Detailed information for compound 1635416

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 548.675 | Formula: C34H36N4O3
  • H donors: 2 H acceptors: 4 LogP: 5.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)CC[C@H]1[C@H](C)/C/2=C/c3[nH]c(c(c3C)C=C)/C=C/3\N=C(/C=c/4\[nH]c5=C(C1=N2)CC(=O)c5c4C)C(=C3C)CC
  • InChi: 1S/C34H36N4O3/c1-8-20-16(3)24-13-26-18(5)22(10-11-31(40)41-7)33(37-26)23-12-30(39)32-19(6)27(38-34(23)32)15-29-21(9-2)17(4)25(36-29)14-28(20)35-24/h8,13-15,18,22,35,38H,1,9-12H2,2-7H3/b24-13-,25-14-,26-13-,27-15-,28-14-,29-15-,33-23-/t18-,22-/m0/s1
  • InChiKey: RYLBYBPLWNFWPG-CMMLGHQLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.6714 0.7948 0.794
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3979 0.4677 0.4656
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0575 0.0605 0.0605
Brugia malayi p70 ribosomal S6 kinase beta 0.0096 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0681 0.0732 0.0732
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0145 0.0091 0.0091
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0554 0.0581 0.0543
Echinococcus granulosus serine protein kinase ATM 0.1613 0.1847 0.1847
Plasmodium vivax hypothetical protein 0.0554 0.0581 0.9493
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0575 0.0605 0.0568
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0554 0.0581 0.0581
Giardia lamblia GTOR 0.843 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0617 0.0655 0.0618
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1613 0.1847 0.1847
Entamoeba histolytica hypothetical protein 0.0554 0.0581 0.0579
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2867 0.3347 0.3321
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0617 0.0655 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.4572 0.5386 0.5368
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0554 0.0581 0.9493
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0575 0.0605 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0581 0.0543
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0575 0.0605 0.0775
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0168 0.0118 0.0118
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0238 0.0202 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.5471 0.6461 0.6447
Trichomonas vaginalis PIKK family atypical protein kinase 0.2856 0.3334 0.3307
Loa Loa (eye worm) hypothetical protein 0.0145 0.0091 0.0091
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2867 0.3347 0.3267
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0617 0.0655 0.0618
Loa Loa (eye worm) phosphatidylinositol 3 0.843 1 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0096 0.0032 0.0032
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.843 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0681 0.0732 0.0732
Schistosoma mansoni immunophilin 0.0168 0.0118 0.0118
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.843 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0554 0.0581 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.5038 0.5943 0.5927
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2909 0.3397 0.3397
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0238 0.0202 0.0202
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.843 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0617 0.0655 0.0654
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0617 0.0655 0.0655
Mycobacterium leprae conserved hypothetical protein 0.0554 0.0581 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.6714 0.7948 0.794
Trichomonas vaginalis PIKK family atypical protein kinase 0.2856 0.3334 0.3307
Loa Loa (eye worm) hypothetical protein 0.0072 0.0004 0.0004
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0575 0.0605 1
Leishmania major hypothetical protein, conserved 0.0649 0.0694 0.0583
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2909 0.3397 0.3397
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0168 0.0118 0.0118
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2909 0.3397 0.3396
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0554 0.0581 0.0581
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1613 0.1847 0.1846
Trichomonas vaginalis PIKK family atypical protein kinase 0.6714 0.7948 0.794
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0554 0.0581 0.0742
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1613 0.1847 0.1846
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0554 0.0581 0.0543
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0168 0.0118 0.5
Entamoeba histolytica hypothetical protein 0.0712 0.0768 0.0767
Echinococcus multilocularis Zinc finger, PHD finger 0.0575 0.0605 0.0605
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0238 0.0202 0.0202
Entamoeba histolytica hypothetical protein 0.0554 0.0581 0.0579
Echinococcus multilocularis rac serine:threonine kinase 0.007 0.0001 0.0001
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0575 0.0605 0.0604
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.6721 0.7956 0.7932
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0554 0.0581 0.9493
Schistosoma mansoni hypothetical protein 0.1243 0.1404 0.1404
Loa Loa (eye worm) hypothetical protein 0.1797 0.2067 0.2067
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1625 0.1861 0.186
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0753 0.0819 0.0782
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0554 0.0581 0.0581
Plasmodium vivax hypothetical protein, conserved 0.0554 0.0581 0.9493
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0168 0.0118 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.843 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0554 0.0581 0.0543
Brugia malayi FAT domain containing protein 0.1243 0.1404 0.1404
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0223 0.0184 0.0145
Leishmania major phosphatidylinositol kinase, putative 0.0554 0.0581 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.6281 0.743 0.742
Trichomonas vaginalis PIKK family atypical protein kinase 0.5655 0.6681 0.6668
Leishmania major phosphatidylinositol kinase related protein, putative 0.0554 0.0581 0.0468
Trichomonas vaginalis PIKK family atypical protein kinase 0.6281 0.743 0.742
Trichomonas vaginalis PIKK family atypical protein kinase 0.6281 0.743 0.742
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0554 0.0581 0.0742
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0575 0.0605 0.0604
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0575 0.0605 0.0605
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0554 0.0581 0.9493
Trichomonas vaginalis PIKK family atypical protein kinase 0.6281 0.743 0.742
Loa Loa (eye worm) phosphatidylinositol 3 0.0554 0.0581 0.0581
Brugia malayi Protein kinase domain containing protein 0.0102 0.004 0.004
Schistosoma mansoni serine/threonine-protein kinase 0.007 0.0001 0.0001
Giardia lamblia Hypothetical protein 0.0554 0.0581 0.0468
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0753 0.0819 0.0782
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0554 0.0581 0.0579
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0168 0.0118 0.0118
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0753 0.0819 0.0818
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0168 0.0118 0.0117
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1797 0.2067 0.2751
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.843 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0689 0.0742 0.0705
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0168 0.0118 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.1625 0.1861 0.1828
Loa Loa (eye worm) hypothetical protein 0.1243 0.1404 0.1404
Onchocerca volvulus 0.0554 0.0581 0.5
Entamoeba histolytica protein kinase, putative 0.0096 0.0032 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.0581 0.0543
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0145 0.0091 0.0091
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0168 0.0118 0.0079
Entamoeba histolytica protein kinase rad3, putative 0.1613 0.1847 0.1846
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0647 0.0692 0.058
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0168 0.0118 0.0079
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0681 0.0732 0.0732
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0181 0.0133 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.6281 0.743 0.742
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1613 0.1847 0.1815
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0575 0.0605 0.0493
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0823 0.0901 0.0901
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1613 0.1847 0.1847
Loa Loa (eye worm) phosphatidylinositol 3 0.2867 0.3347 0.3347
Trichomonas vaginalis PIKK family atypical protein kinase 0.4565 0.5378 0.5359
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0554 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0207 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0554 0.0581 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.4572 0.5386 0.5368
Trichomonas vaginalis PIKK family atypical protein kinase 0.6714 0.7948 0.794
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0554 0.0581 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.2867 0.3347 0.3321
Leishmania major phosphatidylinositol 3-kinase, putative 0.0575 0.0605 0.0493
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0575 0.0605 0.0568
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.843 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0554 0.0581 0.0581
Trichomonas vaginalis immunophilin, putative 0.0168 0.0118 0.0079
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0575 0.0605 0.0605
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0575 0.0605 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.7187 0.8514 0.8508
Loa Loa (eye worm) phosphatidylinositol 3 0.0554 0.0581 0.0581
Loa Loa (eye worm) phosphatidylinositol 3 0.0554 0.0581 0.0581
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0753 0.0819 0.0818
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1613 0.1847 0.1847
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0934 0.1035 0.1035
Trichomonas vaginalis PIKK family atypical protein kinase 0.6281 0.743 0.742
Trichomonas vaginalis PIKK family atypical protein kinase 0.4572 0.5386 0.5368
Trichomonas vaginalis PIKK family atypical protein kinase 0.6714 0.7948 0.794
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0575 0.0605 0.0605
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1243 0.1404 0.1404
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0554 0.0581 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.5005 0.5904 0.5888
Trichomonas vaginalis PIKK family atypical protein kinase 0.2263 0.2625 0.2595
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0168 0.0118 0.0118
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1059 0.1184 0.1183
Entamoeba histolytica protein kinase, putative 0.0102 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.1709 0.1961 0.1961
Loa Loa (eye worm) phosphatidylinositol 3 0.0892 0.0985 0.0985
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0689 0.0742 0.0705
Schistosoma mansoni voltage-gated potassium channel 0.026 0.0229 0.0229
Schistosoma mansoni fkbp-rapamycin associated protein 0.1613 0.1847 0.1847
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0596 0.0631 0.0518
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0639 0.0682 0.0681
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0238 0.0202 0.0202
Loa Loa (eye worm) phosphatidylinositol 3 0.0554 0.0581 0.0581
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0168 0.0118 0.0118
Schistosoma mansoni immunophilin 0.0145 0.0091 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.1797 0.2067 0.2035
Leishmania major phosphatidylinositol 3-kinase, putative 0.2856 0.3334 0.3254
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0168 0.0118 0.0079
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2909 0.3397 0.3396
Loa Loa (eye worm) AGC/AKT protein kinase 0.0102 0.004 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.1613 0.1847 0.1815
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0168 0.0118 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1613 0.1847 0.1815
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.843 1 1
Toxoplasma gondii FATC domain-containing protein 0.1613 0.1847 0.2454
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2909 0.3397 0.3397
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0554 0.0581 0.0581
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0554 0.0581 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.1243 0.1404 0.137
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0554 0.0581 0.0742
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0168 0.0118 0.0117
Leishmania major hypothetical protein, unknown function 0.0554 0.0581 0.0468
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0617 0.0655 0.0655
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0753 0.0819 0.0782
Entamoeba histolytica protein kinase, putative 0.0102 0.004 0.0038
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0823 0.0901 0.0901
Trichomonas vaginalis PIKK family atypical protein kinase 0.4572 0.5386 0.5368
Echinococcus multilocularis serine protein kinase ATM 0.1613 0.1847 0.1847
Entamoeba histolytica hypothetical protein 0.0554 0.0581 0.0579
Schistosoma mansoni immunophilin 0.0168 0.0118 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.6281 0.743 0.742
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.843 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5005 0.5904 0.5888
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0554 0.0581 0.0581
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0168 0.0118 0.0117
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0617 0.0655 0.0618
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0934 0.1035 0.1035
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0712 0.0768 0.0767
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0168 0.0118 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.4565 0.5378 0.5359
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0554 0.0581 0.0579
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0575 0.0605 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.1059 0.1184 0.1149
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1243 0.1404 0.1404
Trichomonas vaginalis PIKK family atypical protein kinase 0.5038 0.5943 0.5927
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0753 0.0819 0.0818
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0199 0.0155 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.843 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0617 0.0655 0.0654
Mycobacterium tuberculosis Conserved hypothetical protein 0.0554 0.0581 0.5
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0681 0.0732 0.0732
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0554 0.0581 0.0581
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.0031 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.843 1 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.6281 0.743 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0554 0.0581 0.0579
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0554 0.0581 0.9493
Trichomonas vaginalis fk506-binding protein, putative 0.0168 0.0118 0.0079
Trypanosoma cruzi target of rapamycin kinase 3 0.6721 0.7956 0.7956
Schistosoma mansoni serine/threonine-protein kinase 0.007 0.0001 0.0001
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1613 0.1847 0.1847
Trichomonas vaginalis PIKK family atypical protein kinase 0.4565 0.5378 0.5359
Loa Loa (eye worm) phosphatidylinositol kinase 0.0554 0.0581 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.5038 0.5943 0.5927
Loa Loa (eye worm) hypothetical protein 0.1613 0.1847 0.1847
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0575 0.0605 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2909 0.3397 0.3397
Onchocerca volvulus 0.0554 0.0581 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0575 0.0605 0.0568
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.843 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0554 0.0581 0.0581
Trichomonas vaginalis PIKK family atypical protein kinase 0.1059 0.1184 0.1149
Entamoeba histolytica hypothetical protein 0.1613 0.1847 0.1846
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0168 0.0118 0.0117
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0168 0.0118 0.0117
Trypanosoma brucei target of rapamycin kinase 3, putative 0.6721 0.7956 0.7948
Echinococcus multilocularis 0.0554 0.0581 0.0581
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.3513 0.4119 0.4096
Echinococcus granulosus serine/threonine protein kinase 0.007 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.2856 0.3334 0.3307
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0575 0.0605 0.0605
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0617 0.0655 0.0654
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0575 0.0605 0.0605
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.843 1 1
Loa Loa (eye worm) hypothetical protein 0.1059 0.1184 0.1184
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0575 0.0605 0.0775
Trichomonas vaginalis PIKK family atypical protein kinase 0.2856 0.3334 0.3307
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0168 0.0118 0.0118
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.843 1 1
Loa Loa (eye worm) hypothetical protein 0.0554 0.0581 0.0581
Loa Loa (eye worm) FKBP5 protein 0.0168 0.0118 0.0118
Giardia lamblia Phosphatidylinositol 4-kinase 0.0554 0.0581 0.0468
Schistosoma mansoni voltage-gated potassium channel 0.026 0.0229 0.0229
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0753 0.0819 0.0819
Echinococcus multilocularis fk506 binding protein 0.0168 0.0118 0.0118
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0575 0.0605 0.0605
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0223 0.0184 0.0145
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0554 0.0581 0.9493
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2856 0.3334 0.3307
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1613 0.1847 0.1847
Leishmania major phosphatidylinositol 4-kinase, putative 0.0554 0.0581 0.0468
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0554 0.0581 0.0579
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0554 0.0581 0.0543
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.843 1 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0934 0.1035 0.1035

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.28 uM Cytotoxicity against human HeLa cells of light exposed compound after 12 hrs by WST-8 assay ChEMBL. 22335896

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22335896

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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