TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 274.355 | Formula: C17H22O3
H donors: 1 H acceptors: 2 LogP: 4.78 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: C/C(=C\COc1ccc(cc1)C(=O)O)/CCC=C(C)C
InChi: 1S/C17H22O3/c1-13(2)5-4-6-14(3)11-12-20-16-9-7-15(8-10-16)17(18)19/h5,7-11H,4,6,12H2,1-3H3,(H,18,19)/b14-11+
InChiKey: RMDHZUUXNBGDEM-SDNWHVSQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0548	0.0586	0.9457
Loa Loa (eye worm)	hypothetical protein	0.1047	0.1189	0.1189
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.1595	0.1852	0.1848
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0175	0.0134	0.0134
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0175	0.0134	0.5
Trypanosoma cruzi	target of rapamycin kinase 3	0.664	0.7958	0.7957
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4511	0.5381	0.5379
Loa Loa (eye worm)	phosphatidylinositol 3	0.0548	0.0586	0.0586
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4977	0.5946	0.5943
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.1595	0.1852	0.1849
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.2877	0.3405	0.3402
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.057	0.0612	0.0611
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.8327	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0548	0.0586	0.0586
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.057	0.0612	0.0612
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6205	0.7432	0.743
Entamoeba histolytica	hypothetical protein	0.0548	0.0586	0.0586
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0548	0.0586	0.0581
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0175	0.0134	0.0129
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.664	0.7958	0.793
Loa Loa (eye worm)	hypothetical protein	0.1595	0.1852	0.1852
Loa Loa (eye worm)	hypothetical protein	0.0203	0.0168	0.0168
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.8327	1	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0613	0.0664	0.066
Loa Loa (eye worm)	hypothetical protein	0.0548	0.0586	0.0586
Loa Loa (eye worm)	hypothetical protein	0.068	0.0745	0.0745
Leishmania major	phosphatidylinositol kinase, putative	0.0548	0.0586	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0004	0.0004
Giardia lamblia	GTOR	0.8327	1	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0548	0.0586	0.0788
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2823	0.3339	0.3335
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0548	0.0586	0.0585
Echinococcus granulosus	serine protein kinase ATM	0.1595	0.1852	0.1849
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0548	0.0586	0.0457
Onchocerca volvulus		0.0548	0.0586	0.5
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.8327	1	1
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0942	0.1062	0.1058
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0548	0.0586	0.0586
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0754	0.0835	0.0831
Schistosoma mansoni	voltage-gated potassium channel	0.0255	0.0231	0.0227
Echinococcus multilocularis	fk506 binding protein	0.0175	0.0134	0.013
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.057	0.0612	0.0612
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0218	0.0186	0.0181
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1047	0.1189	0.1184
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.057	0.0612	0.0611
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2823	0.3339	0.3335
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0175	0.0134	0.013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.8327	1	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0548	0.0586	0.0582
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0175	0.0134	0.0134
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0548	0.0586	0.9457
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.3471	0.4123	0.412
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2823	0.3339	0.3335
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.057	0.0612	0.0608
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0613	0.0664	0.0659
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.057	0.0612	0.0608
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.8327	1	1
Schistosoma mansoni	fkbp-rapamycin associated protein	0.1595	0.1852	0.1849
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0592	0.0638	0.0511
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4945	0.5907	0.5905
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2236	0.2628	0.2624
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0175	0.0134	0.0129
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.1047	0.1189	0.1188
Trypanosoma cruzi	hypothetical protein, conserved	0.0099	0.0042	0.0041
Loa Loa (eye worm)	phosphatidylinositol 3	0.0898	0.1009	0.1009
Loa Loa (eye worm)	hypothetical protein	0.1688	0.1965	0.1965
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0688	0.0755	0.075
Schistosoma mansoni	voltage-gated potassium channel	0.0255	0.0231	0.0227
Echinococcus multilocularis	serine protein kinase ATM	0.1595	0.1852	0.1849
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0942	0.1062	0.1058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4517	0.5389	0.5387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6205	0.7432	0.743
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6633	0.7949	0.7948
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.057	0.0612	0.0608
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.1228	0.1409	0.1405
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0548	0.0586	0.0582
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.2835	0.3353	0.3262
Leishmania major	phosphatidylinositol 3-kinase, putative	0.057	0.0612	0.0484
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.8327	1	1
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.057	0.0612	0.0484
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0548	0.0586	0.0581
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0175	0.0134	0.0134
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.057	0.0612	0.0612
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.057	0.0612	0.0823
Trichomonas vaginalis	PIKK family atypical protein kinase	0.7099	0.8514	0.8513
Onchocerca volvulus		0.0548	0.0586	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0548	0.0586	0.0586
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0754	0.0835	0.0831
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0175	0.0134	0.0134
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4945	0.5907	0.5905
Plasmodium vivax	hypothetical protein, conserved	0.0548	0.0586	0.9457
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0613	0.0664	0.0659
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0942	0.1062	0.1058
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0711	0.0783	0.0783
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0175	0.0134	0.0129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4511	0.5381	0.5379
Entamoeba histolytica	hypothetical protein	0.0548	0.0586	0.0586
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.057	0.0612	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.1047	0.1189	0.1184
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.1228	0.1409	0.1405
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4977	0.5946	0.5943
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0754	0.0835	0.0835
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0548	0.0586	0.0582
Loa Loa (eye worm)	FKBP5 protein	0.0175	0.0134	0.0134
Giardia lamblia	Hypothetical protein	0.0548	0.0586	0.0457
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0613	0.0664	0.0659
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0754	0.0835	0.0831
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0013	0.0013
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0826	0.0922	0.0918
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4517	0.5389	0.5387
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.1595	0.1852	0.1849
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6205	0.7432	0.743
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0548	0.0586	0.0586
Schistosoma mansoni	immunophilin	0.0175	0.0134	0.013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.8327	1	1
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0175	0.0134	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.1595	0.1852	0.1852
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.8327	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.1595	0.1852	0.1852
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.2877	0.3405	0.3402
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0548	0.0586	0.0586
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0548	0.0586	0.9457
Loa Loa (eye worm)	hypothetical protein	0.1228	0.1409	0.1409
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0636	0.0692	0.0692
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0233	0.0205	0.0201
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0548	0.0586	0.0581
Schistosoma mansoni	immunophilin	0.0151	0.0105	0.0101
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0175	0.0134	0.0129
Trichomonas vaginalis	conserved hypothetical protein	0.1776	0.2072	0.2068
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2823	0.3339	0.3335
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0175	0.0134	0.0134
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.2877	0.3405	0.3405
Entamoeba histolytica	protein kinase, putative	0.0068	0.0005	0.0005
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.1595	0.1852	0.1849
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0068	0.0005	0.0005
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0754	0.0835	0.0835
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0548	0.0586	0.0788
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0548	0.0586	0.0582
Schistosoma mansoni	immunophilin	0.0175	0.0134	0.013
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0754	0.0835	0.0835
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0175	0.0134	0.0134
Loa Loa (eye worm)	hypothetical protein	0.1776	0.2072	0.2072
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.8327	1	1
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0548	0.0586	0.0585
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6205	0.7432	0.743
Toxoplasma gondii	target of rapamycin (TOR), putative	0.6205	0.7432	1
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0548	0.0586	0.0582
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.057	0.0612	0.0607
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.057	0.0612	0.0607
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0548	0.0586	0.0457
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6205	0.7432	0.743
Echinococcus multilocularis		0.0548	0.0586	0.0582
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0548	0.0586	0.0585
Brugia malayi	FAT domain containing protein	0.1228	0.1409	0.1409
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0218	0.0186	0.0181
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5586	0.6683	0.6681
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6205	0.7432	0.743
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0548	0.0586	0.0581
Leishmania major	hypothetical protein, unknown function	0.0548	0.0586	0.0457
Schistosoma mansoni	hypothetical protein	0.1228	0.1409	0.1405
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1776	0.2072	0.2788
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1606	0.1866	0.1862
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0754	0.0835	0.0835
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0548	0.0586	0.0581
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0548	0.0586	0.0582
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0175	0.0134	0.0134
Trichomonas vaginalis	PIKK family atypical protein kinase	0.8327	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1595	0.1852	0.1852
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2835	0.3353	0.3349
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4511	0.5381	0.5379
Plasmodium vivax	hypothetical protein	0.0548	0.0586	0.9457
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0206	0.0172	0.0172
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4517	0.5389	0.5387
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0548	0.0586	0.9457
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6633	0.7949	0.7948
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0548	0.0586	0.0586
Entamoeba histolytica	hypothetical protein	0.1595	0.1852	0.1852
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0644	0.0702	0.0576
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0175	0.0134	0.0134
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.068	0.0745	0.0741
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0187	0.0149	0.0149
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6205	0.7432	0.743
Entamoeba histolytica	protein kinase rad3, putative	0.1595	0.1852	0.1852
Echinococcus multilocularis	Zinc finger, PHD finger	0.057	0.0612	0.0608
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0826	0.0922	0.0918
Loa Loa (eye worm)	phosphatidylinositol 3	0.0548	0.0586	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0105	0.0105
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0175	0.0134	0.013
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0688	0.0755	0.075
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0175	0.0134	0.0134
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.1606	0.1866	0.1866
Trichomonas vaginalis	conserved hypothetical protein	0.1228	0.1409	0.1404
Mycobacterium leprae	conserved hypothetical protein	0.0548	0.0586	0.5
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0068	0.0004	0.0004
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0151	0.0105	0.0101
Loa Loa (eye worm)	phosphatidylinositol 3	0.2835	0.3353	0.3353
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0613	0.0664	0.0663
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.8327	1	1
Entamoeba histolytica	protein kinase, putative	0.0068	0.0005	0.0005
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.8327	1	1
Entamoeba histolytica	hypothetical protein	0.0548	0.0586	0.0586
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.057	0.0612	0.0608
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0175	0.0134	0.013
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.057	0.0612	0.0823
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0233	0.0205	0.0205
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0548	0.0586	0.0581
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5405	0.6463	0.6461
Leishmania major	phosphatidylinositol 3-kinase, putative	0.2823	0.3339	0.3248
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0548	0.0586	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1595	0.1852	0.1848
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0548	0.0586	0.0788
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.057	0.0612	0.0608
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0613	0.0664	0.0664
Loa Loa (eye worm)	phosphatidylinositol 3	0.8327	1	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0548	0.0586	0.0582
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1595	0.1852	0.1848
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0548	0.0586	0.0585
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.2835	0.3353	0.3349
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0613	0.0664	0.0664
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4517	0.5389	0.5387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6633	0.7949	0.7948
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.393	0.4679	0.4676
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.057	0.0612	1
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0005	0.0005
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.068	0.0745	0.0745
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0151	0.0105	0.0101
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0233	0.0205	0.0201
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0548	0.0586	0.0585
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.057	0.0612	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.664	0.7958	0.7956
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0548	0.0586	0.9457
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1595	0.1852	0.1852
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6633	0.7949	0.7948
Schistosoma mansoni	hypothetical protein	0.0548	0.0586	0.0582
Toxoplasma gondii	FATC domain-containing protein	0.1595	0.1852	0.2492
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0548	0.0586	0.0457
Entamoeba histolytica	hypothetical protein	0.0711	0.0783	0.0783
Trichomonas vaginalis	immunophilin, putative	0.0175	0.0134	0.0129
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.057	0.0612	0.0607
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0548	0.0586	0.0586
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6633	0.7949	0.7948
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.2823	0.3339	0.3335
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.057	0.0612	0.0607
Loa Loa (eye worm)	phosphatidylinositol 3	0.0065	0.0001	0.0001
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.2877	0.3405	0.3402
Trichomonas vaginalis	fk506-binding protein, putative	0.0175	0.0134	0.0129
Leishmania major	hypothetical protein, conserved	0.0647	0.0705	0.0578
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2877	0.3405	0.3404
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.068	0.0745	0.0741
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0175	0.0134	0.013
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.8327	1	1
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0548	0.0586	0.0582
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4977	0.5946	0.5943
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2877	0.3405	0.3404
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0233	0.0205	0.0205
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.8327	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0613	0.0664	0.0659
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0613	0.0664	0.0664

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Agonist activity at human farnesoid X receptor expressed in human HepG2 cells after 24 hrs by dual-luciferase assay relative to control	ChEMBL.	22472691
FC (functional)	= 0.899	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 1 uM after 24 hrs by dual-luciferase assay relative to control	ChEMBL.	22472691
FC (functional)	= 0.902	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 0.1 uM after 24 hrs by dual-luciferase assay relative to control	ChEMBL.	22472691
FC (functional)	= 0.993	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 5 uM after 24 hrs by dual-luciferase assay relative to control	ChEMBL.	22472691
FC (functional)	= 1.054	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 10 uM after 24 hrs by dual-luciferase assay relative to control	ChEMBL.	22472691
FC (functional)	= 1.348	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 25 uM after 24 hrs by dual-luciferase assay relative to control	ChEMBL.	22472691
FC (functional)	= 1.854	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 50 uM after 24 hrs by dual-luciferase assay relative to control	ChEMBL.	22472691
FC (functional)	= 2.82	Agonist activity at human farnesoid X receptor expressed in human HepG2 cells at 100 uM after 24 hrs by dual-luciferase assay relative to control	ChEMBL.	22472691
IC50 (functional)	> 200 uM	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess method	ChEMBL.	23566521

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2022664

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1635429