Detailed information for compound 1656365

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 398.237 | Formula: C18H17Cl2NO5
  • H donors: 0 H acceptors: 2 LogP: 5.28 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)C/C(=C/c1ccc(c(c1)Cl)Cl)/[N+](=O)[O-]
  • InChi: 1S/C18H17Cl2NO5/c1-24-16-9-12(10-17(25-2)18(16)26-3)7-13(21(22)23)6-11-4-5-14(19)15(20)8-11/h4-6,8-10H,7H2,1-3H3/b13-6-
  • InChiKey: JPBLCHIEIHSGJP-MLPAPPSSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0455 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0044 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0455 0.126
Brugia malayi Smad1 0.0008 0.0076 0.0211
Leishmania major hypothetical protein, conserved 0.0025 0.0492 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0455 1
Schistosoma mansoni polyadenylate binding protein 0.0009 0.0093 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0118 0.0327
Brugia malayi CXXC zinc finger family protein 0.0029 0.0579 0.1604
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0492 0.3845
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0492 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0579 0.1604
Brugia malayi MH2 domain containing protein 0.0123 0.2927 0.8105
Schistosoma mansoni coup transcription factor 0.001 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0327
Schistosoma mansoni hypothetical protein 0.0011 0.0148 0.0148
Schistosoma mansoni thyroid hormone receptor 0.001 0.0118 0.0118
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.004 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0118 0.0327
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0307 0.6617
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0118 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0283 0.6071
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0327
Echinococcus granulosus Eukaryotic translation initiation factor 4H 0.0134 0.3207 0.3207
Echinococcus granulosus FTZ F1 alpha 0.001 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0169 0.4065 0.4065
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.004 0.0111
Loa Loa (eye worm) hypothetical protein 0.0151 0.3611 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0307 0.0849
Echinococcus multilocularis polyadenylate binding protein 0.0009 0.0093 0.0093
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0085 0.0235
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0118 0.0118
Echinococcus multilocularis cpg binding protein 0.003 0.062 0.062
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0076 0.0211
Loa Loa (eye worm) hypothetical protein 0.0024 0.0455 0.126
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0327
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0455 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0307 0.5
Schistosoma mansoni cpg binding protein 0.003 0.062 0.062
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0044 0.0044
Leishmania major poly(A)-binding protein 2 0.0009 0.0093 0.1175
Trypanosoma cruzi polyadenylate-binding protein, putative 0.0009 0.0093 0.1175
Brugia malayi AMP-binding enzyme family protein 0.0007 0.004 0.0111
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0455 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0455 0.9179
Echinococcus multilocularis smad 0.0008 0.0076 0.0076
Trypanosoma brucei polyadenylate-binding protein 2 0.0009 0.0093 0.1175
Brugia malayi hypothetical protein 0.0016 0.0271 0.075
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0118 0.0327
Echinococcus granulosus GPCR family 2 0.0031 0.0649 0.0649
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0076 0.0076
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0118 0.0327
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0307 0.5894
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0118 0.0327
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0088 0.0243
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0492 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.2338 0.6473
Loa Loa (eye worm) hypothetical protein 0.0099 0.2338 0.6473
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0118 0.0118
Brugia malayi MH2 domain containing protein 0.0008 0.0076 0.0211
Brugia malayi nuclear receptor NHR-88 0.001 0.0118 0.0327
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0649 0.1798
Schistosoma mansoni hypothetical protein 0.0031 0.0649 0.0649
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1216 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0118 0.0118
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.004 0.0546
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0118 0.0118
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0455 0.9179
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0118 0.0327
Plasmodium vivax polyadenylate-binding protein, putative 0.0009 0.0093 0.1175
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0044 0.0044
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0118 0.0118
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.004 0.0546
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0118 0.0118
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.004 0.0546
Echinococcus multilocularis GPCR, family 2 0.0031 0.0649 0.0649
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0076 0.0076
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0118 0.0118
Brugia malayi AMP-binding enzyme family protein 0.0007 0.004 0.0111
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.0111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0307 0.0849
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.004 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0118 0.0327
Loa Loa (eye worm) hypothetical protein 0.0024 0.0455 0.126
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.004 0.0546
Schistosoma mansoni hypothetical protein 0.0031 0.0649 0.0649
Brugia malayi MH1 domain containing protein 0.0008 0.0076 0.0211
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0169 0.4065 0.4065
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.2927 0.8105
Loa Loa (eye worm) hypothetical protein 0.0018 0.0307 0.0849
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0148 0.0148
Brugia malayi nuclear hormone receptor 0.001 0.0118 0.0327
Schistosoma mansoni polyadenylate binding protein 0.0009 0.0093 0.0093
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0118 0.0118
Brugia malayi hypothetical protein 0.0025 0.0492 0.1363
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0118 0.0118
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0327
Brugia malayi MH2 domain containing protein 0.0008 0.0076 0.0211
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0118 0.0327
Schistosoma mansoni smad 0.0008 0.0076 0.0076
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0455 0.9179
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0455 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0118 0.0118
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0118 0.0327
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0118 0.0327
Echinococcus granulosus polyadenylate binding protein 0.0009 0.0093 0.0093
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0118 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0283 0.6071
Leishmania major poly(A)-binding protein 3 0.0009 0.0093 0.1175
Onchocerca volvulus 0.0024 0.0455 0.1162
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0118 0.0327
Brugia malayi MH1 domain containing protein 0.0008 0.0076 0.0211
Brugia malayi RNA binding protein 0.0134 0.3207 0.8882
Loa Loa (eye worm) hypothetical protein 0.0031 0.0649 0.1798
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.004 0.0111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0307 0.0849
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0118 0.0118
Brugia malayi hypothetical protein 0.0151 0.3611 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.004 0.0546
Schistosoma mansoni thyroid hormone receptor 0.001 0.0118 0.0118
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.2338 0.6473
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0283 0.6071
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0327
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0118 0.0118
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0088 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0118 0.0327
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0455 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0492 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0455 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0118 0.0327
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.004 0.0546
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0649 0.1798
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.004 0.0111
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0455 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0118 0.0218
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0307 0.5894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0118 0.0327
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0455 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0118 0.0118
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0076 0.0076
Echinococcus multilocularis Smad4 0.0008 0.0076 0.0076
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0118 0.0118
Echinococcus granulosus smad 0.0008 0.0076 0.0076
Echinococcus granulosus Smad4 0.0008 0.0076 0.0076
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0455 0.126
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.004 0.0546
Loa Loa (eye worm) hypothetical protein 0.0018 0.0307 0.0849
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.004 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0118 0.0327
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.004 0.0546
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0118 0.0327
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.004 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0118 0.0327
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1556 0.4309
Loa Loa (eye worm) oxidoreductase 0.0007 0.004 0.0111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1377 0.1377
Schistosoma mansoni hypothetical protein 0.0031 0.0649 0.0649
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0134 0.3207 0.3207
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0118 0.0327
Schistosoma mansoni smad1 5 8 and 0.0008 0.0076 0.0076
Echinococcus granulosus cpg binding protein 0.003 0.062 0.062
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0009 0.0093 0.0258
Schistosoma mansoni nuclear hormone receptor 0.001 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0118 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0118 0.0327
Loa Loa (eye worm) hypothetical protein 0.0007 0.004 0.0111
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0044 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0025 0.0492 0.1363
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0455 0.126
Loa Loa (eye worm) Smad1 0.0008 0.0076 0.0211
Brugia malayi polyadenylate-binding protein 1 0.0009 0.0093 0.0258
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0327
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0649 0.0649
Mycobacterium ulcerans hypothetical protein 0.0024 0.0455 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0455 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.004 0.0546
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0148 0.0148
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0118 0.0218
Echinococcus multilocularis dnaJ subfamily B 0.0407 1 1
Schistosoma mansoni hypothetical protein 0.0031 0.0649 0.0649
Loa Loa (eye worm) hypothetical protein 0.0068 0.1556 0.4309
Trypanosoma brucei polyadenylate-binding protein 1 0.0009 0.0093 0.1175
Loa Loa (eye worm) hypothetical protein 0.0024 0.0455 0.126
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0455 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.004 0.004
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0307 0.6421
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0044 0.0044
Echinococcus multilocularis geminin 0.0169 0.4065 0.4065
Onchocerca volvulus 0.0029 0.0579 0.1509
Schistosoma mansoni smad1 5 8 and 0.0008 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0327
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0455 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0455 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.3207 0.8882
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0118 0.0327
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0118 0.0118
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0118 0.0218
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0088 0.0088
Brugia malayi steroid hormone receptor 0.001 0.0118 0.0327
Schistosoma mansoni polyadenylate binding protein 0.0009 0.0093 0.0093
Schistosoma mansoni cpg binding protein 0.003 0.062 0.062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0283 0.6071
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0455 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0076 0.0076
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0076 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0118 0.0327
Schistosoma mansoni smad1 5 8 and 0.0008 0.0076 0.0076
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0118 0.0118
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0649 0.1798
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0134 0.3207 0.3207
Schistosoma mansoni Smad4 0.0008 0.0076 0.0076
Toxoplasma gondii polyadenylate binding protein, putative 0.0009 0.0093 0.0452
Echinococcus granulosus geminin 0.0169 0.4065 0.4065
Schistosoma mansoni cpg binding protein 0.0029 0.0579 0.0579
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0076 0.0211
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0118 0.0118
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0118 0.0118
Echinococcus multilocularis Eukaryotic translation initiation factor 4H 0.0134 0.3207 0.3207
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0118 0.0118
Brugia malayi AMP-binding enzyme family protein 0.0007 0.004 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0118 0.0327
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.0327
Schistosoma mansoni hypothetical protein 0.0407 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0118 0.0118
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.2927 0.8105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0118 0.0327
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0134 0.3207 0.3207
Brugia malayi AMP-binding enzyme family protein 0.0007 0.004 0.0111
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0492 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0492 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0649 0.0649
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0118 0.0118
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0492 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0649 0.0649
Brugia malayi ecdysteroid receptor 0.001 0.0118 0.0327
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.004 1
Plasmodium falciparum polyadenylate-binding protein, putative 0.0009 0.0093 0.1175
Onchocerca volvulus 0.0151 0.3611 1
Trypanosoma cruzi polyadenylate-binding protein 1, putative 0.0009 0.0093 0.1175
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.2338 0.6473
Schistosoma mansoni hypothetical protein 0.0068 0.1556 0.1556
Onchocerca volvulus 0.001 0.0118 0.0218
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0649 0.0649

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 4.6 uM Cytotoxicity against mouse B16 cells assessed as cell viability after 48 hrs by MTT assay ChEMBL. 22647220

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 22647220

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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