Detailed information for compound 1658449

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.329 | Formula: C15H20N2O7
  • H donors: 5 H acceptors: 6 LogP: -1.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC#Cc1cn(c(=O)[nH]c1=O)[C@@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O
  • InChi: 1S/C15H20N2O7/c1-2-3-4-5-8-6-17(15(23)16-13(8)22)14-12(21)11(20)10(19)9(7-18)24-14/h6,9-12,14,18-21H,2-3,7H2,1H3,(H,16,22,23)/t9-,10-,11+,12-,14-/m1/s1
  • InChiKey: XHEMRIMZCOFGEX-YGEZULPYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.1428 1
Mycobacterium tuberculosis Conserved protein 0.0077 0.0263 0.0883
Schistosoma mansoni hypothetical protein 0.0083 0.0295 0.0295
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0358 0.0355
Schistosoma mansoni intermediate filament proteins 0.0057 0.0151 0.0151
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0263 0.0263
Schistosoma mansoni CD36-like class B scavenger receptor 0.1885 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0122 0.0122
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0003 0.0114
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0003 0.0114
Brugia malayi beta-lactamase family protein 0.0077 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0061 0.0176 0.0176
Schistosoma mansoni lamin 0.0057 0.0151 0.0151
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0122 0.0122
Trichomonas vaginalis esterase, putative 0.0077 0.0263 0.1707
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0358 0.2451
Brugia malayi MAP kinase sur-1 0.0051 0.0122 0.0122
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0068 0.0165
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0263 0.1707
Echinococcus granulosus neuropeptide receptor A26 0.0551 0.2815 0.2815
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0358 0.2451
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0003
Schistosoma mansoni cd36 antigen 0.0712 0.3681 0.3681
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0118 0.048 0.048
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0122 0.0122
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.005 0.0115 0.0115
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0083 0.0295 0.0295
Echinococcus multilocularis musashi 0.0057 0.0151 0.0151
Echinococcus multilocularis CD36 class B scavenger receptor 0.1885 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0358 0.0358
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0264 0.1266 0.1266
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0361 0.0361
Schistosoma mansoni hypothetical protein 0.0083 0.0295 0.0295
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0122 0.0122
Onchocerca volvulus Huntingtin homolog 0.0121 0.0495 0.0492
Echinococcus multilocularis snurportin 1 0.0306 0.1494 0.1494
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.0624 0.0624
Echinococcus granulosus peregrin 0.0029 0.0003 0.0003
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0003 0.0114
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0264 0.1266 0.1266
Brugia malayi intermediate filament protein 0.0057 0.0151 0.0151
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0361 0.0361
Echinococcus multilocularis lamin dm0 0.0057 0.0151 0.0151
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0122 0.0122
Echinococcus granulosus neuropeptide s receptor 0.0551 0.2815 0.2815
Leishmania major hypothetical protein, conserved 0.005 0.0115 0.0508
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0624 0.0624
Brugia malayi follicle stimulating hormone receptor 0.082 0.4265 0.4265
Echinococcus granulosus CD36 class B scavenger receptor 0.1885 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0263 0.1576
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0358 0.2451
Loa Loa (eye worm) hypothetical protein 0.0077 0.0263 0.0263
Giardia lamblia Kinase, PLK 0.0095 0.0358 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0068 0.0165
Schistosoma mansoni gabp alpha 0.0072 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.1885 1 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0263 0.0263
Brugia malayi jmjC domain containing protein 0.0096 0.0361 0.0361
Echinococcus granulosus GPCR family 2 0.0083 0.0295 0.0295
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0594 0.3972
Brugia malayi beta-lactamase 0.0077 0.0263 0.0263
Brugia malayi jmjC domain containing protein 0.0035 0.0036 0.0036
Brugia malayi Calcitonin receptor-like protein seb-1 0.0264 0.1266 0.1266
Brugia malayi RNA, U transporter 1 0.0082 0.0285 0.0285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0624 0.0624
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0115 0.4388
Brugia malayi hypothetical protein 0.0712 0.3681 0.3681
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0358 0.2263
Echinococcus granulosus CD36 class B scavenger receptor 0.1885 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0263 0.0263
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.0295 0.0295
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0068 0.0477
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0232 0.0232
Mycobacterium ulcerans hypothetical protein 0.0155 0.0679 0.4965
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0083 0.0295 0.0295
Echinococcus granulosus CD36 class B scavenger receptor 0.1885 1 1
Loa Loa (eye worm) hypothetical protein 0.018 0.0817 0.0817
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0624 0.0624
Echinococcus granulosus lamin dm0 0.0057 0.0151 0.0151
Loa Loa (eye worm) glutaminase 2 0.0274 0.1322 0.1322
Onchocerca volvulus Huntingtin homolog 0.0121 0.0495 0.0492
Loa Loa (eye worm) hypothetical protein 0.1885 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0263 0.1707
Loa Loa (eye worm) hypothetical protein 0.0712 0.3681 0.3681
Brugia malayi hypothetical protein 0.0712 0.3681 0.3681
Trypanosoma brucei polo-like protein kinase 0.0095 0.0358 0.2508
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0358 0.2451
Schistosoma mansoni ap endonuclease 0.0037 0.0045 0.0045
Loa Loa (eye worm) follicle stimulating hormone receptor 0.082 0.4265 0.4265
Entamoeba histolytica hypothetical protein 0.0118 0.048 1
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0101 0.0433
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0115 1
Onchocerca volvulus 0.0077 0.0263 0.026
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0122 0.0601
Loa Loa (eye worm) hypothetical protein 0.0077 0.0263 0.0263
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0624 0.0624
Schistosoma mansoni hypothetical protein 0.0083 0.0295 0.0295
Onchocerca volvulus 0.0077 0.0263 0.026
Brugia malayi Latrophilin receptor protein 2 0.0083 0.0295 0.0295
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0117 0.0517
Schistosoma mansoni kinase 0.0049 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0083 0.0295 0.0295
Echinococcus multilocularis CD36 class B scavenger receptor 0.1885 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0045 0.172
Schistosoma mansoni hypothetical protein 0.0118 0.048 0.048
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0358 0.0358
Echinococcus multilocularis lamin 0.0057 0.0151 0.0151
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0045 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0263 0.0263
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0003 0.0003
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0045 0.0045
Toxoplasma gondii hypothetical protein 0.0047 0.0101 0.383
Trichomonas vaginalis glutaminase, putative 0.0274 0.1322 1
Mycobacterium ulcerans lipase LipD 0.0077 0.0263 0.1707
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0358 0.2451
Echinococcus multilocularis CD36 class B scavenger receptor 0.1885 1 1
Brugia malayi MH2 domain containing protein 0.0238 0.113 0.113
Leishmania major hypothetical protein, conserved 0.0077 0.0263 0.1576
Schistosoma mansoni CD36-like class B scavenger receptor 0.1885 1 1
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0263 0.0883
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0263 0.0263
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0151 0.0151
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0101 0.0433
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0122 0.0854
Echinococcus multilocularis neuropeptide s receptor 0.0551 0.2815 0.2815
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0118 0.048 0.048
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0624 0.0624
Schistosoma mansoni transcription factor LCR-F1 0.0118 0.048 0.048
Schistosoma mansoni lamin 0.0057 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0712 0.3681 0.3681
Schistosoma mansoni scavenger receptor class B type-2 (sr-B2) 0.1885 1 1
Schistosoma mansoni hypothetical protein 0.018 0.0817 0.0817
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0263 0.0883
Entamoeba histolytica hypothetical protein 0.0118 0.048 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0263 0.0263
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.1428 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0122 0.0555
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0263 0.0263
Plasmodium falciparum phd finger protein, putative 0.0029 0.0003 0.0261
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0122 0.0555
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0263 0.1707
Brugia malayi Bromodomain containing protein 0.0029 0.0003 0.0003
Echinococcus granulosus snurportin 1 0.0306 0.1494 0.1494
Loa Loa (eye worm) hypothetical protein 0.0077 0.0263 0.0263
Brugia malayi Ets-domain containing protein 0.0072 0.0232 0.0232
Echinococcus multilocularis CD36 class B scavenger receptor 0.1885 1 1
Schistosoma mansoni hypothetical protein 0.0029 0.0003 0.0003
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0122 0.0555
Echinococcus multilocularis CD36 class B scavenger receptor 0.1885 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0624 0.0624
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0263 0.1707
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0122 0.0601
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0624 0.0624
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0045 0.0045
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0263 0.5
Loa Loa (eye worm) glutaminase 0.0274 0.1322 0.1322
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0151 0.0151
Echinococcus granulosus lamin 0.0057 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0077 0.0263 0.0263
Mycobacterium tuberculosis Conserved protein 0.0077 0.0263 0.0883
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0358 0.0358
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0036 0.0036
Echinococcus multilocularis neuropeptide receptor A26 0.0551 0.2815 0.2815
Loa Loa (eye worm) hypothetical protein 0.0121 0.0495 0.0495
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0036 0.0036
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.1494 0.1494
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0679 0.2568
Brugia malayi hypothetical protein 0.0121 0.0495 0.0495
Onchocerca volvulus 0.0057 0.0151 0.0149
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0065 0.0065
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0594 0.3972
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.1885 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0045 0.5
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0122 0.3351
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0003 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0122 0.0601
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.1428 1
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0263 0.1843
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0122 0.0555
Echinococcus multilocularis lysosome membrane protein 2 0.1885 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0045 0.119
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.0624 0.0624
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0045 0.0045
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0115 0.4388
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0045 0.0317
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0358 0.0358
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0263 0.1707
Brugia malayi PHD-finger family protein 0.0029 0.0003 0.0003
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0263 0.0883
Loa Loa (eye worm) hypothetical protein 0.0121 0.0495 0.0495
Onchocerca volvulus 0.0077 0.0263 0.026
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.0295 0.0295
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0263 0.0883
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0263 1
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.113 0.113
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0255 0.0255
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0495 0.2513 1
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0122 0.0122
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0358 0.2451
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0594 0.4163
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0263 0.0883
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.005 0.0115 0.0115
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0036 0.0036
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0003 0.0003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0045 0.392
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0263 0.0883
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0358 0.7191
Entamoeba histolytica hypothetical protein 0.0118 0.048 1
Toxoplasma gondii ABC1 family protein 0.0077 0.0263 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0263 0.0263
Echinococcus multilocularis peregrin 0.0029 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0263 0.1576
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0263 0.1707
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0068 0.0165
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0045 0.0045
Onchocerca volvulus Lysosome membrane protein 2 homolog 0.1885 1 1
Echinococcus granulosus intermediate filament protein 0.0057 0.0151 0.0151
Onchocerca volvulus 0.0057 0.0151 0.0149
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0122 0.4637
Schistosoma mansoni hypothetical protein 0.0306 0.1494 0.1494
Schistosoma mansoni ap endonuclease 0.0037 0.0045 0.0045
Echinococcus granulosus CD36 class B scavenger receptor 0.1885 1 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.4218 0.4218
Brugia malayi hypothetical protein 0.005 0.0115 0.0115
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0358 0.2451
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0009 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0122 0.0601
Brugia malayi Ets-domain containing protein 0.0072 0.0232 0.0232
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0232 0.0232
Brugia malayi beta-lactamase family protein 0.0077 0.0263 0.0263
Schistosoma mansoni glutaminase 0.0274 0.1322 0.1322
Brugia malayi hypothetical protein 0.0118 0.048 0.048
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0036 0.0036
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0115 0.0508
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.0295 0.0295
Mycobacterium ulcerans glutaminase 0.0274 0.1322 1
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.1428 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0009 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0171 0.0171
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0122 0.0555
Trypanosoma brucei protein kinase, putative 0.0051 0.0122 0.0854
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0115 0.0809
Brugia malayi Fli-1 protein 0.0218 0.102 0.102
Schistosoma mansoni hypothetical protein 0.0083 0.0295 0.0295
Loa Loa (eye worm) beta-lactamase 0.0077 0.0263 0.0263
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0358 0.2263
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.113 0.113
Toxoplasma gondii exonuclease III APE 0.0037 0.0045 0.172
Brugia malayi hypothetical protein 0.0032 0.002 0.002
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0151 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0115 1
Schistosoma mansoni ets-related 0.0218 0.102 0.102
Echinococcus multilocularis GPCR, family 2 0.0083 0.0295 0.0295
Mycobacterium ulcerans hypothetical protein 0.0077 0.0263 0.1707
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0263 0.1707
Mycobacterium tuberculosis Conserved protein 0.0077 0.0263 0.0883
Brugia malayi latrophilin 2 splice variant baaae 0.018 0.0817 0.0817
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0036 0.0036
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.0295 0.0295
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0115 0.0508
Mycobacterium leprae Probable lipase LipE 0.0077 0.0263 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0264 0.1266 0.1266
Brugia malayi glutaminase DH11.1 0.0274 0.1322 0.1322
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0358 0.2263
Echinococcus granulosus lysosome membrane protein 2 0.1885 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0151 0.0151
Loa Loa (eye worm) fli-1 protein 0.0218 0.102 0.102
Echinococcus granulosus CD36 class B scavenger receptor 0.1885 1 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0263 0.0883
Mycobacterium ulcerans beta-lactamase 0.0077 0.0263 0.1707
Entamoeba histolytica hypothetical protein 0.0118 0.048 1
Loa Loa (eye worm) hypothetical protein 0.0712 0.3681 0.3681
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0003 0.0003
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0122 0.0555

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 95 uM Cytotoxicity against human HeLa cells after 72 hrs ChEMBL. 23369539
IC50 (functional) = 115 uM Cytotoxicity against mouse L1210 cells after 48 hrs ChEMBL. 23369539
Ki (binding) = 303 uM Competitive inhibition of rabbit skeletal muscle glycogen phosphorylase b using Glc-1-P as substrate ChEMBL. 22770609

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.