Detailed information for compound 167388

Basic information

Technical information
  • TDR Targets ID: 167388
  • Name: N-[[2-[(2S)-butan-2-yl]oxyphenyl]methyl]-1,6- naphthyridine-2-carboxamide
  • MW: 335.4 | Formula: C20H21N3O2
  • H donors: 1 H acceptors: 3 LogP: 3.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@H](Oc1ccccc1CNC(=O)c1ccc2c(n1)ccnc2)C
  • InChi: 1S/C20H21N3O2/c1-3-14(2)25-19-7-5-4-6-16(19)13-22-20(24)18-9-8-15-12-21-11-10-17(15)23-18/h4-12,14H,3,13H2,1-2H3,(H,22,24)/t14-/m0/s1
  • InChiKey: QBIVRVOTCLJESK-AWEZNQCLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[[2-[(1S)-1-methylpropoxy]phenyl]methyl]-1,6-naphthyridine-2-carboxamide
  • N-[2-[(1S)-1-methylpropoxy]benzyl]-1,6-naphthyridine-2-carboxamide
  • AIDS-106712
  • AIDS106712
  • [1,6]Naphthyridine-2-carboxylic acid 2-((S)-sec-butoxy)-benzylamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0374 0.1261
Entamoeba histolytica diacylglycerol kinase, putative 0.0053 0.0333 0.0316
Echinococcus granulosus tar DNA binding protein 0.0062 0.0402 0.0402
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0054 0.0106
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0374 0.5291
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0054 0.0106
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0054 0.0054
Trichomonas vaginalis glucosylceramidase, putative 0.049 0.3574 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0097 0.0658 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0054 0.0106
Schistosoma mansoni hypothetical protein 0.0014 0.0048 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.2325 0.6488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Trypanosoma brucei protein kinase, putative 0.0097 0.0658 1
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0053 0.0333 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0374 0.1261
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0053 0.0333 0.4612
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Echinococcus multilocularis Diacylglycerol kinase theta 0.0053 0.0333 0.0333
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0053 0.0333 0.4612
Schistosoma mansoni hypothetical protein 0.0014 0.0048 0.0048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0048 0.0134
Entamoeba histolytica diacylglycerol kinase, putative 0.0053 0.0333 0.0316
Echinococcus granulosus mitogen activated protein kinase 3 0.0097 0.0658 0.0658
Schistosoma mansoni hypothetical protein 0.0031 0.0172 0.0172
Echinococcus multilocularis GPCR, family 2 0.0014 0.0048 0.0048
Leishmania major diacylglycerol kinase, putative 0.0053 0.0333 0.4612
Trichomonas vaginalis bmru protein, putative 0.0053 0.0333 0.0888
Trichomonas vaginalis bmru protein, putative 0.0053 0.0333 0.0888
Onchocerca volvulus 0.0015 0.0054 0.0163
Brugia malayi Ceramide kinase 0.0053 0.0333 0.093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0374 0.1261
Trichomonas vaginalis glucosylceramidase, putative 0.049 0.3574 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0054 0.0054
Schistosoma mansoni cathepsin F (C01 family) 0.001 0.0017 0.0017
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0097 0.0658 1
Loa Loa (eye worm) ctsf protein 0.0015 0.0054 0.0054
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0053 0.0333 0.4612
Echinococcus granulosus cathepsin l1 0.001 0.0017 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0374 0.1261
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0402 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0333 0.0888
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.0279 0.0781
Echinococcus granulosus Diacylglycerol kinase theta 0.0053 0.0333 0.0333
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0054 0.0163
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0054 0.0054
Echinococcus multilocularis sphingosine kinase 1 0.1356 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0054 0.0106
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0053 0.0333 0.0888
Brugia malayi Cathepsin L-like precursor 0.0015 0.0054 0.0152
Loa Loa (eye worm) diacylglycerol kinase 2 0.0053 0.0333 0.0333
Leishmania major cathepsin L-like protease 0.0058 0.0374 0.5291
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0054 0.0106
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0333 0.4612
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0048 0.0048
Brugia malayi Cathepsin L-like precursor 0.001 0.0017 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0374 0.1261
Trichomonas vaginalis glucosylceramidase, putative 0.049 0.3574 1
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.2325 0.6488
Echinococcus granulosus cathepsin L cysteine proteinase 0.0015 0.0054 0.0054
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0097 0.0658 1
Brugia malayi MAP kinase sur-1 0.0097 0.0658 0.184
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0658 0.0658
Onchocerca volvulus 0.0015 0.0054 0.0163
Echinococcus granulosus mitogen activated protein kinase 0.0097 0.0658 0.0658
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0054 0.0106
Brugia malayi Cathepsin L-like precursor 0.0015 0.0054 0.0152
Trypanosoma cruzi major cysteine proteinase, putative 0.0046 0.0281 0.3756
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Loa Loa (eye worm) hypothetical protein 0.0053 0.0333 0.0333
Onchocerca volvulus 0.0015 0.0054 0.0163
Brugia malayi MH2 domain containing protein 0.0117 0.081 0.2267
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0402 0.0402
Brugia malayi Diacylglycerol kinase protein 2 0.0053 0.0333 0.093
Echinococcus multilocularis cathepsin L cysteine protease 0.0015 0.0054 0.0054
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.049 0.3574 0.3574
Trypanosoma cruzi Sphingosine kinase 0.0053 0.0333 0.4612
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.081 0.081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0054 0.0106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0054 0.0106
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0048 0.0048
Entamoeba histolytica diacylglycerol kinase, putative 0.0053 0.0333 0.0316
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.2325 0.6488
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0053 0.0333 0.0333
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0048 0.0048
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0658 0.1801
Giardia lamblia Kinase, CMGC MAPK 0.0097 0.0658 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0054 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Trichomonas vaginalis sphingosine kinase, putative 0.0053 0.0333 0.0888
Schistosoma mansoni hypothetical protein 0.0014 0.0048 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0374 0.1261
Trichomonas vaginalis glucosylceramidase, putative 0.049 0.3574 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0374 0.1261
Toxoplasma gondii diacylglycerol kinase, putative 0.0053 0.0333 0.4612
Onchocerca volvulus 0.0015 0.0054 0.0163
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0054 0.0054
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0048 0.0134
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0053 0.0333 0.4612
Plasmodium vivax diacylglycerol kinase, putative 0.0053 0.0333 1
Onchocerca volvulus Cathepsin F homolog 0.0015 0.0054 0.0163
Trichomonas vaginalis glucosylceramidase, putative 0.049 0.3574 1
Trichomonas vaginalis glucosylceramidase, putative 0.049 0.3574 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0048 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Brugia malayi Cathepsin L-like cysteine proteinase 0.001 0.0017 0.0047
Echinococcus multilocularis cysteine protease 0.0015 0.0054 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0658 0.1801
Plasmodium falciparum diacylglycerol kinase, putative 0.0053 0.0333 1
Brugia malayi diacylglycerol kinase 0.0053 0.0333 0.093
Loa Loa (eye worm) ceramide kinase 0.0053 0.0333 0.0333
Brugia malayi Cathepsin L-like precursor 0.001 0.0017 0.0047
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0097 0.0658 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0054 0.0106
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0015 0.0054 0.0054
Onchocerca volvulus 0.0053 0.0333 0.1368
Loa Loa (eye worm) hypothetical protein 0.0046 0.0279 0.0279
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0658 0.1801
Echinococcus granulosus ceramide kinase 0.0053 0.0333 0.0333
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0053 0.0333 0.0333
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.2325 0.6488
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Loa Loa (eye worm) hypothetical protein 0.0053 0.0333 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.2325 0.6488
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0015 0.0054 0.0106
Brugia malayi Cathepsin L-like precursor 0.0015 0.0054 0.0152
Entamoeba histolytica diacylglycerol kinase, putative 0.0053 0.0333 0.0316
Trypanosoma cruzi diacylglycerol kinase, putative 0.0053 0.0333 0.4612
Echinococcus granulosus Diacylglycerol kinase zeta 0.0053 0.0333 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0097 0.0658 1
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0053 0.0333 0.0888
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0053 0.0333 0.0888
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0097 0.0658 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.0048
Entamoeba histolytica cysteine protease, putative 0.0015 0.0054 0.0038
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0053 0.0333 0.0333
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.049 0.3574 1
Schistosoma mansoni hypothetical protein 0.0053 0.0333 0.0333
Brugia malayi Cathepsin L-like precursor 0.0015 0.0054 0.0152
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.2325 0.6488
Trypanosoma cruzi cruzipain precursor, putative 0.0058 0.0374 0.5291
Schistosoma mansoni sphingoid long chain base kinase 0.1356 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0374 0.1261
Loa Loa (eye worm) hypothetical protein 0.0053 0.0333 0.0333
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0402 0.0402
Schistosoma mansoni cathepsin F (C01 family) 0.0015 0.0054 0.0054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.0279 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0402 0.0402
Trypanosoma cruzi Sphingosine kinase 0.0053 0.0333 0.4612
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0402 0.1125
Trichomonas vaginalis diacylglycerol kinase, putative 0.0053 0.0333 0.0888
Brugia malayi diacylglycerol kinase 0.0053 0.0333 0.093
Echinococcus granulosus GPCR family 2 0.0014 0.0048 0.0048
Onchocerca volvulus Cathepsin L homolog 0.0015 0.0054 0.0163
Schistosoma mansoni diacylglycerol kinase theta 0.0053 0.0333 0.0333
Leishmania major cathepsin L-like protease 0.0058 0.0374 0.5291
Entamoeba histolytica hypothetical protein, conserved 0.1356 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0054 0.0038
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0402 0.0402
Trichomonas vaginalis CMGC family protein kinase 0.0097 0.0658 0.1801
Brugia malayi TAR-binding protein 0.0062 0.0402 0.1125
Loa Loa (eye worm) hypothetical protein 0.001 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0014 0.0048 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0402 0.0402
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.2453 0.6849
Schistosoma mansoni diacylglycerol kinase theta 0.0053 0.0333 0.0333
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0053 0.0336 0.4669
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0374 0.5291
Trypanosoma cruzi diacylglycerol kinase, putative 0.0053 0.0333 0.4612
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0402 0.0402
Mycobacterium tuberculosis Conserved protein 0.1356 1 1
Leishmania major cathepsin L-like protease 0.0058 0.0374 0.5291
Brugia malayi hypothetical protein 0.0053 0.0333 0.093
Mycobacterium ulcerans hypothetical protein 0.1356 1 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0097 0.0658 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0015 0.0054 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0374 0.1261
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.0172 0.0481
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0048 0.0048
Trichomonas vaginalis diacylglycerol kinase, putative 0.0053 0.0333 0.0888
Brugia malayi Cathepsin L-like precursor 0.0015 0.0054 0.0152
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0015 0.0054 0.0054
Onchocerca volvulus 0.0015 0.0054 0.0163
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0053 0.0333 0.0333
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0097 0.0658 0.0658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0374 0.1261
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0053 0.0333 0.4612
Echinococcus granulosus cathepsin l1 0.0015 0.0054 0.0054
Loa Loa (eye worm) RNA binding protein 0.0062 0.0402 0.0402
Onchocerca volvulus 0.0015 0.0054 0.0163
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0058 0.0374 0.1261
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0374 0.5291
Loa Loa (eye worm) fibroinase 0.0015 0.0054 0.0054
Leishmania major hypothetical protein, conserved 0.0053 0.0333 0.4612
Onchocerca volvulus 0.0015 0.0054 0.0163
Schistosoma mansoni sphingosine kinase A B 0.1356 1 1
Leishmania major sphingosine kinase A, B, putative 0.0053 0.0333 0.4612
Echinococcus multilocularis mitogen activated protein kinase 3 0.0097 0.0658 0.0658
Echinococcus multilocularis ceramide kinase 0.0053 0.0333 0.0333
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.081 0.081
Trichomonas vaginalis sphingosine kinase, putative 0.0053 0.0333 0.0888
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0015 0.0054 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0402 0.0402
Onchocerca volvulus Ceramide kinase 1 homolog 0.0053 0.0333 0.1368
Echinococcus multilocularis mitogen activated protein kinase 0.0097 0.0658 0.0658
Leishmania major hypothetical protein, conserved 0.0053 0.0333 0.4612
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0172
Onchocerca volvulus Glucosylceramidase homolog 0.0321 0.2325 1
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0054 0.0152
Brugia malayi RNA binding protein 0.0062 0.0402 0.1125
Plasmodium falciparum diacylglycerol kinase, putative 0.0053 0.0333 1
Loa Loa (eye worm) hypothetical protein 0.1356 1 1
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0053 0.0333 0.0333
Brugia malayi cathepsin L-like precursor 0.001 0.0017 0.0047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0054 0.0106
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.0279 0.0781
Loa Loa (eye worm) cysteine protease 0.0015 0.0054 0.0054
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.2453 0.6849
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.2325 0.6488
Brugia malayi Cathepsin L-like precursor 0.0015 0.0054 0.0152
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0097 0.0658 1
Leishmania major diacylglycerol kinase-like protein 0.0053 0.0333 0.4612
Echinococcus multilocularis cysteine protease 0.0015 0.0054 0.0054
Plasmodium vivax diacylglycerol kinase, putative 0.0053 0.0333 1
Brugia malayi Eye-specific diacylglycerol kinase 0.0053 0.0333 0.093

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 3.1 ug ml-1 Cytotoxicity in the human fibroblast Hs 68 cell line ChEMBL. 10447945
CC50 (functional) = 3.1 ug ml-1 Cytotoxicity in the human fibroblast Hs 68 cell line ChEMBL. 10447945
IC50 (functional) = 0.03 ug ml-1 Anti-HCMV activity in the human fibroblast Hs 68 cell line ChEMBL. 10447945

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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