Detailed information for compound 1723300

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 372.387 | Formula: C20H19F3N4
  • H donors: 0 H acceptors: 2 LogP: 5.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(c1c(ccn2c1nnc2CC1CC1)N1CCc2c(C1)cccc2)(F)F
  • InChi: 1S/C20H19F3N4/c21-20(22,23)18-16(26-9-7-14-3-1-2-4-15(14)12-26)8-10-27-17(11-13-5-6-13)24-25-19(18)27/h1-4,8,10,13H,5-7,9,11-12H2
  • InChiKey: NHWGHJUHFDUWQN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutamate receptor, metabotropic 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0102 0.0114
Loa Loa (eye worm) hypothetical protein 0.012 0.1243 0.1399
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0261 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0102 0.2935
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0237 0.0237
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0394 0.0394
Loa Loa (eye worm) hypothetical protein 0.012 0.1243 0.1399
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0017 0.0017
Loa Loa (eye worm) BRM protein 0.0034 0.0272 0.0307
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0033 0.0261 1
Onchocerca volvulus 0.0231 0.2497 0.4313
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.5789 0.6509
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.5789 0.6509
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0261 0.0268
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0102 0.2935
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0102 0.2935
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0455 0.4744
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0261 0.0268
Onchocerca volvulus Huntingtin homolog 0.012 0.1243 0.2147
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0102 0.0114
Schistosoma mansoni hypothetical protein 0.0031 0.0237 0.0395
Trypanosoma brucei unspecified product 0.0019 0.0102 0.2935
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0102 0.2935
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0261 0.0268
Trichomonas vaginalis glucosylceramidase, putative 0.0795 0.8882 1
Brugia malayi Alpha-L-fucosidase family protein 0.0541 0.6002 0.6758
Echinococcus granulosus dna polymerase eta 0.0019 0.0102 0.0102
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0017 0.0017
Echinococcus multilocularis lysosomal alpha glucosidase 0.0343 0.3771 0.3771
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.5789 0.6509
Trypanosoma brucei glucosidase, putative 0.0033 0.0261 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0261 0.0268
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0261 0.0268
Toxoplasma gondii hypothetical protein 0.0026 0.0186 0.2433
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0753 0.1254
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.056 0.0463
Onchocerca volvulus Glucosylceramidase homolog 0.0522 0.5789 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0033 0.0261 0.0294
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0261 0.0268
Brugia malayi BRM protein 0.0066 0.0631 0.071
Trichomonas vaginalis glucosylceramidase, putative 0.055 0.6107 0.6867
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0343 0.3771 0.4245
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.056 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0102 0.2935
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0102 0.0169
Loa Loa (eye worm) hypothetical protein 0.0075 0.0739 0.0832
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0102 0.2935
Loa Loa (eye worm) alpha-L-fucosidase 0.0541 0.6002 0.6758
Loa Loa (eye worm) hypothetical protein 0.0031 0.0237 0.0267
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.056 0.0463
Echinococcus multilocularis lysosomal alpha glucosidase 0.0343 0.3771 0.3771
Brugia malayi Glycosyl hydrolases family 31 protein 0.0033 0.0261 0.0294
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0051 0.0467 0.0467
Loa Loa (eye worm) hypothetical protein 0.0067 0.0642 0.0723
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0102 0.2935
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0455 0.7716
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0237 0.0267
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.5789 0.6509
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0795 0.8882 1
Brugia malayi MH2 domain containing protein 0.0117 0.1208 0.136
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0261 0.0268
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0055 0.0515 0.0579
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0017 0.0017
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0753 0.0753
Trichomonas vaginalis glucosylceramidase, putative 0.0795 0.8882 1
Schistosoma mansoni metabotropic glutamate receptor 0.003 0.0225 0.0375
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0033 0.0261 0.3433
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.056 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0186 0.2433
Echinococcus granulosus Chromo domain 0.0011 0.0017 0.0017
Echinococcus multilocularis dna polymerase eta 0.0019 0.0102 0.0102
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0753 0.5
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0075 0.0739 0.0739
Schistosoma mansoni hypothetical protein 0.0031 0.0237 0.0395
Loa Loa (eye worm) hypothetical protein 0.0019 0.0102 0.0114
Trypanosoma brucei glycosyl hydrolase-like protein 0.0033 0.0261 1
Schistosoma mansoni alpha-glucosidase 0.0343 0.3771 0.6282
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0069 0.0674 0.1123
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0753 0.0658
Schistosoma mansoni DNA polymerase eta 0.0019 0.0102 0.0169
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0261 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0237 0.0237
Echinococcus multilocularis global transcription activator snf2l2 0.0066 0.0631 0.0631
Schistosoma mansoni metabotropic glutamate receptor 0.0051 0.0467 0.0779
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0753 0.5
Echinococcus granulosus GPCR family 2 0.0031 0.0237 0.0237
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0102 0.2935
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0753 1
Echinococcus multilocularis Chromo domain 0.0011 0.0017 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.056 0.0463
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0261 0.0268
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.5789 0.6509
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0394 0.0656
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0102 0.2935
Brugia malayi Metabotropic glutamate receptor precursor. 0.0061 0.058 0.0653
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0102 0.0088
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0016 0.0065 0.0074
Giardia lamblia DINP protein human, muc B family 0.0019 0.0102 0.5
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.8854 0.8854
Brugia malayi hypothetical protein 0.012 0.1243 0.1399
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1208 0.136
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0012 0.0024 0.0262
Schistosoma mansoni hypothetical protein 0.0031 0.0237 0.0395
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0753 0.0658
Echinococcus granulosus muscleblind protein 0.0146 0.154 0.154
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.056 0.056
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0753 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.056 0.056
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0076 0.0753 0.0848
Echinococcus granulosus lysosomal alpha glucosidase 0.0343 0.3771 0.3771
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0102 0.2935
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0102 0.0088
Schistosoma mansoni alpha-l-fucosidase 0.0541 0.6002 1
Trichomonas vaginalis glucosylceramidase, putative 0.0795 0.8882 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0051 0.0467 0.0467
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.056 0.0932
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0102 0.2935
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0102 0.2935
Loa Loa (eye worm) glutamate receptor 0.0061 0.058 0.0653
Schistosoma mansoni alpha glucosidase 0.0033 0.0261 0.0435
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0394 0.0444
Trichomonas vaginalis sucrase-isomaltase, putative 0.0033 0.0261 0.0268
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0033 0.0261 0.0294
Leishmania major glycosyl hydrolase-like protein 0.0033 0.0261 0.3481
Echinococcus granulosus dna polymerase kappa 0.0019 0.0102 0.0102
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0016 0.0065 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.5789 0.6509
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1208 0.136
Echinococcus multilocularis muscleblind protein 0.0146 0.154 0.154
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0102 0.0114
Schistosoma mansoni helicase 0.0066 0.0631 0.1051
Trichomonas vaginalis maltase-glucoamylase, putative 0.0033 0.0261 0.0268
Brugia malayi follicle stimulating hormone receptor 0.0226 0.2449 0.2757
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0186 0.2433
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0237 0.0267
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0102 0.0102
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0017 0.0017
Onchocerca volvulus Huntingtin homolog 0.012 0.1243 0.2147
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.2449 0.2757
Trichomonas vaginalis glucosylceramidase, putative 0.0795 0.8882 1
Schistosoma mansoni alpha-glucosidase 0.0343 0.3771 0.6282
Trichomonas vaginalis glucosylceramidase, putative 0.055 0.6107 0.6867
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0102 0.2935
Echinococcus granulosus metabotropic glutamate receptor 5 0.0075 0.0739 0.0739
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0795 0.8882 1
Brugia malayi Receptor family ligand binding region containing protein 0.0016 0.0065 0.0074
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.056 0.0932
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0033 0.0261 0.0451
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0991 0.1115
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.056 0.7419
Schistosoma mansoni hypothetical protein 0.0031 0.0237 0.0395
Brugia malayi Glycosyl hydrolases family 31 protein 0.0343 0.3771 0.4245
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0753 0.0753
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.0028
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0261 0.0268
Brugia malayi metabotropic glutamate receptor type 2 0.003 0.0225 0.0254
Leishmania major alpha glucosidase II subunit, putative 0.0033 0.0261 0.3481
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0033 0.0261 0.0268
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0102 0.0102
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0991 0.1115
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0455 0.7716
Loa Loa (eye worm) hypothetical protein 0.0146 0.154 0.1734
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0237 0.0237
Brugia malayi Muscleblind-like protein 0.0146 0.154 0.1734
Echinococcus multilocularis neutral alpha glucosidase AB 0.0033 0.0261 0.0261
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0753 1
Loa Loa (eye worm) BRM protein 0.0042 0.0363 0.0408
Loa Loa (eye worm) hypothetical protein 0.0033 0.0261 0.0294
Echinococcus multilocularis muscleblind protein 1 0.0146 0.154 0.154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0394 0.0656
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0394 0.0394
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0237 0.0237
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0753 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0102 0.0102
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0102 0.0169
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0017 0.0019
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0011 0.0017 0.0017
Brugia malayi Probable ClpP-like protease 0.0076 0.0753 0.0848
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0394 0.0656
Loa Loa (eye worm) helicase DNA-binding protein 0.0011 0.0017 0.0019
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0991 0.1115
Loa Loa (eye worm) glutamate receptor 0.0024 0.016 0.018
Trichomonas vaginalis glucosylceramidase, putative 0.0522 0.5789 0.6509
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0237 0.257 0.2875
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0394 0.0394
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0455 0.0455
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0261 0.0268
Echinococcus granulosus BRK domain containing protein 0.0011 0.0017 0.0017
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0017 0.0017
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0237 0.0267
Trichomonas vaginalis maltase-glucoamylase, putative 0.0033 0.0261 0.0268
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0261 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0261 0.0268
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0394 0.0444
Trichomonas vaginalis glucosylceramidase, putative 0.0795 0.8882 1
Echinococcus multilocularis BRK domain 0.0011 0.0017 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0261 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0102 0.2935
Loa Loa (eye worm) hypothetical protein 0.0097 0.0991 0.1115
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0753 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0394 0.0394
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0237 0.257 0.2875
Echinococcus granulosus global transcription activator snf2l2 0.0066 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.0146 0.154 0.1734
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0795 0.8882 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0261 0.0268
Schistosoma mansoni hypothetical protein 0.0067 0.0642 0.1069
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0642 0.0723
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0033 0.0261 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0033 0.0261 0.0268
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0753 0.5
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0033 0.0261 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0753 1
Echinococcus multilocularis BRK domain containing protein 0.0011 0.0017 0.0017
Echinococcus granulosus neutral alpha glucosidase AB 0.0033 0.0261 0.0261
Echinococcus multilocularis GPCR, family 2 0.0031 0.0237 0.0237

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 149 nM Positive allosteric modulator activity at human mGlu2R expressed in CHO cells incubated for 30 mins by [35S]GTPgammaS binding assay ChEMBL. 23072213
Emax (functional) = 278 % Positive allosteric modulator activity at human mGlu2R expressed in CHO cells incubated for 30 mins by [35S]GTPgammaS binding assay relative to control ChEMBL. 23072213

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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