0.0487
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2675 1 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0024 0.003 0.0023
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2675 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0173 0.059 0.059
Echinococcus multilocularis Zinc finger, PHD finger 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.059 0.059
Entamoeba histolytica protein kinase, putative 0.0036 0.0078 0.0071
Leishmania major hypothetical protein, conserved 0.0173 0.059 0.0496
Leishmania major phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0496
Loa Loa (eye worm) hypothetical protein 0.0333 0.1195 0.1188
Loa Loa (eye worm) hypothetical protein 0.0506 0.1844 0.1838
Trypanosoma cruzi target of rapamycin kinase 3 0.213 0.795 0.7944
Trypanosoma cruzi CYC2-like cyclin, putative 0.0042 0.0099 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0493 0.0493
Trichomonas vaginalis PIKK family atypical protein kinase 0.1442 0.5364 0.5364
Trichomonas vaginalis PIKK family atypical protein kinase 0.1598 0.5952 0.5952
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0173 0.059 0.0516
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.1844 0.1844
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0173 0.059 0.059
Leishmania major phosphatidylinositol 3-kinase, putative 0.0897 0.3314 0.3247
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2675 1 1
Loa Loa (eye worm) hypothetical protein 0.0173 0.059 0.0583
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0173 0.059 0.0561

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.224 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.158 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.874 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.866 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.859 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.853 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.804 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.795 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.743 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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