TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 444.416 | Formula: C16H20N4O9S
H donors: 6 H acceptors: 9 LogP: -2.06 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: O=C(CNC(=O)c1ccc(cc1)S(=O)(=O)N)NCC(=O)N[C@H](C(=O)O)CCC(=O)O
InChi: 1S/C16H20N4O9S/c17-30(28,29)10-3-1-9(2-4-10)15(25)19-7-12(21)18-8-13(22)20-11(16(26)27)5-6-14(23)24/h1-4,11H,5-8H2,(H,18,21)(H,19,25)(H,20,22)(H,23,24)(H,26,27)(H2,17,28,29)/t11-/m0/s1
InChiKey: DARUJPOMBKSIIU-NSHDSACASA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	carbonic anhydrase II	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania braziliensis	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei gambiense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus multilocularis	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania donovani	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Putative carbonic anhydrase 5 precursor	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	carbonic anhydrase 3	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania mexicana	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus granulosus	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania infantum	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania major	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Carbonic anhydrase like protein 2 precursor	carbonic anhydrase II	260 aa	259 aa	32.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0408	0.3524	0.3945
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0035	0.0101	0.0113
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0025	0.0007	0.0008
Onchocerca volvulus		0.0035	0.0101	0.5987
Echinococcus multilocularis	ras-related protein rab-5	0.0042	0.0164	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0147	0.1128	0.1121
Onchocerca volvulus		0.0035	0.0101	0.5987
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0035	0.0101	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0035	0.0101	0.0019
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0035	0.0101	0.0106
Onchocerca volvulus		0.0035	0.0101	0.5987
Leishmania major	malonyl-coa decarboxylase-like protein	0.0164	0.1285	1
Schistosoma mansoni	carbonic anhydrase-related	0.0034	0.0084	0.0077
Brugia malayi	hypothetical protein	0.0035	0.0101	0.0106
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0523	0.4581	0.5161
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0164	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0035	0.0101	0.0094
Trichomonas vaginalis	GTP binding protein rare7l, putative	0.0042	0.0164	1
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0147	0.1128	0.1264
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0035	0.0101	0.0019
Onchocerca volvulus		0.0035	0.0101	0.5987
Onchocerca volvulus		0.0035	0.0101	0.5987
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0523	0.4581	0.5161
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0106
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Brugia malayi	hypothetical protein	0.0035	0.0101	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0164	0.0091
Trypanosoma brucei	RNA helicase, putative	0.1113	1	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0035	0.0101	0.0094
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0035	0.0101	0.0094
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0035	0.0101	0.6167
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.099	0.887	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0035	0.0101	0.0113
Echinococcus granulosus	GTP binding protein Parf	0.0042	0.0164	0.0184
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0523	0.4581	0.5129
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0113
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0035	0.0101	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0164	0.1285	0.1279
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0147	0.1128	0.8769
Echinococcus granulosus	KRAB A domain containing protein	0.0025	0.0007	0.0008
Onchocerca volvulus		0.0035	0.0101	0.5987
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0035	0.0101	0.0106
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0113
Onchocerca volvulus		0.0035	0.0101	0.5987
Trypanosoma cruzi	Rab-like 5, small G protein	0.0042	0.0164	0.1225
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0034	0.0084	0.0087
Echinococcus multilocularis	carbonic anhydrase	0.0034	0.0084	0.0087
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0106
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0035	0.0101	0.0106
Schistosoma mansoni	hypothetical protein	0.0042	0.0164	0.0157
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Onchocerca volvulus	Mitochondrial Rho GTPase homolog	0.0042	0.0164	1
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0408	0.3524	0.3519
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0523	0.4581	0.5129
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Onchocerca volvulus		0.0035	0.0101	0.5987
Echinococcus granulosus	rab protein 3	0.0042	0.0164	0.0184
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0035	0.0101	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Loa Loa (eye worm)	carbonic anhydrase 3	0.0147	0.1128	0.1188
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Schistosoma mansoni	carbonic anhydrase	0.0034	0.0084	0.0077
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0035	0.0101	0.0113
Plasmodium falciparum	ras-related protein Rab-5A	0.0042	0.0164	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0035	0.0101	0.6167
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0035	0.0101	0.0106
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0035	0.0101	0.0113
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0035	0.0101	0.0113
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Schistosoma mansoni	pcd6 interacting protein-related	0.0035	0.0101	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Plasmodium vivax	ras-related protein Rab-5A, putative	0.0042	0.0164	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0408	0.3524	0.3968
Onchocerca volvulus		0.0035	0.0101	0.5987
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0035	0.0101	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Onchocerca volvulus		0.0035	0.0101	0.5987
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0035	0.0101	0.0094
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0034	0.0084	0.0087
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0408	0.3524	0.3915
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Echinococcus granulosus	carbonic anhydrase	0.0034	0.0084	0.0094
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0025	0.0007	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0035	0.0101	0.0106
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0035	0.0101	0.0734
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0147	0.1128	0.1264
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Schistosoma mansoni	hypothetical protein	0.0034	0.0084	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Trypanosoma brucei	carbonic anhydrase-like protein	0.0147	0.1128	0.1121
Onchocerca volvulus		0.0035	0.0101	0.5987
Trichomonas vaginalis	hypothetical protein	0.0042	0.0164	1
Echinococcus multilocularis	hypothetical protein	0.0035	0.0101	0.0106
Schistosoma mansoni	carbonic anhydrase-related	0.0034	0.0084	0.0077
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0035	0.0101	0.0106
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0164	0.1285	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Onchocerca volvulus		0.0042	0.0164	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Trichomonas vaginalis	pten, drome, putative	0.0035	0.0101	0.5987
Brugia malayi	hypothetical protein	0.0035	0.0101	0.0106
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0025	0.0007	0.0008
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Schistosoma mansoni	serine/threonine protein kinase	0.0028	0.0031	0.0024
Giardia lamblia	Protein tyrosine phosphatase	0.0035	0.0101	1
Toxoplasma gondii	hypothetical protein	0.0034	0.0084	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0035	0.0101	0.0019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0106
Brugia malayi	hypothetical protein	0.0035	0.0101	0.0106
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Brugia malayi	hypothetical protein	0.0035	0.0101	0.0106
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0408	0.3524	0.3968
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0035	0.0101	0.0106
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0164	0.1225
Trypanosoma brucei	Rab-like 5, small G protein	0.0042	0.0164	0.0157
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0035	0.0101	0.0106
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	0.0418	0.3617	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0106
Echinococcus granulosus	carbonic anhydrase	0.0034	0.0084	0.0094
Echinococcus multilocularis	carbonic anhydrase	0.0034	0.0084	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0164	0.0091
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0106
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0035	0.0101	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0025	0.0007	0.0008
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0035	0.0101	0.0094
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0164	0.1225
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0113
Echinococcus multilocularis	carbonic anhydrase	0.0034	0.0084	0.0087
Schistosoma mansoni	protein tyrosine phosphatase	0.0035	0.0101	0.0094
Onchocerca volvulus		0.0035	0.0101	0.5987
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0035	0.0101	0.0106
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0147	0.1128	0.8769
Brugia malayi	RAB, member of RAS oncogene family-like 5	0.0042	0.0164	0.0177
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0523	0.4581	0.4577
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Onchocerca volvulus		0.0035	0.0101	0.5987
Onchocerca volvulus		0.0035	0.0101	0.5987
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Brugia malayi	Ras-related protein ypt4	0.0042	0.0164	0.0177
Onchocerca volvulus		0.0035	0.0101	0.5987
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0113
Echinococcus multilocularis		0.0035	0.0101	0.0106
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0113
Echinococcus multilocularis	GTP binding protein Parf	0.0042	0.0164	0.0177
Onchocerca volvulus		0.0035	0.0101	0.5987
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0164	0.1285	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0997	0.8931	1
Entamoeba histolytica	hypothetical protein	0.0042	0.0164	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0523	0.4581	0.5119
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Echinococcus granulosus	carbonic anhydrase	0.0034	0.0084	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Onchocerca volvulus		0.0035	0.0101	0.5987
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0034	0.0084	0.0087
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0035	0.0101	0.0113
Mycobacterium tuberculosis	Possible maturase	0.0025	0.0007	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0035	0.0101	0.0106
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0164	1
Onchocerca volvulus		0.0035	0.0101	0.5987
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0035	0.0101	0.0094
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0035	0.0101	0.0734
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Echinococcus granulosus	RNA directed DNA polymerase	0.0025	0.0007	0.0008
Brugia malayi	Protein-tyrosine phosphatase 1	0.0035	0.0101	0.0106
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0034	0.0084	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0418	0.3617	0.4022
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Brugia malayi	Protein-tyrosine phosphatase	0.0035	0.0101	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Onchocerca volvulus		0.0035	0.0101	0.5987
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0035	0.0101	0.0019
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0035	0.0101	0.0094
Onchocerca volvulus		0.0035	0.0101	0.5987
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0035	0.0101	0.0094
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0164	0.1225
Onchocerca volvulus		0.0035	0.0101	0.5987
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0523	0.4581	0.5161
Echinococcus multilocularis	carbonic anhydrase II	0.0147	0.1128	0.1264
Entamoeba histolytica	hypothetical protein	0.0042	0.0164	1
Leishmania major	hypothetical protein, conserved	0.0042	0.0164	0.0531
Onchocerca volvulus	4.1 G protein, putative homolog	0.0035	0.0101	0.5987
Onchocerca volvulus		0.0035	0.0101	0.5987
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0035	0.0101	0.0106
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0113
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0113
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0147	0.1128	0.1121
Brugia malayi	hypothetical protein	0.0042	0.0164	0.0177
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0035	0.0101	0.0094
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0035	0.0101	0.0094
Brugia malayi	Protein-tyrosine phosphatase	0.0035	0.0101	0.0106
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0034	0.0084	0.0087
Onchocerca volvulus		0.0035	0.0101	0.5987
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0035	0.0101	0.0094
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0035	0.0101	0.0094
Leishmania major	carbonic anhydrase-like protein	0.0147	0.1128	0.8672
Brugia malayi	Protein kinase domain containing protein	0.099	0.887	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0035	0.0101	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0101	0.0019
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0035	0.0101	0.0734
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0035	0.0101	0.0113
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0035	0.0101	0.0106
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0035	0.0101	0.0094
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0035	0.0101	0.0094
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0035	0.0101	0.0019
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0147	0.1128	0.1188
Schistosoma mansoni	carbonic anhydrase-related	0.0034	0.0084	0.0077
Echinococcus multilocularis	rab protein 3	0.0042	0.0164	0.0177
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0035	0.0101	0.0113
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0035	0.0101	0.0019
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.099	0.887	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0035	0.0101	0.6167
Echinococcus granulosus	carbonic anhydrase II	0.0147	0.1128	0.1263
Leishmania major	hypothetical protein, conserved	0.0042	0.0164	0.0531
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0035	0.0101	0.0106
Brugia malayi	putative malonyl-CoA decarboxylase	0.0418	0.3617	0.4073

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 372 nM	Dissociation constant against human carbonic anhydrase II at 37 degree centigrade	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2371119

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1743683