Detailed information for compound 1635438

Basic information

Technical information
  • TDR Targets ID: 1635438
  • Name: [4-[(Z)-2-chloro-1-[4-(2-dimethylaminoethoxy) phenyl]-2-(4-methoxyphenyl)ethenyl]phenyl] 2, 2-dimethylpropanoate
  • MW: 508.048 | Formula: C30H34ClNO4
  • H donors: 0 H acceptors: 1 LogP: 7.63 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)/C(=C(/c1ccc(cc1)OC(=O)C(C)(C)C)\c1ccc(cc1)OCCN(C)C)/Cl
  • InChi: 1S/C30H34ClNO4/c1-30(2,3)29(33)36-26-17-9-22(10-18-26)27(28(31)23-11-13-24(34-6)14-12-23)21-7-15-25(16-8-21)35-20-19-32(4)5/h7-18H,19-20H2,1-6H3/b28-27-
  • InChiKey: WVMNYAPPPKRJIH-DQSJHHFOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[2-chloro-1-[4-(2-dimethylaminoethoxy)phenyl]-2-(4-methoxyphenyl)ethenyl]phenyl] 2,2-dimethylpropanoate
  • [4-[(Z)-2-chloro-1-[4-(2-dimethylaminoethoxy)phenyl]-2-(4-methoxyphenyl)vinyl]phenyl] 2,2-dimethylpropanoate
  • [4-[2-chloro-1-[4-(2-dimethylaminoethoxy)phenyl]-2-(4-methoxyphenyl)vinyl]phenyl] 2,2-dimethylpropanoate
  • 2,2-dimethylpropanoic acid [4-[(Z)-2-chloro-1-[4-(2-dimethylaminoethoxy)phenyl]-2-(4-methoxyphenyl)vinyl]phenyl] ester
  • 2,2-dimethylpropanoic acid [4-[2-chloro-1-[4-(2-dimethylaminoethoxy)phenyl]-2-(4-methoxyphenyl)vinyl]phenyl] ester
  • 2,2-dimethylpropionic acid [4-[(Z)-2-chloro-1-[4-(2-dimethylaminoethoxy)phenyl]-2-(4-methoxyphenyl)vinyl]phenyl] ester
  • 2,2-dimethylpropionic acid [4-[2-chloro-1-[4-(2-dimethylaminoethoxy)phenyl]-2-(4-methoxyphenyl)vinyl]phenyl] ester
  • NCI60_015103

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0173 0.059 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0391 0.1412 0.1412
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Trichomonas vaginalis PIKK family atypical protein kinase 0.1794 0.6688 0.6688
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0173 0.059 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0391 0.1412 0.1406
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0564 0.2061 0.2061
Trypanosoma cruzi Protein kinase B 0.0026 0.0038 0.0008
Schistosoma mansoni fkbp-rapamycin associated protein 0.0506 0.1844 0.1838
Loa Loa (eye worm) phosphatidylinositol kinase 0.0173 0.059 0.0583
Entamoeba histolytica hypothetical protein 0.0173 0.059 0.0583
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0173 0.059 0.0561
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0147 0.0493 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 1 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0083 0.0076
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0173 0.059 0.0583
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.1152 0.1145
Schistosoma mansoni cyclin B 0.0042 0.0099 0.0092
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0173 0.059 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0173 0.059 0.0583
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0099 0.0092
Loa Loa (eye worm) hypothetical protein 0.0564 0.2061 0.2055
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 1 1
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0173 0.059 0.059
Echinococcus granulosus nervana 2 0.0021 0.0019 0.0012
Entamoeba histolytica hypothetical protein 0.0173 0.059 0.0583
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0173 0.059 0.0583
Echinococcus multilocularis 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0173 0.059 0.0516
Onchocerca volvulus 0.0173 0.059 0.4664
Trichomonas vaginalis cyclins, putative 0.0042 0.0099 0.0099
Trichomonas vaginalis cyclin B, putative 0.0042 0.0099 0.0099
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0019 0.0012
Echinococcus granulosus serine/threonine protein kinase 0.0026 0.0038 0.0031
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0173 0.059 0.059
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0099 0.0092
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0391 0.1412 0.1406
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0506 0.1844 0.1838
Leishmania major phosphatidylinositol 4-kinase, putative 0.0173 0.059 0.0496
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0083 0.0076
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0897 0.3314 0.331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.1844 0.1844
Trichomonas vaginalis PIKK family atypical protein kinase 0.1442 0.5364 0.5364
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0173 0.059 0.0707
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.1444 0.5373 0.5373
Trichomonas vaginalis PIKK family atypical protein kinase 0.2128 0.7942 0.7942
Loa Loa (eye worm) TTK protein kinase 0.0147 0.0493 0.0487
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0173 0.059 0.0583
Echinococcus granulosus serine protein kinase ATM 0.0506 0.1844 0.1838
Trichomonas vaginalis cyclins, putative 0.0042 0.0099 0.0099
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.059 0.0583
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0147 0.0493 0.3744
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.059 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0506 0.1844 0.1779
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0173 0.059 0.0583
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0322 0.1152 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0506 0.1844 0.1819
Leishmania major phosphatidylinositol kinase, putative 0.0173 0.059 0.0496
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0173 0.059 0.0561
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0173 0.059 0.059
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0173 0.059 0.0516
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2675 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0173 0.059 0.0561
Loa Loa (eye worm) phosphatidylinositol 3 0.0173 0.059 0.0583
Entamoeba histolytica protein kinase 2, putative 0.0024 0.003 0.0023
Entamoeba histolytica hypothetical protein 0.0506 0.1844 0.1838
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0897 0.3314 0.3262
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0034 0.007 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.1444 0.5373 0.5373
Giardia lamblia Hypothetical protein 0.0173 0.059 0.0583
Entamoeba histolytica PH domain containing protein kinase, putative 0.0026 0.0038 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.2128 0.7942 0.7942
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1265 0.4698 0.4656
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0173 0.059 0.0561
Entamoeba histolytica hypothetical protein 0.0173 0.059 0.0583
Brugia malayi Protein kinase domain containing protein 0.0036 0.0078 0.0071
Echinococcus multilocularis cyclin B 0.0042 0.0099 0.0092
Trichomonas vaginalis cyclin B, putative 0.0042 0.0099 0.0099
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0173 0.059 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.3314 0.3314
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0057
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2675 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0083 0.0076
Loa Loa (eye worm) phosphatidylinositol 3 0.2675 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0173 0.059 0.0583
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0173 0.059 0.0583
Trichomonas vaginalis cyclin B, putative 0.0018 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.1737 0.6471 0.6471
Trichomonas vaginalis cyclin A, putative 0.0042 0.0099 0.0099
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0173 0.059 0.0496
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.059 0.0583
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0173 0.059 0.0583
Trichomonas vaginalis cyclins, putative 0.0029 0.0049 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.3314 0.3314
Trichomonas vaginalis PIKK family atypical protein kinase 0.2128 0.7942 0.7942
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0173 0.059 0.0561
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0897 0.3314 0.331
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0897 0.3314 0.3262
Trypanosoma cruzi cyclin, putative 0.0042 0.0099 0.0069
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0173 0.059 0.059
Loa Loa (eye worm) AGC/AKT protein kinase 0.0036 0.0078 0.0071
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0173 0.059 0.0561
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0897 0.3314 0.331
Echinococcus multilocularis rac serine:threonine kinase 0.0026 0.0038 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0007 0.0007
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0173 0.059 0.0583
Plasmodium vivax hypothetical protein, conserved 0.0173 0.059 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2675 1 1
Trichomonas vaginalis cyclin D, putative 0.0018 0.0007 0.0007
Trypanosoma cruzi cyclin, putative 0.0042 0.0099 0.0069
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0073 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.3314 0.3314
Trichomonas vaginalis PIKK family atypical protein kinase 0.1598 0.5952 0.5952
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0173 0.059 0.0583
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2675 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0173 0.059 0.059
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0173 0.059 0.059
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0583
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0173 0.059 0.0583
Entamoeba histolytica PH domain containing protein kinase, putative 0.0026 0.0038 0.0031
Entamoeba histolytica protein kinase, putative 0.0036 0.0078 0.0071
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0561
Trypanosoma brucei target of rapamycin kinase 3, putative 0.213 0.795 0.7934
Loa Loa (eye worm) phosphatidylinositol 3 0.0173 0.059 0.0583
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0506 0.1844 0.1838
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.2128 0.7942 0.7942
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.1844 0.1844
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0173 0.059 0.0707
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0147 0.0493 0.0487
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0173 0.059 0.0583
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Plasmodium vivax hypothetical protein 0.0173 0.059 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0173 0.059 0.0583
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.213 0.795 0.793
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0493 0.0493
Entamoeba histolytica protein kinase rad3, putative 0.0506 0.1844 0.1838
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2675 1 1
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0147 0.0493 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.059 0.059
Echinococcus multilocularis Zinc finger, PHD finger 0.0173 0.059 0.0583
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0173 0.059 0.059
Entamoeba histolytica protein kinase, putative 0.0036 0.0078 0.0071
Leishmania major hypothetical protein, conserved 0.0173 0.059 0.0496
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0024 0.003 0.0023
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2675 1 1
Loa Loa (eye worm) hypothetical protein 0.0506 0.1844 0.1838
Leishmania major phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0496
Loa Loa (eye worm) hypothetical protein 0.0333 0.1195 0.1188
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.0493 0.0493
Trypanosoma cruzi CYC2-like cyclin, putative 0.0042 0.0099 0.0069
Trypanosoma cruzi target of rapamycin kinase 3 0.213 0.795 0.7944
Trichomonas vaginalis PIKK family atypical protein kinase 0.1442 0.5364 0.5364
Trichomonas vaginalis PIKK family atypical protein kinase 0.1598 0.5952 0.5952
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0173 0.059 0.0516
Leishmania major phosphatidylinositol 3-kinase, putative 0.0897 0.3314 0.3247
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0173 0.059 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.1844 0.1844
Loa Loa (eye worm) hypothetical protein 0.0173 0.059 0.0583
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2675 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0173 0.059 0.0561
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0333 0.1195 0.1168
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0173 0.059 0.059
Giardia lamblia GTOR 0.2675 1 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0897 0.3314 0.3247
Trichomonas vaginalis cyclins, putative 0.0042 0.0099 0.0099
Echinococcus multilocularis nervana 2 0.0021 0.0019 0.0012
Trichomonas vaginalis cyclins, putative 0.0018 0.0007 0.0007
Trichomonas vaginalis cyclin B3, putative 0.0018 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0173 0.059 0.0561
Giardia lamblia G2/mitotic-specific cyclin B 0.0042 0.0099 0.0092
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1111 0.4119 0.4073
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0173 0.059 0.0561
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.3314 0.3314
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0173 0.059 0.0583
Entamoeba histolytica protein kinase, putative 0.0034 0.007 0.0063
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.059 0.0583
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0026
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2675 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0897 0.3314 0.3294
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0173 0.059 0.0583
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0173 0.059 0.0583
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0506 0.1844 0.1838
Loa Loa (eye worm) phosphatidylinositol 3 0.0173 0.059 0.0583
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0173 0.059 1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0024 0.003 0.0402
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2675 1 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0026 0.0038 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.0322 0.1152 0.1145
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0019 0.0012
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0173 0.059 0.0583
Brugia malayi Protein kinase domain containing protein 0.0322 0.1152 0.1145
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0173 0.059 0.0583
Giardia lamblia Kinase, TTK 0.0147 0.0493 0.0487
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0173 0.059 0.0583
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0173 0.059 0.0707
Schistosoma mansoni serine/threonine-protein kinase 0.0026 0.0038 0.0031
Toxoplasma gondii FATC domain-containing protein 0.0506 0.1844 0.2412
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0322 0.1152 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.199 0.7422 0.7422
Trichomonas vaginalis PIKK family atypical protein kinase 0.1444 0.5373 0.5373
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0173 0.059 1
Brugia malayi FAT domain containing protein 0.0391 0.1412 0.1406
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0173 0.059 0.0707
Trichomonas vaginalis PIKK family atypical protein kinase 0.2128 0.7942 0.7942
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0173 0.059 0.059
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0897 0.3314 0.331
Trichomonas vaginalis PIKK family atypical protein kinase 0.2675 1 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0173 0.059 1
Mycobacterium leprae conserved hypothetical protein 0.0173 0.059 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.059 0.0583
Trichomonas vaginalis cyclin B, putative 0.0042 0.0099 0.0099
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.2284 0.8529 0.8529
Mycobacterium tuberculosis Conserved hypothetical protein 0.0173 0.059 0.5
Leishmania major hypothetical protein, unknown function 0.0173 0.059 0.0496
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0583
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0024 0.003 0.0023
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0506 0.1844 0.1838
Giardia lamblia Kinase, AGC PKA 0.0024 0.003 0.0023
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0173 0.059 0.0583
Echinococcus granulosus Glutaredoxin protein 5 0.0021 0.0019 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.1583 0.5892 0.5892
Echinococcus granulosus nervana 2 0.0021 0.0019 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0718 0.264 0.264
Brugia malayi Protein kinase domain containing protein 0.0147 0.0493 0.0487
Schistosoma mansoni serine/threonine-protein kinase 0.0026 0.0038 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0333 0.1195 0.1195
Loa Loa (eye worm) hypothetical protein 0.0545 0.1991 0.1985
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0322 0.1152 0.1145
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0096 0.0089
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0583
Echinococcus multilocularis Glutaredoxin protein 5 0.0021 0.0019 0.0012
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0173 0.059 1
Echinococcus multilocularis serine protein kinase ATM 0.0506 0.1844 0.1838
Loa Loa (eye worm) hypothetical protein 0.0042 0.0099 0.0092
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2675 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0506 0.1844 0.1838
Loa Loa (eye worm) hypothetical protein 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.0897 0.3314 0.3314
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0173 0.059 0.0707
Echinococcus granulosus serine threonine protein kinase nrc 0.0024 0.003 0.0023
Trichomonas vaginalis cyclin D, putative 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0391 0.1412 0.1406
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0516
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0173 0.059 0.0583
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0173 0.059 0.059
Brugia malayi p70 ribosomal S6 kinase beta 0.0034 0.007 0.0063
Trichomonas vaginalis cyclin B, putative 0.0042 0.0099 0.0099
Trichomonas vaginalis cyclins, putative 0.0042 0.0099 0.0099
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0564 0.2061 0.2708
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0073 0.0073
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0897 0.3314 0.3294
Loa Loa (eye worm) phosphatidylinositol 3 0.0897 0.3314 0.331
Loa Loa (eye worm) hypothetical protein 0.0042 0.0099 0.0092
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0506 0.1844 0.1819
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0083 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.1583 0.5892 0.5892
Leishmania major phosphatidylinositol kinase related protein, putative 0.0173 0.059 0.0496
Trypanosoma cruzi cyclin 6, putative 0.0042 0.0099 0.0069
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0173 0.059 0.0583
Echinococcus granulosus cyclin B 0.0042 0.0099 0.0092
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0322 0.1152 0.1145
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0173 0.059 0.0583
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0173 0.059 0.0583
Trichomonas vaginalis PIKK family atypical protein kinase 0.1442 0.5364 0.5364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0333 0.1195 0.1195
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.059 0.0583
Schistosoma mansoni hypothetical protein 0.0391 0.1412 0.1406
Trichomonas vaginalis PIKK family atypical protein kinase 0.1598 0.5952 0.5952
Entamoeba histolytica hypothetical protein 0.0173 0.059 0.0583
Echinococcus multilocularis nervana 2 0.0021 0.0019 0.0012
Loa Loa (eye worm) phosphatidylinositol 3 0.0173 0.059 0.0583
Schistosoma mansoni hypothetical protein 0.0173 0.059 0.0583
Entamoeba histolytica cyclin, putative 0.0042 0.0099 0.0092
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0078 0.0078
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0096 0.0089
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0173 0.059 0.059
Onchocerca volvulus 0.0173 0.059 0.4664
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0322 0.1152 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.1444 0.5373 0.5373
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0506 0.1844 0.1838
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2675 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0173 0.059 1
Trypanosoma brucei mitotic cyclin 6 0.0042 0.0099 0.0021
Toxoplasma gondii target of rapamycin (TOR), putative 0.199 0.7422 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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