TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 422.907 | Formula: C23H23ClN4O2
H donors: 1 H acceptors: 3 LogP: 5.42 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccc(cc1Cl)O[C@@H]1C(C)(C)[C@H](C1(C)C)NC(=O)c1cccn2c1cnc2
InChi: 1S/C23H23ClN4O2/c1-22(2)20(27-19(29)16-6-5-9-28-13-26-12-18(16)28)23(3,4)21(22)30-15-8-7-14(11-25)17(24)10-15/h5-10,12-13,20-21H,1-4H3,(H,27,29)/t20-,21-
InChiKey: PSRBRZRAUSMLCK-MEMLXQNLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3449	0.6664	0.6643
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3835	0.7424	0.7407
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0344	0.0539	0.0539
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0186	0.0227	0.0227
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0885	0.1607	0.1607
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0344	0.0539	0.0368
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.5141	1	1
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0161	0.0178	0.0178
Plasmodium vivax	hypothetical protein	0.0344	0.0539	0.8615
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0628	0.1099	0.1099
Loa Loa (eye worm)	phosphatidylinositol 3	0.0344	0.0539	0.0505
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.1003	0.1839	0.1839
Trichomonas vaginalis	conserved hypothetical protein	0.1105	0.204	0.1988
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0885	0.1607	0.1607
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0344	0.0539	0.049
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.5141	1	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1105	0.204	0.2696
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0161	0.0178	0.0178
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0595	0.1033	0.1033
Trichomonas vaginalis	fk506-binding protein, putative	0.0161	0.0178	0.0115
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0344	0.0539	0.0478
Giardia lamblia	Hypothetical protein	0.0344	0.0539	0.0368
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0628	0.1099	0.1041
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0104	0.0064	0.0028
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0344	0.0539	0.0478
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3835	0.7424	0.7407
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0344	0.0539	0.0368
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0374	0.0597	0.074
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0374	0.0597	0.0536
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0344	0.0539	0.8615
Toxoplasma gondii	target of rapamycin (TOR), putative	0.3835	0.7424	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3835	0.7424	0.7407
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0344	0.0539	0.0539
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0161	0.0178	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0134	0.0099
Loa Loa (eye worm)	phosphatidylinositol 3	0.0344	0.0539	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0063	0.0027
Loa Loa (eye worm)	phosphatidylinositol 3	0.0344	0.0539	0.0505
Brugia malayi	FAT domain containing protein	0.0761	0.136	0.1316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1003	0.1839	0.1786
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0161	0.0178	0.0127
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0536	0.0918	0.0859
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0344	0.0539	0.0539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4098	0.7943	0.793
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2796	0.5375	0.5345
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0344	0.0539	0.0539
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0174	0.0203	0.014
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0344	0.0539	0.0539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2792	0.5367	0.5337
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1764	0.3339	0.3218
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0993	0.1818	0.1775
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0628	0.1099	0.1041
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0374	0.0597	0.0597
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3835	0.7424	0.7407
Toxoplasma gondii	FATC domain-containing protein	0.0993	0.1818	0.2396
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0161	0.0178	0.0178
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0525	0.0896	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0179	0.0143
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0465	0.0778	0.0778
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0993	0.1818	0.1818
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2796	0.5375	0.5345
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0433	0.0715	0.0715
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1764	0.3339	0.3296
Leishmania major	hypothetical protein, unknown function	0.0344	0.0539	0.0368
Loa Loa (eye worm)	hypothetical protein	0.0993	0.1818	0.1788
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0433	0.0715	0.0655
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0344	0.0539	0.0505
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.5141	1	1
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0374	0.0597	0.0597
Schistosoma mansoni	hypothetical protein	0.0344	0.0539	0.0539
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0993	0.1818	0.1765
Echinococcus multilocularis		0.0344	0.0539	0.0539
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0139	0.0134	0.0134
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0525	0.0896	0.0896
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0097	0.0052	0.0016
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0374	0.0597	0.0597
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.2426	0.4645	0.461
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4098	0.7943	0.793
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.5141	1	1
Entamoeba histolytica	protein kinase, putative	0.0097	0.0052	0.0052
Loa Loa (eye worm)	phosphatidylinositol 3	0.5141	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1764	0.3339	0.3296
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0433	0.0715	0.0655
Schistosoma mansoni	immunophilin	0.0139	0.0134	0.0134
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1753	0.3318	0.3197
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3337	0.6443	0.642
Schistosoma mansoni	immunophilin	0.0161	0.0178	0.0178
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0344	0.0539	0.0539
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0374	0.0597	0.0597
Schistosoma mansoni	voltage-gated potassium channel	0.0203	0.0261	0.0261
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0374	0.0597	0.0597
Entamoeba histolytica	hypothetical protein	0.0344	0.0539	0.0539
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1802	0.3415	0.3415
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1802	0.3415	0.3381
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0477	0.08	0.0634
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0161	0.0178	0.0178
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0374	0.0597	0.0427
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0089	0.0036	0.0036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1753	0.3318	0.3275
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4098	0.7943	0.793
Mycobacterium leprae	conserved hypothetical protein	0.0344	0.0539	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0433	0.0715	0.0715
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.5141	1	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0433	0.0715	0.0715
Schistosoma mansoni	voltage-gated potassium channel	0.0203	0.0261	0.0261
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1802	0.3415	0.3415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3074	0.5924	0.5897
Leishmania major	phosphatidylinositol kinase, putative	0.0344	0.0539	0.0368
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.5141	1	1
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0161	0.0178	0.0115
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0525	0.0896	0.0848
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.4102	0.7951	0.7938
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0374	0.0597	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0344	0.0539	0.8615
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0186	0.0227	0.0176
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0374	0.0597	0.0536
Entamoeba histolytica	hypothetical protein	0.0568	0.0981	0.0981
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0161	0.0178	0.5
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0344	0.0539	0.8615
Entamoeba histolytica	hypothetical protein	0.0993	0.1818	0.1818
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0344	0.0539	0.0368
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4098	0.7943	0.793
Echinococcus granulosus	serine protein kinase ATM	0.0993	0.1818	0.1818
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0344	0.0539	0.0661
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0993	0.1818	0.1818
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.4102	0.7951	0.7914
Echinococcus multilocularis	fk506 binding protein	0.0161	0.0178	0.0178
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0344	0.0539	0.0661
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0344	0.0539	0.8615
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3835	0.7424	0.7407
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5141	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0089	0.0035	0.0035
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0344	0.0539	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0525	0.0896	0.0863
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0344	0.0539	0.5
Leishmania major	hypothetical protein, conserved	0.0433	0.0714	0.0546
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.5141	1	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0174	0.0203	0.014
Trypanosoma cruzi	target of rapamycin kinase 3	0.4102	0.7951	0.7951
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0161	0.0178	0.0115
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0161	0.0178	0.0115
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0993	0.1818	0.1818
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0761	0.136	0.136
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0344	0.0539	0.0539
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0374	0.0597	0.0536
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.5141	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0344	0.0539	0.0478
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1802	0.3415	0.3415
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0374	0.0597	0.0563
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0993	0.1818	0.1765
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3074	0.5924	0.5897
Loa Loa (eye worm)	hypothetical protein	0.0344	0.0539	0.0505
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2792	0.5367	0.5337
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0161	0.0178	0.0178
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0344	0.0539	0.0478
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.5141	1	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1753	0.3318	0.3275
Loa Loa (eye worm)	FKBP5 protein	0.0161	0.0178	0.0143
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0374	0.0597	0.0597
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0761	0.136	0.136
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.5141	1	1
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0374	0.0597	0.0597
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0433	0.0715	0.0655
Echinococcus multilocularis	Zinc finger, PHD finger	0.0374	0.0597	0.0597
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1753	0.3318	0.3275
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.2148	0.4097	0.4058
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0344	0.0539	0.049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0648	0.1139	0.1081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5141	1	1
Onchocerca volvulus		0.0344	0.0539	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0344	0.0539	0.8615
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0993	0.1818	0.1818
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0344	0.0539	0.0478
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1753	0.3318	0.3275
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0344	0.0539	0.8615
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0186	0.0227	0.0227
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0374	0.0597	0.0548
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0161	0.0178	0.0127
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0628	0.1099	0.1099
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0257	0.0368	0.0318
Entamoeba histolytica	hypothetical protein	0.0344	0.0539	0.0539
Entamoeba histolytica	hypothetical protein	0.0344	0.0539	0.0539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4098	0.7943	0.793
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0374	0.0597	0.0427
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0885	0.1607	0.1607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3835	0.7424	0.7407
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2796	0.5375	0.5345
Loa Loa (eye worm)	hypothetical protein	0.0648	0.1139	0.1107
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0993	0.1818	0.1765
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0595	0.1033	0.1033
Onchocerca volvulus		0.0344	0.0539	0.5
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0344	0.0539	0.0539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.438	0.85	0.849
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0374	0.0597	0.0536
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0374	0.0597	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0344	0.0539	0.0661
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0161	0.0178	0.0115
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.5141	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0374	0.0597	0.0597
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0374	0.0597	0.0597
Loa Loa (eye worm)	phosphatidylinositol 3	0.1764	0.3339	0.3315
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0404	0.0657	0.0487
Entamoeba histolytica	protein kinase rad3, putative	0.0993	0.1818	0.1818
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0284	0.042	0.042
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0536	0.0918	0.0859
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0648	0.1139	0.1139
Loa Loa (eye worm)	hypothetical protein	0.1039	0.1909	0.188
Entamoeba histolytica	protein kinase, putative	0.0104	0.0064	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0761	0.136	0.1305
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0161	0.0178	0.0178
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1383	0.2588	0.254
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3059	0.5894	0.5868
Loa Loa (eye worm)	hypothetical protein	0.0761	0.136	0.1329
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0344	0.0539	0.0539
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0344	0.0539	0.049
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1802	0.3415	0.3415
Echinococcus multilocularis	serine protein kinase ATM	0.0993	0.1818	0.1818
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5141	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0993	0.1818	0.1818
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0161	0.0178	0.5
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0993	0.1818	0.1818
Brugia malayi	Protein kinase domain containing protein	0.0104	0.0064	0.0013
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1802	0.3415	0.3415
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0161	0.0178	0.0178
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1753	0.3318	0.3275
Loa Loa (eye worm)	hypothetical protein	0.1105	0.204	0.2011
Trichomonas vaginalis	immunophilin, putative	0.0161	0.0178	0.0115
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0139	0.0134	0.0134
Loa Loa (eye worm)	phosphatidylinositol 3	0.0344	0.0539	0.0505
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0433	0.0715	0.0655
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0186	0.0227	0.0192
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0628	0.1099	0.1053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3074	0.5924	0.5897
Loa Loa (eye worm)	phosphatidylinositol 3	0.0826	0.1489	0.1458
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0374	0.0597	0.074
Schistosoma mansoni	hypothetical protein	0.0761	0.136	0.136
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0344	0.0539	0.0478
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2792	0.5367	0.5337
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0161	0.0178	0.0143
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0568	0.0981	0.0981
Trichomonas vaginalis	conserved hypothetical protein	0.0648	0.1139	0.1081
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0433	0.0715	0.0715
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0161	0.0178	0.0178
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3059	0.5894	0.5868
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0344	0.0539	0.0539
Giardia lamblia	GTOR	0.5141	1	1
Schistosoma mansoni	immunophilin	0.0161	0.0178	0.0178
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0344	0.0539	0.0539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3835	0.7424	0.7407
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0993	0.1818	0.1775
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2796	0.5375	0.5345
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0628	0.1099	0.1099
Entamoeba histolytica	protein kinase, putative	0.0104	0.0064	0.0064
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0628	0.1099	0.1041
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0433	0.0715	0.0667
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0161	0.0178	0.0178
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0344	0.0539	0.0539
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0344	0.0539	0.0539

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2013128

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1632759