Detailed information for compound 1725064

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 458.552 | Formula: C27H30N4O3
  • H donors: 1 H acceptors: 5 LogP: 5.94 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCOc1ccc(cc1)c1cc(C(=O)O)c2c(n1)n(nc2)Cc1ccncc1
  • InChi: 1S/C27H30N4O3/c1-2-3-4-5-6-7-16-34-22-10-8-21(9-11-22)25-17-23(27(32)33)24-18-29-31(26(24)30-25)19-20-12-14-28-15-13-20/h8-15,17-18H,2-7,16,19H2,1H3,(H,32,33)
  • InChiKey: ZDZHQHXKLNDKIW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0073 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0142
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0327 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0073 0.0142
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0327 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0194 0.038
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0205 0.0775
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0374 0.0732
Echinococcus multilocularis microtubule associated protein 2 0.073 0.8032 0.8032
Loa Loa (eye worm) transcription factor SMAD2 0.0469 0.5108 1
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0009 0.0011
Brugia malayi MH1 domain containing protein 0.0018 0.0033 0.0066
Trichomonas vaginalis esterase, putative 0.0037 0.0251 0.0852
Echinococcus granulosus GPCR family 2 0.0031 0.0182 0.0182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0073 0.0073
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0205 0.7703
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0142
Loa Loa (eye worm) hypothetical protein 0.0033 0.0205 0.04
Brugia malayi jmjC domain containing protein 0.0015 0.0009 0.0017
Schistosoma mansoni hypothetical protein 0.0031 0.0182 0.0226
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.024 0.2535 0.3156
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0165 0.0561
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0251 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0251 0.0203
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.024 0.2535 0.8607
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0073 0.0073
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0205 0.6247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0335 0.0417
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0335 0.0335
Toxoplasma gondii preprocathepsin c precursor, putative 0.024 0.2535 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0227 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0255 0.0867
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0142
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0487 0.0953
Entamoeba histolytica hypothetical protein 0.0035 0.0228 0.5765
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0251 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0251 0.0203
Leishmania major pyruvate kinase 0.0033 0.0205 0.6247
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.0066
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0073 0.009
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0327 0.0327
Brugia malayi jmjC domain containing protein 0.0015 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.0251 0.0491
Brugia malayi jmjC domain containing protein 0.0015 0.0009 0.0017
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0182 0.0182
Brugia malayi MH2 domain containing protein 0.0032 0.0194 0.038
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0049 0.1497
Schistosoma mansoni hypothetical protein 0.0031 0.0182 0.0226
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0251 0.0203
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0142
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0073 0.0073
Brugia malayi Cytochrome P450 family protein 0.0048 0.0374 0.0732
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0073 0.0142
Schistosoma mansoni hypothetical protein 0.0067 0.0584 0.0727
Schistosoma mansoni hypothetical protein 0.0031 0.0182 0.0226
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0073 0.0073
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0009 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0073 0.0142
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0098 0.0931 0.1822
Echinococcus granulosus microtubule associated protein 2 0.073 0.8032 0.8032
Schistosoma mansoni Smad4 0.0032 0.0194 0.0242
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0073 0.0073
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0073 0.0142
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0327 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0251 0.0491
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0227 0.0282
Onchocerca volvulus 0.0037 0.0251 0.0621
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0251 0.0312
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0251 0.0491
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0182 0.0355
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0327 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0931 0.1822
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.2568 0.5028
Echinococcus granulosus pyruvate kinase 0.0017 0.0025 0.0025
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0025 0.0063
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0487 0.0487
Brugia malayi Smad1 0.0032 0.0194 0.038
Loa Loa (eye worm) beta-lactamase 0.0037 0.0251 0.0491
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0327 1
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0025 0.0063
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0327 0.0327
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0201 0.0762
Echinococcus granulosus pyruvate kinase 0.0033 0.0205 0.0205
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0251 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0227 0.0769
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0487 0.0487
Echinococcus multilocularis pyruvate kinase 0.0033 0.0205 0.0205
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0182 0.0182
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.8696 0.8696
Echinococcus granulosus smad 0.0032 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0487 0.0606
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0251 0.0852
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0225 0.2366 0.2366
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0227 0.0227
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0073 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0073 0.0142
Brugia malayi beta-lactamase family protein 0.0037 0.0251 0.0491
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0073 0.009
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0194 0.0194
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0049 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.01 0.0341
Plasmodium vivax SET domain protein, putative 0.0035 0.0227 0.0864
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0227 0.0769
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0182 0.0355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0073 0.0142
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0009 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0182 0.0182
Entamoeba histolytica hypothetical protein 0.0035 0.0228 0.5765
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0194 0.0194
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0073 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0251 0.7664
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0073 0.0073
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0194 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0101 0.0342
Brugia malayi Cytochrome P450 family protein 0.0019 0.0049 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0073 0.0142
Brugia malayi nuclear hormone receptor 0.0021 0.0073 0.0142
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0487 0.0606
Trichomonas vaginalis set domain proteins, putative 0.0277 0.2946 1
Schistosoma mansoni hypothetical protein 0.0031 0.0182 0.0226
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0009 0.0264
Mycobacterium tuberculosis Conserved protein 0.0037 0.0251 0.0203
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0073 0.0073
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 0.1486 0.1486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0227 0.0769
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0049 0.0096
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0009 0.0009
Schistosoma mansoni pyruvate kinase 0.0033 0.0205 0.0255
Leishmania major pyruvate kinase 0.0033 0.0205 0.6247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0101 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0126 0.0429
Brugia malayi beta-lactamase 0.0037 0.0251 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.0683
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0101 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0327 0.1111
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0487 0.0487
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0327 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0227 0.0227
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0205 0.0694
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.2493 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0327 0.0641
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0073 0.0142
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0205 0.04
Schistosoma mansoni smad1 5 8 and 0.0032 0.0194 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0129 0.0438
Brugia malayi MH1 domain containing protein 0.0032 0.0194 0.038
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0093 0.0181
Schistosoma mansoni pyruvate kinase 0.0017 0.0025 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0073 0.0142
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0251 0.0203
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0037 0.0251 0.0491
Onchocerca volvulus 0.0277 0.2946 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.024 0.2535 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0251 0.0491
Schistosoma mansoni smad1 5 8 and 0.0032 0.0194 0.0242
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0251 0.0251
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0205 0.04
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0205 0.0459
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0251 0.7664
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0073 0.0073
Brugia malayi MH2 domain containing protein 0.0032 0.0194 0.038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0126 0.0429
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0487 0.0487
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0142
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0205 0.04
Brugia malayi MH1 domain containing protein 0.0018 0.0033 0.0066
Chlamydia trachomatis pyruvate kinase 0.0033 0.0205 0.5
Brugia malayi beta-lactamase family protein 0.0037 0.0251 0.0491
Echinococcus granulosus pyruvate kinase 0.0033 0.0205 0.0205
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0025 0.0063
Toxoplasma gondii cathepsin CPC1 0.024 0.2535 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0251 0.7664
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0584 0.1143
Entamoeba histolytica hypothetical protein 0.0035 0.0228 0.5765
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0073 0.0142
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0009 0.0264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0335 0.0417
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.024 0.2535 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0931 0.1822
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0073 0.0073
Onchocerca volvulus 0.0037 0.0251 0.0621
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0017
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0251 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0327 0.1111
Loa Loa (eye worm) hypothetical protein 0.0067 0.0584 0.1143
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0251 0.0852
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0327 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0073 0.009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0182 0.0355
Toxoplasma gondii ABC1 family protein 0.0037 0.0251 0.0959
Mycobacterium ulcerans lipase LipD 0.0037 0.0251 1
Echinococcus granulosus ecdysone induced protein 78C 0.0235 0.2478 0.2478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0227 0.0769
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0068 0.207
Loa Loa (eye worm) hypothetical protein 0.0037 0.0251 0.0491
Brugia malayi jmjC domain containing protein 0.0058 0.0487 0.0953
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0251 0.0251
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0073 0.009
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0073 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0129 0.0438
Mycobacterium leprae Probable lipase LipE 0.0037 0.0251 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0009 0.0017
Echinococcus multilocularis Smad4 0.0032 0.0194 0.0194
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0039 0.1204
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0251 0.0203
Loa Loa (eye worm) nuclear factor I 0.0018 0.0033 0.0066
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0073 0.0142
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0073 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0335 0.0417
Loa Loa (eye worm) hypothetical protein 0.0023 0.0093 0.0181
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0227 0.6934
Mycobacterium tuberculosis Conserved protein 0.0037 0.0251 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.0683
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0205 0.0775
Echinococcus multilocularis pyruvate kinase 0.0033 0.0205 0.0205
Schistosoma mansoni coup transcription factor 0.0021 0.0073 0.009
Schistosoma mansoni pyruvate kinase 0.0033 0.0205 0.0255
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0073 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0129 0.0438
Echinococcus multilocularis pyruvate kinase 0.0026 0.0127 0.0127
Leishmania major cytochrome p450-like protein 0.0019 0.0049 0.1497
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0251 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0073 0.0073
Entamoeba histolytica hypothetical protein 0.0035 0.0228 0.5765
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0049 0.0096
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0073 0.0142
Brugia malayi jmjC domain containing protein 0.0015 0.0009 0.0017
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0251 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.0683
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0251 0.0852
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0073 0.0142
Giardia lamblia Pyruvate kinase 0.0033 0.0205 0.0717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0101 0.0342
Echinococcus granulosus pyruvate kinase 0.0017 0.0025 0.0025
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0194 0.038
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0205 0.0694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0155 0.0525
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0205 0.0459
Plasmodium falciparum pyruvate kinase 0.0033 0.0205 0.0775
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.1248 0.1248
Echinococcus granulosus phd:f box containing protein 0.0015 0.0009 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0251 0.0959
Brugia malayi MH2 domain containing protein 0.0469 0.5108 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0251 0.0852
Brugia malayi steroid hormone receptor 0.0021 0.0073 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0073 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.0683
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.0683
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.01 0.0341
Echinococcus multilocularis pyruvate kinase 0.0017 0.0025 0.0025
Brugia malayi MH1 domain containing protein 0.0032 0.0194 0.038
Onchocerca volvulus 0.0035 0.0227 0.0537
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0073 0.009
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.024 0.2535 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0049 0.0096
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.0683
Mycobacterium ulcerans beta-lactamase 0.0037 0.0251 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0327 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0228 0.0228
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0335 0.0655
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0228 0.0228
Echinococcus multilocularis pyruvate kinase 0.0017 0.0025 0.0025
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0205 0.04
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0049 0.1497
Echinococcus multilocularis smad 0.0032 0.0194 0.0194
Onchocerca volvulus 0.0037 0.0251 0.0621
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0009 0.0009
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.1248 0.1248
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0227 0.0282
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0073 0.009
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0205 0.0459
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0205 0.6247
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0227 0.0282
Brugia malayi Pre-SET motif family protein 0.0243 0.2568 0.5028
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0227 0.6934
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0009 0.0009
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0009 0.0017
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0182 0.0355
Schistosoma mansoni microtubule-associated protein tau 0.073 0.8032 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0009 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0073 0.009
Loa Loa (eye worm) MH2 domain-containing protein 0.0469 0.5108 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0182 0.0182
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0931 0.1822
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0227 0.6934
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0073 0.0142
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0335 0.0655
Leishmania major hypothetical protein, conserved 0.0037 0.0251 0.7664
Echinococcus multilocularis pyruvate kinase 0.0017 0.0025 0.0025
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0009 0.0011
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0073 0.0073
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.024 0.2535 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0251 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0073 0.0142
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0335 0.0335
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0009 0.0011
Schistosoma mansoni smad 0.0032 0.0194 0.0242
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0227 0.0864
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0205 0.04
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0225 0.2366 0.2366
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0327 1
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0251 0.0203
Echinococcus multilocularis ecdysone induced protein 78C 0.0235 0.2478 0.2478
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0251 0.0852
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0142
Echinococcus granulosus Smad4 0.0032 0.0194 0.0194
Leishmania major hypothetical protein, conserved 0.0015 0.0009 0.0264
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0073 0.0142
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0212 0.0212
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0205 0.6247
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0073 0.0142
Loa Loa (eye worm) hypothetical protein 0.0015 0.0009 0.0017
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0009 0.0264
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0073 0.009
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0009 0.0011
Brugia malayi jmjC domain containing protein 0.0058 0.0487 0.0953
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0073 0.0142
Loa Loa (eye worm) hypothetical protein 0.0037 0.0251 0.0491
Giardia lamblia Dipeptidyl-peptidase I precursor 0.024 0.2535 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0201 0.0683
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0021 0.0073 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0073 0.0142
Schistosoma mansoni thyroid hormone receptor 0.0147 0.1486 0.185
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0073 0.0142
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0327 0.0641
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0073 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.01 0.0341
Schistosoma mansoni thyroid hormone receptor 0.0147 0.1486 0.185
Schistosoma mansoni hypothetical protein 0.0035 0.0228 0.0284
Brugia malayi Pre-SET motif family protein 0.0035 0.0227 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0327 0.1111
Brugia malayi ecdysteroid receptor 0.0021 0.0073 0.0142
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0228 0.0284
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0335 0.0335
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0335 0.0335
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0073 0.0073
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0487 0.0606
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0049 0.1497
Schistosoma mansoni hypothetical protein 0.0126 0.1248 0.1554
Brugia malayi hypothetical protein 0.0035 0.0228 0.0446
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0227 0.0282
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0073 0.0073
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0182 0.0182
Loa Loa (eye worm) Smad1 0.0032 0.0194 0.038
Schistosoma mansoni smad1 5 8 and 0.0032 0.0194 0.0242
Echinococcus granulosus pyruvate kinase 0.0017 0.0025 0.0025
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0009 0.0009
Giardia lamblia GTOR 0.0044 0.0327 0.1206
Brugia malayi nuclear receptor NHR-88 0.0021 0.0073 0.0142
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0194 0.0242
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0205 0.6247
Loa Loa (eye worm) hypothetical protein 0.0035 0.0227 0.0444
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0251 0.0312

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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