Detailed information for compound 1635418

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 767.698 | Formula: C40H42IN5O3
  • H donors: 2 H acceptors: 4 LogP: 6.64 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)CC[C@H]1[C@H](C)/C/2=C/c3[nH]c(c(c3C)/C=C/c3cc[n+](cc3)C)/C=C/3\N=C(/C=c/4\[nH]c5=C(C1=N2)CC(=O)c5c4C)C(=C3C)CC.[I-]
  • InChi: 1S/C40H41N5O3.HI/c1-8-26-21(2)31-19-35-27(10-9-25-13-15-45(6)16-14-25)22(3)30(42-35)18-32-23(4)28(11-12-37(47)48-7)39(43-32)29-17-36(46)38-24(5)33(44-40(29)38)20-34(26)41-31;/h9-10,13-16,18-20,23,28H,8,11-12,17H2,1-7H3,(H,41,42,43,44);1H/b32-18-;/t23-,28-;/m0./s1
  • InChiKey: GRJAGDFRRROHAL-YHOLQDMNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.142 0.3455 0.3455
Leishmania major hypothetical protein, conserved 0.0362 0.0763 0.0648
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.011 0.0123 0.0123
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0288 0.0577 0.0566
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0062 0.0001 0.0001
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.142 0.3455 0.3455
Trichomonas vaginalis PIKK family atypical protein kinase 0.3185 0.7944 0.7942
Loa Loa (eye worm) phosphatidylinositol kinase 0.0268 0.0525 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.3323 0.3315
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.142 0.3455 0.3454
Trichomonas vaginalis PIKK family atypical protein kinase 0.2387 0.5915 0.591
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0224 0.0413 0.0405
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.033 0.0682 0.0671
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3993 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.033 0.0682 0.068
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0393 0.0843 0.0835
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3993 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0268 0.0525 0.0517
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.011 0.0123 0.0115
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0288 0.0577 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3188 0.7953 0.795
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0268 0.0525 0.0525
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0224 0.0413 0.0413
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0268 0.0525 0.0514
Entamoeba histolytica hypothetical protein 0.0423 0.0919 0.0918
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.011 0.0123 0.0112
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0288 0.0577 0.0566
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0268 0.0525 0.8858
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0774 0.1812 0.1802
Schistosoma mansoni hypothetical protein 0.0268 0.0525 0.0517
Trichomonas vaginalis PIKK family atypical protein kinase 0.3185 0.7944 0.7942
Toxoplasma gondii FATC domain-containing protein 0.0774 0.1812 0.2439
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0268 0.0525 0.0525
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0774 0.1812 0.1805
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1379 0.3351 0.3268
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.033 0.0682 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.2176 0.5378 0.5373
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0774 0.1812 0.1812
Mycobacterium tuberculosis Conserved hypothetical protein 0.0268 0.0525 0.5
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0268 0.0525 0.0705
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.033 0.0682 0.068
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0268 0.0525 0.0517
Loa Loa (eye worm) phosphatidylinositol 3 0.3993 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0288 0.0577 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.3185 0.7944 0.7942
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1881 0.4628 0.4622
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0288 0.0577 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0393 0.0843 0.0841
Loa Loa (eye worm) hypothetical protein 0.0065 0.0008 0.0008
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0095 0.0085 0.0077
Entamoeba histolytica protein kinase, putative 0.0066 0.0012 0.001
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3993 1 1
Schistosoma mansoni immunophilin 0.0095 0.0085 0.0077
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1379 0.3351 0.3343
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.033 0.0682 0.0682
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3993 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2591 0.6434 0.643
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.011 0.0123 0.0115
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0288 0.0577 0.0775
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0224 0.0413 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0525 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.3323 0.3315
Entamoeba histolytica hypothetical protein 0.0268 0.0525 0.0524
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0288 0.0577 0.0569
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.011 0.0123 0.0112
Loa Loa (eye worm) phosphatidylinositol 3 0.0268 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0095 0.0085 0.0085
Mycobacterium leprae conserved hypothetical protein 0.0268 0.0525 0.5
Loa Loa (eye worm) AGC/AKT protein kinase 0.0066 0.0012 0.0012
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0401 0.0863 0.0852
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.011 0.0123 0.0115
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0594 0.1354 0.1346
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0785 0.184 0.1839
Trichomonas vaginalis PIKK family atypical protein kinase 0.2173 0.537 0.5364
Plasmodium vivax hypothetical protein 0.0268 0.0525 0.8858
Trichomonas vaginalis PIKK family atypical protein kinase 0.2176 0.5378 0.5373
Trichomonas vaginalis PIKK family atypical protein kinase 0.3185 0.7944 0.7942
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0268 0.0525 0.8858
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0196 0.0342 0.0341
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0268 0.0525 0.0524
Loa Loa (eye worm) phosphatidylinositol 3 0.1379 0.3351 0.3351
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0774 0.1812 0.1811
Entamoeba histolytica protein kinase rad3, putative 0.0774 0.1812 0.1811
Trichomonas vaginalis PIKK family atypical protein kinase 0.2981 0.7426 0.7423
Echinococcus multilocularis Zinc finger, PHD finger 0.0288 0.0577 0.0569
Loa Loa (eye worm) hypothetical protein 0.0506 0.113 0.113
Entamoeba histolytica hypothetical protein 0.0774 0.1812 0.1811
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.011 0.0123 0.5
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.036 0.0758 0.0642
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0178 0.0296 0.0295
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0393 0.0843 0.0835
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0642 0.1477 0.147
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0209 0.0376 0.0364
Trichomonas vaginalis PIKK family atypical protein kinase 0.2679 0.6657 0.6653
Trichomonas vaginalis PIKK family atypical protein kinase 0.2981 0.7426 0.7423
Giardia lamblia Hypothetical protein 0.0268 0.0525 0.0406
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0268 0.0525 0.0525
Echinococcus multilocularis fk506 binding protein 0.011 0.0123 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.3993 1 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0642 0.1477 0.147
Leishmania major hypothetical protein, unknown function 0.0268 0.0525 0.0406
Loa Loa (eye worm) hypothetical protein 0.0862 0.2035 0.2035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0785 0.184 0.1831
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0268 0.0525 0.0517
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0464 0.1024 0.1023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0525 0.0514
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.011 0.0123 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0862 0.2035 0.2026
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3993 1 1
Brugia malayi Protein kinase domain containing protein 0.0066 0.0012 0.001
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0464 0.1024 0.1024
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0268 0.0525 0.0705
Schistosoma mansoni immunophilin 0.011 0.0123 0.0115
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0268 0.0525 0.0517
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0464 0.1024 0.1023
Leishmania major phosphatidylinositol 4-kinase, putative 0.0268 0.0525 0.0406
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0288 0.0577 0.0566
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0288 0.0577 0.0566
Trichomonas vaginalis PIKK family atypical protein kinase 0.2981 0.7426 0.7423
Echinococcus multilocularis 0.0268 0.0525 0.0517
Giardia lamblia Phosphatidylinositol 4-kinase 0.0268 0.0525 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.2981 0.7426 0.7423
Toxoplasma gondii target of rapamycin (TOR), putative 0.2981 0.7426 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0268 0.0525 0.0517
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0268 0.0525 0.8858
Loa Loa (eye worm) hypothetical protein 0.0594 0.1354 0.1354
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0774 0.1812 0.1805
Trichomonas vaginalis fk506-binding protein, putative 0.011 0.0123 0.0112
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3993 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0774 0.1812 0.1812
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0268 0.0525 0.0524
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.142 0.3455 0.3449
Leishmania major phosphatidylinositol 3-kinase, putative 0.1368 0.3323 0.3239
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.142 0.3455 0.3449
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.011 0.0123 0.0122
Loa Loa (eye worm) hypothetical protein 0.0774 0.1812 0.1812
Entamoeba histolytica protein kinase, putative 0.0066 0.0012 0.001
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0268 0.0525 0.0514
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0224 0.0413 0.0405
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0352 0.0738 0.0736
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0095 0.0085 0.0077
Schistosoma mansoni immunophilin 0.011 0.0123 0.0115
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0862 0.2035 0.274
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0288 0.0577 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.0594 0.1354 0.1343
Trichomonas vaginalis PIKK family atypical protein kinase 0.2387 0.5915 0.591
Loa Loa (eye worm) phosphatidylinositol 3 0.0601 0.1372 0.1372
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0464 0.1024 0.1024
Trichomonas vaginalis PIKK family atypical protein kinase 0.238 0.5897 0.5892
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.011 0.0123 0.0123
Plasmodium vivax hypothetical protein, conserved 0.0268 0.0525 0.8858
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.033 0.0682 0.0671
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.011 0.0123 0.0123
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0506 0.113 0.113
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0423 0.0919 0.0918
Entamoeba histolytica hypothetical protein 0.0268 0.0525 0.0524
Trichomonas vaginalis PIKK family atypical protein kinase 0.2173 0.537 0.5364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.113 0.112
Trichomonas vaginalis PIKK family atypical protein kinase 0.2176 0.5378 0.5373
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0774 0.1812 0.1805
Trichomonas vaginalis PIKK family atypical protein kinase 0.3993 1 1
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.011 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.2981 0.7426 0.7423
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0268 0.0525 0.0524
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0268 0.0525 0.0517
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.011 0.0123 0.0112
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0268 0.0525 0.0525
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0464 0.1024 0.1013
Loa Loa (eye worm) hypothetical protein 0.0071 0.0024 0.0024
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.033 0.0682 0.0671
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0268 0.0525 0.0517
Trichomonas vaginalis PIKK family atypical protein kinase 0.3185 0.7944 0.7942
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0288 0.0577 0.0569
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0642 0.1477 0.147
Echinococcus granulosus serine protein kinase ATM 0.0774 0.1812 0.1805
Trichomonas vaginalis PIKK family atypical protein kinase 0.2176 0.5378 0.5373
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0532 0.1197 0.119
Trichomonas vaginalis PIKK family atypical protein kinase 0.2981 0.7426 0.7423
Onchocerca volvulus 0.0268 0.0525 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0268 0.0525 0.0525
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0464 0.1024 0.1013
Leishmania major phosphatidylinositol 3-kinase, putative 0.0288 0.0577 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.1379 0.3351 0.3343
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0288 0.0577 0.0459
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3993 1 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0288 0.0577 0.0577
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0288 0.0577 0.0775
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.011 0.0123 0.0123
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0268 0.0525 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.3399 0.849 0.8488
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0309 0.063 0.0513
Echinococcus multilocularis serine protein kinase ATM 0.0774 0.1812 0.1805
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0594 0.1354 0.1346
Loa Loa (eye worm) hypothetical protein 0.0805 0.1891 0.1891
Trichomonas vaginalis conserved hypothetical protein 0.0506 0.113 0.112
Trypanosoma cruzi hypothetical protein, conserved 0.0094 0.0082 0.0082
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0401 0.0863 0.0852
Schistosoma mansoni voltage-gated potassium channel 0.0245 0.0465 0.0457
Trichomonas vaginalis PIKK family atypical protein kinase 0.238 0.5897 0.5892
Trichomonas vaginalis PIKK family atypical protein kinase 0.1073 0.2572 0.2563
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.011 0.0123 0.0112
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0268 0.0525 0.0517
Loa Loa (eye worm) FKBP5 protein 0.011 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0594 0.1354 0.1346
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0288 0.0577 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.3993 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.3323 0.3315
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.011 0.0123 0.0115
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.033 0.0682 0.0671
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0288 0.0577 0.0569
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3993 1 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0268 0.0525 0.8858
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.167 0.4091 0.4084
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0288 0.0577 0.0569
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.3323 0.3315
Onchocerca volvulus 0.0268 0.0525 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3993 1 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0532 0.1197 0.119
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1368 0.3323 0.3315
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0268 0.0525 0.0705
Leishmania major phosphatidylinositol kinase related protein, putative 0.0268 0.0525 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0774 0.1812 0.1802
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0268 0.0525 0.0525
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0209 0.0376 0.0364
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0288 0.0577 0.0575
Schistosoma mansoni voltage-gated potassium channel 0.0245 0.0465 0.0457
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0464 0.1024 0.1013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0268 0.0525 0.0524
Trichomonas vaginalis immunophilin, putative 0.011 0.0123 0.0112
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0268 0.0525 0.0514
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3188 0.7953 0.7927
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.011 0.0123 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0774 0.1812 0.1811
Trichomonas vaginalis PIKK family atypical protein kinase 0.2981 0.7426 0.7423
Entamoeba histolytica hypothetical protein 0.0268 0.0525 0.0524
Loa Loa (eye worm) hypothetical protein 0.0393 0.0843 0.0843
Loa Loa (eye worm) hypothetical protein 0.0268 0.0525 0.0525
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.033 0.0682 0.0674
Leishmania major phosphatidylinositol kinase, putative 0.0268 0.0525 0.0406
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0065 0.0008 0.0007
Giardia lamblia GTOR 0.3993 1 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3993 1 1
Loa Loa (eye worm) hypothetical protein 0.0194 0.0338 0.0338
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.011 0.0123 0.0122
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.011 0.0123 0.0122
Trypanosoma cruzi target of rapamycin kinase 3 0.3188 0.7953 0.7953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0774 0.1812 0.1802
Brugia malayi FAT domain containing protein 0.0594 0.1354 0.1352
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0268 0.0525 0.8858
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0288 0.0577 0.0577
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.142 0.3455 0.3449
Schistosoma mansoni fkbp-rapamycin associated protein 0.0774 0.1812 0.1805
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0288 0.0577 0.0575
Loa Loa (eye worm) phosphatidylinositol 3 0.0268 0.0525 0.0525
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3993 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2173 0.537 0.5364
Trichomonas vaginalis PIKK family atypical protein kinase 0.2387 0.5915 0.591
Loa Loa (eye worm) phosphatidylinositol 3 0.0268 0.0525 0.0525

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 7.94 uM Cytotoxicity against human HeLa cells of light exposed compound after 12 hrs by WST-8 assay ChEMBL. 22335896

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22335896

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.