TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 482.978 | Formula: C22H27ClN2O6S
H donors: 1 H acceptors: 4 LogP: 4.23 Rotable bonds: 14
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCS(=O)(=O)NC(=O)/C=C/c1ccc(cc1Oc1ncccc1Cl)OCCOC
InChi: 1S/C22H27ClN2O6S/c1-3-4-5-15-32(27,28)25-21(26)11-9-17-8-10-18(30-14-13-29-2)16-20(17)31-22-19(23)7-6-12-24-22/h6-12,16H,3-5,13-15H2,1-2H3,(H,25,26)/b11-9+
InChiKey: PBLUAYDREMPFRL-PKNBQFBNSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	peroxisome proliferator-activated receptor gamma	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	ecdysone induced protein 78C	peroxisome proliferator-activated receptor gamma	477 aa	447 aa	28.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0644	0.1432	0.1408
Leishmania major	hypothetical protein, unknown function	0.0288	0.0601	0.03
Loa Loa (eye worm)	hypothetical protein	0.0929	0.2096	0.2096
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0845	0.19	0.1896
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0288	0.0601	0.0575
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0475	0.1037	0.1037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0288	0.0601	0.0597
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0164	0.0311	0.0284
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4317	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0288	0.0601	0.054
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0644	0.1432	0.1408
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0164	0.0311	0.0311
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2896	0.6685	0.6684
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3221	0.7444	0.7443
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0288	0.0601	0.0597
Entamoeba histolytica	hypothetical protein	0.0288	0.0601	0.0601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3221	0.7444	0.7443
Toxoplasma gondii	target of rapamycin (TOR), putative	0.3221	0.7444	1
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0288	0.0601	0.0575
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0288	0.0601	0.03
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0308	0.0647	0.0642
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0308	0.0647	0.0642
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3221	0.7444	0.7443
Echinococcus multilocularis		0.0288	0.0601	0.0575
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0028	0.0028
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0475	0.1037	0.0978
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0288	0.0601	0.0808
Schistosoma mansoni	voltage-gated potassium channel	0.016	0.0302	0.0275
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0288	0.0601	0.0575
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0475	0.1037	0.1037
Echinococcus multilocularis	fk506 binding protein	0.0164	0.0311	0.0284
Trichomonas vaginalis	conserved hypothetical protein	0.0929	0.2096	0.2092
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.4317	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0415	0.0896	0.0892
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0164	0.0311	0.0306
Schistosoma mansoni	hypothetical protein	0.0641	0.1423	0.1399
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0845	0.19	0.19
Mycobacterium leprae	conserved hypothetical protein	0.0288	0.0601	0.5
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0042	0.0028	0.0028
Loa Loa (eye worm)	phosphatidylinositol 3	0.0288	0.0601	0.0601
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0137	0.0248	0.0244
Schistosoma mansoni	immunophilin	0.0164	0.0311	0.0284
Entamoeba histolytica	hypothetical protein	0.0834	0.1875	0.1875
Schistosoma mansoni	immunophilin	0.0141	0.0258	0.0231
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0375	0.0805	0.0509
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0164	0.0311	0.0247
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0407	0.0879	0.0853
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3221	0.7444	0.7443
Entamoeba histolytica	protein kinase rad3, putative	0.0834	0.1875	0.1875
Echinococcus multilocularis	Zinc finger, PHD finger	0.0308	0.0647	0.0621
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.054	0.1188	0.1163
Loa Loa (eye worm)	phosphatidylinositol 3	0.1486	0.3395	0.3395
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0834	0.1875	0.1875
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2346	0.5403	0.5401
Plasmodium vivax	hypothetical protein	0.0288	0.0601	0.8654
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3442	0.7959	0.7958
Trichomonas vaginalis	PIKK family atypical protein kinase	0.235	0.5411	0.5409
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0288	0.0601	0.8654
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0164	0.0311	0.0311
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0288	0.0601	0.0601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3442	0.7959	0.7958
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.2034	0.4675	0.4673
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0308	0.0647	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0407	0.0879	0.0879
Entamoeba histolytica	protein kinase, putative	0.0033	0.0005	0.0005
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0137	0.0248	0.0244
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0834	0.1875	0.1822
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0288	0.0601	0.5
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0288	0.0601	0.0808
Loa Loa (eye worm)	phosphatidylinositol 3	0.4317	1	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0288	0.0601	0.0575
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0347	0.0738	0.0738
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0308	0.0647	0.0621
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0288	0.0601	0.054
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0834	0.1875	0.1853
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1486	0.3395	0.3183
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0347	0.0738	0.0738
Trichomonas vaginalis	PIKK family atypical protein kinase	0.235	0.5411	0.5409
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0288	0.0601	0.054
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0308	0.0647	0.0621
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2801	0.6464	0.6463
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0164	0.0311	0.0247
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0147	0.0271	0.0244
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0308	0.0647	0.0869
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0288	0.0601	0.0597
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1475	0.337	0.3367
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0258	0.0258
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0347	0.0738	0.0677
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1486	0.3395	0.3391
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.4317	1	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.0005	0.0005
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.4317	1	1
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0407	0.0879	0.0853
Entamoeba histolytica	hypothetical protein	0.0288	0.0601	0.0601
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.4317	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0147	0.0271	0.0271
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1524	0.3485	0.3485
Trichomonas vaginalis	PIKK family atypical protein kinase	0.258	0.5949	0.5947
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0164	0.0311	0.0247
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0347	0.0738	0.0734
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.4317	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0347	0.0738	0.0738
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3442	0.7959	0.7958
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0288	0.0601	0.0601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1475	0.337	0.3367
Schistosoma mansoni	voltage-gated potassium channel	0.016	0.0302	0.0275
Leishmania major	hypothetical protein, conserved	0.0377	0.0809	0.0514
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1524	0.3485	0.3442
Entamoeba histolytica	protein kinase, putative	0.0033	0.0005	0.0005
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0308	0.0647	0.0642
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1524	0.3485	0.3442
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0288	0.0601	0.8654
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0834	0.1875	0.1871
Schistosoma mansoni	hypothetical protein	0.0288	0.0601	0.0575
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3442	0.7959	0.7958
Toxoplasma gondii	FATC domain-containing protein	0.0834	0.1875	0.2519
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0288	0.0601	0.0601
Entamoeba histolytica	hypothetical protein	0.0436	0.0945	0.0945
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0164	0.0311	0.0306
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0308	0.0647	0.0642
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0288	0.0601	0.054
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0164	0.0311	0.0311
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0308	0.0647	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.3445	0.7967	0.7966
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.4317	1	1
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0164	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0407	0.0879	0.0879
Loa Loa (eye worm)	hypothetical protein	0.0288	0.0601	0.0601
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0347	0.0738	0.0712
Leishmania major	phosphatidylinositol kinase, putative	0.0288	0.0601	0.03
Brugia malayi	Protein kinase domain containing protein	0.0033	0.0005	0.0005
Giardia lamblia	GTOR	0.4317	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3221	0.7444	0.7443
Giardia lamblia	Hypothetical protein	0.0288	0.0601	0.03
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0288	0.0601	0.0597
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.3445	0.7967	0.7902
Trichomonas vaginalis	immunophilin, putative	0.0164	0.0311	0.0306
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0834	0.1875	0.1875
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2346	0.5403	0.5401
Trichomonas vaginalis	PIKK family atypical protein kinase	0.258	0.5949	0.5947
Loa Loa (eye worm)	phosphatidylinositol 3	0.0288	0.0601	0.0601
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0308	0.0647	0.0585
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1524	0.3485	0.3467
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0834	0.1875	0.1853
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0308	0.0647	0.0647
Loa Loa (eye worm)	phosphatidylinositol 3	0.0288	0.0601	0.0601
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.4317	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0834	0.1875	0.1871
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0288	0.0601	0.8654
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0641	0.1423	0.1399
Schistosoma mansoni	immunophilin	0.0164	0.0311	0.0284
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0141	0.0258	0.0231
Trypanosoma cruzi	target of rapamycin kinase 3	0.3445	0.7967	0.7954
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.1804	0.4137	0.4134
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0288	0.0601	0.8654
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0308	0.0647	0.0621
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1475	0.337	0.3367
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0347	0.0738	0.0734
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0308	0.0647	0.0621
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.4317	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0605	0.134	0.134
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0308	0.0647	0.0585
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4317	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1475	0.337	0.3367
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0141	0.0258	0.0231
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0288	0.0601	0.0575
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0164	0.0311	0.0306
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0169	0.0324	0.0324
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0475	0.1037	0.1033
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0288	0.0601	0.0601
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0164	0.0311	0.0284
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0164	0.0311	0.0284
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0308	0.0647	0.0647
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1475	0.337	0.3367
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0288	0.0601	0.0808
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0288	0.0601	0.03
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0288	0.0601	0.054
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0834	0.1875	0.1871
Onchocerca volvulus		0.0288	0.0601	0.5
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.4317	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0546	0.1202	0.1145
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0308	0.0647	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1486	0.3395	0.3391
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.4317	1	1
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0308	0.0647	0.0346
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0308	0.0647	0.0647
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0308	0.0647	0.0869
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0164	0.0311	0.0306
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0288	0.0601	0.0597
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3676	0.8505	0.8505
Onchocerca volvulus		0.0288	0.0601	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0288	0.0601	0.0601
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0475	0.1037	0.1033
Echinococcus granulosus	serine protein kinase ATM	0.0834	0.1875	0.1853
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3221	0.7444	0.7443
Trichomonas vaginalis	PIKK family atypical protein kinase	0.235	0.5411	0.5409
Trichomonas vaginalis	conserved hypothetical protein	0.0546	0.1202	0.1198
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0288	0.0601	0.0575
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0308	0.0647	0.0621
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0644	0.1432	0.1408
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3442	0.7959	0.7958
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2571	0.5926	0.5924
Trichomonas vaginalis	PIKK family atypical protein kinase	0.116	0.2634	0.2631
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0164	0.0311	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0641	0.1423	0.1423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0546	0.1202	0.1198
Loa Loa (eye worm)	hypothetical protein	0.0871	0.1961	0.1961
Trypanosoma cruzi	hypothetical protein, conserved	0.0089	0.0137	0.0072
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0415	0.0896	0.0892
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0187	0.0364	0.0364
Echinococcus multilocularis	serine protein kinase ATM	0.0834	0.1875	0.1853
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0328	0.0693	0.0394
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0288	0.0601	0.0597
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0164	0.0311	0.0247
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0368	0.0787	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0127	0.0226	0.0226
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0147	0.0271	0.0244
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0929	0.2096	0.2816
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1475	0.337	0.3157
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1524	0.3485	0.3467
Loa Loa (eye worm)	FKBP5 protein	0.0164	0.0311	0.0311
Loa Loa (eye worm)	hypothetical protein	0.0834	0.1875	0.1875
Loa Loa (eye worm)	phosphatidylinositol 3	0.0059	0.0065	0.0065
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0834	0.1875	0.1853
Trichomonas vaginalis	fk506-binding protein, putative	0.0164	0.0311	0.0306
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.4317	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0834	0.1875	0.1822
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0288	0.0601	0.0601
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1524	0.3485	0.3467
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0288	0.0601	0.8654
Brugia malayi	FAT domain containing protein	0.0641	0.1423	0.1423
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0288	0.0601	0.0575
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0288	0.0601	0.03
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0164	0.0311	0.5
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0475	0.1037	0.1033
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0087	0.0087
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0347	0.0738	0.0734
Trichomonas vaginalis	PIKK family atypical protein kinase	0.235	0.5411	0.5409
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.054	0.1188	0.1163
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0834	0.1875	0.1853
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4317	1	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0147	0.0271	0.0271
Entamoeba histolytica	hypothetical protein	0.0288	0.0601	0.0601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3221	0.7444	0.7443
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0164	0.0311	0.0311
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2571	0.5926	0.5924
Plasmodium vivax	hypothetical protein, conserved	0.0288	0.0601	0.8654
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0347	0.0738	0.0734
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0164	0.0311	0.5
Loa Loa (eye worm)	hypothetical protein	0.0546	0.1202	0.1202
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0436	0.0945	0.0945
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0288	0.0601	0.0575
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2346	0.5403	0.5401
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0308	0.0647	0.0647
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0641	0.1423	0.1399
Trichomonas vaginalis	PIKK family atypical protein kinase	0.258	0.5949	0.5947
Trichomonas vaginalis	conserved hypothetical protein	0.0641	0.1423	0.1419
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0475	0.1037	0.0978

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	> 10000 nM	Transactivation of human PPARgamma1 expressed in CHO-K1 cells co-expressing RXRalpha and PPRE after 1 day by luciferase reporter gene assay	ChEMBL.	22503460

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2024614

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1635432