TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 510.585 | Formula: C26H34N6O5
H donors: 1 H acceptors: 6 LogP: 1.08 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@@H](N1C[C@@H](C)[C@@H](OCc2n(CCCC1=O)nnc2)CN(C(=O)c1noc(c1)c1ccccc1)C)C
InChi: 1S/C26H34N6O5/c1-18-14-31(19(2)16-33)25(34)10-7-11-32-21(13-27-29-32)17-36-24(18)15-30(3)26(35)22-12-23(37-28-22)20-8-5-4-6-9-20/h4-6,8-9,12-13,18-19,24,33H,7,10-11,14-17H2,1-3H3/t18-,19+,24+/m1/s1
InChiKey: DZRIWTKXHLXUTO-IMWIBFENSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0018	0.0122	0.0472
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.0122	0.012
Echinococcus granulosus	fmrfamide receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0136	0.0134
Trypanosoma cruzi	Pyridoxal-dependent decarboxylase conserved domain containing protein, putative	0.0014	0.0061	0.0129
Schistosoma mansoni	cercarial elastase (S01 family)	0.0019	0.0136	0.0098
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Echinococcus granulosus	sex peptide receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0655	0.0654
Echinococcus granulosus	dro:myosuppressin receptor	0.0018	0.0122	0.012
Brugia malayi	G-protein coupled receptor	0.0018	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Brugia malayi	Diacylglycerol kinase protein 2	0.0012	0.0039	0.0039
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0018	0.0122	0.0084
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Loa Loa (eye worm)	brix domain-containing protein	0.0018	0.012	0.0118
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0018	0.0122	0.0084
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0012	0.0039	0.0037
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.0122	0.0084
Onchocerca volvulus		0.0018	0.0122	0.0472
Mycobacterium ulcerans	glutamate decarboxylase	0.0014	0.0061	0.0053
Brugia malayi	G-protein coupled receptor	0.0018	0.0122	0.0122
Brugia malayi	Eye-specific diacylglycerol kinase	0.0012	0.0039	0.0039
Schistosoma mansoni	phenylalanine decarboxylase	0.0014	0.0061	0.0023
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0107	0.0105
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0627	0.0626
Onchocerca volvulus		0.0018	0.0122	0.0472
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0019	0.0136	0.0136
Echinococcus granulosus	allatostatin A receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Brugia malayi	biogenic amine synthesis related protein 1	0.0014	0.0061	0.0061
Onchocerca volvulus		0.0019	0.0136	0.0553
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0305	0.0303
Echinococcus multilocularis	insulin receptor	0.0227	0.3104	0.3103
Brugia malayi	G protein-coupled receptor F59B2.13	0.0018	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0136	0.0134
Brugia malayi	G protein-coupled receptor	0.0018	0.0122	0.0122
Echinococcus granulosus	glycoprotein Antigen 5	0.0019	0.0136	0.0134
Brugia malayi	hypothetical protein	0.0018	0.0122	0.0122
Brugia malayi	putative neuropeptide receptor	0.0018	0.0122	0.0122
Trypanosoma brucei	sphingosine 1-phosphate lyase, putative	0.0119	0.1572	1
Schistosoma mansoni	cpg binding protein	0.0032	0.033	0.0292
Schistosoma mansoni	hypothetical protein	0.0018	0.0122	0.0084
Leishmania major	hypothetical protein, conserved	0.0135	0.1801	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0107	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0039	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Toxoplasma gondii	kringle domain-containing protein	0.0135	0.1801	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0227	0.3104	0.3103
Schistosoma mansoni	hypothetical protein	0.0018	0.0122	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Onchocerca volvulus		0.0018	0.0122	0.0472
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0018	0.0122	0.0084
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0655	0.0655
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0018	0.0122	0.0084
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0019	0.0136	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0061	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.0122	0.0084
Schistosoma mansoni	cercarial elastase (S01 family)	0.0019	0.0136	0.0098
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0018	0.0122	0.012
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0655	0.0654
Echinococcus multilocularis	aromatic amino acid decarboxylase	0.0014	0.0061	0.0059
Brugia malayi	Melatonin receptor type 1A	0.0018	0.0122	0.0122
Onchocerca volvulus		0.0018	0.0122	0.0472
Toxoplasma gondii	brix domain-containing protein	0.0018	0.012	0.0463
Schistosoma mansoni	tyrosine kinase	0.0381	0.5311	0.5293
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0018	0.0122	0.012
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.0122	0.012
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.0061	0.0129
Loa Loa (eye worm)	TDC-1 protein	0.0014	0.0061	0.0059
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.0122	0.012
Mycobacterium ulcerans	hypothetical protein	0.0019	0.0136	0.0229
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.0122	0.012
Echinococcus granulosus	muscleblind protein	0.016	0.2147	0.2146
Echinococcus multilocularis	muscleblind protein	0.016	0.2147	0.2146
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0018	0.0122	0.012
Onchocerca volvulus		0.0018	0.0122	0.0472
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0018	0.0122	0.0122
Echinococcus multilocularis		0.0219	0.3003	0.3002
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0122	0.012
Echinococcus multilocularis	g-protein coupled receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Brugia malayi	Protein kinase domain containing protein	0.0227	0.3104	0.3104
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0122	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Brugia malayi	diacylglycerol kinase	0.0012	0.0039	0.0039
Schistosoma mansoni	cercarial elastase (S01 family)	0.0019	0.0136	0.0098
Brugia malayi	hypothetical protein	0.0018	0.0122	0.0122
Loa Loa (eye worm)	melatonin receptor type 1A	0.0018	0.0122	0.012
Echinococcus granulosus	neuropeptide FF receptor 2	0.0018	0.0122	0.012
Brugia malayi	glutamate decarboxylase, 67 kDa isoform	0.0014	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Schistosoma mansoni	tyrosine kinase	0.0227	0.3104	0.3078
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0019	0.0136	0.0098
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Loa Loa (eye worm)	eye-specific diacylglycerol kinase	0.0012	0.0039	0.0037
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.0122	0.012
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0122	0.0084
Echinococcus multilocularis	peter pan	0.0018	0.012	0.0118
Brugia malayi	Aromatic-L-amino-acid decarboxylase	0.0014	0.0061	0.0061
Echinococcus granulosus	Mastin	0.0019	0.0136	0.0134
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.0122	0.012
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0018	0.0122	0.012
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0018	0.0122	0.0472
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0018	0.0122	0.0084
Echinococcus granulosus	peter pan	0.0018	0.012	0.0118
Echinococcus multilocularis	epidermal growth factor receptor	0.0381	0.5311	0.531
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0655	0.0654
Echinococcus multilocularis	Mastin	0.0019	0.0136	0.0134
Echinococcus granulosus	neuropeptide receptor A26	0.0018	0.0122	0.012
Schistosoma mansoni	amine GPCR	0.0018	0.0122	0.0084
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.0122	0.0084
Echinococcus multilocularis	somatostatin receptor	0.0018	0.0122	0.012
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0107	0.0105
Echinococcus multilocularis	epidermal growth factor receptor	0.0709	1	1
Schistosoma mansoni	peter pan-related	0.0018	0.012	0.0082
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Echinococcus multilocularis	allatostatin A receptor	0.0018	0.0122	0.012
Onchocerca volvulus		0.0018	0.0122	0.0472
Brugia malayi	hypothetical protein	0.0018	0.0122	0.0122
Echinococcus granulosus	sphingosine 1 phosphate lyase 1	0.0119	0.1572	0.1571
Loa Loa (eye worm)	hypothetical protein	0.016	0.2147	0.2146
Brugia malayi	hypothetical protein	0.0019	0.0136	0.0136
Echinococcus granulosus	sphingosine kinase 1	0.031	0.4294	0.4293
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0019	0.0136	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0107	0.0105
Echinococcus granulosus	neuropeptide receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	sphingosine-1-phosphate lyase 1	0.0014	0.0061	0.0059
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0018	0.0122	0.012
Leishmania major	sphingosine 1-phosphate lyase	0.0119	0.1572	0.8701
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0227	0.3104	0.3103
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.1689	0.1688
Onchocerca volvulus		0.0019	0.0136	0.0553
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0122	0.012
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Schistosoma mansoni	hypothetical protein	0.0019	0.0136	0.0098
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.0122	0.012
Plasmodium vivax	hypothetical protein, conserved	0.0018	0.012	0.0463
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.1689	0.1688
Echinococcus granulosus	cpg binding protein	0.0032	0.033	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Onchocerca volvulus		0.0031	0.0305	0.151
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Entamoeba histolytica	hypothetical protein, conserved	0.031	0.4294	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0122	0.012
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0136	0.0134
Echinococcus multilocularis	transmembrane protease serine 3	0.0019	0.0136	0.0134
Onchocerca volvulus		0.0018	0.0122	0.0472
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0018	0.0122	0.0084
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Onchocerca volvulus		0.0018	0.0122	0.0472
Schistosoma mansoni	hypothetical protein	0.0017	0.0107	0.0069
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0122	0.0084
Echinococcus granulosus	enteropeptidase	0.0019	0.0136	0.0134
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0018	0.0122	0.012
Brugia malayi	Dopamine receptor protein 2	0.0018	0.0122	0.0122
Schistosoma mansoni	sphingoid long chain base kinase	0.031	0.4294	0.4272
Brugia malayi	ORL1-like opioid receptor	0.0018	0.0122	0.0122
Echinococcus granulosus	Diacylglycerol kinase zeta	0.0012	0.0039	0.0037
Echinococcus granulosus	zinc finger protein 598	0.0018	0.0119	0.0117
Schistosoma mansoni	phenylalanine decarboxylase	0.0014	0.0061	0.0023
Schistosoma mansoni	hypothetical protein	0.0017	0.0107	0.0069
Plasmodium falciparum	BRIX domain, putative	0.0018	0.012	0.0463
Trypanosoma cruzi	hypothetical protein, conserved	0.0135	0.1801	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0019	0.0136	0.0098
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0122	0.0084
Loa Loa (eye worm)	hypothetical protein	0.031	0.4294	0.4293
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.0122	0.012
Brugia malayi	Trypsin family protein	0.0019	0.0136	0.0136
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0627	0.0627
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0018	0.0122	0.012
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0107	0.0105
Brugia malayi	Serotonin receptor	0.0018	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0136	0.0134
Schistosoma mansoni	hypothetical protein	0.0437	0.6113	0.6098
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Schistosoma mansoni	cercarial elastase (S01 family)	0.0019	0.0136	0.0098
Echinococcus multilocularis	neuropeptide Y receptor	0.0018	0.0122	0.012
Entamoeba histolytica	s phingosine-1-phosphate lyase 1, putative	0.0119	0.1572	0.3604
Echinococcus multilocularis	sex peptide receptor	0.0018	0.0122	0.012
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0122	0.0084
Schistosoma mansoni	hypothetical protein	0.0036	0.0387	0.0349
Echinococcus multilocularis	glycoprotein Antigen 5	0.0019	0.0136	0.0134
Schistosoma mansoni	hypothetical protein	0.0135	0.1801	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0018	0.0122	0.012
Echinococcus multilocularis	ceramide kinase	0.0012	0.0039	0.0037
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0018	0.0122	0.012
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0122	0.0084
Loa Loa (eye worm)	hypothetical protein	0.016	0.2147	0.2146
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Loa Loa (eye worm)	TYRA-2 protein	0.0018	0.0122	0.012
Schistosoma mansoni	phenylalanine decarboxylase	0.0014	0.0061	0.0023
Trypanosoma cruzi	sphingosine 1-phosphate lyase, putative	0.0119	0.1572	0.8701
Brugia malayi	Ceramide kinase	0.0012	0.0039	0.0039
Trypanosoma cruzi	peter pan protein, putative	0.0018	0.012	0.0463
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0018	0.0122	0.012
Brugia malayi	diacylglycerol kinase	0.0012	0.0039	0.0039
Onchocerca volvulus		0.0019	0.0136	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1572	0.1571
Trypanosoma cruzi	Pyridoxal-dependent decarboxylase conserved domain containing protein, putative	0.0014	0.0061	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus multilocularis	neuropeptides capa receptor	0.0018	0.0122	0.012
Echinococcus granulosus	dnaJ subfamily B	0.0437	0.6113	0.6112
Brugia malayi	larval opioid receptor	0.0018	0.0122	0.0122
Echinococcus granulosus	epidermal growth factor receptor	0.0709	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0122	0.0084
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0018	0.0122	0.012
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0018	0.0122	0.012
Echinococcus granulosus	Diacylglycerol kinase theta	0.0012	0.0039	0.0037
Schistosoma mansoni	opsin-like receptor	0.0018	0.0122	0.0084
Echinococcus granulosus	neuropeptide Y receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1801	0.18
Loa Loa (eye worm)	G-protein coupled receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus multilocularis	sphingosine 1 phosphate lyase 1	0.0119	0.1572	0.1571
Echinococcus multilocularis	G protein coupled receptor 139	0.0018	0.0122	0.012
Brugia malayi	Trypsin family protein	0.0019	0.0136	0.0136
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0122	0.012
Trypanosoma brucei	Pyridoxal-dependent decarboxylase conserved domain containing protein, putative	0.0014	0.0061	0.0148
Loa Loa (eye worm)	ceramide kinase	0.0012	0.0039	0.0037
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0709	1	1
Schistosoma mansoni	myosin xvIII	0.0018	0.0122	0.0084
Echinococcus multilocularis	neuropeptide receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Schistosoma mansoni	cercarial elastase (S01 family)	0.0019	0.0136	0.0098
Brugia malayi	hypothetical protein	0.0018	0.0122	0.0122
Echinococcus granulosus	7tm_1 domain containing protein	0.0018	0.0122	0.012
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0381	0.5311	0.531
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0122	0.0084
Schistosoma mansoni	sphingosine phosphate lyase	0.0119	0.1572	0.154
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Schistosoma mansoni	cercarial elastase (S01 family)	0.0019	0.0136	0.0098
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0122	0.012
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0018	0.0122	0.0122
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0122	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0039	0.0037
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0018	0.0122	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0107	0.0107
Brugia malayi	follicle stimulating hormone receptor	0.0018	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus granulosus	orexin receptor type 2	0.0018	0.0122	0.012
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0122	0.012
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0122	0.0084
Onchocerca volvulus		0.0018	0.0122	0.0472
Schistosoma mansoni	hypothetical protein	0.0017	0.0107	0.0069
Echinococcus multilocularis	neuropeptide receptor A26	0.0018	0.0122	0.012
Trichomonas vaginalis	group II pyridoxal-5-phosphate decarboxylase, putative	0.0014	0.0061	0.2777
Brugia malayi	hypothetical protein	0.0018	0.0122	0.0122
Schistosoma mansoni	hypothetical protein	0.0019	0.0136	0.0098
Echinococcus multilocularis	orexin receptor type 2	0.0018	0.0122	0.012
Onchocerca volvulus	Peter pan protein homolog	0.0018	0.012	0.0463
Brugia malayi	RE15519p	0.0018	0.0122	0.0122
Schistosoma mansoni	neuropeptide f receptor 76f	0.0018	0.0122	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus granulosus	pyridoxal dependent decarboxylase	0.0014	0.0061	0.0059
Leishmania major	peter pan protein, putative	0.0018	0.012	0.0463
Leishmania major	hypothetical protein, conserved	0.0014	0.0061	0.0129
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.0796	0.0761
Schistosoma mansoni	neuropeptide F-like receptor	0.0018	0.0122	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Mycobacterium tuberculosis	Probable glutamate decarboxylase GadB	0.0014	0.0061	0.0053
Brugia malayi	hypothetical protein	0.0018	0.0122	0.0122
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0018	0.0122	0.012
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0387	0.0387
Echinococcus granulosus	neuropeptides capa receptor	0.0018	0.0122	0.012
Echinococcus granulosus	epidermal growth factor receptor	0.0381	0.5311	0.531
Echinococcus multilocularis	pyridoxal dependent decarboxylase	0.0014	0.0061	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0122	0.0084
Schistosoma mansoni	hypothetical protein	0.0018	0.0122	0.0084
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0019	0.0136	0.0134
Entamoeba histolytica	brix domain containing protein	0.0018	0.012	0.0192
Echinococcus granulosus	hypothetical protein	0.0018	0.0122	0.012
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0018	0.0122	0.0122
Schistosoma mansoni	tyrosine kinase	0.0381	0.5311	0.5293
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0018	0.0122	0.012
Brugia malayi	Dopamine receptor protein 1	0.0018	0.0122	0.0122
Onchocerca volvulus		0.0018	0.0122	0.0472
Brugia malayi	hypothetical protein	0.0018	0.0122	0.0122
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0018	0.0122	0.0084
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Schistosoma mansoni	phenylalanine decarboxylase	0.0014	0.0061	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0122	0.012
Mycobacterium ulcerans	glutamate decarboxylase	0.0014	0.0061	0.0053
Brugia malayi	Serotonin receptor	0.0018	0.0122	0.0122
Brugia malayi	Trypsin family protein	0.0019	0.0136	0.0136
Echinococcus granulosus	aromatic amino acid decarboxylase	0.0014	0.0061	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Brugia malayi	Trypsin family protein	0.0019	0.0136	0.0136
Brugia malayi	Pyridoxal-dependent decarboxylase conserved domain containing protein	0.0014	0.0061	0.0061
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0122	0.0084
Schistosoma mansoni	tyrosine kinase	0.0377	0.5253	0.5235
Schistosoma mansoni	adenoreceptor	0.0018	0.0122	0.0084
Giardia lamblia	Peter pan protein	0.0018	0.012	0.5
Schistosoma mansoni	tyrosine kinase	0.0227	0.3104	0.3078
Brugia malayi	Brix domain containing protein	0.0018	0.012	0.012
Echinococcus multilocularis	g protein coupled receptor	0.0018	0.0122	0.012
Schistosoma mansoni	sphingosine kinase A B	0.031	0.4294	0.4272
Onchocerca volvulus		0.0018	0.0122	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus granulosus	GPCR family 2	0.0017	0.0107	0.0105
Schistosoma mansoni	cpg binding protein	0.0032	0.033	0.0292
Schistosoma mansoni	amine GPCR	0.0018	0.0122	0.0084
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0018	0.0122	0.0122
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0018	0.0122	0.012
Echinococcus multilocularis	neuropeptide s receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus multilocularis	muscleblind protein 1	0.016	0.2147	0.2146
Echinococcus granulosus	g protein coupled receptor	0.0018	0.0122	0.012
Echinococcus granulosus	tissue type plasminogen activator	0.0135	0.1801	0.18
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0018	0.0122	0.0122
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0122	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0039	0.0037
Schistosoma mansoni	neuropeptide receptor	0.0018	0.0122	0.0084
Onchocerca volvulus		0.0019	0.0136	0.0553
Schistosoma mansoni	tyrosine kinase	0.0377	0.5253	0.5235
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0019	0.0136	0.0134
Plasmodium falciparum	cysteine repeat modular protein 1	0.0135	0.1801	1
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0305	0.0305
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0655	0.0654
Brugia malayi	putative neuropeptide receptor NPR1	0.0018	0.0122	0.0122
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0019	0.0136	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus multilocularis	acylglycerol kinase, mitochondrial	0.0012	0.0039	0.0037
Echinococcus multilocularis	Diacylglycerol kinase zeta	0.0012	0.0039	0.0037
Brugia malayi	neuropeptide F receptor	0.0018	0.0122	0.0122
Schistosoma mansoni	hypothetical protein	0.0017	0.0107	0.0069
Onchocerca volvulus		0.0018	0.0122	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Trypanosoma brucei	brix domain containing protein, putative	0.0018	0.012	0.0532
Mycobacterium tuberculosis	Conserved protein	0.031	0.4294	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Echinococcus multilocularis	dro:myosuppressin receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	diacylglycerol kinase 2	0.0012	0.0039	0.0037
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Onchocerca volvulus		0.0019	0.0136	0.0553
Onchocerca volvulus		0.0018	0.0122	0.0472
Echinococcus granulosus	biogenic amine 5HT receptor	0.0018	0.0122	0.012
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0018	0.0122	0.0122
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0018	0.0122	0.012
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0655	0.0619
Echinococcus multilocularis	tissue type plasminogen activator	0.0135	0.1801	0.18
Schistosoma mansoni	amine GPCR	0.0018	0.0122	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Trypanosoma cruzi	sphingosine 1-phosphate lyase, putative	0.0119	0.1572	0.8701
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0627	0.0627
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.0122	0.012
Brugia malayi	hypothetical protein	0.0012	0.0039	0.0039
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Schistosoma mansoni	tyrosine kinase	0.0709	1	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0627	0.0626
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.0122	0.012
Brugia malayi	MH2 domain containing protein	0.0128	0.1689	0.1689
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0387	0.0385
Brugia malayi	hypothetical protein	0.0018	0.0122	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Schistosoma mansoni	amine GPCR	0.0018	0.0122	0.0084
Schistosoma mansoni	cercarial elastase (S01 family)	0.0019	0.0136	0.0098
Echinococcus granulosus	somatostatin receptor	0.0018	0.0122	0.012
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0122	0.012
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0018	0.0122	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Loa Loa (eye worm)	glutamate decarboxylase GAD1	0.0014	0.0061	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0019	0.0136	0.0098
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0107	0.0107
Echinococcus multilocularis	enteropeptidase	0.0019	0.0136	0.0134
Echinococcus multilocularis	fmrfamide receptor	0.0018	0.0122	0.012
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0018	0.0122	0.012
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0107	0.0105
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0018	0.0122	0.012
Echinococcus multilocularis	cpg binding protein	0.0032	0.033	0.0328
Brugia malayi	Kringle domain containing protein	0.0135	0.1801	0.1801
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0019	0.0136	0.0134
Brugia malayi	sulfakinin receptor protein	0.0018	0.0122	0.0122
Schistosoma mansoni	tyrosine kinase	0.0377	0.5253	0.5235
Echinococcus multilocularis	serotonin receptor	0.0018	0.0122	0.012
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0227	0.3104	0.3103
Echinococcus multilocularis	serotonin receptor	0.0018	0.0122	0.012
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0122	0.0084
Brugia malayi	Trypsin-like protease protein 5	0.0019	0.0136	0.0136
Loa Loa (eye worm)	TK/ROR protein kinase	0.0139	0.1859	0.1857
Onchocerca volvulus		0.0018	0.0122	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0018	0.0122	0.012
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0135	0.1801	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0018	0.0122	0.0472
Loa Loa (eye worm)	trypsin family protein	0.0019	0.0136	0.0134
Schistosoma mansoni	cercarial elastase (S01 family)	0.0019	0.0136	0.0098
Echinococcus granulosus	serotonin receptor	0.0018	0.0122	0.012
Brugia malayi	Muscleblind-like protein	0.016	0.2147	0.2147
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0019	0.0136	0.0098
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Schistosoma mansoni	cercarial elastase (S01 family)	0.0019	0.0136	0.0098
Schistosoma mansoni	peter pan-related	0.0018	0.012	0.0082
Brugia malayi	AKH receptor	0.0018	0.0122	0.0122
Echinococcus granulosus	neuropeptide receptor	0.0018	0.0122	0.012
Schistosoma mansoni	cercarial elastase (S01 family)	0.0019	0.0136	0.0098
Onchocerca volvulus		0.0019	0.0136	0.0553
Schistosoma mansoni	histamine h1 receptor	0.0018	0.0122	0.0084
Echinococcus multilocularis	dnaJ subfamily B	0.0437	0.6113	0.6112
Echinococcus granulosus	acylglycerol kinase mitochondrial	0.0012	0.0039	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0136	0.0134
Brugia malayi	Pyridoxal-dependent decarboxylase conserved domain containing protein	0.0119	0.1572	0.1572
Mycobacterium ulcerans	hypothetical protein	0.031	0.4294	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0122	0.0084
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0018	0.0122	0.012
Trichomonas vaginalis	ssf, putative	0.0018	0.012	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Brugia malayi	Dopamine receptor	0.0018	0.0122	0.0122
Onchocerca volvulus		0.0018	0.0122	0.0472
Echinococcus granulosus	G protein coupled receptor 139	0.0018	0.0122	0.012
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus granulosus	transmembrane protease serine 3	0.0019	0.0136	0.0134
Brugia malayi	neuropeptide F receptor	0.0018	0.0122	0.0122
Loa Loa (eye worm)	neuropeptide F receptor	0.0018	0.0122	0.012
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0018	0.0122	0.0084
Schistosoma mansoni	biogenic amine receptor	0.0018	0.0122	0.0084
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0655	0.0619
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0019	0.0136	0.0098
Onchocerca volvulus		0.0135	0.1801	1
Echinococcus granulosus	insulin receptor	0.0227	0.3104	0.3103
Brugia malayi	glutamate decarboxylase putative	0.0014	0.0061	0.0061
Brugia malayi	hypothetical protein	0.0018	0.0122	0.0122
Brugia malayi	GnHR receptor homolog	0.0018	0.0122	0.0122
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0018	0.0122	0.012
Echinococcus granulosus	7TM GPCR rhodopsin	0.0018	0.0122	0.012
Echinococcus multilocularis	sphingosine kinase 1	0.031	0.4294	0.4293
Schistosoma mansoni	cpg binding protein	0.0031	0.0305	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Echinococcus granulosus	neuropeptide s receptor	0.0018	0.0122	0.012
Schistosoma mansoni	growth hormone secretagogue receptor	0.0018	0.0122	0.0084
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0697	0.3736
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0018	0.0122	0.0084
Brugia malayi	Protein kinase domain containing protein	0.0139	0.1859	0.1859
Trypanosoma cruzi	peter pan protein, putative	0.0018	0.012	0.0463
Onchocerca volvulus		0.0018	0.0122	0.0472
Schistosoma mansoni	amine GPCR	0.0018	0.0122	0.0084
Echinococcus granulosus	ceramide kinase	0.0012	0.0039	0.0037
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0655	0.0619
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0019	0.0136	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0122	0.012
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0019	0.0136	0.0098
Schistosoma mansoni	opsin-like receptor	0.0018	0.0122	0.0084
Echinococcus multilocularis	zinc finger protein 598	0.0018	0.0119	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0136	0.0134
Brugia malayi	hypothetical protein	0.0018	0.0122	0.0122
Echinococcus granulosus	g-protein coupled receptor	0.0018	0.0122	0.012
Echinococcus granulosus	tm gpcr rhodopsin	0.0018	0.0122	0.012
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0655	0.0654
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0122	0.0084
Loa Loa (eye worm)	aromatic L-amino acid decarboxylase	0.0014	0.0061	0.0059
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0018	0.0122	0.0084
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0018	0.0122	0.012
Schistosoma mansoni	opsin-like receptor	0.0018	0.0122	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0136	0.0134
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0018	0.0122	0.0084
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0107	0.0105
Echinococcus granulosus	rhodopsin orphan GPCR	0.0018	0.0122	0.012

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3548 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2140205

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1704575