Detailed information for compound 1635412

Basic information

Technical information
  • TDR Targets ID: 1635412
  • Name: 2-piperidin-1-yl-3,4-dihydro-2H-phenanthren-1 -one
  • MW: 279.376 | Formula: C19H21NO
  • H donors: 0 H acceptors: 1 LogP: 4.29 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(CCc2c1ccc1c2cccc1)N1CCCCC1
  • InChi: 1S/C19H21NO/c21-19-17-9-8-14-6-2-3-7-15(14)16(17)10-11-18(19)20-12-4-1-5-13-20/h2-3,6-9,18H,1,4-5,10-13H2
  • InChiKey: DEWCHKWQJYCBCB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(1-piperidyl)-3,4-dihydro-2H-phenanthren-1-one
  • 2-piperidino-3,4-dihydro-2H-phenanthren-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0556 0.0631 0.0507
Schistosoma mansoni fkbp-rapamycin associated protein 0.1492 0.1845 0.1845
Schistosoma mansoni voltage-gated potassium channel 0.026 0.0248 0.0248
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0651 0.0754 0.0717
Loa Loa (eye worm) hypothetical protein 0.1578 0.1955 0.1955
Loa Loa (eye worm) phosphatidylinositol 3 0.0858 0.1023 0.1023
Brugia malayi Protein kinase domain containing protein 0.01 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0979 0.118 0.1179
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0169 0.0131 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.2091 0.262 0.259
Trichomonas vaginalis PIKK family atypical protein kinase 0.4625 0.5903 0.5887
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0513 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.1149 0.14 0.1399
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0534 0.0603 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.6203 0.7948 0.7939
Trichomonas vaginalis PIKK family atypical protein kinase 0.5803 0.743 0.7419
Trichomonas vaginalis PIKK family atypical protein kinase 0.4225 0.5386 0.5367
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0901 0.1079 0.1079
Toxoplasma gondii FATC domain-containing protein 0.1492 0.1845 0.2449
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0717 0.0839 0.0839
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0513 0.0576 0.0576
Loa Loa (eye worm) phosphatidylinositol kinase 0.0513 0.0576 0.0575
Trichomonas vaginalis PIKK family atypical protein kinase 0.6638 0.8511 0.8505
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0534 0.0603 0.0603
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0534 0.0603 0.0565
Plasmodium vivax hypothetical protein, conserved 0.0513 0.0576 0.9422
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0169 0.0131 0.0131
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0534 0.0603 0.0603
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7787 1 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0534 0.0603 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2653 0.3348 0.3321
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0717 0.0839 0.0839
Trichomonas vaginalis PIKK family atypical protein kinase 0.4654 0.5941 0.5924
Brugia malayi FAT domain containing protein 0.1149 0.14 0.1399
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0979 0.118 0.118
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0534 0.0603 0.0603
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0513 0.0576 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.4219 0.5377 0.5358
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0169 0.0131 0.009
Entamoeba histolytica hypothetical protein 0.0674 0.0784 0.0784
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0901 0.1079 0.1079
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0577 0.0659 0.0659
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0169 0.0131 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.4625 0.5903 0.5887
Loa Loa (eye worm) phosphatidylinositol 3 0.0513 0.0576 0.0575
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7787 1 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0513 0.0576 0.0451
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0169 0.0131 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.5803 0.743 0.7419
Loa Loa (eye worm) hypothetical protein 0.1492 0.1845 0.1844
Trichomonas vaginalis PIKK family atypical protein kinase 0.4225 0.5386 0.5367
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0787 0.0931 0.0931
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0717 0.0839 0.0802
Entamoeba histolytica protein kinase, putative 0.01 0.0041 0.0041
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0577 0.0659 0.0658
Schistosoma mansoni immunophilin 0.0169 0.0131 0.0131
Entamoeba histolytica hypothetical protein 0.0513 0.0576 0.0576
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0513 0.0576 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.1149 0.14 0.1364
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0513 0.0576 0.9422
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0513 0.0576 0.0575
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2695 0.3403 0.3403
Echinococcus granulosus serine protein kinase ATM 0.1492 0.1845 0.1845
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7787 1 1
Entamoeba histolytica protein kinase rad3, putative 0.1492 0.1845 0.1845
Loa Loa (eye worm) FKBP5 protein 0.0169 0.0131 0.013
Entamoeba histolytica hypothetical protein 0.1492 0.1845 0.1845
Entamoeba histolytica protein kinase, putative 0.01 0.0041 0.0041
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2695 0.3403 0.3403
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0169 0.0131 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.2641 0.3333 0.3306
Loa Loa (eye worm) hypothetical protein 0.1662 0.2065 0.2064
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0169 0.0131 0.013
Loa Loa (eye worm) hypothetical protein 0.0146 0.01 0.01
Leishmania major phosphatidylinositol 4-kinase, putative 0.0513 0.0576 0.0451
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0238 0.022 0.022
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.06 0.0688 0.0688
Trypanosoma cruzi target of rapamycin kinase 3 0.6209 0.7956 0.7956
Schistosoma mansoni immunophilin 0.0169 0.0131 0.0131
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0169 0.0131 0.0131
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1492 0.1845 0.1845
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0513 0.0576 0.0576
Trichomonas vaginalis conserved hypothetical protein 0.0979 0.118 0.1144
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0534 0.0603 0.0565
Leishmania major phosphatidylinositol kinase related protein, putative 0.0513 0.0576 0.0451
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7787 1 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2695 0.3403 0.3403
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0534 0.0603 0.0565
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1492 0.1845 0.1844
Mycobacterium leprae conserved hypothetical protein 0.0513 0.0576 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4654 0.5941 0.5924
Trichomonas vaginalis PIKK family atypical protein kinase 0.4219 0.5377 0.5358
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1492 0.1845 0.1845
Echinococcus multilocularis voltage gated potassium channel 0.0069 0.0001 0.0001
Echinococcus granulosus voltage gated potassium channel 0.0069 0.0001 0.0001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.6209 0.7956 0.7947
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0169 0.0131 0.5
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0513 0.0576 0.9422
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0513 0.0576 0.9422
Trichomonas vaginalis PIKK family atypical protein kinase 0.5803 0.743 0.7419
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7787 1 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0094 0.0033 0.0032
Leishmania major hypothetical protein, unknown function 0.0513 0.0576 0.0451
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0643 0.0744 0.0743
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0577 0.0659 0.0659
Loa Loa (eye worm) phosphatidylinositol 3 0.0513 0.0576 0.0575
Giardia lamblia GTOR 0.7787 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0203 0.0175 0.0175
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0901 0.1079 0.1079
Trichomonas vaginalis PIKK family atypical protein kinase 0.7787 1 1
Onchocerca volvulus 0.0513 0.0576 0.5
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0513 0.0576 0.0576
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0513 0.0576 0.9422
Trichomonas vaginalis PIKK family atypical protein kinase 0.1492 0.1845 0.1811
Trichomonas vaginalis PIKK family atypical protein kinase 0.2641 0.3333 0.3306
Onchocerca volvulus 0.0513 0.0576 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0223 0.02 0.0159
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0534 0.0603 0.0479
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0169 0.0131 0.0131
Schistosoma mansoni voltage-gated potassium channel 0.026 0.0248 0.0248
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0717 0.0839 0.0839
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0513 0.0576 0.0576
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0169 0.0131 0.009
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0513 0.0576 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.7787 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.2641 0.3333 0.3245
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0169 0.0131 0.013
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0534 0.0603 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0979 0.118 0.1144
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7787 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0534 0.0603 0.0603
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0577 0.0659 0.0659
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0534 0.0603 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.2641 0.3333 0.3306
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0069 0.0001 0.0001
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3246 0.4117 0.4093
Loa Loa (eye worm) hypothetical protein 0.0513 0.0576 0.0575
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7787 1 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0094 0.0033 0.0032
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7787 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0577 0.0659 0.062
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2653 0.3348 0.3321
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0146 0.01 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.2641 0.3333 0.3306
Trichomonas vaginalis PIKK family atypical protein kinase 0.5054 0.6459 0.6445
Trichomonas vaginalis fk506-binding protein, putative 0.0169 0.0131 0.009
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0534 0.0603 0.0603
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0513 0.0576 0.0576
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0238 0.022 0.022
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0534 0.0603 0.0603
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0513 0.0576 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.4225 0.5386 0.5367
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0577 0.0659 0.062
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2653 0.3348 0.326
Plasmodium vivax hypothetical protein 0.0513 0.0576 0.9422
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1492 0.1845 0.1845
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0577 0.0659 0.0659
Trichomonas vaginalis PIKK family atypical protein kinase 0.7787 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0513 0.0576 0.0575
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0534 0.0603 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0513 0.0576 0.0537
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1492 0.1845 0.1811
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0513 0.0576 0.0537
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0146 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0643 0.0744 0.0743
Entamoeba histolytica protein kinase, putative 0.0094 0.0033 0.0033
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0534 0.0603 0.0771
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3675 0.4672 0.4651
Trichomonas vaginalis PIKK family atypical protein kinase 0.6203 0.7948 0.7939
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.6209 0.7956 0.7929
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0534 0.0603 0.0603
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0001 0.0001
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0513 0.0576 0.0576
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0238 0.022 0.0219
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0534 0.0603 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0674 0.0784 0.0784
Echinococcus multilocularis fk506 binding protein 0.0169 0.0131 0.0131
Entamoeba histolytica hypothetical protein 0.0513 0.0576 0.0576
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1492 0.1845 0.1845
Loa Loa (eye worm) phosphatidylinositol 3 0.0513 0.0576 0.0575
Trichomonas vaginalis PIKK family atypical protein kinase 0.6203 0.7948 0.7939
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1492 0.1845 0.1845
Loa Loa (eye worm) phosphatidylinositol 3 0.0513 0.0576 0.0575
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2695 0.3403 0.3403
Leishmania major hypothetical protein, conserved 0.061 0.0702 0.0579
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0169 0.0131 0.0131
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2695 0.3403 0.3403
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0534 0.0603 0.0771
Loa Loa (eye worm) hypothetical protein 0.0074 0.0007 0.0006
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2641 0.3333 0.3306
Trichomonas vaginalis PIKK family atypical protein kinase 0.6203 0.7948 0.7939
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0513 0.0576 0.0537
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0577 0.0659 0.062
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0577 0.0659 0.062
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7787 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0238 0.022 0.0219
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2695 0.3403 0.3403
Trichomonas vaginalis PIKK family atypical protein kinase 0.4654 0.5941 0.5924
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0513 0.0576 0.0576
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7787 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0169 0.0131 0.0131
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0643 0.0744 0.0744
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7787 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1662 0.2065 0.2032
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0169 0.0131 0.0131
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0717 0.0839 0.0839
Trichomonas vaginalis immunophilin, putative 0.0169 0.0131 0.009
Giardia lamblia Hypothetical protein 0.0513 0.0576 0.0451
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0001 0.0001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0717 0.0839 0.0802
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0513 0.0576 0.0734
Loa Loa (eye worm) AGC/AKT protein kinase 0.01 0.0041 0.004
Toxoplasma gondii target of rapamycin (TOR), putative 0.5803 0.743 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0513 0.0576 0.0575
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0513 0.0576 0.9422
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0534 0.0603 0.0603
Leishmania major phosphatidylinositol 3-kinase, putative 0.0534 0.0603 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0513 0.0576 0.0537
Trichomonas vaginalis PIKK family atypical protein kinase 0.5803 0.743 0.7419
Trichomonas vaginalis PIKK family atypical protein kinase 0.5803 0.743 0.7419
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0069 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0513 0.0576 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.5803 0.743 0.7419
Trichomonas vaginalis PIKK family atypical protein kinase 0.5223 0.6679 0.6665
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0513 0.0576 0.0537
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0223 0.02 0.0159
Schistosoma mansoni hypothetical protein 0.1149 0.14 0.14
Schistosoma mansoni hypothetical protein 0.0513 0.0576 0.0576
Loa Loa (eye worm) phosphatidylinositol 3 0.7787 1 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0169 0.0131 0.0131
Leishmania major phosphatidylinositol kinase, putative 0.0513 0.0576 0.0451
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0513 0.0576 0.0576
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0717 0.0839 0.0802
Trichomonas vaginalis PIKK family atypical protein kinase 0.1504 0.1859 0.1826
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1662 0.2065 0.2747
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1149 0.14 0.14
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0513 0.0576 0.0734
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0513 0.0576 0.0734
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0513 0.0576 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.6203 0.7948 0.7939
Trichomonas vaginalis PIKK family atypical protein kinase 0.4225 0.5386 0.5367
Loa Loa (eye worm) hypothetical protein 0.0207 0.0179 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.4219 0.5377 0.5358
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0513 0.0576 0.0576
Loa Loa (eye worm) phosphatidylinositol 3 0.2653 0.3348 0.3348
Echinococcus multilocularis serine protein kinase ATM 0.1492 0.1845 0.1845
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0787 0.0931 0.0931
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0534 0.0603 0.0565
Trichomonas vaginalis PIKK family atypical protein kinase 0.5803 0.743 0.7419
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1492 0.1845 0.1844
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0185 0.015 0.015
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0643 0.0744 0.0744
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0169 0.0131 0.0131
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0608 0.0699 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.1492 0.1845 0.1811
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0169 0.0131 0.0131
Schistosoma mansoni immunophilin 0.0146 0.01 0.01
Mycobacterium tuberculosis Conserved hypothetical protein 0.0513 0.0576 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0097 0.0037 0.0037
Echinococcus multilocularis 0.0513 0.0576 0.0576
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1149 0.14 0.14
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1504 0.1859 0.1859
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0169 0.0131 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0651 0.0754 0.0717

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.