Detailed information for compound 1696780

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 406.453 | Formula: C19H22N2O6S
  • H donors: 1 H acceptors: 4 LogP: 2.54 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCO/C(=C/1\C(=N[C@]2([C@H]([C@@H]1c1ccc(cc1S2)[N+](=O)[O-])C(=O)OCC)C)C)/O
  • InChi: 1S/C19H22N2O6S/c1-5-26-17(22)14-10(3)20-19(4)16(18(23)27-6-2)15(14)12-8-7-11(21(24)25)9-13(12)28-19/h7-9,15-16,22H,5-6H2,1-4H3/b17-14+/t15-,16-,19-/m1/s1
  • InChiKey: WOSXQVHCZORUMF-RAQPGAAPSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcium channel, voltage-dependent, L type, alpha 1C subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Muscle calcium channel subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei gambiense calcium channel protein, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent N-type calcium channel subunit alpha-1B, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Toxoplasma gondii transporter, cation channel family protein Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni voltage-gated cation channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type D subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) voltage-dependent calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Neospora caninum hypothetical protein Get druggable targets OG5_126791 All targets in OG5_126791
Loa Loa (eye worm) calcium channel Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent L type calcium channel subunit Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu Get druggable targets OG5_126791 All targets in OG5_126791
Echinococcus multilocularis voltage dependent calcium channel type d subunit Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav1 Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum expressed protein Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma congolense Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative Get druggable targets OG5_126791 All targets in OG5_126791
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma mansoni high voltage-activated calcium channel Cav2A Get druggable targets OG5_126791 All targets in OG5_126791
Schistosoma japonicum Voltage-dependent calcium channel type A subunit alpha-1, putative Get druggable targets OG5_126791 All targets in OG5_126791

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus tubulin subunit beta 0.0188 1 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0188 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0073 0.2278 0.2278
Echinococcus multilocularis Tubulin beta 2C chain 0.0188 1 1
Echinococcus multilocularis tubulin subunit TubB 0.0112 0.4866 0.4866
Entamoeba histolytica tubulin family protein 0.0188 1 1
Echinococcus granulosus tubulin alpha chain 0.0112 0.4866 0.4866
Echinococcus granulosus tubulin alpha chain 0.0112 0.4866 0.4866
Echinococcus granulosus tubulin alpha 1C chain 0.0112 0.4866 0.4866
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0093 0.3617 0.3617
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0056 0.1187 0.1187
Trichomonas vaginalis tubulin alpha chain, putative 0.0188 1 1
Echinococcus granulosus tubulin epsilon chain 0.0089 0.3372 0.3372
Echinococcus multilocularis voltage dependent calcium channel 0.0093 0.3617 0.3617
Trichomonas vaginalis tubulin gamma chain, putative 0.0089 0.3372 0.3372
Schistosoma mansoni tubulin subunit alpha 0.0112 0.4866 0.4866
Schistosoma mansoni tubulin subunit beta 0.0188 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0112 0.4866 0.4866
Echinococcus multilocularis Tubulin beta 2C chain 0.0188 1 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.3617 0.3617
Loa Loa (eye worm) hypothetical protein 0.01 0.4082 0.4082
Brugia malayi Tubulin alpha-2 chain 0.0112 0.4866 0.4866
Brugia malayi Trypsin family protein 0.01 0.4082 0.4082
Schistosoma mansoni tubulin subunit beta 0.0188 1 1
Leishmania major beta tubulin 0.0188 1 1
Schistosoma mansoni tubulin subunit beta 0.0188 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0073 0.2278 0.2278
Schistosoma mansoni alpha tubulin 0.0112 0.4866 0.4866
Echinococcus granulosus tubulin subunit TubB 0.0112 0.4866 0.4866
Plasmodium falciparum tubulin beta chain 0.0188 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0112 0.4866 0.4866
Trichomonas vaginalis tubulin beta chain, putative 0.0112 0.4866 0.4866
Loa Loa (eye worm) alpha-tubulin 0.0112 0.4866 0.4866
Echinococcus multilocularis beta tubulin 0.0188 1 1
Leishmania major beta tubulin 0.0188 1 1
Toxoplasma gondii alpha-tubulin I, putative 0.0112 0.4866 0.4866
Echinococcus multilocularis Tubulin beta 2C chain 0.0188 1 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0093 0.3617 0.3617
Leishmania major alpha tubulin 0.0112 0.4866 0.4866
Brugia malayi alpha-tubulin 0.0112 0.4866 0.4866
Schistosoma mansoni tubulin subunit gamma 0.0089 0.3372 0.3372
Trypanosoma cruzi tubulin gamma chain 0.0089 0.3372 0.3372
Loa Loa (eye worm) tubulin gamma chain 0.0089 0.3372 0.3372
Trichomonas vaginalis tubulin beta chain, putative 0.0112 0.4866 0.4866
Entamoeba histolytica tubulin alpha-1 chain 0.0112 0.4866 0.2253
Loa Loa (eye worm) BEN-1 protein 0.0188 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0188 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.4082 0.4082
Loa Loa (eye worm) hypothetical protein 0.0061 0.1493 0.1493
Leishmania major alpha tubulin 0.0112 0.4866 0.4866
Echinococcus multilocularis tubulin alpha chain 0.0112 0.4866 0.4866
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0093 0.3617 0.3617
Giardia lamblia Alpha-tubulin 0.0112 0.4866 0.4866
Plasmodium vivax tubulin epsilon chain, putative 0.0089 0.3372 0.3372
Toxoplasma gondii alpha tubulin TUBA1 0.0112 0.4866 0.4866
Trichomonas vaginalis tubulin, putative 0.0188 1 1
Leishmania major alpha tubulin 0.0112 0.4866 0.4866
Trichomonas vaginalis tubulin beta chain, putative 0.0112 0.4866 0.4866
Echinococcus granulosus tubulin alpha chain 0.0112 0.4866 0.4866
Loa Loa (eye worm) alpha-tubulin 0.0112 0.4866 0.4866
Loa Loa (eye worm) tubulin beta-4 chain 0.0188 1 1
Toxoplasma gondii beta-tubulin, putative 0.0188 1 1
Echinococcus granulosus voltage dependent calcium channel 0.0093 0.3617 0.3617
Loa Loa (eye worm) hypothetical protein 0.01 0.4082 0.4082
Schistosoma mansoni tubulin subunit beta 0.0188 1 1
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0093 0.3617 0.3617
Leishmania major beta tubulin 0.0188 1 1
Leishmania major beta tubulin 0.0188 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.0112 0.4866 0.4866
Leishmania major alpha tubulin 0.0112 0.4866 0.4866
Leishmania major beta tubulin 0.0188 1 1
Plasmodium vivax tubulin alpha chain, putative 0.0112 0.4866 0.4866
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0112 0.4866 0.4866
Trypanosoma brucei beta tubulin 0.0188 1 1
Leishmania major alpha tubulin 0.0112 0.4866 0.4866
Echinococcus multilocularis hypothetical protein 0.0112 0.4866 0.4866
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0061 0.1493 0.1493
Echinococcus multilocularis tubulin alpha 1C chain 0.0112 0.4866 0.4866
Trypanosoma brucei alpha tubulin 0.0112 0.4866 0.4866
Echinococcus granulosus tubulin alpha 1C chain 0.0112 0.4866 0.4866
Echinococcus multilocularis tubulin beta 1 chain 0.0188 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0112 0.4866 0.4866
Brugia malayi tubulin alpha-2 chain 0.0112 0.4866 0.4866
Echinococcus granulosus peroxisome assembly protein 26 0.0112 0.4866 0.4866
Leishmania major beta tubulin 0.0188 1 1
Trypanosoma brucei beta tubulin 0.0188 1 1
Plasmodium falciparum tubulin gamma chain 0.0089 0.3372 0.3372
Echinococcus multilocularis voltage dependent calcium channel 0.0093 0.3617 0.3617
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0093 0.3617 0.3617
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0093 0.3617 0.3617
Giardia lamblia Alpha-tubulin 0.0112 0.4866 0.4866
Echinococcus multilocularis tubulin alpha 0.0089 0.3372 0.3372
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.005 0.0784 0.0784
Giardia lamblia Beta tubulin 0.0188 1 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0112 0.4866 0.4866
Trypanosoma brucei epsilon tubulin 0.0089 0.3372 0.3372
Entamoeba histolytica tubulin family protein 0.0188 1 1
Leishmania major beta tubulin 0.0188 1 1
Echinococcus multilocularis beta tubulin 0.0188 1 1
Schistosoma mansoni alpha tubulin 0.0112 0.4866 0.4866
Loa Loa (eye worm) hypothetical protein 0.0073 0.2278 0.2278
Onchocerca volvulus 0.01 0.4082 1
Echinococcus granulosus Tubulin beta 2C chain 0.0188 1 1
Brugia malayi tubulin alpha chain - mouse 0.0112 0.4866 0.4866
Schistosoma mansoni alpha tubulin 0.0112 0.4866 0.4866
Brugia malayi Tubulin gamma chain 0.0089 0.3372 0.3372
Toxoplasma gondii beta tubulin 0.0188 1 1
Loa Loa (eye worm) BEN-1 protein 0.0188 1 1
Echinococcus multilocularis tubulin alpha chain 0.0112 0.4866 0.4866
Echinococcus multilocularis tubulin alpha 3 chain 0.0112 0.4866 0.4866
Echinococcus granulosus beta tubulin 0.0188 1 1
Echinococcus granulosus tubulin alpha chain 0.0112 0.4866 0.4866
Trichomonas vaginalis tubulin, putative 0.005 0.0784 0.0784
Loa Loa (eye worm) tubulin alpha-2 chain 0.0112 0.4866 0.4866
Toxoplasma gondii beta-1 tubulin, putative 0.0188 1 1
Treponema pallidum cell division protein FtsZ 0.0039 0 0.5
Giardia lamblia Gamma tubulin 0.0089 0.3372 0.3372
Leishmania major alpha tubulin 0.0112 0.4866 0.4866
Echinococcus granulosus tubulin alpha 3 chain 0.0112 0.4866 0.4866
Loa Loa (eye worm) calcium channel 0.0093 0.3617 0.3617
Schistosoma mansoni tubulin subunit alpha 0.0112 0.4866 0.4866
Echinococcus granulosus alpha tubulin 0.0112 0.4866 0.4866
Loa Loa (eye worm) tubulin beta-2A chain 0.0188 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0112 0.4866 0.4866
Plasmodium vivax tubulin beta chain, putative 0.0188 1 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0188 1 1
Leishmania major beta tubulin 0.0188 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.0089 0.3372 0.3372
Leishmania major beta tubulin 0.0188 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0073 0.2278 0.2278
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0089 0.3372 0.3372
Echinococcus granulosus Tubulin beta 2C chain 0.0188 1 1
Giardia lamblia Beta tubulin 0.0188 1 1
Leishmania major beta tubulin 0.0188 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0188 1 1
Echinococcus granulosus tubulin gamma 1 chain 0.0089 0.3372 0.3372
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0056 0.1187 0.1187
Loa Loa (eye worm) tubulin alpha chain 0.0112 0.4866 0.4866
Plasmodium vivax tubulin alpha chain, putative 0.0112 0.4866 0.4866
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0093 0.3617 0.3617
Echinococcus granulosus beta tubulin 0.0188 1 1
Echinococcus multilocularis tubulin epsilon chain 0.0089 0.3372 0.3372
Echinococcus granulosus Tubulin alpha 1 chain 0.0112 0.4866 0.4866
Trichomonas vaginalis tubulin beta chain, putative 0.0112 0.4866 0.4866
Trichomonas vaginalis tubulin epsilon chain, putative 0.0112 0.4866 0.4866
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0188 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0188 1 1
Trypanosoma brucei epsilon tubulin 0.0089 0.3372 0.3372
Trichomonas vaginalis tubulin epsilon chain, putative 0.0188 1 1
Plasmodium vivax tubulin gamma chain, putative 0.0089 0.3372 0.3372
Leishmania major alpha tubulin 0.0112 0.4866 0.4866
Leishmania major beta tubulin 0.0188 1 1
Leishmania major beta tubulin 0.0188 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0188 1 1
Leishmania major gamma-tubulin 0.0089 0.3372 0.3372
Brugia malayi beta-tubulin, identical 0.0188 1 1
Echinococcus multilocularis tubulin alpha chain 0.0112 0.4866 0.4866
Leishmania major beta tubulin 0.0188 1 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0089 0.3372 0.3372
Echinococcus multilocularis tubulin gamma 1 chain 0.0089 0.3372 0.3372
Echinococcus granulosus tubulin beta 1 chain 0.0188 1 1
Echinococcus multilocularis tubulin alpha chain 0.0112 0.4866 0.4866
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0039 0.0044 0.0044
Echinococcus multilocularis Tubulin alpha 1 chain 0.0112 0.4866 0.4866
Leishmania major epsilon tubulin, putative 0.0089 0.3372 0.3372
Schistosoma mansoni tubulin subunit alpha 0.0112 0.4866 0.4866
Echinococcus multilocularis peroxisome assembly protein 26 0.0112 0.4866 0.4866
Trypanosoma brucei alpha tubulin 0.0112 0.4866 0.4866
Brugia malayi Tubulin beta chain 0.005 0.0784 0.0784
Loa Loa (eye worm) tubulin beta chain 0.0188 1 1
Schistosoma mansoni tubulin subunit beta 0.0188 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0112 0.4866 0.4866
Echinococcus granulosus tubulin alpha chain 0.0112 0.4866 0.4866
Trypanosoma brucei alpha tubulin 0.0112 0.4866 0.4866
Leishmania major alpha tubulin 0.0112 0.4866 0.4866
Mycobacterium tuberculosis Cell division protein FtsZ 0.0039 0 0.5
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0093 0.3617 0.3617
Schistosoma mansoni tubulin subunit beta 0.0188 1 1
Leishmania major beta tubulin 0.0188 1 1
Brugia malayi Tubulin alpha-2 chain 0.0112 0.4866 0.4866
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.4082 0.4082
Trichomonas vaginalis tubulin epsilon chain, putative 0.0188 1 1
Trypanosoma brucei epsilon tubulin 0.0089 0.3372 0.3372
Leishmania major alpha tubulin 0.0112 0.4866 0.4866
Plasmodium falciparum alpha tubulin 1 0.0112 0.4866 0.4866
Echinococcus granulosus Tubulin beta 2C chain 0.0188 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0112 0.4866 0.4866
Leishmania major beta tubulin 0.0188 1 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0073 0.2278 0.2278
Trypanosoma cruzi epsilon tubulin, putative 0.0089 0.3372 0.3372
Onchocerca volvulus 0.0091 0.3488 0.8201
Giardia lamblia Beta tubulin 0.0188 1 1
Echinococcus multilocularis tubulin subunit beta 0.0188 1 1
Plasmodium falciparum alpha tubulin 2 0.0112 0.4866 0.4866
Schistosoma mansoni voltage-gated cation channel 0.0093 0.3617 0.3617
Mycobacterium leprae cell division protein FtsZ 0.0039 0 0.5
Trypanosoma brucei beta tubulin 0.0188 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.0784 0.0784
Trichomonas vaginalis tubulin beta chain, putative 0.0112 0.4866 0.4866
Mycobacterium ulcerans cell division protein FtsZ 0.0039 0 0.5
Leishmania major beta tubulin 0.0188 1 1
Loa Loa (eye worm) tubulin alpha chain 0.0112 0.4866 0.4866
Trichomonas vaginalis tubulin beta chain, putative 0.0188 1 1
Schistosoma mansoni tubulin subunit epsilon 0.0089 0.3372 0.3372
Trypanosoma brucei beta tubulin 0.0089 0.3372 0.3372
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0093 0.3617 0.3617
Loa Loa (eye worm) beta-tubulin 0.0188 1 1
Brugia malayi Tubulin alpha chain 0.0112 0.4866 0.4866
Trypanosoma cruzi beta tubulin, putative 0.0188 1 1
Trypanosoma cruzi alpha tubulin, putative 0.0112 0.4866 0.4866
Leishmania major alpha tubulin 0.0112 0.4866 0.4866
Entamoeba histolytica tubulin alpha chain, putative 0.0112 0.4866 0.2253
Loa Loa (eye worm) hypothetical protein 0.0112 0.4866 0.4866
Echinococcus multilocularis Tubulin beta 2C chain 0.0188 1 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0061 0.1493 0.1493
Echinococcus multilocularis tubulin alpha chain 0.0112 0.4866 0.4866
Trichomonas vaginalis tubulin gamma chain, putative 0.0089 0.3372 0.3372
Trypanosoma brucei alpha tubulin, putative 0.005 0.0784 0.0784
Echinococcus multilocularis tubulin alpha 3 chain 0.0112 0.4866 0.4866
Leishmania major alpha tubulin 0.0112 0.4866 0.4866
Trypanosoma brucei tubulin gamma chain 0.0089 0.3372 0.3372
Trichomonas vaginalis tubulin alpha chain, putative 0.005 0.0784 0.0784
Trypanosoma brucei beta tubulin 0.0188 1 1
Trypanosoma brucei alpha tubulin 0.0112 0.4866 0.4866
Trichomonas vaginalis tubulin alpha chain, putative 0.005 0.0784 0.0784
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0039 0 0.5
Trichomonas vaginalis tubulin alpha chain, putative 0.005 0.0784 0.0784
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0093 0.3617 0.3617
Leishmania major beta tubulin 0.0188 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0089 0.3372 0.3372
Leishmania major alpha tubulin 0.0112 0.4866 0.4866
Trichomonas vaginalis tubulin, putative 0.005 0.0784 0.0784
Echinococcus granulosus tubulin alpha 0.0089 0.3372 0.3372
Leishmania major beta tubulin 0.0188 1 1
Echinococcus multilocularis sodium channel protein 0.0039 0.0044 0.0044

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.000005 M Inhibition of [3H]-nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesicles ChEMBL. 2435904

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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