Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Cholinesterase | 574 aa | 590 aa | 25.1 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 472 aa | 27.5 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 586 aa | 27.1 % | |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Echinococcus granulosus | BC026374 protein S09 family | Cholinesterase | 574 aa | 642 aa | 34.4 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 549 aa | 29.5 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Loa Loa (eye worm) | hypothetical protein | Cholinesterase | 574 aa | 573 aa | 26.4 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Cholinesterase | 574 aa | 560 aa | 29.3 % |
Echinococcus multilocularis | neuroligin | Cholinesterase | 574 aa | 493 aa | 26.2 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Cholinesterase | 574 aa | 547 aa | 29.4 % |
Loa Loa (eye worm) | hypothetical protein | Cholinesterase | 574 aa | 520 aa | 27.1 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Cholinesterase | 574 aa | 636 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | fatty acid elongase, putative | 0.082 | 0.1067 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0192 | 0.0045 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0192 | 0.0045 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0 | 0.5 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.6316 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0192 | 0.0045 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.082 | 0.1067 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.6316 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0192 | 0.0045 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.6316 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.6316 | 1 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.082 | 0.1067 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0192 | 0.0045 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0192 | 0.0045 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0192 | 0.0045 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.6316 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0192 | 0.0045 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.082 | 0.1067 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.6316 | 1 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.082 | 0.1067 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.6316 | 1 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.0192 | 0.0045 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0192 | 0.0045 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11.74 uM | Inhibition of equine serum BuChE using S-butyrylthiocholine chloride substrate by Ellman's method based spectrophotometry | ChEMBL. | 23454132 |
IC50 (binding) | = 13.64 uM | Inhibition of AChE (unknown origin) using acetylthiocholine iodide substrate by Ellman's method based spectrophotometry | ChEMBL. | 23454132 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.