Detailed information for compound 1670876

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 285.343 | Formula: C10H11N3O3S2
  • H donors: 3 H acceptors: 3 LogP: 0.1 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)NN=C1CCS(=O)(=O)c2c1cc(O)cc2
  • InChi: 1S/C10H11N3O3S2/c11-10(17)13-12-8-3-4-18(15,16)9-2-1-6(14)5-7(8)9/h1-2,5,14H,3-4H2,(H3,11,13,17)
  • InChiKey: PIJQMRSZGYFZCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cathepsin B precursor 0.006 0.0418 0.5
Schistosoma mansoni patched 1 0.0043 0.021 0.021
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0921 1
Loa Loa (eye worm) cathepsin B 0.006 0.0418 0.0807
Schistosoma mansoni inositol monophosphatase 0.0037 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0171 0.1801 0.3478
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0131 0.1688
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.1456 0.2446
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0131 0.0687
Schistosoma mansoni hypothetical protein 0.0041 0.019 0.019
Brugia malayi Cathepsin L-like precursor 0.0032 0.0072 0.0139
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0131 0.1688
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0665 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.006 0.0418 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.009 0.0795 0.0795
Loa Loa (eye worm) hypothetical protein 0.008 0.0665 0.1283
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0665 0.5
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0665 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0131 0.0337
Echinococcus granulosus cathepsin l cysteine peptidase 0.0032 0.0072 0.0121
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.0064 0.0748
Echinococcus granulosus SAM and MBT domain containing protein 0.0372 0.4308 0.7239
Echinococcus multilocularis cysteine protease 0.0032 0.0072 0.0121
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0072 0.0121
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.1801 0.1801
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0921 0.1548
Echinococcus granulosus chromobox protein 2 0.0191 0.2047 0.3441
Loa Loa (eye worm) cysteine protease 0.0032 0.0072 0.0139
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0665 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.094 0.094
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0504 0.5951 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0028 0.0025 0.0139
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0665 1
Echinococcus multilocularis chromobox protein 2 0.0191 0.2047 0.3441
Plasmodium vivax vivapain-2 0.0032 0.0072 0.087
Echinococcus granulosus expressed conserved protein 0.0094 0.0845 0.1421
Echinococcus granulosus histone acetyltransferase MYST2 0.0093 0.0828 0.1392
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0171 0.1801 0.1801
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0665 0.1117
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0665 1
Schistosoma mansoni sex comb on midleg homolog 0.0257 0.2874 0.2874
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.1801 0.1801
Schistosoma mansoni hypothetical protein 0.0317 0.3615 0.3615
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0072 0.0121
Brugia malayi Cathepsin L-like precursor 0.0032 0.0072 0.0139
Loa Loa (eye worm) MBCTL1 0.0093 0.0828 0.16
Toxoplasma gondii cathepsin B 0.006 0.0418 0.6197
Schistosoma mansoni chromobox protein 0.0191 0.2047 0.2047
Plasmodium vivax JmjC domain containing protein 0.0028 0.0025 0.0139
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0324 0.0544
Brugia malayi Cathepsin L-like precursor 0.0032 0.0072 0.0139
Loa Loa (eye worm) inositol-1 0.0037 0.0131 0.0252
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.021 0.0405
Echinococcus multilocularis cathepsin b 0.0171 0.1801 0.3026
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0093 0.0828 0.1392
Echinococcus granulosus polycomb protein SCMH1 0.0257 0.2874 0.483
Schistosoma mansoni hypothetical protein 0.0041 0.019 0.019
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0317 0.3615 0.6074
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0032 0.0072 0.087
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0131 0.1688
Loa Loa (eye worm) fibroinase 0.0032 0.0072 0.0139
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0131 0.0219
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0665 0.1117
Loa Loa (eye worm) hypothetical protein 0.0442 0.5179 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0504 0.5951 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0372 0.4308 0.4308
Loa Loa (eye worm) hypothetical protein 0.01 0.0921 0.1778
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0324 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0132 0.1324 0.2556
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.1801 0.1801
Brugia malayi mbt repeat family protein 0.0442 0.5179 1
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0324 0.0544
Echinococcus multilocularis cathepsin b 0.0171 0.1801 0.3026
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0665 1
Brugia malayi Probable ClpP-like protease 0.008 0.0665 0.1283
Toxoplasma gondii PLU-1 family protein 0.0042 0.0204 0.2895
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0324 1
Brugia malayi jmjC domain containing protein 0.0132 0.1324 0.2556
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0442 0.5179 1
Echinococcus multilocularis expressed conserved protein 0.0094 0.0845 0.1421
Schistosoma mansoni jumonji/arid domain-containing protein 0.009 0.0795 0.0795
Plasmodium vivax vivapain-2 0.0032 0.0072 0.087
Echinococcus multilocularis lysine specific demethylase 5A 0.0075 0.0608 0.1022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0072 0.0139
Schistosoma mansoni inositol monophosphatase 0.0037 0.0131 0.0131
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0665 1
Onchocerca volvulus 0.0292 0.3307 0.6336
Echinococcus multilocularis protein patched 0.0043 0.021 0.0352
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0324 0.4744
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.006 0.0418 1
Brugia malayi Cathepsin L-like precursor 0.0032 0.0072 0.0139
Brugia malayi CHE-14 protein 0.0043 0.021 0.0405
Echinococcus granulosus cathepsin b 0.0171 0.1801 0.3026
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.021 0.0352
Loa Loa (eye worm) mbt repeat family protein 0.0267 0.3004 0.58
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0131 0.0219
Brugia malayi cathepsin B-like cysteine proteinase 0.0171 0.1801 0.3478
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.021 0.0352
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0921 0.1548
Brugia malayi mbt repeat family protein 0.0267 0.3004 0.58
Brugia malayi Cathepsin L-like precursor 0.0032 0.0072 0.0139
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.0418 0.0418
Brugia malayi Inositol-1 0.0037 0.0131 0.0252
Loa Loa (eye worm) ctsf protein 0.0032 0.0072 0.0139
Giardia lamblia Cathepsin B precursor 0.006 0.0418 0.5
Echinococcus granulosus cathepsin b 0.0171 0.1801 0.3026
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0093 0.0828 0.16
Loa Loa (eye worm) hypothetical protein 0.0053 0.033 0.0637
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0131 0.1688
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.011 0.1049 0.1762
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0032 0.0072 0.0139
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0083 0.1033
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0072 0.0121
Echinococcus granulosus cathepsin L cysteine proteinase 0.0032 0.0072 0.0121
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0131 0.1688
Schistosoma mansoni hypothetical protein 0.0041 0.019 0.019
Plasmodium falciparum cysteine proteinase falcipain 3 0.0032 0.0072 0.087
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0317 0.3615 0.6074
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0131 0.1769
Echinococcus multilocularis cysteine protease 0.0032 0.0072 0.0121
Loa Loa (eye worm) hypothetical protein 0.0043 0.021 0.0405
Trypanosoma brucei cysteine peptidase C (CPC) 0.006 0.0418 1
Schistosoma mansoni hypothetical protein 0.0041 0.019 0.019
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0072 0.0139
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0921 0.1778
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0665 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0093 0.0828 0.0828
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0093 0.0828 0.1392
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0665 1
Echinococcus granulosus histone acetyltransferase myst3 0.0039 0.0165 0.0277
Toxoplasma gondii cathepsin CPL 0.0032 0.0072 0.087
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.006 0.0418 0.1999
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.1456 0.2446
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0072 0.0121
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0072 0.0072
Echinococcus multilocularis histone acetyltransferase MYST2 0.0093 0.0828 0.1392
Echinococcus multilocularis SAM and MBT domain containing protein 0.0372 0.4308 0.7239
Echinococcus granulosus Protein patched homolog 1 0.0043 0.021 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.021 0.3972
Echinococcus multilocularis polycomb protein SCMH1 0.0257 0.2874 0.483
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0171 0.1801 1
Schistosoma mansoni phd finger protein 0.0039 0.0165 0.0165
Brugia malayi Cathepsin L-like precursor 0.0032 0.0072 0.0139
Schistosoma mansoni sex comb on midleg homolog 0.0257 0.2874 0.2874
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0131 0.0337
Loa Loa (eye worm) hypothetical protein 0.0093 0.0828 0.16
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0665 0.0665
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0072 0.0072
Echinococcus granulosus lysine specific demethylase 5A 0.009 0.0795 0.1336
Echinococcus granulosus cathepsin l1 0.0032 0.0072 0.0121
Echinococcus multilocularis histone acetyltransferase myst3 0.0039 0.0165 0.0277
Giardia lamblia Cathepsin B precursor 0.006 0.0418 0.5
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0072 0.0139
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0032 0.0072 0.087
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0665 0.5
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.011 0.1049 0.1762
Echinococcus multilocularis protein dispatched 1 0.0049 0.0285 0.0479

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10000 nM Inhibition of human liver cathepsin B using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analysis ChEMBL. 24900494
IC50 (binding) > 10000 nM Inhibition of human liver cathepsin L using Z-R-R-AMC as substrate preincubated with compound for 5 mins measured after 20 mins by fluorescence analysis ChEMBL. 24900494

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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