TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 351.346 | Formula: C21H15F2NO2
H donors: 2 H acceptors: 2 LogP: 5.04 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(c(c1)F)Nc1ccc2c(c1)CCc1c(C2=O)cc(cc1)O
InChi: 1S/C21H15F2NO2/c22-14-4-8-20(19(23)10-14)24-15-5-7-17-13(9-15)2-1-12-3-6-16(25)11-18(12)21(17)26/h3-11,24-25H,1-2H2
InChiKey: KKQGWXPVVNVWOA-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	lactate dehydrogenase protein	0.0094	0.1044	0.1044
Plasmodium vivax	RNA helicase-1, putative	0.0049	0.0388	0.3715
Trichomonas vaginalis	rotamase, putative	0.0033	0.015	0.0746
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1044	0.1509
Brugia malayi	RE18450p	0.0042	0.0275	0.1368
Plasmodium vivax	lactate dehydrogenase	0.0094	0.1044	1
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0049	0.0388	0.1929
Loa Loa (eye worm)	glycerol-3-phosphate dehydrogenase	0.0042	0.0275	0.0397
Brugia malayi	eukaryotic initiation factor 4A	0.0049	0.0388	0.1929
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0037	0.0205	0.1018
Trypanosoma cruzi	FAD dependent oxidoreductase, putative	0.0042	0.0275	0.1368
Trypanosoma cruzi	glycosomal malate dehydrogenase, putative	0.0037	0.0205	0.1018
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase, putative	0.0042	0.0275	0.1368
Trypanosoma cruzi	cytosolic malate dehydrogenase, putative	0.0037	0.0205	0.1018
Brugia malayi	intermediate filament protein	0.0028	0.0075	0.0372
Trypanosoma brucei	cytosolic malate dehydrogenase	0.0037	0.0205	0.1018
Mycobacterium leprae	Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase)	0.0042	0.0275	0.0105
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0038	0.0225	0.1117
Brugia malayi	lactate dehydrogenase.	0.0094	0.1044	0.5192
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0049	0.0388	0.1929
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.015	0.0746
Brugia malayi	P38 map kinase family protein 2	0.0152	0.1881	0.9359
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0161	0.201	1
Onchocerca volvulus	Putative fad oxidoreductase	0.0042	0.0275	0.7089
Echinococcus multilocularis	ubiquitin specific protease 41	0.0038	0.0225	0.0225
Trypanosoma cruzi	cytosolic malate dehydrogenase, putative	0.0037	0.0205	0.1018
Schistosoma mansoni	rotamase	0.0033	0.015	0.015
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.1881	0.1881
Echinococcus multilocularis	microtubule associated protein 2	0.0711	1	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0038	0.0225	0.0225
Onchocerca volvulus		0.0028	0.0075	0.1927
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.1881	0.1881
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.1881	0.1881
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0049	0.0388	0.0388
Toxoplasma gondii	peptidylprolyl isomerase	0.0032	0.0139	0.069
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0152	0.1881	0.272
Echinococcus granulosus	lamin	0.0028	0.0075	0.0075
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0049	0.0388	0.1929
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0049	0.0388	1
Mycobacterium ulcerans	hypothetical protein	0.0161	0.201	0.269
Mycobacterium leprae	Possible thiamine biosynthesis oxidoreductase ThiO	0.0042	0.0275	0.0105
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial	0.0042	0.0275	0.1368
Echinococcus granulosus	cytosolic malate dehydrogenase	0.0037	0.0205	0.0205
Plasmodium vivax	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0042	0.0275	0.2634
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0152	0.1881	0.9359
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0049	0.0388	0.1929
Echinococcus granulosus	L lactate dehydrogenase B chain	0.0094	0.1044	0.1044
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.015	0.0746
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0139	0.069
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0161	0.201	1
Trypanosoma brucei	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0042	0.0275	0.1368
Plasmodium falciparum	L-lactate dehydrogenase	0.0094	0.1044	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0038	0.0225	0.1117
Trypanosoma cruzi	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Brugia malayi	3-oxo-5-alpha-steroid 4-dehydrogenase 1	0.0161	0.201	1
Leishmania major	malate dehydrogenase, putative	0.0037	0.0205	0.0353
Trichomonas vaginalis	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Trypanosoma cruzi	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0161	0.201	1
Trichomonas vaginalis	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0042	0.0275	0.0105
Echinococcus granulosus	expressed protein	0.0033	0.015	0.015
Chlamydia trachomatis	D-amino acid dehydrogenase	0.0042	0.0275	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0275	0.0397
Echinococcus granulosus	glycerol 3 phosphate dehydrogenase	0.0042	0.0275	0.0275
Treponema pallidum	ATP-dependent RNA helicase	0.0049	0.0388	0.5
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0498	0.6915	1
Echinococcus multilocularis	lamin	0.0028	0.0075	0.0075
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase	0.0042	0.0275	0.0105
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0038	0.0225	0.1117
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0042	0.0275	0.1368
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0049	0.0388	0.0388
Echinococcus multilocularis	lamin dm0	0.0028	0.0075	0.0075
Trypanosoma brucei	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0042	0.0275	0.1368
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0049	0.0388	0.0388
Brugia malayi	cDNA sequence BC016226	0.0042	0.0275	0.1368
Onchocerca volvulus		0.0028	0.0075	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0075	0.0108
Echinococcus multilocularis	glycerol 3 phosphate dehydrogenase	0.0042	0.0275	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0388	0.0561
Echinococcus granulosus	lactate dehydrogenase a	0.0094	0.1044	0.1044
Schistosoma mansoni	ATP:guanidino kinase (Smc74)	0.0042	0.0275	0.0275
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0049	0.0388	0.03
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0037	0.0205	0.1018
Entamoeba histolytica	steroid 5-alpha reductase, putative	0.0161	0.201	1
Schistosoma mansoni	d-amino acid oxidase	0.0498	0.6915	0.6915
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0042	0.0275	0.1368
Toxoplasma gondii	lactate dehydrogenase LDH2	0.0094	0.1044	0.5192
Echinococcus granulosus	mitogen activated protein kinase 14	0.0152	0.1881	0.1881
Leishmania major	malate dehydrogenase	0.0037	0.0205	0.0353
Echinococcus granulosus	mitogen activated protein kinase 11	0.0152	0.1881	0.1881
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0037	0.0205	0.1018
Trichomonas vaginalis	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Leishmania major	hypothetical protein, conserved	0.0042	0.0275	0.0728
Mycobacterium tuberculosis	Possible thiamine biosynthesis oxidoreductase ThiO	0.0042	0.0275	0.0115
Schistosoma mansoni	malate dehydrogenase	0.0094	0.1044	0.1044
Trypanosoma brucei	mitochondrial malate dehydrogenase	0.0037	0.0205	0.1018
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0038	0.0225	0.0225
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0038	0.0225	0.0459
Leishmania major	malate dehydrogenase, putative	0.0094	0.1044	0.4836
Plasmodium vivax	lactate/malate dehydrogenase, putative	0.0037	0.0205	0.196
Echinococcus granulosus	FAD dependent oxidoreductase domain containing protein	0.0042	0.0275	0.0275
Schistosoma mansoni	lamin	0.0028	0.0075	0.0075
Trichomonas vaginalis	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Trypanosoma brucei	glycosomal malate dehydrogenase	0.0037	0.0205	0.1018
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0042	0.0275	0.1368
Plasmodium vivax	malate dehydrogenase, putative	0.0094	0.1044	1
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.1881	0.9359
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0049	0.0388	1
Schistosoma mansoni	lamin	0.0028	0.0075	0.0075
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0038	0.0225	0.5792
Schistosoma mansoni	NAD dehydrogenase	0.0042	0.0275	0.0275
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.1881	0.1881
Echinococcus granulosus	ubiquitin specific protease 41	0.0038	0.0225	0.0225
Trypanosoma cruzi	glycosomal malate dehydrogenase, putative	0.0037	0.0205	0.1018
Loa Loa (eye worm)	malate dehydrogenase	0.0037	0.0205	0.0296
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0049	0.0388	0.1929
Entamoeba histolytica	malate dehydrogenase,cytoplasmic, putative	0.0037	0.0205	0.1018
Trichomonas vaginalis	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 20	0.0042	0.0275	0.1368
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0275	0.0397
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0139	0.069
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.015	0.0217
Schistosoma mansoni	malate dehydrogenase	0.0037	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0161	0.201	0.2906
Toxoplasma gondii	malate dehydrogenase MDH	0.0094	0.1044	0.5192
Echinococcus multilocularis	lactate dehydrogenase protein	0.0094	0.1044	0.1044
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0457	0.6311	1
Echinococcus multilocularis	geminin	0.0175	0.2207	0.2207
Echinococcus multilocularis	lactate dehydrogenase a	0.0094	0.1044	0.1044
Entamoeba histolytica	anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative	0.0042	0.0275	0.1368
Trypanosoma cruzi	mitochondrial malate dehydrogenase, putative	0.0037	0.0205	0.1018
Entamoeba histolytica	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Schistosoma mansoni	fad oxidoreductase	0.0042	0.0275	0.0275
Trypanosoma brucei	FAD dependent oxidoreductase, putative	0.0042	0.0275	0.1368
Schistosoma mansoni	L-lactate dehydrogenase	0.0037	0.0205	0.0205
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0152	0.1881	0.9311
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0038	0.0225	0.1117
Trypanosoma brucei	malate dehydrogenase-related	0.0037	0.0205	0.1018
Schistosoma mansoni	microtubule-associated protein tau	0.0711	1	1
Schistosoma mansoni	hypothetical protein	0.0175	0.2207	0.2207
Trichomonas vaginalis	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0042	0.0275	0.1368
Loa Loa (eye worm)	hypothetical protein	0.0498	0.6915	1
Leishmania major	3-oxo-5-alpha-steroid 4-dehydrogenase-like protein	0.0161	0.201	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0139	0.069
Trypanosoma cruzi	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0038	0.0225	0.0225
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0049	0.0388	0.0388
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0139	0.069
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase GlpD2	0.0042	0.0275	0.0105
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0225	0.1117
Plasmodium falciparum	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0042	0.0275	0.2634
Trichomonas vaginalis	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Echinococcus multilocularis	L lactate dehydrogenase	0.0058	0.051	0.051
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0075	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0225	0.0325
Echinococcus granulosus	geminin	0.0175	0.2207	0.2207
Schistosoma mansoni	malate dehydrogenase	0.0037	0.0205	0.0205
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0049	0.0388	0.0388
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0049	0.0388	0.3715
Brugia malayi	pyruvate dehydrogenase phosphatase regulatory subunit precursor	0.0042	0.0275	0.1368
Echinococcus granulosus	lactate dehydrogenase a	0.0094	0.1044	0.1044
Toxoplasma gondii	lactate dehydrogenase LDH1	0.0094	0.1044	0.5192
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0049	0.0388	0.1929
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0161	0.201	1
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0042	0.0275	0.1368
Trichomonas vaginalis	3-oxo-5-alpha-steroid 4-dehydrogenase, putative	0.0161	0.201	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0038	0.0225	0.1117
Schistosoma mansoni	hypothetical protein	0.0175	0.2207	0.2207
Plasmodium falciparum	lactate dehydrogenase, putative	0.0037	0.0205	0.196
Echinococcus multilocularis	musashi	0.0028	0.0075	0.0075
Leishmania major	cytosolic malate dehydrogenase	0.0037	0.0205	0.0353
Echinococcus granulosus	malate dehydrogenase	0.0037	0.0205	0.0205
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0038	0.0225	0.0225
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0049	0.0388	0.1929
Leishmania major	glycerol-3-phosphate dehydrogenase-like protein	0.0042	0.0275	0.0728
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0042	0.0275	0.1368
Toxoplasma gondii	hypothetical protein	0.0042	0.0275	0.1368
Giardia lamblia	Malate dehydrogenase	0.0037	0.0205	0.5276
Plasmodium falciparum	malate dehydrogenase	0.0094	0.1044	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0067	0.0097
Echinococcus granulosus	cytosolic malate dehydrogenase	0.0037	0.0205	0.0205
Echinococcus multilocularis	L lactate dehydrogenase B chain	0.0094	0.1044	0.1044
Leishmania major	eukaryotic initiation factor 4a, putative	0.0049	0.0388	0.1331
Echinococcus multilocularis	FAD dependent oxidoreductase domain containing protein	0.0042	0.0275	0.0275
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0038	0.0225	0.1117
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0042	0.0275	0.7089
Toxoplasma gondii	FAD-dependent glycerol-3-phosphate dehydrogenase	0.0042	0.0275	0.1368
Echinococcus multilocularis	lactate dehydrogenase a	0.0094	0.1044	0.1044
Entamoeba histolytica	malate dehydrogenase, putative	0.0094	0.1044	0.5192
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.0498	0.6915	1
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0038	0.0225	0.0225
Echinococcus granulosus	malate dehydrogenase	0.0037	0.0205	0.0205
Loa Loa (eye worm)	malate dehydrogenase	0.0037	0.0205	0.0296
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0075	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0275	0.0397
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0038	0.0225	0.0225
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0049	0.0388	0.1929
Echinococcus granulosus	L lactate dehydrogenase	0.0058	0.051	0.051
Trichomonas vaginalis	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Echinococcus multilocularis	lactate dehydrogenase a	0.0094	0.1044	0.1044
Echinococcus multilocularis	cytosolic malate dehydrogenase	0.0037	0.0205	0.0205
Mycobacterium ulcerans	thiamine biosynthesis oxidoreductase ThiO	0.0042	0.0275	0.0105
Leishmania major	glycosomal malate dehydrogenase	0.0037	0.0205	0.0353
Trichomonas vaginalis	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Echinococcus granulosus	intermediate filament protein	0.0028	0.0075	0.0075
Wolbachia endosymbiont of Brugia malayi	malate dehydrogenase	0.0094	0.1044	0.5
Trichomonas vaginalis	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Brugia malayi	Probable malate dehydrogenase, mitochondrial precursor	0.0037	0.0205	0.1018
Echinococcus multilocularis	malate dehydrogenase	0.0037	0.0205	0.0205
Echinococcus multilocularis	expressed protein	0.0033	0.015	0.015
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0037	0.0205	0.1018
Brugia malayi	Malate dehydrogenase, cytoplasmic	0.0037	0.0205	0.1018
Schistosoma mansoni	glycerol-3-phosphate dehydrogenase	0.0042	0.0275	0.0275
Trichomonas vaginalis	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Echinococcus multilocularis	malate dehydrogenase	0.0037	0.0205	0.0205
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0049	0.0388	0.0388
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0038	0.0225	0.1117
Toxoplasma gondii	3-oxo-5-alpha-steroid 4-dehydrogenase	0.0161	0.201	1
Trichomonas vaginalis	rotamase, putative	0.0032	0.0139	0.069
Schistosoma mansoni	malate dehydrogenase	0.0037	0.0205	0.0205
Schistosoma mansoni	L-lactate dehydrogenase	0.0094	0.1044	0.1044
Leishmania major	eukaryotic initiation factor 4a, putative	0.0049	0.0388	0.1331
Echinococcus multilocularis	cytosolic malate dehydrogenase	0.0037	0.0205	0.0205
Brugia malayi	dimethylglycine dehydrogenase, mitochondrial precursor, putative	0.0042	0.0275	0.1368
Trypanosoma brucei	3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative	0.0161	0.201	1
Onchocerca volvulus	Dimethylglycine dehydrogenase, mitochondrial homolog	0.0042	0.0275	0.7089
Leishmania major	mitochondrial malate dehydrogenase	0.0037	0.0205	0.0353
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0075	0.0075
Echinococcus granulosus	lamin dm0	0.0028	0.0075	0.0075
Schistosoma mansoni	fad oxidoreductase	0.0042	0.0275	0.0275
Leishmania major	hypothetical protein, conserved	0.0042	0.0275	0.0728
Trichomonas vaginalis	malate dehydrogenase, putative	0.0037	0.0205	0.1018
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0075	0.0108
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.1881	0.9359
Onchocerca volvulus	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog	0.0042	0.0275	0.7089

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.02 uM	Inhibition of p38alpha by immunosorbent based kinase assay	ChEMBL.	22676210
IC50 (binding)	= 0.049 uM	Competitive inhibition of p38alpha MAP kinase (unknown origin) in presence of 100 uM ATP	ChEMBL.	24131218
IC50 (binding)	= 0.7 uM	Inhibition of p38alpha-dependent TNFalpha production in human whole blood	ChEMBL.	22676210
IC50 (binding)	= 1.247 uM	Inhibition of p38alpha MAP kinase in human whole blood assessed as inhibition of LPS-induced TNFalpha release by ELISA	ChEMBL.	24131218

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2152793

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1721635