TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 420.544 | Formula: C26H32N2O3
H donors: 0 H acceptors: 1 LogP: 4.81 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: C/C(=C\c1ccccc1)/CN(C(=O)c1ccc2c(c1)OCCO2)CCC1CCCN1C
InChi: 1S/C26H32N2O3/c1-20(17-21-7-4-3-5-8-21)19-28(14-12-23-9-6-13-27(23)2)26(29)22-10-11-24-25(18-22)31-16-15-30-24/h3-5,7-8,10-11,17-18,23H,6,9,12-16,19H2,1-2H3/b20-17+
InChiKey: GTCPVFWDKLPXPL-LVZFUZTISA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	atypical chemokine receptor 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	atypical chemokine receptor 3	362 aa	379 aa	19.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0189	0.0284	0.0267
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0315	0.0555	0.0548
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3174	0.6669	0.666
Toxoplasma gondii	target of rapamycin (TOR), putative	0.3529	0.743	1
Brugia malayi	FAT domain containing protein	0.0701	0.1381	0.1381
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0315	0.0555	0.0548
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.4731	1	1
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0159	0.0221	0.0221
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0924	0.1856	0.1834
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0315	0.0555	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0504	0.0959	0.0959
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0315	0.0555	0.0555
Leishmania major	hypothetical protein, unknown function	0.0315	0.0555	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0701	0.1381	0.1381
Loa Loa (eye worm)	hypothetical protein	0.1017	0.2055	0.2055
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1017	0.2055	0.2749
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4731	1	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0159	0.0221	0.0214
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0315	0.0555	0.0555
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0159	0.0221	0.0195
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0504	0.0959	0.0952
Entamoeba histolytica	protein kinase, putative	0.0068	0.0027	0.0009
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0504	0.0959	0.0934
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0315	0.0555	0.0725
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0315	0.0555	0.0529
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.743	0.7423
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0335	0.0597	0.0597
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0335	0.0597	0.0597
Leishmania major	phosphatidylinositol kinase, putative	0.0315	0.0555	0.0341
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.743	0.7423
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0315	0.0555	0.0555
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0315	0.0555	0.0555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.743	0.7423
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0159	0.0221	0.0195
Loa Loa (eye worm)	phosphatidylinositol 3	0.0315	0.0555	0.0555
Schistosoma mansoni	immunophilin	0.0137	0.0175	0.0175
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0068	0.0027	0.0027
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0315	0.0555	0.0529
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0924	0.1856	0.1842
Schistosoma mansoni	hypothetical protein	0.0701	0.1381	0.1381
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0443	0.0828	0.0804
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0159	0.0221	0.0195
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.018	0.0265	0.0239
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0315	0.0555	0.8885
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2574	0.5386	0.5373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3771	0.7948	0.7942
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0315	0.0555	0.0555
Plasmodium vivax	hypothetical protein	0.0315	0.0555	0.8885
Trichomonas vaginalis	PIKK family atypical protein kinase	0.257	0.5378	0.5365
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0913	0.1833	0.1833
Loa Loa (eye worm)	phosphatidylinositol 3	0.1625	0.3356	0.3356
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0335	0.0597	0.0571
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0569	0.1099	0.1099
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0913	0.1833	0.1833
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.743	0.7423
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0403	0.0743	0.0534
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0159	0.0221	0.0221
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0435	0.0812	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0238	0.0238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0913	0.1833	0.1811
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0375	0.0682	0.0657
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2574	0.5386	0.5373
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0913	0.1833	0.1827
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0315	0.0555	0.0548
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1625	0.3356	0.3338
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0335	0.0597	0.0597
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0375	0.0682	0.0665
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.4731	1	1
Onchocerca volvulus		0.0315	0.0555	0.5
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0315	0.0555	0.0529
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0913	0.1833	0.1833
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0315	0.0555	0.0725
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0064	0.0018	0.0018
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0435	0.0812	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0175	0.0175
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3771	0.7948	0.7942
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.223	0.4651	0.4637
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0335	0.0597	0.058
Entamoeba histolytica	protein kinase, putative	0.0068	0.0027	0.0009
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.4731	1	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.4731	1	1
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0137	0.0175	0.0175
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1625	0.3356	0.3338
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0375	0.0682	0.0657
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1614	0.3334	0.3316
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0192	0.0292	0.0292
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0159	0.0221	0.0204
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0335	0.0597	0.0571
Onchocerca volvulus		0.0315	0.0555	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.307	0.6448	0.6438
Entamoeba histolytica	hypothetical protein	0.0315	0.0555	0.0538
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0335	0.0597	0.0781
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1664	0.344	0.3435
Loa Loa (eye worm)	phosphatidylinositol 3	0.0059	0.0008	0.0008
Echinococcus multilocularis	Zinc finger, PHD finger	0.0335	0.0597	0.0597
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0159	0.0221	0.5
Leishmania major	hypothetical protein, conserved	0.0405	0.0748	0.0538
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1664	0.344	0.344
Mycobacterium leprae	conserved hypothetical protein	0.0315	0.0555	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3771	0.7948	0.7942
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1614	0.3334	0.3316
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.4731	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0375	0.0682	0.0665
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0375	0.0682	0.0682
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2828	0.593	0.5919
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1664	0.344	0.344
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0192	0.0292	0.0292
Loa Loa (eye worm)	FKBP5 protein	0.0159	0.0221	0.0221
Entamoeba histolytica	hypothetical protein	0.0315	0.0555	0.0538
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.4731	1	1
Loa Loa (eye worm)	hypothetical protein	0.0435	0.0812	0.0812
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.3775	0.7956	0.795
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0335	0.0597	0.0384
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0192	0.0292	0.0292
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0315	0.0555	0.0548
Entamoeba histolytica	hypothetical protein	0.0464	0.0874	0.0857
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0159	0.0221	0.0214
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0335	0.0597	0.0571
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0315	0.0555	0.0529
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3771	0.7948	0.7942
Schistosoma mansoni	hypothetical protein	0.0315	0.0555	0.0555
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0913	0.1833	0.1811
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0315	0.0555	0.8885
Toxoplasma gondii	FATC domain-containing protein	0.0913	0.1833	0.2449
Echinococcus granulosus	serine protein kinase ATM	0.0913	0.1833	0.1833
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0315	0.0555	0.0529
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0159	0.0221	0.0214
Trypanosoma cruzi	target of rapamycin kinase 3	0.3775	0.7956	0.7954
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0315	0.0555	0.0538
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.743	0.7423
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.4731	1	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0315	0.0555	0.0555
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0375	0.0682	0.0657
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0435	0.0812	0.0812
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0315	0.0555	0.0341
Brugia malayi	p70 ribosomal S6 kinase beta	0.0064	0.0018	0.0018
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0171	0.0247	0.0247
Giardia lamblia	GTOR	0.4731	1	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.3775	0.7956	0.791
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0159	0.0221	0.0204
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0159	0.0221	0.0221
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0315	0.0555	0.8885
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0675	0.1325	0.1325
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0913	0.1833	0.1833
Echinococcus multilocularis	serine protein kinase ATM	0.0913	0.1833	0.1833
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1664	0.344	0.3435
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0335	0.0597	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0315	0.0555	0.0555
Loa Loa (eye worm)	phosphatidylinositol 3	0.4731	1	1
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0335	0.0597	0.0597
Trichomonas vaginalis	PIKK family atypical protein kinase	0.257	0.5378	0.5365
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2828	0.593	0.5919
Loa Loa (eye worm)	phosphatidylinositol 3	0.0315	0.0555	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0315	0.0555	0.0555
Schistosoma mansoni	immunophilin	0.0159	0.0221	0.0221
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0335	0.0597	0.059
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0159	0.0221	0.0221
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1614	0.3334	0.3316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4731	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0635	0.124	0.124
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0335	0.0597	0.058
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.4731	1	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0375	0.0682	0.0682
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1614	0.3334	0.3316
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0335	0.0597	1
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0315	0.0555	0.8885
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.1976	0.4107	0.4091
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0598	0.1159	0.1153
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0315	0.0555	0.0555
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.4731	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0913	0.1833	0.1833
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0315	0.0555	0.0548
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0315	0.0555	0.0341
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0315	0.0555	0.0725
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1614	0.3334	0.3316
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0335	0.0597	0.0781
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.018	0.0265	0.0239
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0315	0.0555	0.0555
Schistosoma mansoni	voltage-gated potassium channel	0.021	0.033	0.033
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0504	0.0959	0.0934
Echinococcus multilocularis	fk506 binding protein	0.0159	0.0221	0.0221
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0335	0.0597	0.0597
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0701	0.1381	0.1381
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3771	0.7948	0.7942
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0315	0.0555	0.0341
Trichomonas vaginalis	conserved hypothetical protein	0.0598	0.1159	0.1135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2574	0.5386	0.5373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.743	0.7423
Entamoeba histolytica	protein kinase rad3, putative	0.0913	0.1833	0.1819
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0315	0.0555	0.0555
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0504	0.0959	0.0934
Echinococcus multilocularis		0.0315	0.0555	0.0555
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0159	0.0221	0.0214
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0315	0.0555	0.0529
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0335	0.0597	0.0571
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0335	0.0597	0.0597
Trichomonas vaginalis	PIKK family atypical protein kinase	0.403	0.85	0.8496
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1625	0.3356	0.3206
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0335	0.0597	0.059
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0335	0.0597	0.0384
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.4731	1	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0355	0.064	0.0428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0913	0.1833	0.1811
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0443	0.0828	0.0804
Schistosoma mansoni	voltage-gated potassium channel	0.021	0.033	0.033
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0675	0.1325	0.1325
Trypanosoma cruzi	hypothetical protein, conserved	0.009	0.0074	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0956	0.1925	0.1925
Loa Loa (eye worm)	hypothetical protein	0.0598	0.1159	0.1159
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0159	0.0221	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2816	0.5904	0.5893
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1271	0.2599	0.2579
Trichomonas vaginalis	conserved hypothetical protein	0.0701	0.1381	0.1358
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0315	0.0555	0.8885
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0913	0.1833	0.1833
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0315	0.0555	0.0555
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1664	0.344	0.344
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0159	0.0221	0.0221
Entamoeba histolytica	hypothetical protein	0.0913	0.1833	0.1819
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.4731	1	1
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0913	0.1833	0.1833
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1614	0.3334	0.3183
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0159	0.0221	0.0221
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1664	0.344	0.344
Trichomonas vaginalis	conserved hypothetical protein	0.1017	0.2055	0.2034
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0192	0.0292	0.0292
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0396	0.0727	0.071
Loa Loa (eye worm)	phosphatidylinositol 3	0.0315	0.0555	0.0555
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0159	0.0221	0.0221
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0137	0.0175	0.0175
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0504	0.0959	0.0942
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0675	0.1325	0.1325
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0335	0.0597	0.0597
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2828	0.593	0.5919
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0701	0.1381	0.1381
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0464	0.0874	0.0857
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0598	0.1159	0.1135
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0159	0.0221	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.257	0.5378	0.5365
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0315	0.0555	0.0555
Trichomonas vaginalis	immunophilin, putative	0.0159	0.0221	0.0195
Plasmodium vivax	hypothetical protein, conserved	0.0315	0.0555	0.8885
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2816	0.5904	0.5893
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0375	0.0682	0.0657
Trichomonas vaginalis	fk506-binding protein, putative	0.0159	0.0221	0.0195
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.743	0.7423
Giardia lamblia	Hypothetical protein	0.0315	0.0555	0.0341
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4731	1	1
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0569	0.1099	0.1099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2574	0.5386	0.5373
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0913	0.1833	0.1827
Schistosoma mansoni	immunophilin	0.0159	0.0221	0.0221
Entamoeba histolytica	hypothetical protein	0.0315	0.0555	0.0538
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0375	0.0682	0.0675
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0504	0.0959	0.0952
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0027	0.0027
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0315	0.0555	0.0555

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 6.1	Displacement of [125I]-CXCL12 from human CXCR7 expressed in HEK293 cells after 3 hrs	ChEMBL.	22424612

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2013221

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1635415