TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 342.407 | Formula: C20H23FN2O2
H donors: 0 H acceptors: 0 LogP: 4.13 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCCC(C1)O/N=C/c1ccccc1OCc1cccc(c1)F
InChi: 1S/C20H23FN2O2/c1-23-11-5-9-19(14-23)25-22-13-17-7-2-3-10-20(17)24-15-16-6-4-8-18(21)12-16/h2-4,6-8,10,12-13,19H,5,9,11,14-15H2,1H3/b22-13+
InChiKey: RYJIDEOXCRQAFX-LPYMAVHISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Brugia malayi	SET domain containing protein	0.0012	0.0024	0.0024
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Brugia malayi	SET domain containing protein	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Plasmodium falciparum	SET domain protein, putative	0.0012	0.0024	1
Trichomonas vaginalis	set domain proteins, putative	0.0012	0.0024	1
Brugia malayi	SET domain containing protein	0.0012	0.0024	0.0024
Echinococcus granulosus	SET and MYND domain containing protein 4	0.0012	0.0024	0.0024
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0012	0.0024	0.0024
Brugia malayi	Pre-SET motif family protein	0.0012	0.0024	0.0024
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0012	0.0024	0.0024
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Echinococcus granulosus	histone lysine methyltransferase setb	0.0012	0.0024	0.0024
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0012	0.0024	0.0024
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma cruzi	D-ala D-ala ligase C-terminus/SET domain containing protein, putative	0.0012	0.0024	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase seto7	0.0012	0.0024	0.0024
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Echinococcus multilocularis	myeloid:lymphoid or mixed lineage leukemia 5	0.0012	0.0024	0.0024
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0012	0.0024	0.0024
Echinococcus multilocularis	histone lysine n methyltransferase setd8	0.0012	0.0024	0.0024
Plasmodium vivax	SET domain protein, putative	0.0012	0.0024	1
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Plasmodium falciparum	histone-lysine N-methyltransferase, putative	0.0012	0.0024	1
Echinococcus granulosus	myeloid:lymphoid or mixed lineage leukemia 5	0.0012	0.0024	0.0024
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0012	0.0024	0.0024
Plasmodium vivax	SET domain protein, putative	0.0012	0.0024	1
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0012	0.0024	1
Echinococcus multilocularis	histone lysine N methyltransferase E(z)	0.0784	1	1
Echinococcus multilocularis	SET domain containing protein 3	0.0012	0.0024	0.0024
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0012	0.0024	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0012	0.0024	0.0024
Echinococcus multilocularis	histone lysine N methyltransferase SETD2	0.0012	0.0024	0.0024
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0012	0.0024	0.0024
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0012	0.0024	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0012	0.0024	1
Giardia lamblia	hypothetical protein	0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Plasmodium vivax	SET domain protein, putative	0.0012	0.0024	1
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Trypanosoma cruzi	TPR repeat/SET domain containing protein, putative	0.0012	0.0024	0.5
Entamoeba histolytica	hypothetical protein	0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Schistosoma mansoni	ran binding protein 9-related	0.0012	0.0024	0.0024
Chlamydia trachomatis	hypothetical protein	0.0012	0.0024	0.5
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0012	0.0024	0.0024
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Schistosoma mansoni	enhancer of zeste ezh	0.0784	1	1
Plasmodium vivax	SET domain containing protein	0.0012	0.0024	1
Brugia malayi	SET domain containing protein	0.0012	0.0024	0.0024
Trypanosoma brucei	hypothetical protein, conserved	0.0012	0.0024	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0012	0.0024	0.0024
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Loa Loa (eye worm)	SET domain-containing protein	0.0784	1	1
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Loa Loa (eye worm)	SET domain-containing protein	0.0012	0.0024	0.0024
Brugia malayi	SET domain containing protein	0.0012	0.0024	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0024	1
Entamoeba histolytica	hypothetical protein	0.0012	0.0024	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0012	0.0024	0.0024
Trichomonas vaginalis	PHD finger protein, putative	0.0012	0.0024	1
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Echinococcus multilocularis	SET and MYND domain containing protein 4	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma cruzi	ATP-grasp domain containing protein, putative	0.0012	0.0024	0.5
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0024	0.5
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0012	0.0024	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Trypanosoma cruzi	TPR repeat/SET domain containing protein, putative	0.0012	0.0024	0.5
Giardia lamblia	Hypothetical protein	0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0024	0.5
Loa Loa (eye worm)	SET domain-containing protein	0.0012	0.0024	0.0024
Onchocerca volvulus		0.0012	0.0024	1
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Loa Loa (eye worm)	histone methyltransferase	0.0012	0.0024	0.0024
Echinococcus granulosus	SET and MYND domain containing protein 4	0.0012	0.0024	0.0024
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Echinococcus granulosus	histone lysine N methyltransferase Ez	0.0784	1	1
Plasmodium vivax	histone-lysine N-methyltransferase, putative	0.0012	0.0024	1
Echinococcus granulosus	SET and MYND domain containing protein 5	0.0012	0.0024	0.0024
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0012	0.0024	1
Brugia malayi	SET domain containing protein	0.0012	0.0024	0.0024
Echinococcus granulosus	histone lysine n methyltransferase suv420h1	0.0012	0.0024	0.0024
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0024	0.5
Toxoplasma gondii	histone lysine methyltransferase SET8	0.0012	0.0024	1
Echinococcus multilocularis	histone lysine n methyltransferase suv420h1	0.0012	0.0024	0.0024
Onchocerca volvulus		0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0012	0.0024	1
Plasmodium falciparum	SET domain protein, putative	0.0012	0.0024	1
Trypanosoma cruzi	TPR repeat/SET domain containing protein, putative	0.0012	0.0024	0.5
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma brucei	predicted SET domain protein	0.0012	0.0024	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL5	0.0012	0.0024	0.0024
Echinococcus granulosus	histone lysine N methyltransferase SETD2	0.0012	0.0024	0.0024
Toxoplasma gondii	apical complex lysine methyltransferase	0.0012	0.0024	1
Echinococcus multilocularis	SET and MYND domain containing protein 5	0.0012	0.0024	0.0024
Trichomonas vaginalis	PHD finger protein, putative	0.0012	0.0024	1
Schistosoma mansoni	mixed-lineage leukemia 5 mll5	0.0012	0.0024	0.0024
Plasmodium vivax	SET domain containing protein	0.0012	0.0024	1
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0012	0.0024	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0012	0.0024	0.0024
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0024	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0012	0.0024	0.0024
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma brucei	TPR repeat/SET domain containing protein, putative	0.0012	0.0024	1
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Echinococcus granulosus	SET domain containing protein 3	0.0012	0.0024	0.0024
Schistosoma mansoni	SET domain protein	0.0012	0.0024	0.0024
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Brugia malayi	SET domain containing protein	0.0012	0.0024	0.0024
Onchocerca volvulus		0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0012	0.0024	0.0024
Echinococcus multilocularis	SET (trithorax:polycomb) domain containing protein	0.0012	0.0024	0.0024
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Brugia malayi	Pre-SET motif family protein	0.0012	0.0024	0.0024
Giardia lamblia	Hypothetical protein	0.0012	0.0024	1
Schistosoma mansoni	set and mynd domain containing	0.0012	0.0024	0.0024
Schistosoma mansoni	set and mynd domain containing	0.0012	0.0024	0.0024
Giardia lamblia	Histone methyltransferase HMT2	0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma cruzi	D-ala D-ala ligase C-terminus/SET domain containing protein, putative	0.0012	0.0024	0.5
Schistosoma mansoni	set and mynd domain containing	0.0012	0.0024	0.0024
Trypanosoma brucei	hypothetical protein, conserved	0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Echinococcus multilocularis	histone lysine N methyltransferase NSD3	0.0012	0.0024	0.0024
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Entamoeba histolytica	hypothetical protein, conserved domain containing	0.0012	0.0024	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0012	0.0024	0.0024
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0012	0.0024	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Leishmania major	SET domain protein, putative	0.0012	0.0024	0.5
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Echinococcus multilocularis	histone lysine N methyltransferase, H3 lysine 36	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Entamoeba histolytica	hypothetical protein	0.0012	0.0024	1
Trypanosoma brucei	conserved protein, unknown function	0.0012	0.0024	1
Brugia malayi	SET domain containing protein	0.0012	0.0024	0.0024
Treponema pallidum	cell division protein (ftsJ)	0.001	0	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0012	0.0024	0.0024
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0012	0.0024	1
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Trypanosoma brucei	ATP-grasp domain containing protein, putative	0.0012	0.0024	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Plasmodium vivax	variant-silencing SET protein, putative	0.0012	0.0024	1
Schistosoma mansoni	huntingtin interacting protein-related	0.0012	0.0024	0.0024
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0012	0.0024	0.0024
Plasmodium falciparum	histone-lysine N-methyltransferase SET7	0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Echinococcus granulosus	histone lysine N methyltransferase NSD3	0.0012	0.0024	0.0024
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0012	0.0024	0.0024
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0024	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0012	0.0024	1
Echinococcus multilocularis	SET and MYND domain containing protein 4	0.0012	0.0024	0.0024
Trypanosoma cruzi	TPR repeat/SET domain containing protein, putative	0.0012	0.0024	0.5
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0012	0.0024	0.0024
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0012	0.0024	0.0024
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0012	0.0024	0.0024
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Plasmodium vivax	SET domain protein, putative	0.0012	0.0024	1
Brugia malayi	Protein set-1	0.0012	0.0024	0.0024
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Trichomonas vaginalis	mixed-lineage leukemia protein, mll, putative	0.0012	0.0024	1
Echinococcus granulosus	histone lysine N methyltransferase H3 lysine 36	0.0012	0.0024	0.0024
Giardia lamblia	Set-2, putative	0.0012	0.0024	1
Schistosoma mansoni	suppressor of variegation 4-20-related	0.0012	0.0024	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Echinococcus granulosus	histone lysine N methyltransferase MLL5	0.0012	0.0024	0.0024
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0012	0.0024	0.0024
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Schistosoma mansoni	hypothetical protein	0.0012	0.0024	0.0024
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Plasmodium falciparum	histone-lysine N-methyltransferase SET2	0.0012	0.0024	1
Giardia lamblia	Histone methyltransferase HMT1	0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0024	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0012	0.0024	1
Trichomonas vaginalis	mixed-lineage leukemia protein, mll, putative	0.0012	0.0024	1
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Toxoplasma gondii	histone lysine methyltransferase SET2	0.0012	0.0024	1
Echinococcus granulosus	SET trithorax:polycomb domain containing protein	0.0012	0.0024	0.0024
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Echinococcus granulosus	histone lysine n methyltransferase setd8	0.0012	0.0024	0.0024
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Loa Loa (eye worm)	histone methyltransferase	0.0012	0.0024	0.0024
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Schistosoma mansoni	set and mynd domain containing	0.0012	0.0024	0.0024
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0012	0.0024	0.0024
Brugia malayi	SET domain containing protein	0.0012	0.0024	0.0024
Trypanosoma brucei	SET domain containing protein, putative	0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0024	1
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Schistosoma mansoni	hypothetical protein	0.0012	0.0024	0.0024
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0012	0.0024	1
Leishmania major	hypothetical protein, conserved	0.0012	0.0024	0.5
Schistosoma mansoni	SET domain protein	0.0012	0.0024	0.0024
Trypanosoma brucei	TPR repeat/SET domain containing protein, putative	0.0012	0.0024	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0012	0.0024	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0012	0.0024	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0024	0.0024
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0012	0.0024	1
Plasmodium falciparum	histone-lysine N-methyltransferase, putative	0.0012	0.0024	1
Trypanosoma brucei	D-ala D-ala ligase C-terminus/SET domain containing protein, putative	0.0012	0.0024	1
Trichomonas vaginalis	mixed-lineage leukemia protein, mll, putative	0.0012	0.0024	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (ADMET)	= 136 %	Cytotoxicity against mouse H22 cells assessed as cell viability at 5 uM	ChEMBL.	23353734

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2333253

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1735255