Detailed information for compound 1713567

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 547.483 | Formula: C21H27BrN2O6S2
  • H donors: 1 H acceptors: 5 LogP: 2.96 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@@H](N1C[C@H](C)[C@H](Oc2c(S1(=O)=O)ccc(c2)Br)CN(S(=O)(=O)c1ccccc1)C)C
  • InChi: 1S/C21H27BrN2O6S2/c1-15-12-24(16(2)14-25)32(28,29)21-10-9-17(22)11-19(21)30-20(15)13-23(3)31(26,27)18-7-5-4-6-8-18/h4-11,15-16,20,25H,12-14H2,1-3H3/t15-,16-,20+/m0/s1
  • InChiKey: HIPOFMXLOVDGIW-TWOQFEAHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0039 0.0122 0.0121
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Trypanosoma brucei trypanothione reductase 0.004 0.014 1
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 1, putative 0.0039 0.0122 0.8726
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.2753 0.2753
Echinococcus multilocularis WD repeat containing protein 48 0.0722 1 1
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0359 0.0359
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase family 2, putative 0.0039 0.0122 0.8726
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0122
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0039 0.0122 0.019
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.0884 0.8342
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0359 0.0359
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0039 0.0122 0.0121
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0122 0.0121
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0122
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0039 0.0122 0.0121
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0122
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0148 0.0147
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0122
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0722 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0039 0.0122 0.5
Toxoplasma gondii hypothetical protein 0.0412 0.5512 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0222
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0039 0.0122 0.019
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0039 0.0122 0.5
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Plasmodium falciparum glutathione reductase 0.004 0.014 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0222
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0039 0.0122 0.019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0359 0.0341
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0039 0.0122 0.0121
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0222
Echinococcus multilocularis ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase 0.0039 0.0122 0.0105
Schistosoma mansoni hypothetical protein 0.0041 0.0155 0.025
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 36 0.0039 0.0122 0.0121
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0039 0.0122 0.019
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0102 0.1031 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 12 0.0039 0.0122 0.0121
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0222
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0039 0.0122 0.0105
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.1031 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Plasmodium falciparum thioredoxin reductase 0.004 0.014 1
Giardia lamblia DUB-1 0.0039 0.0122 0.5
Plasmodium vivax SET domain protein, putative 0.0032 0.0018 0.1269
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0039 0.0122 0.019
Schistosoma mansoni peptidase 0.0039 0.0122 0.019
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0039 0.0122 0.019
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 24 0.0039 0.0122 0.0105
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0122
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0039 0.0122 0.019
Trypanosoma cruzi Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 47 0.0039 0.0122 0.0121
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0359 0.062
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0122 0.5
Onchocerca volvulus 0.0039 0.0122 0.0329
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 0.0039 0.0122 0.0121
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0039 0.0122 0.019
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Brugia malayi hypothetical protein 0.0039 0.0122 0.0122
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0018 0.0032
Toxoplasma gondii hypothetical protein 0.0039 0.0122 0.0222
Echinococcus multilocularis Ubiquitin carboxyl terminal hydrolase 48 0.0039 0.0122 0.0105
Schistosoma mansoni hypothetical protein 0.0039 0.0122 0.019
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Echinococcus granulosus ubiquitin specific peptidase 30 (C19 family) 0.0039 0.0122 0.0121
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0039 0.0122 0.0105
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0122 0.5
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 2, putative 0.0039 0.0122 0.8726
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.0884 0.8342
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0039 0.0122 0.019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0359 0.0341
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0039 0.0122 0.019
Plasmodium falciparum ubiquitin specific protease, putative 0.0039 0.0122 0.8726
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0222
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0102 0.1031 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0039 0.0122 0.019
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0122 0.0121
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.043 0.043
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0039 0.0122 0.8726
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.014 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0122 0.019
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 16 0.0039 0.0122 0.0121
Onchocerca volvulus 0.0039 0.0122 0.0329
Plasmodium vivax glutathione reductase, putative 0.004 0.014 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0148 0.013
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Trypanosoma cruzi Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0039 0.0122 0.019
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0039 0.0122 0.0122
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0039 0.0122 0.019
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 12 0.0039 0.0122 0.0105
Giardia lamblia Hypothetical protein 0.0039 0.0122 0.5
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 14 0.0039 0.0122 0.0105
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.5
Entamoeba histolytica hypothetical protein 0.0039 0.0122 0.5
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0122
Schistosoma mansoni calpain-7 (C02 family) 0.0039 0.0122 0.019
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Brugia malayi Pre-SET motif family protein 0.0032 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 0.0039 0.0122 0.0105
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Onchocerca volvulus 0.0039 0.0122 0.0329
Schistosoma mansoni hypothetical protein 0.0412 0.5512 1
Loa Loa (eye worm) thioredoxin reductase 0.004 0.014 0.014
Brugia malayi glutathione reductase 0.004 0.014 0.014
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Loa Loa (eye worm) hypothetical protein 0.006 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0039 0.0122 0.0121
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0122 0.8726
Echinococcus granulosus WD repeat containing protein 48 0.0722 1 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0039 0.0122 0.0105
Toxoplasma gondii thioredoxin reductase 0.004 0.014 0.0254
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0039 0.0122 0.0105
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.0884 0.8342
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0032 0.0018 0.0018
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0039 0.0122 0.8726
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0039 0.0122 0.0122
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 2, putative 0.0039 0.0122 0.8726
Leishmania major ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0018 0.0017
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 47 0.0039 0.0122 0.0105
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 14 0.0039 0.0122 0.8726
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0359 0.0358
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Echinococcus granulosus Ubiquitin carboxyl terminal hydrolase 48 0.0039 0.0122 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0359 0.062
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0222
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0039 0.0122 0.019
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0039 0.0122 0.8726
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0039 0.0122 0.0105
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0102 0.1031 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0039 0.0122 0.0105
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 24 0.0039 0.0122 0.0121
Leishmania major trypanothione reductase 0.004 0.014 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0039 0.0122 0.0121
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0155
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Loa Loa (eye worm) glutathione reductase 0.004 0.014 0.014
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0122 0.0121
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0222
Plasmodium falciparum ubiquitin specific protease, putative 0.0039 0.0122 0.8726
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Echinococcus granulosus ubiquitin specific peptidase c family 0.0039 0.0122 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0359 0.062
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0039 0.0122 0.0222
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.0884 0.8342
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Schistosoma mansoni hypothetical protein 0.031 0.4048 0.7334
Echinococcus granulosus 5'partial|Ubiquitin carboxyl terminal hydrolase 48 0.0039 0.0122 0.0121
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0222
Echinococcus multilocularis expressed protein 0.0039 0.0122 0.0105
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0039 0.0122 0.5
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0222
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 20 0.0039 0.0122 0.0105
Trichomonas vaginalis set domain proteins, putative 0.0251 0.3194 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0222
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0039 0.0122 0.0121
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0122 0.0105
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase family 2 protein 0.0039 0.0122 0.0222
Toxoplasma gondii ubiquitin-specific protease USP4 0.0039 0.0122 0.0222
Plasmodium vivax thioredoxin reductase, putative 0.004 0.014 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 23 0.0039 0.0122 0.0121
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0122 0.0105
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.043 0.043
Trypanosoma brucei Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 16 0.0039 0.0122 0.0105
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Onchocerca volvulus 0.0251 0.3194 1
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0122
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0039 0.0122 0.0105
Brugia malayi Pre-SET motif family protein 0.0221 0.2753 0.2753
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Mycobacterium tuberculosis Probable reductase 0.0092 0.0884 0.8342
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0039 0.0122 0.0121
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Brugia malayi Thioredoxin reductase 0.004 0.014 0.014
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0122 0.0105
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.043 0.043
Brugia malayi ubiquitin specific protease 14 0.0039 0.0122 0.0122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0359 0.0358
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0039 0.0122 0.019
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0039 0.0122 0.0222
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 14 0.0039 0.0122 0.0121
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.0884 0.8342
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0122 0.019
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0039 0.0122 0.019
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0039 0.0122 0.8726
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0122 0.5
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0039 0.0122 0.0122
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0122 0.8726
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0039 0.0122 0.0105
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0039 0.0122 0.019
Trypanosoma brucei Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0122
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0039 0.0122 0.5
Plasmodium vivax ubiquitin specific protease, putative 0.0039 0.0122 0.8726
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0039 0.0122 0.019
Echinococcus multilocularis ubiquitin specific peptidase 42 (C19 family) 0.0039 0.0122 0.0105
Schistosoma mansoni hypothetical protein 0.031 0.4048 0.7334
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 36 0.0039 0.0122 0.0105
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0122 0.0122
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 20 0.0039 0.0122 0.0121
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0039 0.0122 0.8726
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0039 0.0122 0.019
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0122 0.8726
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0039 0.0122 0.0122
Schistosoma mansoni calpain-7 (C02 family) 0.0039 0.0122 0.019

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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