TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 451.967 | Formula: C25H27ClFN5
H donors: 1 H acceptors: 2 LogP: 5.03 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)Cc1ccc(cc1)Nc1ncc(c(n1)c1ccc(c(c1)Cl)F)C1CC1
InChi: 1S/C25H27ClFN5/c1-31-10-12-32(13-11-31)16-17-2-7-20(8-3-17)29-25-28-15-21(18-4-5-18)24(30-25)19-6-9-23(27)22(26)14-19/h2-3,6-9,14-15,18H,4-5,10-13,16H2,1H3,(H,28,29,30)
InChiKey: OANXWUNQGWUAEP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	AXL receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_132328	All targets in OG5_132328

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.055	0.2012	0.2004
Trichomonas vaginalis	immunophilin, putative	0.0058	0.0106	0.0096
Loa Loa (eye worm)	phosphatidylinositol 3	0.2612	1	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0169	0.0532	0.0523
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0058	0.0106	0.5
Loa Loa (eye worm)	phosphatidylinositol 3	0.0169	0.0532	0.0532
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0169	0.0532	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0532	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0494	0.1793	0.1786
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.2612	1	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0169	0.0532	0.0514
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0058	0.0106	0.0087
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0876	0.3273	0.3267
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0876	0.3273	0.3201
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1561	0.5927	0.5923
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0876	0.3273	0.3252
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0876	0.3273	0.3261
Entamoeba histolytica	hypothetical protein	0.0169	0.0532	0.0431
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0494	0.1793	0.1778
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.2612	1	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0876	0.3273	0.3261
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0169	0.0532	0.0431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2077	0.7929	0.7927
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0494	0.1793	0.1706
Brugia malayi	FAT domain containing protein	0.0382	0.1359	0.1343
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0876	0.3273	0.3267
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0169	0.0532	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0169	0.0532	0.0523
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0876	0.3273	0.3267
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0169	0.0532	0.0431
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0494	0.1793	0.1778
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0169	0.0532	0.0514
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0169	0.0532	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2077	0.7929	0.7927
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0169	0.0532	0.0431
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0169	0.0532	0.0514
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0494	0.1793	0.1767
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0169	0.0532	0.0431
Entamoeba histolytica	hypothetical protein	0.0169	0.0532	0.0431
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0169	0.0532	0.0514
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1943	0.7407	0.7404
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.005	0.0074	0.0056
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0169	0.0532	0.0532
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0058	0.0106	0.0075
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.2612	1	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0494	0.1793	0.1706
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0169	0.0532	0.0502
Trichomonas vaginalis	PIKK family atypical protein kinase	0.141	0.5344	0.534
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0169	0.0532	0.0523
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1408	0.5336	0.5331
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0058	0.0106	0.0096
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0169	0.0532	0.0523
Onchocerca volvulus		0.0169	0.0532	0.5
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0169	0.0532	0.0532
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0058	0.0106	0.0087
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0169	0.0532	1
Entamoeba histolytica	hypothetical protein	0.0169	0.0532	0.0431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1545	0.5867	0.5863
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0169	0.0532	0.0514
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.208	0.7937	0.7915
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0169	0.0532	0.0502
Loa Loa (eye worm)	hypothetical protein	0.0382	0.1359	0.1359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1561	0.5927	0.5923
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0325	0.114	0.1132
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0169	0.0532	0.0431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.223	0.852	0.8519
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0169	0.0532	0.0523
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0169	0.0532	0.0502
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0169	0.0532	0.0431
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0169	0.0532	0.0514
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.2612	1	1
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0876	0.3273	0.3201
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0169	0.0532	0.0514
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0169	0.0532	0.0523
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0169	0.0532	0.0431
Loa Loa (eye worm)	phosphatidylinositol 3	0.0169	0.0532	0.0532
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.1235	0.4665	0.4608
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0169	0.0532	0.0514
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2077	0.7929	0.7927
Leishmania major	phosphatidylinositol kinase, putative	0.0169	0.0532	0.0431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1943	0.7407	0.7404
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0169	0.0532	0.0514
Trichomonas vaginalis	PIKK family atypical protein kinase	0.141	0.5344	0.534
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0169	0.0532	0.0514
Leishmania major	hypothetical protein, unknown function	0.0169	0.0532	0.0431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2612	1	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0169	0.0532	0.0523
Leishmania major	hypothetical protein, conserved	0.0169	0.0532	0.0431
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0169	0.0532	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0494	0.1793	0.1793
Echinococcus multilocularis	serine protein kinase ATM	0.0494	0.1793	0.1778
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2077	0.7929	0.7927
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0169	0.0532	0.0523
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0382	0.1359	0.1343
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0169	0.0532	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.141	0.5344	0.534
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0058	0.0106	0.0096
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0876	0.3273	0.3201
Entamoeba histolytica	protein kinase rad3, putative	0.0494	0.1793	0.1706
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0169	0.0532	0.0431
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.005	0.0074	0.0056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0701	0.2594	0.2588
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0169	0.0532	0.0502
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1545	0.5867	0.5863
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0169	0.0532	0.0502
Schistosoma mansoni	immunophilin	0.0058	0.0106	0.0075
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0876	0.3273	0.3201
Loa Loa (eye worm)	phosphatidylinositol 3	0.0169	0.0532	0.0532
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0058	0.0106	0.0087
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0169	0.0532	0.0431
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0169	0.0532	0.0431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1696	0.6449	0.6446
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0169	0.0532	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0532	0.1941	0.1941
Loa Loa (eye worm)	hypothetical protein	0.0325	0.114	0.114
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2612	1	1
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0494	0.1793	0.1778
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0876	0.3273	0.3267
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0169	0.0532	0.0523
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.2612	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0169	0.0532	0.0523
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0494	0.1793	0.1786
Loa Loa (eye worm)	phosphatidylinositol 3	0.0876	0.3273	0.3273
Schistosoma mansoni	hypothetical protein	0.0382	0.1359	0.1332
Schistosoma mansoni	hypothetical protein	0.0169	0.0532	0.0502
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.1085	0.4083	0.402
Loa Loa (eye worm)	phosphatidylinositol 3	0.0169	0.0532	0.0532
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0169	0.0532	0.0431
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.2612	1	1
Plasmodium vivax	hypothetical protein	0.0169	0.0532	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0169	0.0532	0.0431
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0169	0.0532	0.0523
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0876	0.3273	0.3201
Giardia lamblia	GTOR	0.2612	1	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0169	0.0532	0.0431
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0169	0.0532	1
Trichomonas vaginalis	conserved hypothetical protein	0.0325	0.114	0.1132
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0169	0.0532	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0532	0.0532
Trichomonas vaginalis	fk506-binding protein, putative	0.0058	0.0106	0.0096
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0058	0.0106	0.0087
Loa Loa (eye worm)	phosphatidylinositol 3	0.0169	0.0532	0.0532
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0169	0.0532	0.0514
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0058	0.0106	0.0087
Mycobacterium leprae	conserved hypothetical protein	0.0169	0.0532	0.5
Toxoplasma gondii	FATC domain-containing protein	0.0494	0.1793	0.1835
Echinococcus multilocularis		0.0169	0.0532	0.0514
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0169	0.0532	0.0514
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0169	0.0532	0.0514
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0058	0.0106	0.0106
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0494	0.1793	0.1778
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1943	0.7407	0.7404
Entamoeba histolytica	hypothetical protein	0.0494	0.1793	0.1706
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0169	0.0532	0.0514
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0169	0.0532	0.0431
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0494	0.1793	0.1767
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0876	0.3273	0.3201
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0169	0.0532	0.0431
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0876	0.3273	0.3261
Onchocerca volvulus		0.0169	0.0532	0.5
Entamoeba histolytica	hypothetical protein	0.0169	0.0532	0.0431
Loa Loa (eye worm)	FKBP5 protein	0.0058	0.0106	0.0106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2077	0.7929	0.7927
Trichomonas vaginalis	PIKK family atypical protein kinase	0.141	0.5344	0.534
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0169	0.0532	0.0523
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.2612	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1408	0.5336	0.5331
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0169	0.0532	0.0431
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0169	0.0532	0.0431
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0169	0.0532	0.0431
Echinococcus multilocularis	Zinc finger, PHD finger	0.0169	0.0532	0.0514
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0169	0.0532	0.0514
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0494	0.1793	0.1706
Loa Loa (eye worm)	hypothetical protein	0.055	0.2012	0.2012
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0058	0.0106	0.5
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.2612	1	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0169	0.0532	0.0431
Trichomonas vaginalis	conserved hypothetical protein	0.0382	0.1359	0.1351
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.2612	1	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.2612	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0169	0.0532	0.0523
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0018	0.0018
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0169	0.0532	0.0514
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0169	0.0532	0.0431
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0169	0.0532	0.0523
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0169	0.0532	0.0502
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0169	0.0532	0.0431
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1943	0.7407	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1752	0.6668	0.6665
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1943	0.7407	0.7404
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0169	0.0532	0.0514
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0494	0.1793	0.1786
Schistosoma mansoni	immunophilin	0.0058	0.0106	0.0075
Schistosoma mansoni	immunophilin	0.005	0.0074	0.0043
Trypanosoma cruzi	target of rapamycin kinase 3	0.208	0.7937	0.7915
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0382	0.1359	0.1343
Giardia lamblia	Hypothetical protein	0.0169	0.0532	0.0431
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0169	0.0532	0.0431
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1943	0.7407	0.7404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1561	0.5927	0.5923
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0169	0.0532	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1943	0.7407	0.7404
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1408	0.5336	0.5331
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0169	0.0532	0.0514
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0169	0.0532	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0169	0.0532	0.0431
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.2612	1	1
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0169	0.0532	0.0431
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0494	0.1793	0.1706
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1943	0.7407	0.7404
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0169	0.0532	0.0502
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0876	0.3273	0.3267
Plasmodium vivax	hypothetical protein, conserved	0.0169	0.0532	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0169	0.0532	1
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0169	0.0532	0.0431
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0169	0.0532	0.0523
Echinococcus multilocularis	fk506 binding protein	0.0058	0.0106	0.0087
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0169	0.0532	0.0431
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0325	0.114	0.1046
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0169	0.0532	0.0514
Echinococcus granulosus	serine protein kinase ATM	0.0494	0.1793	0.1778
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0169	0.0532	0.0514
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2612	1	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.208	0.7937	0.7915
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.055	0.2012	0.2153
Loa Loa (eye worm)	hypothetical protein	0.005	0.0074	0.0074

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.4 uM	Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis	ChEMBL.	22247788

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2022967

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1638483