Detailed information for compound 1726149

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.356 | Formula: C19H18N2O6
  • H donors: 2 H acceptors: 5 LogP: 0.97 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H]1OC(=O)N2[C@H]1COc1c2ccc(c1)c1ccc(nc1)C(=O)[C@H](O)C
  • InChi: 1S/C19H18N2O6/c1-10(23)18(24)13-4-2-12(7-20-13)11-3-5-14-16(6-11)26-9-15-17(8-22)27-19(25)21(14)15/h2-7,10,15,17,22-23H,8-9H2,1H3/t10-,15+,17+/m1/s1
  • InChiKey: DOCZCUVTYQVYMT-PHEKWQANSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus peroxidasin 0.011 0.1609 0.2716
Echinococcus multilocularis nmda type glutamate receptor 0.002 0.0186 0.0186
Echinococcus granulosus neuropeptide receptor A26 0.0371 0.573 0.9675
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0113 0.0316
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0015 0.0103 0.0034
Onchocerca volvulus Peroxidasin homolog 0.011 0.1609 0.4328
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0113 0.0316
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0049 0.0641 0.1083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0015 0.0113 0.0316
Leishmania major DNA polymerase kappa, putative 0.0015 0.0103 0.0034
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.1631 0.2753
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0015 0.0113 0.0316
Schistosoma mansoni transcription factor LCR-F1 0.0049 0.0641 0.1732
Onchocerca volvulus Peroxidasin homolog 0.011 0.1609 0.4328
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0103 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0103 0.0201
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0103 0.0278
Onchocerca volvulus 0.0234 0.3569 1
Schistosoma mansoni coup transcription factor 0.0015 0.0113 0.0305
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0113 0.0191
Loa Loa (eye worm) hypothetical protein 0.0015 0.0113 0.0316
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0234 0.3569 0.3569
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0079 0.1122 0.3031
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0014 0.0091 0.0255
Echinococcus multilocularis neuropeptide receptor A26 0.0371 0.573 0.573
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0014 0.0091 0.0153
Brugia malayi Animal haem peroxidase family protein 0.011 0.1609 0.4507
Echinococcus granulosus geminin 0.0243 0.3702 0.6251
Loa Loa (eye worm) hypothetical protein 0.0015 0.0113 0.0316
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.002 0.0186 0.0186
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0084 0.1201 0.3366
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0014 0.0098 0.5
Echinococcus multilocularis Niemann Pick C1 protein 0.0078 0.1103 0.1103
Echinococcus multilocularis glutamate receptor 2 0.0008 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0103 0.0201
Schistosoma mansoni glutamate receptor NMDA 0.0008 0.0006 0.0016
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0008 0.0006 0.001
Echinococcus multilocularis ecdysone induced protein 78C 0.0015 0.0113 0.0113
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0064 0.0876 0.1479
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Onchocerca volvulus Peroxidase homolog 0.011 0.1609 0.4328
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0008 0.0006 0.001
Loa Loa (eye worm) acetyltransferase 0.0103 0.1497 0.4195
Trichomonas vaginalis lipase containing protein, putative 0.0234 0.3569 1
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0113 0.0305
Plasmodium falciparum histone acetyltransferase GCN5 0.0028 0.0311 1
Schistosoma mansoni hypothetical protein 0.0027 0.0294 0.0793
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0113 0.0305
Onchocerca volvulus 0.0038 0.0476 0.105
Leishmania major DNA polymerase eta, putative 0.0015 0.0103 0.0034
Entamoeba histolytica acetyltransferase, GNAT family 0.0028 0.0311 0.2177
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0113 0.0316
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0064 0.0876 0.0876
Loa Loa (eye worm) latrophilin receptor protein 2 0.0027 0.0294 0.0823
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0103 0.0201
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0078 0.1103 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0103 0.1497 0.1497
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.1631 0.1631
Schistosoma mansoni ap endonuclease 0.0014 0.0091 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0113 0.0316
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.003 0.0351 1
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Trypanosoma brucei lipase domain protein, putative 0.0234 0.3569 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0113 0.0316
Echinococcus multilocularis sterol regulatory element binding protein 0.0033 0.0401 0.0401
Trichomonas vaginalis lipase containing protein, putative 0.0234 0.3569 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0008 0.0006 0.0006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0876 0.2366
Echinococcus granulosus histone acetyltransferase KAT2B 0.003 0.0351 0.0593
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0113 0.0305
Schistosoma mansoni hypothetical protein 0.0027 0.0294 0.0793
Trypanosoma brucei lipase domain protein, putative 0.0234 0.3569 1
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Leishmania major hypothetical protein, conserved 0.0234 0.3569 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0113 0.0316
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Brugia malayi Latrophilin receptor protein 2 0.0027 0.0294 0.0823
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0103 0.0034
Brugia malayi acetyltransferase, GNAT family protein 0.0103 0.1497 0.4195
Echinococcus multilocularis survival motor neuron protein 1 0.0187 0.2827 0.2827
Onchocerca volvulus Dual oxidase homolog 0.011 0.1609 0.4328
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0064 0.0876 0.2455
Loa Loa (eye worm) hypothetical protein 0.0015 0.0103 0.0288
Echinococcus granulosus expressed conserved protein 0.0073 0.1028 0.1736
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0103 0.0278
Schistosoma mansoni hypothetical protein 0.0027 0.0294 0.0793
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0027 0.0294 0.0496
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0113 0.0316
Brugia malayi Lipase family protein 0.0234 0.3569 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0027 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0113 0.0316
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0113 0.0305
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0049 0.0641 0.0641
Echinococcus multilocularis protein dispatched 1 0.0038 0.0476 0.0476
Brugia malayi hypothetical protein 0.0049 0.0641 0.1796
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0015 0.0113 0.0191
Loa Loa (eye worm) hypothetical protein 0.0187 0.2827 0.7919
Echinococcus granulosus FTZ F1 alpha 0.0015 0.0113 0.0191
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0015 0.0113 0.0113
Echinococcus multilocularis neuropeptide s receptor 0.0371 0.573 0.573
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0103 0.0034
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0113 0.0316
Echinococcus multilocularis expressed conserved protein 0.0073 0.1028 0.1028
Brugia malayi MH2 domain containing protein 0.0081 0.1153 0.323
Brugia malayi exodeoxyribonuclease III family protein 0.0014 0.0091 0.0255
Loa Loa (eye worm) hypothetical protein 0.0015 0.0113 0.0316
Schistosoma mansoni DNA polymerase eta 0.0015 0.0103 0.0278
Echinococcus granulosus dna polymerase eta 0.0015 0.0103 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0113 0.0316
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0015 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0015 0.0113 0.0316
Echinococcus multilocularis FTZ F1 alpha 0.0015 0.0113 0.0113
Echinococcus multilocularis thyroid hormone receptor alpha 0.0015 0.0113 0.0113
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0014 0.0098 0.6178
Echinococcus granulosus ecdysone induced protein 78C 0.0015 0.0113 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0015 0.0113 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0401 0.0892
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0103 0.0034
Echinococcus granulosus histone acetyltransferase KAT2B 0.01 0.1452 0.2451
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0103 0.0288
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0015 0.0113 0.0191
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0103 0.1497 0.4044
Echinococcus multilocularis peroxidasin 0.011 0.1609 0.1609
Loa Loa (eye worm) animal heme peroxidase 0.011 0.1609 0.4507
Onchocerca volvulus 0.011 0.1609 0.4328
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0084 0.1201 0.3366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0015 0.0113 0.0316
Schistosoma mansoni hypothetical protein 0.0243 0.3702 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0103 0.0118
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.003 0.0351 0.0748
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0027 0.0294 0.0294
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0113 0.0305
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0015 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0038 0.0476 0.1285
Echinococcus granulosus survival motor neuron protein 1 0.0187 0.2827 0.4773
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0033 0.0401 0.1124
Schistosoma mansoni hypothetical protein 0.0058 0.0781 0.211
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0113 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0103 0.0201
Brugia malayi Animal haem peroxidase family protein 0.011 0.1609 0.4507
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0027 0.0294 0.0496
Echinococcus granulosus nmda type glutamate receptor 0.002 0.0186 0.0314
Loa Loa (eye worm) hypothetical protein 0.0078 0.1103 0.309
Onchocerca volvulus 0.011 0.1609 0.4328
Plasmodium vivax histone acetyltransferase GCN5, putative 0.003 0.0351 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0027 0.0294 0.0823
Schistosoma mansoni survival motor neuron protein 0.0038 0.0476 0.1285
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0014 0.0091 0.0091
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0015 0.0113 0.0191
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0014 0.0091 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0113 0.0316
Loa Loa (eye worm) hypothetical protein 0.0041 0.052 0.1456
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0103 0.0201
Loa Loa (eye worm) lipase 0.0234 0.3569 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0113 0.0113
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0113 0.0316
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0113 0.0305
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0103 0.0201
Echinococcus granulosus Protein patched homolog 1 0.0033 0.0401 0.0677
Brugia malayi CHE-14 protein 0.0033 0.0401 0.1124
Giardia lamblia Histone acetyltransferase GCN5 0.0028 0.0311 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0015 0.0113 0.0316
Loa Loa (eye worm) steroid hormone receptor 0.0015 0.0113 0.0316
Brugia malayi Calcitonin receptor-like protein seb-1 0.0084 0.1201 0.3366
Onchocerca volvulus 0.011 0.1609 0.4328
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0103 0.0201
Echinococcus granulosus GPCR family 2 0.0027 0.0294 0.0496
Trypanosoma cruzi DNA polymerase kappa, putative 0.0015 0.0103 0.0034
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0008 0.0006 0.0006
Echinococcus granulosus neuropeptide s receptor 0.0371 0.573 0.9675
Echinococcus multilocularis geminin 0.0243 0.3702 0.3702
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0014 0.0098 0.6178
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0103 0.0288
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0014 0.0091 0.5
Brugia malayi hypothetical protein 0.0187 0.2827 0.7919
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0008 0.0006 0.001
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0015 0.0103 0.0034
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Brugia malayi Steroid receptor seven-up type 2 0.0015 0.0113 0.0316
Trichomonas vaginalis bromodomain-containing protein, putative 0.003 0.0351 0.0748
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0113 0.0305
Echinococcus multilocularis dna polymerase eta 0.0015 0.0103 0.0103
Giardia lamblia DINP protein human, muc B family 0.0015 0.0103 0.054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0113 0.0316
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0038 0.0476 0.1333
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0014 0.0098 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0078 0.1103 0.309
Trichomonas vaginalis DNA polymerase eta, putative 0.0015 0.0103 0.0034
Echinococcus multilocularis GPCR, family 2 0.0027 0.0294 0.0294
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0064 0.0876 0.2455
Loa Loa (eye worm) transcription factor SMAD2 0.0081 0.1153 0.323
Loa Loa (eye worm) MH2 domain-containing protein 0.0081 0.1153 0.323
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0113 0.0316
Onchocerca volvulus Peroxidase homolog 0.011 0.1609 0.4328
Trypanosoma brucei DNA polymerase IV, putative 0.0015 0.0103 0.0201
Loa Loa (eye worm) hypothetical protein 0.0015 0.0113 0.0316
Schistosoma mansoni peroxidasin 0.011 0.1609 0.4345
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0015 0.0113 0.0316
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0014 0.0098 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0008 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0027 0.0294 0.0793
Schistosoma mansoni hypothetical protein 0.0049 0.0641 0.1732
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0383 0.5922 0.5922
Entamoeba histolytica hypothetical protein 0.0049 0.0641 0.5437
Trypanosoma cruzi hypothetical protein, conserved 0.0234 0.3569 1
Brugia malayi Peroxidasin 0.011 0.1609 0.4507
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0103 0.0201
Brugia malayi latrophilin 2 splice variant baaae 0.0058 0.0781 0.2189
Brugia malayi hypothetical protein 0.011 0.1609 0.4507
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0876 0.2366
Entamoeba histolytica hypothetical protein 0.0049 0.0641 0.5437
Echinococcus multilocularis dna polymerase kappa 0.0015 0.0103 0.0103
Echinococcus multilocularis protein patched 0.0033 0.0401 0.0401
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0113 0.0305
Schistosoma mansoni hypothetical protein 0.0032 0.0382 0.1032
Brugia malayi ecdysteroid receptor 0.0015 0.0113 0.0316
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0015 0.0103 1
Loa Loa (eye worm) animal heme peroxidase 0.011 0.1609 0.4507
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0008 0.0006 0.001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0015 0.0113 0.0191
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0064 0.0876 0.1479
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0103 0.0201
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Loa Loa (eye worm) hypothetical protein 0.0084 0.1201 0.3366
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0113 0.0305
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0234 0.3569 0.6027
Schistosoma mansoni peroxidasin 0.011 0.1609 0.4345
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0113 0.0305
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0103 0.0288
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.0103 0.0201
Entamoeba histolytica hypothetical protein 0.0049 0.0641 0.5437
Brugia malayi steroid hormone receptor 0.0015 0.0113 0.0316
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0008 0.0006 0.0006
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.003 0.0351 1
Mycobacterium ulcerans DNA polymerase IV 0.0015 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Schistosoma mansoni hypothetical protein 0.0032 0.0382 0.1032
Entamoeba histolytica hypothetical protein 0.0049 0.0641 0.5437
Brugia malayi Animal haem peroxidase family protein 0.011 0.1609 0.4507
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0064 0.0876 0.2366
Loa Loa (eye worm) animal heme peroxidase 0.011 0.1609 0.4507
Loa Loa (eye worm) hypothetical protein 0.0027 0.0294 0.0823
Brugia malayi nuclear receptor NHR-88 0.0015 0.0113 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0015 0.0113 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0113 0.0316
Loa Loa (eye worm) hypothetical protein 0.011 0.1609 0.4507
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0113 0.0191
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0113 0.0305
Echinococcus granulosus Niemann Pick C1 protein 0.0078 0.1103 0.1862
Brugia malayi Animal haem peroxidase family protein 0.011 0.1609 0.4507
Trypanosoma brucei unspecified product 0.0015 0.0103 0.0201
Echinococcus granulosus glutamate receptor 2 0.0008 0.0006 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0064 0.0876 0.0876
Schistosoma mansoni hypothetical protein 0.0032 0.0382 0.1032
Schistosoma mansoni hypothetical protein 0.0032 0.0382 0.1032
Loa Loa (eye worm) blistered cuticle protein 3 0.011 0.1609 0.4507
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0103 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0113 0.0316
Schistosoma mansoni hypothetical protein 0.0243 0.3702 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0015 0.0113 0.0191
Schistosoma mansoni ap endonuclease 0.0014 0.0091 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0103 0.0201
Brugia malayi Animal haem peroxidase family protein 0.011 0.1609 0.4507
Schistosoma mansoni patched 1 0.0033 0.0401 0.1084
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0015 0.0113 0.0113
Brugia malayi Blistered cuticle protein 3 0.011 0.1609 0.4507
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0058 0.0781 0.2189
Loa Loa (eye worm) hypothetical protein 0.0015 0.0113 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0103 0.0201
Echinococcus granulosus tm gpcr rhodopsin 0.0383 0.5922 1
Trypanosoma cruzi hypothetical protein, conserved 0.0234 0.3569 1
Loa Loa (eye worm) animal heme peroxidase 0.011 0.1609 0.4507
Echinococcus granulosus sterol regulatory element binding protein 0.0033 0.0401 0.0677
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0103 0.0173
Brugia malayi nuclear hormone receptor 0.0015 0.0113 0.0316
Chlamydia trachomatis glutamine binding protein 0.0014 0.0098 0.5
Echinococcus granulosus dna polymerase kappa 0.0015 0.0103 0.0173
Loa Loa (eye worm) hypothetical protein 0.0015 0.0113 0.0316
Onchocerca volvulus Chorion peroxidase homolog 0.011 0.1609 0.4328
Loa Loa (eye worm) hypothetical protein 0.0033 0.0401 0.1124

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 18.4 % Inhibition of human ERG at 30 uM relative to control ChEMBL. 23428155

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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