Detailed information for compound 1647111

Basic information

Technical information
  • TDR Targets ID: 1647111
  • Name: 3-ethyl-1-[[2-[[2-[(ethylcarbamothioylamino)c arbamoyl]phenyl]amino]benzoyl]amino]thiourea
  • MW: 459.588 | Formula: C20H25N7O2S2
  • H donors: 7 H acceptors: 2 LogP: 3.18 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCNC(=S)NNC(=O)c1ccccc1Nc1ccccc1C(=O)NNC(=S)NCC
  • InChi: 1S/C20H25N7O2S2/c1-3-21-19(30)26-24-17(28)13-9-5-7-11-15(13)23-16-12-8-6-10-14(16)18(29)25-27-20(31)22-4-2/h5-12,23H,3-4H2,1-2H3,(H,24,28)(H,25,29)(H2,21,26,30)(H2,22,27,31)
  • InChiKey: GKJIXJBUVXETAO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-ethyl-1-[[[2-[[2-[[N'-(ethylamino-thioxomethyl)hydrazino]-oxomethyl]phenyl]amino]phenyl]-oxomethyl]amino]thiourea
  • 3-ethyl-1-[[2-[[2-[(ethylthiocarbamoylamino)carbamoyl]phenyl]amino]benzoyl]amino]thiourea
  • 3-ethyl-1-[[2-[[2-[(ethylcarbamothioylamino)carbamoyl]phenyl]amino]phenyl]carbonylamino]thiourea
  • NSC698457
  • AIDS152991
  • N-Ethyl-2-(2-(2-((2-((ethylamino)carbothioyl)hydrazino)carbonyl)anilino)benzoyl)hydrazinecarbothioamide
  • NCI60_035274
  • AIDS-152991

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0218 0.056 0.0505
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0218 0.056 0.0505
Toxoplasma gondii target of rapamycin (TOR), putative 0.2518 0.7414 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2518 0.7414 0.7413
Trichomonas vaginalis PIKK family atypical protein kinase 0.2271 0.6678 0.6676
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0218 0.056 0.0505
Entamoeba histolytica protein kinase rad3, putative 0.064 0.1818 0.1818
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0058 0.0081 0.0024
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0495 0.1384 0.1335
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2695 0.7944 0.7927
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0058 0.0081 0.5
Entamoeba histolytica hypothetical protein 0.0218 0.056 0.056
Giardia lamblia Phosphatidylinositol 4-kinase 0.0218 0.056 0.0483
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0218 0.056 0.0483
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0218 0.056 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.064 0.1818 0.1813
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3385 1 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0058 0.0081 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0713 0.2036 0.2031
Schistosoma mansoni hypothetical protein 0.0495 0.1384 0.1335
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0218 0.056 0.056
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3385 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3385 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0218 0.056 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.056 0.0554
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0058 0.0081 0.0081
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0218 0.056 0.0554
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0218 0.056 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0218 0.056 0.0554
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0218 0.056 0.0505
Echinococcus granulosus serine protein kinase ATM 0.064 0.1818 0.177
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0218 0.056 0.0505
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0218 0.056 0.0554
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0218 0.056 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0422 0.1166 0.1161
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2695 0.7944 0.7942
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3385 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0713 0.2036 0.2745
Entamoeba histolytica protein kinase, putative 0.0033 0.0006 0.0006
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0058 0.0081 0.0075
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0218 0.056 0.056
Trichomonas vaginalis PIKK family atypical protein kinase 0.2518 0.7414 0.7413
Trichomonas vaginalis PIKK family atypical protein kinase 0.2518 0.7414 0.7413
Trichomonas vaginalis PIKK family atypical protein kinase 0.2023 0.5939 0.5936
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0218 0.056 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.1825 0.5349 0.5347
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0218 0.056 0.056
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3385 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.056 0.0554
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0218 0.056 0.0483
Loa Loa (eye worm) phosphatidylinositol 3 0.0218 0.056 0.056
Trichomonas vaginalis PIKK family atypical protein kinase 0.1135 0.3293 0.3289
Leishmania major phosphatidylinositol 4-kinase, putative 0.0218 0.056 0.0483
Loa Loa (eye worm) hypothetical protein 0.064 0.1818 0.1818
Trichomonas vaginalis PIKK family atypical protein kinase 0.2518 0.7414 0.7413
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0218 0.056 0.056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0218 0.056 0.056
Plasmodium vivax hypothetical protein 0.0218 0.056 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3385 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1135 0.3293 0.3238
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0218 0.056 0.0554
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0218 0.056 0.0554
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0422 0.1166 0.1094
Loa Loa (eye worm) AGC/AKT protein kinase 0.0033 0.0006 0.0006
Leishmania major phosphatidylinositol kinase related protein, putative 0.0218 0.056 0.0483
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0058 0.0081 0.0081
Brugia malayi FAT domain containing protein 0.0495 0.1384 0.1384
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0218 0.056 0.0755
Echinococcus granulosus serine:threonine protein kinase SMG1 0.064 0.1818 0.177
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1135 0.3293 0.3254
Trichomonas vaginalis fk506-binding protein, putative 0.0058 0.0081 0.0075
Loa Loa (eye worm) hypothetical protein 0.0218 0.056 0.056
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0218 0.056 0.0483
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1406 0.41 0.4097
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3385 1 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0218 0.056 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0218 0.056 0.056
Leishmania major phosphatidylinositol kinase, putative 0.0218 0.056 0.0483
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0218 0.056 0.056
Toxoplasma gondii FATC domain-containing protein 0.064 0.1818 0.2451
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0218 0.056 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.1135 0.3293 0.3289
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.064 0.1818 0.177
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1135 0.3293 0.3293
Entamoeba histolytica hypothetical protein 0.0218 0.056 0.056
Entamoeba histolytica hypothetical protein 0.0218 0.056 0.056
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0218 0.056 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.2693 0.7935 0.7934
Entamoeba histolytica hypothetical protein 0.0218 0.056 0.056
Trichomonas vaginalis PIKK family atypical protein kinase 0.1828 0.5358 0.5355
Schistosoma mansoni immunophilin 0.0058 0.0081 0.0024
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0218 0.056 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1825 0.5349 0.5347
Trichomonas vaginalis PIKK family atypical protein kinase 0.3385 1 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0218 0.056 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0058 0.0081 0.0024
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0058 0.0081 0.0024
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0218 0.056 0.0554
Trichomonas vaginalis immunophilin, putative 0.0058 0.0081 0.0075
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0218 0.056 0.0505
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0218 0.056 0.0554
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0218 0.056 0.0505
Entamoeba histolytica hypothetical protein 0.064 0.1818 0.1818
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0218 0.056 0.0554
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0218 0.056 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0058 0.0081 0.5
Schistosoma mansoni hypothetical protein 0.0218 0.056 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.2518 0.7414 0.7413
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.064 0.1818 0.1818
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0218 0.056 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.1828 0.5358 0.5355
Trichomonas vaginalis PIKK family atypical protein kinase 0.2518 0.7414 0.7413
Trichomonas vaginalis PIKK family atypical protein kinase 0.3385 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0218 0.056 0.0554
Loa Loa (eye worm) phosphatidylinositol kinase 0.0218 0.056 0.056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0218 0.056 0.056
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0218 0.056 0.0483
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.064 0.1818 0.177
Leishmania major hypothetical protein, unknown function 0.0218 0.056 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.064 0.1818 0.1813
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0218 0.056 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.2693 0.7935 0.7934
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0218 0.056 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.1828 0.5358 0.5355
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0218 0.056 0.0505
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0495 0.1384 0.1335
Trichomonas vaginalis PIKK family atypical protein kinase 0.1135 0.3293 0.3289
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0218 0.056 0.056
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.064 0.1818 0.175
Trichomonas vaginalis PIKK family atypical protein kinase 0.289 0.8524 0.8524
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0218 0.056 0.0755
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0218 0.056 1
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0058 0.0081 0.0081
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0218 0.056 0.056
Loa Loa (eye worm) phosphatidylinositol 3 0.3385 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0218 0.056 0.0755
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0218 0.056 0.0505
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1135 0.3293 0.3254
Mycobacterium leprae conserved hypothetical protein 0.0218 0.056 0.5
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0218 0.056 0.056
Leishmania major hypothetical protein, conserved 0.0218 0.056 0.0483
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1601 0.4681 0.4678
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0218 0.056 0.056
Trichomonas vaginalis PIKK family atypical protein kinase 0.2693 0.7935 0.7934
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0218 0.056 0.056
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.064 0.1818 0.1818
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3385 1 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.056 0.056
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1135 0.3293 0.3289
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3385 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0218 0.056 0.0554
Loa Loa (eye worm) FKBP5 protein 0.0058 0.0081 0.0081
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0218 0.056 0.0755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0908 0.2616 0.2612
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0218 0.056 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.2003 0.5879 0.5876
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1135 0.3293 0.3238
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0058 0.0081 0.0081
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0218 0.056 0.0505
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0218 0.056 0.0755
Trichomonas vaginalis PIKK family atypical protein kinase 0.2198 0.646 0.6458
Loa Loa (eye worm) hypothetical protein 0.069 0.1965 0.1965
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0081 0.0075
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0218 0.056 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0218 0.056 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0422 0.1166 0.1161
Trichomonas vaginalis PIKK family atypical protein kinase 0.1135 0.3293 0.3289
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0218 0.056 0.056
Echinococcus multilocularis serine protein kinase ATM 0.064 0.1818 0.177
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1135 0.3293 0.3238
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3385 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.064 0.1818 0.1813
Trichomonas vaginalis PIKK family atypical protein kinase 0.2693 0.7935 0.7934
Entamoeba histolytica protein kinase, putative 0.0033 0.0006 0.0006
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0218 0.056 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.0495 0.1384 0.1379
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1135 0.3293 0.3254
Onchocerca volvulus 0.0218 0.056 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0218 0.056 0.0483
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1135 0.3293 0.3289
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0218 0.056 0.056
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0218 0.056 0.0483
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3385 1 1
Loa Loa (eye worm) hypothetical protein 0.0713 0.2036 0.2036
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0218 0.056 0.0554
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0218 0.056 0.0554
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0081 0.0075
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0218 0.056 0.0554
Schistosoma mansoni fkbp-rapamycin associated protein 0.064 0.1818 0.177
Loa Loa (eye worm) phosphatidylinositol 3 0.0218 0.056 0.056
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3385 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0218 0.056 0.0554
Trichomonas vaginalis PIKK family atypical protein kinase 0.1135 0.3293 0.3289
Brugia malayi Protein kinase domain containing protein 0.0033 0.0006 0.0006
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0058 0.0081 0.0075
Leishmania major phosphatidylinositol 3-kinase, putative 0.1135 0.3293 0.3238
Loa Loa (eye worm) phosphatidylinositol 3 0.1135 0.3293 0.3293
Trichomonas vaginalis PIKK family atypical protein kinase 0.2023 0.5939 0.5936
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0218 0.056 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.1825 0.5349 0.5347
Loa Loa (eye worm) hypothetical protein 0.005 0.0058 0.0058
Mycobacterium tuberculosis Conserved hypothetical protein 0.0218 0.056 0.5
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0218 0.056 0.0505
Loa Loa (eye worm) phosphatidylinositol 3 0.0218 0.056 0.056
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0058 0.0081 0.0081
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0218 0.056 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.2003 0.5879 0.5876
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0218 0.056 0.0483
Echinococcus multilocularis fk506 binding protein 0.0058 0.0081 0.0024
Trypanosoma cruzi target of rapamycin kinase 3 0.2695 0.7944 0.7927
Echinococcus multilocularis Zinc finger, PHD finger 0.0218 0.056 0.0505
Loa Loa (eye worm) hypothetical protein 0.0495 0.1384 0.1384
Trichomonas vaginalis PIKK family atypical protein kinase 0.2023 0.5939 0.5936
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0218 0.056 0.056
Loa Loa (eye worm) hypothetical protein 0.0422 0.1166 0.1166
Plasmodium vivax hypothetical protein, conserved 0.0218 0.056 1
Echinococcus multilocularis 0.0218 0.056 0.0505
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.064 0.1818 0.1818
Loa Loa (eye worm) phosphatidylinositol 3 0.0218 0.056 0.056
Giardia lamblia Hypothetical protein 0.0218 0.056 0.0483
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0218 0.056 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.2693 0.7935 0.7934
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0218 0.056 0.0505
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.064 0.1818 0.175
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0218 0.056 0.0505
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0218 0.056 0.056
Giardia lamblia GTOR 0.3385 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0218 0.056 0.0554
Schistosoma mansoni immunophilin 0.0058 0.0081 0.0024
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0218 0.056 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.2518 0.7414 0.7413
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.064 0.1818 0.1813
Onchocerca volvulus 0.0218 0.056 0.5
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0218 0.056 0.0505
Trichomonas vaginalis PIKK family atypical protein kinase 0.1828 0.5358 0.5355

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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