Detailed information for compound 1635414

Basic information

Technical information
  • TDR Targets ID: 1635414
  • Name: 3,4-dimethoxy-N-[(E)-2-methyl-3-phenylprop-2- enyl]-N-[2-(1-methylpyrrolidin-2-yl)ethyl]ben zamide
  • MW: 422.56 | Formula: C26H34N2O3
  • H donors: 0 H acceptors: 1 LogP: 5.03 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C(=O)N(C/C(=C/c1ccccc1)/C)CCC1CCCN1C
  • InChi: 1S/C26H34N2O3/c1-20(17-21-9-6-5-7-10-21)19-28(16-14-23-11-8-15-27(23)2)26(29)22-12-13-24(30-3)25(18-22)31-4/h5-7,9-10,12-13,17-18,23H,8,11,14-16,19H2,1-4H3/b20-17+
  • InChiKey: BKSVQXNMVYSZEC-LVZFUZTISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3,4-dimethoxy-N-[(E)-2-methyl-3-phenyl-prop-2-enyl]-N-[2-(1-methylpyrrolidin-2-yl)ethyl]benzamide
  • 3,4-dimethoxy-N-[(E)-2-methyl-3-phenylprop-2-enyl]-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens atypical chemokine receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor atypical chemokine receptor 3 362 aa 379 aa 19.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0302 0.0537 0.0724
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0867 0.182 0.1772
Mycobacterium tuberculosis Conserved hypothetical protein 0.0302 0.0537 0.5
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0302 0.0537 0.0535
Loa Loa (eye worm) phosphatidylinositol 3 0.4474 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0392 0.0742 0.0742
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0331 0.0605 0.0603
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1542 0.3349 0.3283
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0302 0.0537 0.0482
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0867 0.182 0.1818
Trichomonas vaginalis PIKK family atypical protein kinase 0.2437 0.538 0.5375
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0392 0.0742 0.0742
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0331 0.0605 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.211 0.4639 0.4634
Trichomonas vaginalis PIKK family atypical protein kinase 0.3568 0.7945 0.7943
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0093 0.0065 0.0063
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0485 0.0953 0.0953
Entamoeba histolytica protein kinase, putative 0.0069 0.001 0.001
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1542 0.3349 0.3343
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0392 0.0742 0.0688
Loa Loa (eye worm) hypothetical protein 0.0104 0.009 0.009
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4474 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4474 1 1
Brugia malayi Protein kinase domain containing protein 0.0069 0.001 0.001
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0331 0.0605 0.0603
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0302 0.0537 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.2905 0.644 0.6437
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0331 0.0605 0.0815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.0537 0.0528
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0108 0.0099 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.0247 0.0414 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.1531 0.3325 0.3318
Trichomonas vaginalis PIKK family atypical protein kinase 0.1531 0.3325 0.3318
Trichomonas vaginalis PIKK family atypical protein kinase 0.3568 0.7945 0.7943
Loa Loa (eye worm) phosphatidylinositol kinase 0.0302 0.0537 0.0537
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1582 0.3441 0.3402
Trichomonas vaginalis fk506-binding protein, putative 0.0108 0.0099 0.009
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0436 0.0842 0.075
Loa Loa (eye worm) hypothetical protein 0.0066 0.0002 0.0002
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0331 0.0605 0.0596
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1582 0.3441 0.3402
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0485 0.0953 0.0951
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0302 0.0537 0.0535
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4474 1 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0108 0.0099 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.0247 0.0414 0.0412
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1582 0.3441 0.3441
Trichomonas vaginalis PIKK family atypical protein kinase 0.2676 0.5922 0.5918
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0392 0.0742 0.0742
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4474 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0392 0.0742 0.0733
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0302 0.0537 0.0482
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0226 0.0367 0.0367
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0331 0.0605 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3572 0.7953 0.7951
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0867 0.182 0.1812
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0302 0.0537 0.8663
Toxoplasma gondii FATC domain-containing protein 0.0867 0.182 0.2451
Schistosoma mansoni hypothetical protein 0.0302 0.0537 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.3568 0.7945 0.7943
Giardia lamblia Phosphatidylinositol 4-kinase 0.0302 0.0537 0.0443
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0331 0.0605 0.0596
Entamoeba histolytica hypothetical protein 0.0529 0.1052 0.1052
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0108 0.0099 0.009
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0302 0.0537 0.0482
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.085 0.1781 0.1779
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0302 0.0537 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.3339 0.7426 0.7424
Trichomonas vaginalis PIKK family atypical protein kinase 0.3003 0.6663 0.6659
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0226 0.0367 0.0365
Loa Loa (eye worm) hypothetical protein 0.0965 0.2042 0.2042
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.085 0.1781 0.1779
Leishmania major hypothetical protein, unknown function 0.0302 0.0537 0.0443
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0302 0.0537 0.0535
Loa Loa (eye worm) hypothetical protein 0.0566 0.1136 0.1136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.0537 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0878 0.1845 0.1837
Echinococcus multilocularis fk506 binding protein 0.0108 0.0099 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.4474 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0302 0.0537 0.0724
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0566 0.1136 0.1084
Loa Loa (eye worm) AGC/AKT protein kinase 0.0069 0.001 0.001
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0562 0.1127 0.1125
Schistosoma mansoni immunophilin 0.0108 0.0099 0.0097
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0302 0.0537 0.0535
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0108 0.0099 0.0099
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4474 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0965 0.2042 0.2035
Trichomonas vaginalis PIKK family atypical protein kinase 0.3339 0.7426 0.7424
Giardia lamblia Hypothetical protein 0.0302 0.0537 0.0443
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0302 0.0537 0.0535
Toxoplasma gondii target of rapamycin (TOR), putative 0.3339 0.7426 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0302 0.0537 0.0443
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0331 0.0605 0.0596
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0331 0.0605 0.0596
Echinococcus multilocularis 0.0302 0.0537 0.0535
Trichomonas vaginalis PIKK family atypical protein kinase 0.3339 0.7426 0.7424
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0093 0.0065 0.0063
Loa Loa (eye worm) phosphatidylinositol 3 0.0302 0.0537 0.0537
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0108 0.0099 0.0041
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0108 0.0099 0.0097
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0496 0.0979 0.097
Loa Loa (eye worm) hypothetical protein 0.0664 0.1358 0.1358
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0878 0.1845 0.1845
Mycobacterium leprae conserved hypothetical protein 0.0302 0.0537 0.5
Entamoeba histolytica protein kinase, putative 0.0069 0.001 0.001
Loa Loa (eye worm) phosphatidylinositol 3 0.1542 0.3349 0.3349
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0867 0.182 0.182
Plasmodium vivax hypothetical protein 0.0302 0.0537 0.8663
Trichomonas vaginalis PIKK family atypical protein kinase 0.2433 0.5371 0.5367
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0302 0.0537 0.0537
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0302 0.0537 0.8663
Trichomonas vaginalis PIKK family atypical protein kinase 0.3568 0.7945 0.7943
Trichomonas vaginalis PIKK family atypical protein kinase 0.2437 0.538 0.5375
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0212 0.0333 0.0324
Entamoeba histolytica hypothetical protein 0.0867 0.182 0.182
Loa Loa (eye worm) hypothetical protein 0.0197 0.0299 0.0299
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0485 0.0953 0.0951
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0108 0.0099 0.0041
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0424 0.0815 0.0815
Trichomonas vaginalis PIKK family atypical protein kinase 0.3339 0.7426 0.7424
Entamoeba histolytica protein kinase rad3, putative 0.0867 0.182 0.182
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0589 0.1189 0.1181
Echinococcus multilocularis Zinc finger, PHD finger 0.0331 0.0605 0.0603
Echinococcus granulosus serine protein kinase ATM 0.0867 0.182 0.1818
Trichomonas vaginalis PIKK family atypical protein kinase 0.2437 0.538 0.5375
Trichomonas vaginalis PIKK family atypical protein kinase 0.3339 0.7426 0.7424
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0589 0.1189 0.1181
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0302 0.0537 0.0535
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.085 0.1781 0.1779
Trichomonas vaginalis PIKK family atypical protein kinase 0.3568 0.7945 0.7943
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0331 0.0605 0.0603
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0331 0.0605 0.0511
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4474 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0331 0.0605 0.0511
Trichomonas vaginalis PIKK family atypical protein kinase 0.1542 0.3349 0.3343
Trichomonas vaginalis PIKK family atypical protein kinase 0.3811 0.8495 0.8494
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0331 0.0605 0.0605
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0331 0.0605 0.0815
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0108 0.0099 0.0041
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0302 0.0537 0.0528
Onchocerca volvulus 0.0302 0.0537 0.5
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0562 0.1127 0.1125
Loa Loa (eye worm) phosphatidylinositol 3 0.0302 0.0537 0.0537
Echinococcus multilocularis serine protein kinase ATM 0.0867 0.182 0.1818
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0362 0.0675 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.1204 0.2584 0.2577
Trichomonas vaginalis PIKK family atypical protein kinase 0.2666 0.5898 0.5894
Trichomonas vaginalis immunophilin, putative 0.0108 0.0099 0.009
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0589 0.1189 0.1138
Loa Loa (eye worm) hypothetical protein 0.0903 0.19 0.19
Schistosoma mansoni immunophilin 0.0093 0.0065 0.0063
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0664 0.1358 0.1356
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0288 0.0506 0.0506
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0496 0.0979 0.097
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4474 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0867 0.182 0.1818
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0108 0.0099 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0302 0.0537 0.0537
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1582 0.3441 0.3439
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0867 0.182 0.1772
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0302 0.0537 0.8663
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0664 0.1358 0.1356
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0108 0.0099 0.009
Loa Loa (eye worm) hypothetical protein 0.0093 0.0065 0.0065
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0302 0.0537 0.0528
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0226 0.0367 0.0365
Leishmania major hypothetical protein, conserved 0.0394 0.0746 0.0654
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0965 0.2042 0.275
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1582 0.3441 0.3439
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0108 0.0099 0.0099
Leishmania major phosphatidylinositol 3-kinase, putative 0.1531 0.3325 0.3258
Loa Loa (eye worm) hypothetical protein 0.0867 0.182 0.182
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0058 0.0058
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0392 0.0742 0.0733
Trichomonas vaginalis PIKK family atypical protein kinase 0.2666 0.5898 0.5894
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0108 0.0099 0.0099
Plasmodium vivax hypothetical protein, conserved 0.0302 0.0537 0.8663
Entamoeba histolytica hypothetical protein 0.0302 0.0537 0.0537
Trichomonas vaginalis PIKK family atypical protein kinase 0.2433 0.5371 0.5367
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0108 0.0099 0.009
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0529 0.1052 0.1052
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0589 0.1189 0.1138
Loa Loa (eye worm) phosphatidylinositol 3 0.079 0.1644 0.1644
Trichomonas vaginalis PIKK family atypical protein kinase 0.2676 0.5922 0.5918
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0331 0.0605 0.0605
Trichomonas vaginalis conserved hypothetical protein 0.0664 0.1358 0.135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0566 0.1136 0.1127
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0302 0.0537 0.0535
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.0062 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0566 0.1136 0.1127
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0392 0.0742 0.0733
Entamoeba histolytica hypothetical protein 0.0302 0.0537 0.0537
Loa Loa (eye worm) FKBP5 protein 0.0108 0.0099 0.0099
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0867 0.182 0.1818
Trichomonas vaginalis PIKK family atypical protein kinase 0.2437 0.538 0.5375
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0589 0.1189 0.1189
Trichomonas vaginalis PIKK family atypical protein kinase 0.4474 1 1
Schistosoma mansoni immunophilin 0.0108 0.0099 0.0097
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0302 0.0537 0.0537
Trichomonas vaginalis PIKK family atypical protein kinase 0.3339 0.7426 0.7424
Trichomonas vaginalis PIKK family atypical protein kinase 0.3339 0.7426 0.7424
Entamoeba histolytica hypothetical protein 0.0302 0.0537 0.0537
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3572 0.7953 0.7933
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0108 0.0099 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0302 0.0537 0.0528
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0867 0.182 0.182
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4474 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0212 0.0333 0.0324
Leishmania major phosphatidylinositol kinase, putative 0.0302 0.0537 0.0443
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0066 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0485 0.0953 0.0953
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0392 0.0742 0.074
Loa Loa (eye worm) hypothetical protein 0.0302 0.0537 0.0537
Giardia lamblia GTOR 0.4474 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0867 0.182 0.1812
Brugia malayi FAT domain containing protein 0.0664 0.1358 0.1358
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0302 0.0537 0.8663
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0108 0.0099 0.0099
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0108 0.0099 0.009
Trypanosoma cruzi target of rapamycin kinase 3 0.3572 0.7953 0.7941
Trichomonas vaginalis PIKK family atypical protein kinase 0.2676 0.5922 0.5918
Loa Loa (eye worm) phosphatidylinositol 3 0.0302 0.0537 0.0537
Trichomonas vaginalis PIKK family atypical protein kinase 0.2433 0.5371 0.5367
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0331 0.0605 0.0605
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4474 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0302 0.0537 0.0537
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1582 0.3441 0.3439
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0331 0.0605 0.055
Schistosoma mansoni fkbp-rapamycin associated protein 0.0867 0.182 0.1818
Schistosoma mansoni hypothetical protein 0.0664 0.1358 0.1356
Trichomonas vaginalis PIKK family atypical protein kinase 0.4474 1 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0108 0.0099 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.1531 0.3325 0.3318
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0331 0.0605 0.055
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0108 0.0099 0.0099
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0302 0.0537 0.0535
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1871 0.4097 0.4092
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0302 0.0537 0.8663
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0331 0.0605 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.1531 0.3325 0.3318
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0392 0.0742 0.0733
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4474 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0331 0.0605 0.0603
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1531 0.3325 0.3318
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0302 0.0537 0.0724
Leishmania major phosphatidylinositol kinase related protein, putative 0.0302 0.0537 0.0443
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0302 0.0537 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0867 0.182 0.1812
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4474 1 1
Onchocerca volvulus 0.0302 0.0537 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0589 0.1189 0.1189
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0108 0.0099 0.0041
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0261 0.0445 0.0445
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0589 0.1189 0.1181
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0302 0.0537 0.0537
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0226 0.0367 0.0367
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0331 0.0605 0.0605

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 7.6 Displacement of [125I]-CXCL12 from human CXCR7 expressed in HEK293 cells after 3 hrs ChEMBL. 22424612

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.