Detailed information for compound 1743879

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 762.897 | Formula: C35H58N10O9
  • H donors: 11 H acceptors: 9 LogP: -3.79 Rotable bonds: 30
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC[C@@H](C(=O)N[C@H](C(=O)CN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(=O)N)CCCN=C(N)N)CC(C)C)CC(C)C)Cc1ccccc1)N
  • InChi: 1S/C35H58N10O9/c1-19(2)13-25(41-17-28(47)24(43-30(49)22(36)18-46)15-21-9-6-5-7-10-21)32(51)44-26(14-20(3)4)33(52)42-23(11-8-12-40-35(38)39)31(50)45-27(34(53)54)16-29(37)48/h5-7,9-10,19-20,22-27,41,46H,8,11-18,36H2,1-4H3,(H2,37,48)(H,42,52)(H,43,49)(H,44,51)(H,45,50)(H,53,54)(H4,38,39,40)/t22-,23-,24-,25-,26-,27-/m0/s1
  • InChiKey: XEIPCRKHBIUXOB-QCOJBMJGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0031
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0068 0.019
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0028
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0046 0.0186 0.0461
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.106 0.2943
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.0481 0.0481
Brugia malayi Niemann-Pick C1 protein precursor 0.0196 0.1101 0.3076
Loa Loa (eye worm) hypothetical protein 0.0063 0.0285 0.0797
Loa Loa (eye worm) RNA binding protein 0.0064 0.0292 0.0816
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0048 0.0135
Onchocerca volvulus 0.0048 0.0198 0.0428
Brugia malayi intermediate filament protein 0.0027 0.0068 0.019
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.0481 0.119
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0124 0.0334
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0032 0.006
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0595 0.3549 1
Schistosoma mansoni survival motor neuron protein 0.0049 0.02 0.0495
Schistosoma mansoni DNA polymerase eta 0.002 0.0023 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0088 0.0246
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0186 0.0438
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0186 0.0495
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0088 0.0088
Echinococcus multilocularis expressed protein 0.0046 0.0186 0.0186
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0186 0.0495
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0023 0.0063
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0595 0.3549 1
Echinococcus granulosus expressed conserved protein 0.0184 0.1028 0.2545
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0135
Echinococcus multilocularis muscleblind protein 1 0.06 0.3579 0.3579
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.0984
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0088 0.0246
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0088 0.0218
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0124 0.0306
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0048 0.3297
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0124 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0088 0.0246
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0048 0.0135
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0124 0.0334
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0285 0.0285
Onchocerca volvulus 0.0027 0.0068 0.0056
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0595 0.3549 0.3549
Toxoplasma gondii ABC1 family protein 0.0036 0.0124 0.0259
Loa Loa (eye worm) hypothetical protein 0.0048 0.0198 0.0554
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0079 0.0161
Brugia malayi beta-lactamase family protein 0.0036 0.0124 0.0345
Plasmodium vivax importin-beta 2, putative 0.0029 0.0079 0.0193
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0023 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0088 0.0246
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0088 0.0088
Schistosoma mansoni intermediate filament proteins 0.0027 0.0068 0.0168
Brugia malayi RNA, U transporter 1 0.0083 0.0407 0.1138
Schistosoma mansoni thyroid hormone receptor 0.003 0.0088 0.0218
Brugia malayi RNA binding protein 0.0064 0.0292 0.0816
Echinococcus granulosus lamin dm0 0.0027 0.0068 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0088 0.0246
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0048 0.0073
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.073 0.204
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0124 0.0345
Loa Loa (eye worm) hypothetical protein 0.0084 0.0416 0.1163
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0088 0.0088
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0046 0.0186 0.0521
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0088 0.0218
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0124 0.0334
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0048 0.0073
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0124 0.0286
Schistosoma mansoni thyroid hormone receptor 0.003 0.0088 0.0218
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.1114 0.3112
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0048 0.3297
Echinococcus granulosus tumor protein p63 0.0331 0.1928 0.4772
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0595 0.3549 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0088 0.0218
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0292 0.0723
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0048 0.3297
Entamoeba histolytica serine/threonine protein kinase, putative 0.0189 0.106 0.2943
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Echinococcus granulosus snurportin 1 0.031 0.1799 0.4454
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0475 0.1283
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0079 0.0161
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0088 0.0246
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.0984
Loa Loa (eye worm) hypothetical protein 0.0135 0.073 0.204
Plasmodium falciparum eukaryotic initiation factor 4A 0.0595 0.3549 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0292 0.0723
Entamoeba histolytica hypothetical protein 0.0108 0.0561 0.1525
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0079 0.0133
Schistosoma mansoni hypothetical protein 0.0135 0.073 0.1807
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.1364 0.1364
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0088 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0088 0.0246
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Brugia malayi TAR-binding protein 0.0064 0.0292 0.0816
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0028
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0124 0.0334
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0031
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0068 0.019
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0292 0.0816
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.0181
Echinococcus granulosus importin subunit beta 1 0.0029 0.0079 0.0196
Loa Loa (eye worm) hypothetical protein 0.0198 0.1114 0.3112
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0088 0.0246
Schistosoma mansoni hypothetical protein 0.0108 0.0561 0.1387
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0285 0.0704
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0124 0.0286
Schistosoma mansoni hypothetical protein 0.0063 0.0285 0.0706
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0088 0.0246
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.1114 0.3112
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0023 0.1018
Echinococcus multilocularis Niemann Pick C1 protein 0.0196 0.1101 0.1101
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0088 0.0246
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.1364 0.3376
Echinococcus multilocularis lamin 0.0027 0.0068 0.0068
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0595 0.3549 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0285 0.0285
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0285 0.0706
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0088 0.0218
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0088 0.0088
Mycobacterium tuberculosis Conserved protein 0.0036 0.0124 0.0334
Mycobacterium tuberculosis Conserved protein 0.0036 0.0124 0.0334
Onchocerca volvulus Serine\/threonine kinase homolog 0.0189 0.106 0.2891
Leishmania major GTP-binding protein, putative 0.0021 0.0032 0.0028
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0135
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0088 0.0218
Trichomonas vaginalis esterase, putative 0.0036 0.0124 0.0286
Echinococcus granulosus expressed protein 0.0046 0.0186 0.0461
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0023 0.0049
Echinococcus granulosus GPCR family 2 0.0063 0.0285 0.0706
Entamoeba histolytica hypothetical protein 0.0108 0.0561 0.1525
Echinococcus multilocularis expressed conserved protein 0.0184 0.1028 0.1028
Schistosoma mansoni hypothetical protein 0.0049 0.02 0.0495
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0595 0.3549 1
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0088 0.0246
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0345
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0595 0.3549 0.8785
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0088 0.0246
Giardia lamblia Kinase, PLK 0.0189 0.106 0.2943
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0088 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0088 0.0246
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0595 0.3549 0.8785
Schistosoma mansoni hypothetical protein 0.0063 0.0285 0.0706
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0285 0.0797
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0595 0.3549 0.3549
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0095 0.0481 0.1343
Brugia malayi ecdysteroid receptor 0.003 0.0088 0.0246
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0023 0.1018
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0196 0.1101 0.3076
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0124 0.0124
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0285 0.0797
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0124 0.0286
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0595 0.3549 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0189 0.106 0.2624
Echinococcus granulosus eukaryotic initiation factor 4A 0.0595 0.3549 0.8785
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0416 0.103
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0416 0.1116
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0088 0.0218
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0124 0.0306
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0048 0.0073
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0011 0.0017
Echinococcus multilocularis lamin dm0 0.0027 0.0068 0.0068
Onchocerca volvulus 0.0049 0.02 0.0433
Mycobacterium ulcerans lipase LipD 0.0036 0.0124 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0088 0.0088
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0028
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0046 0.0066
Onchocerca volvulus 0.0027 0.0068 0.0056
Schistosoma mansoni hypothetical protein 0.031 0.1799 0.4454
Mycobacterium ulcerans hypothetical protein 0.0024 0.0048 0.3297
Echinococcus granulosus lamin 0.0027 0.0068 0.0168
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0292 0.0292
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0595 0.3549 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0048 0.3297
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0048 0.0121
Schistosoma mansoni hypothetical protein 0.0063 0.0285 0.0706
Loa Loa (eye worm) hypothetical protein 0.06 0.3579 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0088 0.0246
Entamoeba histolytica Ran family GTPase 0.0021 0.0032 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0088 0.0246
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0056
Plasmodium falciparum importin beta, putative 0.0029 0.0079 0.0193
Echinococcus multilocularis muscleblind protein 0.06 0.3579 0.3579
Echinococcus multilocularis tumor protein p63 0.0331 0.1928 0.1928
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.02 0.0559
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0088 0.0218
Echinococcus granulosus Niemann Pick C1 protein 0.0196 0.1101 0.2725
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0048 0.0073
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.0984
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.006
Entamoeba histolytica hypothetical protein 0.0108 0.0561 0.1525
Schistosoma mansoni transient receptor potential channel 0.0063 0.0285 0.0704
Brugia malayi hypothetical protein 0.0108 0.0561 0.1566
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0416 0.0416
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0292 0.0723
Onchocerca volvulus 0.0036 0.0124 0.0215
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Plasmodium vivax RNA helicase-1, putative 0.0595 0.3549 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0595 0.3549 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0048 0.0073
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0046 0.0066
Loa Loa (eye worm) hypothetical protein 0.0239 0.1364 0.3811
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0031
Onchocerca volvulus 0.0036 0.0124 0.0215
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.0063
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.0481 0.119
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0046 0.0066
Schistosoma mansoni kinase 0.0096 0.049 0.1214
Schistosoma mansoni ran 0.0021 0.0032 0.008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0117 0.0327
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0345
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0068 0.019
Loa Loa (eye worm) hypothetical protein 0.0032 0.0098 0.0273
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0088 0.0218
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0561 0.1387
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0088 0.0246
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.132 0.3709
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.1799 0.5028
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0088 0.0218
Echinococcus multilocularis dna polymerase eta 0.002 0.0023 0.0023
Brugia malayi steroid hormone receptor 0.003 0.0088 0.0246
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0011 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0222
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0032 0.0032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0088 0.0218
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0595 0.3549 0.8785
Entamoeba histolytica hypothetical protein 0.0024 0.0046 0.0066
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.404 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0345
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0088 0.0218
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0189 0.106 0.2943
Echinococcus multilocularis dna polymerase kappa 0.002 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0081 0.0398 0.0984
Brugia malayi CHE-14 protein 0.0084 0.0416 0.1163
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0595 0.3549 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0088 0.0246
Echinococcus granulosus dna polymerase eta 0.002 0.0023 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0124 0.0286
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0196 0.1101 0.3058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.1114 0.3112
Leishmania major eukaryotic initiation factor 4a, putative 0.0595 0.3549 1
Schistosoma mansoni lamin 0.0027 0.0068 0.0168
Echinococcus multilocularis GPCR, family 2 0.0063 0.0285 0.0285
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0475 0.1283
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.133 0.3716
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0088 0.0088
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0285 0.0704
Echinococcus granulosus tar DNA binding protein 0.0064 0.0292 0.0723
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.0461 0.0461
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0046 0.0186 0.0521
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0135
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0088 0.0218
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0048 0.3297
Trichomonas vaginalis ran, putative 0.0021 0.0032 0.0028
Schistosoma mansoni coup transcription factor 0.003 0.0088 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0088 0.0246
Trypanosoma cruzi polo-like protein kinase, putative 0.0189 0.106 0.2943
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0088 0.0246
Trypanosoma brucei polo-like protein kinase 0.0189 0.106 0.2943
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0345
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0124 0.0318
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0063
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0199 0.1119 0.2771
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.404 0.404
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0048 0.3297
Echinococcus granulosus muscleblind protein 0.06 0.3579 0.8858
Leishmania major importin beta-1 subunit, putative 0.0024 0.0046 0.0066
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0561 0.0561
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0088 0.0088
Brugia malayi Importin beta-1 subunit 0.0029 0.0079 0.0222
Mycobacterium ulcerans hypothetical protein 0.0036 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0091
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0117 0.0327
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0124 1
Loa Loa (eye worm) hypothetical protein 0.0595 0.3549 0.9917
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0088 0.0246
Loa Loa (eye worm) hypothetical protein 0.0103 0.0532 0.1487
Loa Loa (eye worm) hypothetical protein 0.06 0.3579 1
Brugia malayi eukaryotic initiation factor 4A 0.0595 0.3549 0.9917
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0561 0.1387
Onchocerca volvulus 0.0036 0.0124 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0124 0.0286
Schistosoma mansoni transient receptor potential channel 0.0095 0.0481 0.119
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0124 0.0334
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0031
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0189 0.106 0.2963
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0088 0.0113
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0124 0.0334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0088 0.0246
Echinococcus granulosus Niemann Pick C1 protein 0.028 0.1615 0.3999
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0088 0.0218
Brugia malayi beta-lactamase 0.0036 0.0124 0.0345
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0048 0.0073
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0124 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0292 0.0816
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0124 0.0286
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0048 0.0135
Echinococcus multilocularis protein patched 0.0084 0.0416 0.0416
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0595 0.3549 1
Echinococcus multilocularis snurportin 1 0.031 0.1799 0.1799
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0285 0.0706
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0023 0.0049
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0023 0.0056
Echinococcus granulosus dna polymerase kappa 0.002 0.0023 0.0056
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0091
Brugia malayi beta-lactamase family protein 0.0036 0.0124 0.0345
Toxoplasma gondii TIM10 family protein, putative 0.0046 0.0186 0.0438
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0088 0.0088
Onchocerca volvulus 0.003 0.0088 0.0113
Schistosoma mansoni patched 1 0.0084 0.0416 0.103
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0345
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0088 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0189 0.106 0.2624
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0189 0.106 0.106
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0285 0.0797
Echinococcus multilocularis Niemann Pick C1 protein 0.028 0.1615 0.1615
Schistosoma mansoni ran 0.0021 0.0032 0.008
Mycobacterium ulcerans beta-lactamase 0.0036 0.0124 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0189 0.106 0.2963
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0595 0.3549 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0124 0.0345
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0124 0.0286
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0046 0.0066
Mycobacterium tuberculosis Conserved protein 0.0036 0.0124 0.0334
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0088 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Echinococcus multilocularis protein dispatched 1 0.0096 0.0489 0.0489
Echinococcus multilocularis musashi 0.0027 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0059 0.0265 0.0741
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0124 0.0334
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0048 0.3297
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0292 0.0723
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0345
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0416 0.103
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0088 0.0218
Leishmania major hypothetical protein, conserved 0.0036 0.0124 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0088 0.0246
Loa Loa (eye worm) hypothetical protein 0.0027 0.0068 0.019
Schistosoma mansoni nuclear hormone receptor 0.003 0.0088 0.0218
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0088 0.0218
Brugia malayi Muscleblind-like protein 0.06 0.3579 1
Brugia malayi hypothetical protein 0.0239 0.1364 0.3811
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0117 0.029
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0048 0.0121
Entamoeba histolytica hypothetical protein 0.0108 0.0561 0.1525
Schistosoma mansoni importin beta-1 0.0029 0.0079 0.0196
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0285 0.0285
Treponema pallidum ATP-dependent RNA helicase 0.0595 0.3549 0.5
Schistosoma mansoni lamin 0.0027 0.0068 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0189 0.106 0.2943
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0292 0.0816
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0124 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.0124 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0292 0.0723
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.133 0.3716
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0117 0.0117
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0198 0.0491
Echinococcus granulosus microtubule associated protein 2 0.0676 0.404 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0124 0.0306
Brugia malayi MH2 domain containing protein 0.0233 0.133 0.3716
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0028
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.0461 0.1142
Schistosoma mansoni transient receptor potential channel 0.0063 0.0285 0.0704
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0595 0.3549 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0088 0.0246
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0416 0.1163
Echinococcus granulosus FTZ F1 alpha 0.003 0.0088 0.0218
Brugia malayi nuclear hormone receptor 0.003 0.0088 0.0246
Loa Loa (eye worm) beta-lactamase 0.0036 0.0124 0.0345
Echinococcus granulosus intermediate filament protein 0.0027 0.0068 0.0168
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0088 0.0113
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.0063
Schistosoma mansoni hypothetical protein 0.0063 0.0285 0.0706
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0285 0.0285
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0023
Brugia malayi nuclear receptor NHR-88 0.003 0.0088 0.0246
Loa Loa (eye worm) hypothetical protein 0.003 0.0088 0.0246

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 1000 uM Agonist activity in human platelet aggregation ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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