Detailed information for compound 1649517

Basic information

Technical information
  • TDR Targets ID: 1649517
  • Name: 5-(4-methoxyphenyl)-N-[[5-(4-nitrophenyl)fura n-2-yl]methylideneamino]-1,2,4-triazin-3-amin e
  • MW: 416.39 | Formula: C21H16N6O4
  • H donors: 1 H acceptors: 5 LogP: 3.67 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1cnnc(n1)N/N=C/c1ccc(o1)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C21H16N6O4/c1-30-17-8-4-14(5-9-17)19-13-23-26-21(24-19)25-22-12-18-10-11-20(31-18)15-2-6-16(7-3-15)27(28)29/h2-13H,1H3,(H,24,25,26)/b22-12+
  • InChiKey: NXTACUHNJBVHTQ-WSDLNYQXSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(4-methoxyphenyl)-N-[[5-(4-nitrophenyl)-2-furyl]methyleneamino]-1,2,4-triazin-3-amine
  • [5-(4-methoxyphenyl)-1,2,4-triazin-3-yl]-[[5-(4-nitrophenyl)-2-furyl]methyleneamino]amine
  • 5-(4-nitrophenyl)-2-furaldehyde [5-(4-methoxyphenyl)-1,2,4-triazin-3-yl]hydrazone
  • MLS000724516
  • SMR000306109

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens acid phosphatase 1, soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans 3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene Get druggable targets OG5_127571 All targets in OG5_127571
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein Get druggable targets OG5_127571 All targets in OG5_127571
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans C terminus of potential Low molecular weight phosphoTyrosine Phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA Get druggable targets OG5_127571 All targets in OG5_127571
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) Get druggable targets OG5_127571 All targets in OG5_127571
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Onchocerca volvulus Get druggable targets OG5_127571 All targets in OG5_127571
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) phosphotyrosine protein phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Mycobacterium tuberculosis Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) acid phosphatase 1, soluble 112 aa 107 aa 24.3 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0288 0.018
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0464 0.6029
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0288 0.018
Brugia malayi hypothetical protein 0.0045 0.0288 0.0288
Echinococcus multilocularis protein dispatched 1 0.0058 0.0545 0.044
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0148 0.2834
Onchocerca volvulus 0.0045 0.0288 0.0363
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0045 0.0288 0.0206
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0288 0.0206
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1959 0.7378
Onchocerca volvulus 0.0045 0.0288 0.0363
Echinococcus granulosus geminin 0.0205 0.3419 0.3363
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1736 0.4081
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0045 0.0288 0.018
Schistosoma mansoni hypothetical protein 0.0041 0.021 0.0101
Echinococcus granulosus expressed conserved protein 0.0112 0.1594 0.1523
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0584 0.0584
Onchocerca volvulus 0.0045 0.0288 0.0363
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0288 0.018
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0523 0.0523
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.3836 0.7503
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.011 0.2104
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0226 0.3836 1
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0045 0.0288 0.018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.3836 0.7503
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Toxoplasma gondii thioredoxin reductase 0.0057 0.0523 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.2244 1
Brugia malayi Protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0045 0.0288 0.018
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0584 0.0584
Leishmania major tyrosine specific protein phosphatase, putative 0.0045 0.0288 0.3745
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0226 0.3836 0.3836
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0045 0.0288 0.3745
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.3836 1
Onchocerca volvulus 0.0045 0.0288 0.0363
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0045 0.0288 0.0288
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0045 0.0288 0.018
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0769 1
Onchocerca volvulus 0.0226 0.3836 0.7593
Schistosoma mansoni hypothetical protein 0.0049 0.0368 0.0261
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.0769 0.1017
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0045 0.0288 0.018
Brugia malayi hypothetical protein 0.0182 0.2984 0.2984
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.054 1 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Loa Loa (eye worm) protein-tyrosine phosphatase 0.054 1 1
Onchocerca volvulus 0.0045 0.0288 0.0363
Onchocerca volvulus 0.0045 0.0288 0.0363
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0411 0.746 0.7432
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0045 0.0288 0.018
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0045 0.0288 0.018
Echinococcus multilocularis hypothetical protein 0.0045 0.0288 0.018
Echinococcus multilocularis geminin 0.0205 0.3419 0.3345
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0404 0.0323
Onchocerca volvulus 0.0045 0.0288 0.0363
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Onchocerca volvulus 0.0045 0.0288 0.0363
Echinococcus multilocularis expressed conserved protein 0.0112 0.1594 0.1501
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.007 0.0769 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0404 0.0297
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0045 0.0288 0.018
Onchocerca volvulus 0.0045 0.0288 0.0363
Trichomonas vaginalis set domain proteins, putative 0.0286 0.5017 1
Brugia malayi Protein-tyrosine phosphatase 1 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0045 0.0288 0.018
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.054 1 1
Leishmania major trypanothione reductase 0.0057 0.0523 0.6803
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0045 0.0288 0.0206
Schistosoma mansoni hypothetical protein 0.0205 0.3419 0.3345
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0045 0.0288 0.0206
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0288 0.018
Echinococcus multilocularis 0.0045 0.0288 0.018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Echinococcus granulosus protein tyrosine phosphatase n9 0.0045 0.0288 0.0206
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0045 0.0288 0.018
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0045 0.0288 0.018
Trypanosoma brucei trypanothione reductase 0.0057 0.0523 0.6803
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0045 0.0288 0.018
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0045 0.0288 0.0206
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0288 0.0206
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Onchocerca volvulus 0.0045 0.0288 0.0363
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0288 0.0206
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0045 0.0288 0.0288
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Echinococcus multilocularis dna polymerase eta 0.0054 0.0464 0.0358
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0288 0.018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0288 0.0206
Schistosoma mansoni protein tyrosine phosphatase 0.0045 0.0288 0.018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0288 0.0206
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0119 0.1736 0.1736
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Brugia malayi hypothetical protein 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0054 0.0464 0.0464
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1959 0.7378
Echinococcus granulosus dna polymerase eta 0.0054 0.0464 0.0383
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Onchocerca volvulus 0.0045 0.0288 0.0363
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.3836 0.7503
Brugia malayi Thioredoxin reductase 0.0057 0.0523 0.0523
Schistosoma mansoni hypothetical protein 0.0049 0.0368 0.0261
Plasmodium falciparum glutathione reductase 0.0057 0.0523 1
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.2737 0.2656
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Brugia malayi glutathione reductase 0.0057 0.0523 0.0523
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0523 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.011 0.011
Plasmodium vivax SET domain protein, putative 0.0036 0.011 0.2104
Onchocerca volvulus 0.0045 0.0288 0.0363
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1736 0.1644
Onchocerca volvulus 0.0286 0.5017 1
Onchocerca volvulus 0.0182 0.2984 0.5857
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0156 0.2469 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0045 0.0288 0.0288
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.3836 1
Onchocerca volvulus 0.0045 0.0288 0.0363
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.2244 0.8844
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Plasmodium falciparum thioredoxin reductase 0.0057 0.0523 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0045 0.0288 0.018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Schistosoma mansoni patched 1 0.0051 0.0404 0.0297
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0404 0.0323
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0464 0.6029
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0411 0.746 0.7432
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0226 0.3836 0.3836
Brugia malayi hypothetical protein 0.0045 0.0288 0.0288
Loa Loa (eye worm) protein tyrosine phosphatase 0.0045 0.0288 0.0288
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0045 0.0288 0.0206
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0045 0.0288 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0404 0.0245
Loa Loa (eye worm) hypothetical protein 0.0062 0.0629 0.0629
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0045 0.0288 0.018
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.3836 0.7503
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0288 0.0206
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0045 0.0288 0.018
Onchocerca volvulus 0.0045 0.0288 0.0363
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0523 0.0418
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.2244 0.8844
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0523 0.0443
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0288 0.018
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0045 0.0288 0.0288
Brugia malayi Protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Onchocerca volvulus 0.0045 0.0288 0.0363
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0226 0.3836 0.5
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.2244 0.8844
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0411 0.746 0.746
Leishmania major DNA polymerase eta, putative 0.0054 0.0464 0.6029
Brugia malayi hypothetical protein 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0041 0.021 0.021
Leishmania major DNA polymerase eta, putative 0.0038 0.0148 0.1928
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.011 0.0026
Schistosoma mansoni protein tyrosine phosphatase 0.0045 0.0288 0.018
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0045 0.0288 0.018
Onchocerca volvulus 0.0045 0.0288 0.0363
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Onchocerca volvulus 0.0045 0.0288 0.0363
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0045 0.0288 0.0206
Onchocerca volvulus 0.0045 0.0288 0.0363
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0045 0.0288 0.018
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.3836 0.7503
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0288 0.0206
Onchocerca volvulus 0.0045 0.0288 0.0363
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1959 0.7378
Brugia malayi hypothetical protein 0.0045 0.0288 0.0288
Mycobacterium tuberculosis Probable reductase 0.013 0.1959 0.7378
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.054 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0045 0.0288 0.018
Plasmodium vivax glutathione reductase, putative 0.0057 0.0523 1
Onchocerca volvulus 0.0045 0.0288 0.0363
Onchocerca volvulus 0.0045 0.0288 0.0363
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0045 0.0288 0.018
Loa Loa (eye worm) hypothetical protein 0.006 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0051 0.0404 0.0404
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0045 0.0288 0.3745
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0411 0.746 0.7439
Schistosoma mansoni hypothetical protein 0.0205 0.3419 0.3345
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1959 0.7378
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0584 0.0584
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0045 0.0288 0.0288
Onchocerca volvulus 4.1 G protein, putative homolog 0.0045 0.0288 0.0363
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0045 0.0288 0.018
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0404 0.0404
Leishmania major hypothetical protein, conserved 0.007 0.0769 1
Brugia malayi Pre-SET motif family protein 0.0036 0.011 0.011
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.054 1 1
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0045 0.0288 0.3745
Loa Loa (eye worm) hypothetical protein 0.0182 0.2984 0.2984
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0148 0.1928
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.2737 0.2676
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1772 0.168
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Schistosoma mansoni DNA polymerase eta 0.0054 0.0464 0.0358
Trypanosoma brucei protein tyrosine phosphatase 1 0.0045 0.0288 0.3745
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0045 0.0288 0.3745
Echinococcus multilocularis protein patched 0.0051 0.0404 0.0297
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0045 0.0288 0.018
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0769 1
Schistosoma mansoni hypothetical protein 0.0049 0.0368 0.0261
Onchocerca volvulus 0.0045 0.0288 0.0363
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1959 0.7378
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0045 0.0288 0.0206
Schistosoma mansoni hypothetical protein 0.0049 0.0368 0.0261
Brugia malayi Pre-SET motif family protein 0.0251 0.4335 0.4335
Onchocerca volvulus 0.0045 0.0288 0.0363
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0045 0.0288 0.018
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1736 0.1736
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.0769 0.1017
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0045 0.0288 0.018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.3836 0.7503
Loa Loa (eye worm) hypothetical protein 0.0045 0.0288 0.0288
Schistosoma mansoni pcd6 interacting protein-related 0.0045 0.0288 0.018
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0045 0.0288 0.0288
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0288 0.0288
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0288 0.0206
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.4335 0.4335
Brugia malayi CHE-14 protein 0.0051 0.0404 0.0404
Schistosoma mansoni protein tyrosine phosphatase 0.0045 0.0288 0.018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0411 0.746 0.746
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1736 0.1666
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.054 1 1
Loa Loa (eye worm) glutathione reductase 0.0057 0.0523 0.0523
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0045 0.0288 0.018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0288 0.0288
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0523 0.6803
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0045 0.0288 0.018

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 6.62 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 50 uM PUBCHEM_BIOASSAY: Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID782] ChEMBL. No reference
IC50 (functional) 80 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0474 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8199 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.0323 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.