Detailed information for compound 1744780

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1257.32 | Formula: C59H72N18O14
  • H donors: 17 H acceptors: 16 LogP: -4.9 Rotable bonds: 42
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N1CC=C[C@H]1C(=O)NCC(=O)N)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H](NC(=O)[C@@H]1NCCC1=O)Cc1nc[nH]c1)CO)Cc1nc[nH]c1)CC(=O)O
  • InChi: 1S/C59H72N18O14/c60-15-6-5-12-39(59(91)77-17-7-13-46(77)57(89)67-27-48(61)80)70-51(83)40(18-31-23-65-37-10-3-1-8-35(31)37)72-55(87)44(22-49(81)82)74-53(85)42(20-33-25-62-29-68-33)73-56(88)45(28-78)76-52(84)41(19-32-24-66-38-11-4-2-9-36(32)38)71-54(86)43(21-34-26-63-30-69-34)75-58(90)50-47(79)14-16-64-50/h1-4,7-11,13,23-26,29-30,39-46,50,64-66,78H,5-6,12,14-22,27-28,60H2,(H2,61,80)(H,62,68)(H,63,69)(H,67,89)(H,70,83)(H,71,86)(H,72,87)(H,73,88)(H,74,85)(H,75,90)(H,76,84)(H,81,82)/t39-,40-,41-,42-,43-,44-,45-,46-,50+/m0/s1
  • InChiKey: LGTGCPOJKQMYSV-ZLPZQQKISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0606 1
Plasmodium falciparum tyrosine kinase-like protein 0.0119 0.2221 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0036 0.057 0.1609
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0189 0.3597 0.4336
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0262 0.1181
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Onchocerca volvulus 0.0308 0.5954 1
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.057 0.0958
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Brugia malayi SH2 domain containing protein 0.0189 0.3597 0.6041
Loa Loa (eye worm) hypothetical protein 0.0119 0.2221 0.3731
Echinococcus granulosus protein kinase 0.0119 0.2221 0.2221
Onchocerca volvulus 0.0119 0.2221 0.3731
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.2221 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0119 0.2221 0.2221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Loa Loa (eye worm) beta-lactamase 0.0038 0.0606 0.1018
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0119 0.2221 0.2221
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus granulosus epidermal growth factor receptor 0.0119 0.2221 0.2221
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0189 0.3597 0.3597
Echinococcus granulosus ephrin type A receptor 4 A 0.0119 0.2221 0.2221
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0119 0.2221 0.3731
Brugia malayi STAT protein, DNA binding domain containing protein 0.0189 0.3597 0.6041
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Echinococcus granulosus SH2 domain containing adapter protein F 0.0189 0.3597 0.3597
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.5954 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0189 0.3597 0.3597
Plasmodium vivax protein kinase, putative 0.0119 0.2221 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0119 0.2221 0.2221
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Echinococcus multilocularis SHC transforming protein 3 0.0189 0.3597 0.3597
Echinococcus granulosus tyrosine protein kinase pr2 0.0119 0.2221 0.2221
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0189 0.3597 0.6041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0308 0.5954 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0119 0.2221 0.3731
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0119 0.2221 0.2221
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.002 0.0262 0.1181
Echinococcus granulosus activated cdc42 kinase 1 0.0119 0.2221 0.2221
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0119 0.2221 0.6516
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0606 0.2729
Loa Loa (eye worm) hypothetical protein 0.0038 0.0606 0.1018
Echinococcus multilocularis N chimaerin 0.0189 0.3597 0.3597
Echinococcus granulosus dnaJ subfamily B 0.0426 0.8295 0.8295
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0016 0.0172 0.0172
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0036 0.057 0.2567
Echinococcus multilocularis NCK adaptor protein 0.0189 0.3597 0.3597
Schistosoma mansoni protein kinase 0.0119 0.2221 0.2678
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.112 0.135
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0047 0.0047
Echinococcus multilocularis protein KINase family member (kin 25) 0.0119 0.2221 0.2221
Mycobacterium tuberculosis Conserved protein 0.0038 0.0606 0.1316
Echinococcus multilocularis tyrosine protein kinase Abl 0.0308 0.5954 0.5954
Giardia lamblia Protein 21.1 0.0119 0.2221 1
Giardia lamblia Kinase, NEK 0.0119 0.2221 1
Schistosoma mansoni ephrin receptor 0.0119 0.2221 0.2678
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Echinococcus multilocularis tensin 0.0189 0.3597 0.3597
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0308 0.5954 0.5954
Echinococcus granulosus tyrosine protein kinase Fyn 0.0308 0.5954 0.5954
Onchocerca volvulus 0.0308 0.5954 1
Echinococcus granulosus tyrosine kinase 0.0119 0.2221 0.2221
Echinococcus multilocularis tyrosine kinase 0.0308 0.5954 0.5954
Entamoeba histolytica hypothetical protein 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0262 0.1181
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.5954 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.002 0.0262 0.0316
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Trypanosoma cruzi hypothetical protein, conserved 0.0179 0.3409 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Brugia malayi SH2 domain containing protein 0.0189 0.3597 0.6041
Brugia malayi hypothetical protein 0.0119 0.2221 0.3731
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0308 0.5954 0.5954
Echinococcus granulosus tyrosine protein kinase csk 0.0119 0.2221 0.2221
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0189 0.3597 0.3597
Onchocerca volvulus 0.0308 0.5954 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0606 0.1316
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Loa Loa (eye worm) TK/EGFR protein kinase 0.0119 0.2221 0.3731
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Schistosoma mansoni tyrosine kinase 0.0308 0.5954 0.7178
Loa Loa (eye worm) TK protein kinase 0.0119 0.2221 0.3731
Echinococcus granulosus activin receptor type 0.0119 0.2221 0.2221
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0119 0.2221 0.2221
Loa Loa (eye worm) TK/Met protein kinase 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.5954 1
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0119 0.2221 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.2221 0.3731
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0119 0.2221 0.2221
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.057 0.0958
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Echinococcus granulosus signal transduction protein lnk realted 0.0189 0.3597 0.3597
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0036 0.057 0.0688
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Entamoeba histolytica tyrosin kinase, putative 0.0119 0.2221 0.3731
Entamoeba histolytica serine/threonine kinase, putative 0.0119 0.2221 0.3731
Schistosoma mansoni protein kinase 0.0119 0.2221 0.2678
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0606 0.1018
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0189 0.3597 0.4336
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Brugia malayi Protein kinase domain containing protein 0.0308 0.5954 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Echinococcus granulosus tyrosine protein kinase csk 0.0119 0.2221 0.2221
Onchocerca volvulus 0.0189 0.3597 0.6041
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0119 0.2221 0.3731
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0189 0.3597 0.6041
Echinococcus granulosus fibroblast growth factor receptor 4 0.0119 0.2221 0.2221
Entamoeba histolytica tyrosin kinase, putative 0.0119 0.2221 0.3731
Echinococcus granulosus tyrosine kinase 0.0308 0.5954 0.5954
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Echinococcus multilocularis tensin 0.0189 0.3597 0.3597
Loa Loa (eye worm) TK protein kinase 0.0119 0.2221 0.3731
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.2221 1
Brugia malayi RhoGAP domain containing protein 0.0189 0.3597 0.6041
Echinococcus granulosus serine protein kinase ATM 0.002 0.0262 0.0262
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0119 0.2221 0.2221
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0189 0.3597 0.3597
Echinococcus multilocularis SH2 motif 0.0189 0.3597 0.3597
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0308 0.5954 0.5954
Brugia malayi SH2 domain containing protein 0.0189 0.3597 0.6041
Trypanosoma brucei Flagellum attachment zone protein 20 0.0119 0.2221 1
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0119 0.2221 0.3731
Echinococcus granulosus retinal guanylyl cyclase 2 0.0119 0.2221 0.2221
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Loa Loa (eye worm) TK/ACK protein kinase 0.0119 0.2221 0.3731
Echinococcus multilocularis tyrosine kinase 0.0119 0.2221 0.2221
Schistosoma mansoni fkbp-rapamycin associated protein 0.002 0.0262 0.0316
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Onchocerca volvulus 0.0189 0.3597 0.6041
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0119 0.2221 0.2221
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0189 0.3597 0.6041
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0189 0.3597 0.6041
Echinococcus granulosus retinal guanylyl cyclase 2 0.0119 0.2221 0.2221
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Leishmania major protein kinase, putative 0.0119 0.2221 0.6266
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Brugia malayi hypothetical protein 0.0189 0.3597 0.6041
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0189 0.3597 0.3597
Trichomonas vaginalis esterase, putative 0.0038 0.0606 0.2729
Schistosoma mansoni tensin-related 0.0189 0.3597 0.4336
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Schistosoma mansoni tensin 0.0189 0.3597 0.4336
Loa Loa (eye worm) TK/RYK protein kinase 0.0119 0.2221 0.3731
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0606 0.0606
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.5954 1
Loa Loa (eye worm) serine/threonine protein kinase 0.0119 0.2221 0.3731
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0119 0.2221 0.2221
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Brugia malayi hypothetical protein 0.0119 0.2221 0.3731
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0036 0.057 0.057
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0119 0.2221 0.2221
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0308 0.5954 0.5954
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Schistosoma mansoni tyrosine protein kinase 0.0119 0.2221 0.2678
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0011 0.0011
Echinococcus granulosus tyrosine protein kinase Srms 0.0308 0.5954 0.5954
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Echinococcus granulosus tyrosine protein kinase shark 0.0308 0.5954 0.5954
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0606 0.0606
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus multilocularis heat shock protein 70 0.0119 0.2221 0.2221
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Loa Loa (eye worm) protein kinase domain-containing protein 0.0119 0.2221 0.3731
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Schistosoma mansoni tensin 0.0189 0.3597 0.4336
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0119 0.2221 0.2221
Mycobacterium leprae Probable lipase LipE 0.0038 0.0606 1
Onchocerca volvulus 0.0119 0.2221 0.3731
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0119 0.2221 0.6516
Trichomonas vaginalis AGC family protein kinase 0.0119 0.2221 1
Schistosoma mansoni protein kinase 0.0119 0.2221 0.2678
Loa Loa (eye worm) TK protein kinase 0.0119 0.2221 0.3731
Onchocerca volvulus 0.0119 0.2221 0.3731
Loa Loa (eye worm) TK protein kinase 0.0119 0.2221 0.3731
Entamoeba histolytica hypothetical protein 0.0119 0.2221 0.3731
Echinococcus granulosus N chimaerin 0.0189 0.3597 0.3597
Echinococcus granulosus c src tyrosine kinase 0.0308 0.5954 0.5954
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Schistosoma mansoni suppressor of cytokine signaling 0.0189 0.3597 0.4336
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0606 0.1018
Schistosoma mansoni hypothetical protein 0.0426 0.8295 1
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Leishmania major hypothetical protein, conserved 0.0186 0.3545 1
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Loa Loa (eye worm) SH2 domain-containing protein 0.0189 0.3597 0.6041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.2221 0.3731
Onchocerca volvulus 0.0038 0.0606 0.1018
Loa Loa (eye worm) TK/FER protein kinase 0.0119 0.2221 0.3731
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0606 0.1018
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Toxoplasma gondii protein kinase domain-containing protein 0.0119 0.2221 1
Entamoeba histolytica receptor protein kinase, putative 0.0119 0.2221 0.3731
Brugia malayi SH2 domain containing protein 0.0189 0.3597 0.6041
Entamoeba histolytica serine/threonine kinase, putative 0.0119 0.2221 0.3731
Schistosoma mansoni cpg binding protein 0.003 0.0456 0.055
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0456 0.0766
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0308 0.5954 0.5954
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.057 0.1673
Echinococcus multilocularis tyrosine protein kinase csk 0.0119 0.2221 0.2221
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0119 0.2221 0.2221
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0308 0.1386
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0119 0.2221 0.3731
Echinococcus multilocularis signal transduction protein lnk realted 0.0189 0.3597 0.3597
Echinococcus multilocularis activated cdc42 kinase 1 0.0119 0.2221 0.2221
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0308 0.5954 0.5954
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0036 0.057 0.1673
Onchocerca volvulus 0.0308 0.5954 1
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.2221 0.2678
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0189 0.3597 0.4336
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Loa Loa (eye worm) STAT protein 0.0189 0.3597 0.6041
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Schistosoma mansoni tensin 0.0189 0.3597 0.4336
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0119 0.2221 0.3731
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.2221 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0308 0.5954 0.7178
Echinococcus multilocularis SH2 motif 0.0189 0.3597 0.3597
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Loa Loa (eye worm) TK/FER protein kinase 0.0119 0.2221 0.3731
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0036 0.057 0.1609
Entamoeba histolytica hypothetical protein 0.0119 0.2221 0.3731
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0308 0.5954 0.5954
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus multilocularis integrin linked protein kinase 0.0119 0.2221 0.2221
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus granulosus SH2 motif 0.0189 0.3597 0.3597
Echinococcus multilocularis tyrosine protein kinase shark 0.0308 0.5954 0.5954
Loa Loa (eye worm) TK/CSK protein kinase 0.0119 0.2221 0.3731
Schistosoma mansoni cpg binding protein 0.0032 0.049 0.0591
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0119 0.2221 1
Schistosoma mansoni ephrin receptor 0.0119 0.2221 0.2678
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus granulosus cpg binding protein 0.0032 0.049 0.049
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Brugia malayi Protein kinase domain containing protein 0.0308 0.5954 1
Echinococcus granulosus NCK adaptor protein 0.0189 0.3597 0.3597
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.002 0.0262 0.077
Echinococcus granulosus tyrosine protein kinase ABL1 0.0308 0.5954 0.5954
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0189 0.3597 0.4336
Trichomonas vaginalis protein kinase atn1, putative 0.0119 0.2221 1
Echinococcus granulosus epidermal growth factor receptor 0.0119 0.2221 0.2221
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0119 0.2221 0.3731
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0119 0.2221 0.2221
Schistosoma mansoni growth factor receptor-bound protein 0.0189 0.3597 0.4336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0172 0.0774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0606 0.2729
Entamoeba histolytica hypothetical protein 0.0119 0.2221 0.3731
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.2221 1
Entamoeba histolytica hypothetical protein 0.0119 0.2221 0.3731
Brugia malayi ephrin receptor 1 precursor 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Echinococcus granulosus tyrosine protein kinase Src64B 0.0308 0.5954 0.5954
Entamoeba histolytica hypothetical protein 0.0119 0.2221 0.3731
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0119 0.2221 0.2221
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0262 0.0441
Brugia malayi FAT domain containing protein 0.0016 0.0172 0.0289
Echinococcus granulosus tyrosine protein kinase HCK 0.0119 0.2221 0.2221
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0036 0.057 0.0958
Loa Loa (eye worm) hypothetical protein 0.0119 0.2221 0.3731
Toxoplasma gondii ABC1 family protein 0.0038 0.0606 0.2729
Loa Loa (eye worm) TK/ALK protein kinase 0.0119 0.2221 0.3731
Brugia malayi bone morphogenetic protein type 1 receptor 0.0119 0.2221 0.3731
Schistosoma mansoni shc transforming protein 0.0189 0.3597 0.4336
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0262 0.1181
Entamoeba histolytica hypothetical protein 0.0119 0.2221 0.3731
Echinococcus multilocularis c src tyrosine kinase 0.0308 0.5954 0.5954
Brugia malayi SH2 domain containing protein 0.0308 0.5954 1
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0119 0.2221 0.3731
Loa Loa (eye worm) hypothetical protein 0.0016 0.0172 0.0289
Echinococcus granulosus suppressor of cytokine signaling 7 0.0189 0.3597 0.3597
Onchocerca volvulus 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Schistosoma mansoni protein kinase 0.0119 0.2221 0.2678
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Schistosoma mansoni tyrosine kinase 0.0308 0.5954 0.7178
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0119 0.2221 0.3731
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0036 0.057 0.2567
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Schistosoma mansoni adapter molecule crk 0.0189 0.3597 0.4336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0308 0.1386
Brugia malayi Protein kinase domain containing protein 0.0308 0.5954 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0189 0.3597 0.3597
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Entamoeba histolytica tyrosin kinase, putative 0.0119 0.2221 0.3731
Echinococcus granulosus natriuretic peptide receptor 1 0.0119 0.2221 0.2221
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0308 0.5954 0.5954
Schistosoma mansoni suppressor of cytokine signaling 0.0189 0.3597 0.4336
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Schistosoma mansoni hypothetical protein 0.0016 0.0172 0.0207
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0119 0.2221 0.2678
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0036 0.057 0.0958
Echinococcus granulosus serine:threonine protein kinase SMG1 0.002 0.0262 0.0262
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Schistosoma mansoni protein kinase 0.0119 0.2221 0.2678
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0119 0.2221 0.2221
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0119 0.2221 0.2221
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0011 0.0011
Echinococcus multilocularis protein tyrosine kinase 0.0119 0.2221 0.2221
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0308 0.1386
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0013 0.0127 0.0371
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0986 0.4437
Loa Loa (eye worm) hypothetical protein 0.0022 0.0308 0.0517
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Entamoeba histolytica cysteine surface protein, putative 0.0119 0.2221 0.3731
Loa Loa (eye worm) TK/DDR protein kinase 0.0119 0.2221 0.3731
Brugia malayi Tyrosine-protein kinase abl-1 0.0308 0.5954 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0036 0.057 0.2567
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0606 0.5
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Echinococcus multilocularis cpg binding protein 0.0032 0.049 0.049
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0189 0.3597 0.6041
Echinococcus granulosus tyrosine protein kinase 0.0119 0.2221 0.2221
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus granulosus insulin receptor 0.0119 0.2221 0.2221
Onchocerca volvulus 0.0308 0.5954 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.057 0.2567
Brugia malayi Protein kinase domain containing protein 0.0308 0.5954 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0606 0.1316
Loa Loa (eye worm) hypothetical protein 0.0038 0.0606 0.1018
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0119 0.2221 0.2221
Schistosoma mansoni growth factor receptor-bound protein 0.0189 0.3597 0.4336
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0606 0.2729
Echinococcus granulosus retinal guanylyl cyclase 2 0.0119 0.2221 0.2221
Onchocerca volvulus Tyrosine kinase homolog 0.0119 0.2221 0.3731
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0189 0.3597 0.3597
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0036 0.057 0.1673
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Brugia malayi SH2 domain containing protein 0.0308 0.5954 1
Echinococcus multilocularis transfer RNA-Thr 0.0119 0.2221 0.2221
Echinococcus granulosus SH2 domain containing protein 7 0.0189 0.3597 0.3597
Entamoeba histolytica hypothetical protein 0.0119 0.2221 0.3731
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0606 0.0731
Giardia lamblia Kinase 0.0119 0.2221 1
Loa Loa (eye worm) TK protein kinase 0.0119 0.2221 0.3731
Entamoeba histolytica serine/threonine kinase, putative 0.0119 0.2221 0.3731
Schistosoma mansoni protein tyrosine kinase 0.0119 0.2221 0.2678
Brugia malayi SH2 domain containing protein 0.0189 0.3597 0.6041
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0119 0.2221 0.2221
Onchocerca volvulus 0.0119 0.2221 0.3731
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Echinococcus multilocularis raf serine:threonine protein kinase 0.0119 0.2221 0.2221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0189 0.3597 0.3597
Trypanosoma cruzi protein kinase, putative 0.0119 0.2221 0.6516
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0189 0.3597 0.3597
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0189 0.3597 0.3597
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0119 0.2221 0.2678
Brugia malayi hypothetical protein 0.0308 0.5954 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus granulosus SH2 motif 0.0189 0.3597 0.3597
Loa Loa (eye worm) hypothetical protein 0.0038 0.0606 0.1018
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Entamoeba histolytica hypothetical protein 0.002 0.0262 0.0441
Schistosoma mansoni tensin-related 0.0189 0.3597 0.4336
Entamoeba histolytica receptor protein kinase, putative 0.0119 0.2221 0.3731
Loa Loa (eye worm) hypothetical protein 0.0119 0.2221 0.3731
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0606 0.2729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0127 0.057
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Trypanosoma brucei Pseudokinase, putative 0.0119 0.2221 1
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Toxoplasma gondii STE kinase 0.0119 0.2221 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0119 0.2221 1
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Schistosoma mansoni protein kinase 0.0119 0.2221 0.2678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Schistosoma mansoni hypothetical protein 0.0119 0.2221 0.2678
Schistosoma mansoni tyrosine kinase 0.0308 0.5954 0.7178
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0262 0.1181
Schistosoma mansoni cpg binding protein 0.0032 0.049 0.0591
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0606 0.1316
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.2221 1
Leishmania major protein kinase, putative 0.0119 0.2221 0.6266
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Loa Loa (eye worm) TK/FER protein kinase 0.0119 0.2221 0.3731
Schistosoma mansoni protein kinase 0.0119 0.2221 0.2678
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0262 0.1181
Onchocerca volvulus 0.0308 0.5954 1
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Echinococcus granulosus tyrosine protein kinase Fyn 0.0308 0.5954 0.5954
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0262 0.0441
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Brugia malayi Variant SH3 domain containing protein 0.0189 0.3597 0.6041
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0119 0.2221 0.2678
Entamoeba histolytica serine/threonine kinase, putative 0.0119 0.2221 0.3731
Trichomonas vaginalis CAMK family protein kinase 0.0119 0.2221 1
Schistosoma mansoni serine/threonine RGC 0.0119 0.2221 0.2678
Brugia malayi Variant SH3 domain containing protein 0.0189 0.3597 0.6041
Brugia malayi SRC-1 0.0308 0.5954 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.2221 0.3731
Entamoeba histolytica hypothetical protein 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0262 0.1181
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0119 0.2221 0.3731
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0045 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0308 0.5954 1
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Schistosoma mansoni protein kinase 0.0119 0.2221 0.2678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0119 0.2221 0.2221
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0119 0.2221 0.2678
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0189 0.3597 0.6041
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0606 0.2729
Echinococcus granulosus protein tyrosine kinase 0.0119 0.2221 0.2221
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0119 0.2221 0.2221
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0119 0.2221 0.2221
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0119 0.2221 1
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Trypanosoma cruzi protein kinase, putative 0.0119 0.2221 0.6516
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0119 0.2221 1
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Onchocerca volvulus 0.0189 0.3597 0.6041
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0119 0.2221 0.2221
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0047 0.0079
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0119 0.2221 0.2221
Schistosoma mansoni GTPase activating protein 0.0189 0.3597 0.4336
Loa Loa (eye worm) TK protein kinase 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0036 0.057 0.2567
Brugia malayi integrin-linked kinase 0.0119 0.2221 0.3731
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0308 0.5954 0.5954
Brugia malayi beta-lactamase family protein 0.0038 0.0606 0.1018
Echinococcus granulosus tyrosine kinase 0.0308 0.5954 0.5954
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.5954 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0119 0.2221 0.3731
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0036 0.057 0.0688
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Echinococcus multilocularis protein kinase 0.0119 0.2221 0.2221
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Entamoeba histolytica protein kinase, putative 0.0189 0.3597 0.6041
Loa Loa (eye worm) TK protein kinase 0.0308 0.5954 1
Schistosoma mansoni protein kinase 0.0119 0.2221 0.2678
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.057 0.2567
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0262 0.1181
Brugia malayi Tensin 0.0189 0.3597 0.6041
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0119 0.2221 0.3731
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0606 0.2729
Loa Loa (eye worm) TK/ROR protein kinase 0.0119 0.2221 0.3731
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.5954 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0456 0.0766
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0513 1 1
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Onchocerca volvulus 0.0189 0.3597 0.6041
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.002 0.0262 0.0441
Brugia malayi protein-tyrosine kinase 0.0308 0.5954 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0119 0.2221 0.3731
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0189 0.3597 0.6041
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0016 0.0172 0.0172
Loa Loa (eye worm) TK/FER protein kinase 0.0119 0.2221 0.3731
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.2221 0.2678
Loa Loa (eye worm) TK/EPH protein kinase 0.0119 0.2221 0.3731
Onchocerca volvulus 0.0119 0.2221 0.3731
Echinococcus granulosus tyrosine protein kinase Blk 0.0308 0.5954 0.5954
Mycobacterium ulcerans hypothetical protein 0.0038 0.0606 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0022 0.0308 0.1386
Loa Loa (eye worm) RGC/RGC protein kinase 0.0119 0.2221 0.3731
Loa Loa (eye worm) hypothetical protein 0.0119 0.2221 0.3731
Echinococcus multilocularis growth factor receptor bound protein 2 0.0189 0.3597 0.3597
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0606 0.1316
Echinococcus granulosus kinase suppressor of Ras 1 0.0119 0.2221 0.2221
Loa Loa (eye worm) hypothetical protein 0.0119 0.2221 0.3731
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0036 0.057 0.057
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0011 0.0013
Mycobacterium ulcerans beta-lactamase 0.0038 0.0606 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0119 0.2221 0.2678
Echinococcus multilocularis natriuretic peptide receptor 1 0.0119 0.2221 0.2221
Brugia malayi Tyrosine-protein kinase PR2 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Brugia malayi Guanylyl cyclase protein 23 0.0119 0.2221 0.3731
Loa Loa (eye worm) hypothetical protein 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Entamoeba histolytica serine/threonine kinase, putative 0.0119 0.2221 0.3731
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.057 0.1673
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0119 0.2221 0.3731
Entamoeba histolytica ankyrin repeat protein 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Loa Loa (eye worm) hypothetical protein 0.0308 0.5954 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0119 0.2221 0.3731
Echinococcus granulosus receptor type guanylyl cyclase 0.0119 0.2221 0.2221
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0036 0.057 0.1673
Echinococcus multilocularis insulin receptor 0.0119 0.2221 0.2221
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0119 0.2221 0.2221
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Brugia malayi Protein kinase domain containing protein 0.0308 0.5954 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0119 0.2221 0.3731
Schistosoma mansoni tyrosine kinase 0.0308 0.5954 0.7178
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0189 0.3597 0.3597
Echinococcus multilocularis epidermal growth factor receptor 0.0119 0.2221 0.2221
Entamoeba histolytica ankyrin repeat protein 0.0119 0.2221 0.3731
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0189 0.3597 0.6041
Echinococcus multilocularis activin receptor type 0.0119 0.2221 0.2221
Loa Loa (eye worm) hypothetical protein 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.2221 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0308 0.5954 0.5954
Brugia malayi tRNA modification GTPase TrmE family protein 0.0189 0.3597 0.6041
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0119 0.2221 0.2678
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0189 0.3597 0.6041
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0606 0.1316
Trichomonas vaginalis TK family protein kinase 0.0119 0.2221 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Echinococcus multilocularis epidermal growth factor receptor 0.0119 0.2221 0.2221
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0119 0.2221 0.3731
Echinococcus granulosus activated cdc42 kinase 1 0.0119 0.2221 0.2221
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0308 0.5954 0.5954
Plasmodium vivax tyrosine kinase-like protein, putative 0.0119 0.2221 1
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0119 0.2221 0.3731
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Trypanosoma brucei protein kinase, putative 0.0119 0.2221 1
Brugia malayi Variant SH3 domain containing protein 0.0189 0.3597 0.6041
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0308 0.5954 0.5954
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Onchocerca volvulus 0.0038 0.0606 0.1018
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0606 0.1316
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0262 0.077
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0119 0.2221 0.2221
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0036 0.057 0.1609
Schistosoma mansoni protein kinase 0.0119 0.2221 0.2678
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0011 0.0011
Echinococcus multilocularis tyrosine protein kinase pr2 0.0119 0.2221 0.2221
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0119 0.2221 0.3731
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Loa Loa (eye worm) phosphatidylinositol 3 0.0036 0.057 0.0958
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus granulosus hypothetical protein 0.0189 0.3597 0.3597
Loa Loa (eye worm) RGC/RGC protein kinase 0.0119 0.2221 0.3731
Echinococcus multilocularis FL cytokine receptor 0.0119 0.2221 0.2221
Giardia lamblia Kinase, NEK 0.0119 0.2221 1
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Loa Loa (eye worm) hypothetical protein 0.002 0.0262 0.0441
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.5954 1
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Toxoplasma gondii FATC domain-containing protein 0.002 0.0262 0.1181
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0119 0.2221 0.3731
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0308 0.5954 0.5954
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0189 0.3597 0.3597
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0606 0.0731
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Loa Loa (eye worm) TK/FER protein kinase 0.0119 0.2221 0.3731
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0189 0.3597 0.3597
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Mycobacterium ulcerans lipase LipD 0.0038 0.0606 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0036 0.057 0.057
Schistosoma mansoni signal transduction protein lnk-related 0.0189 0.3597 0.4336
Entamoeba histolytica hypothetical protein 0.0119 0.2221 0.3731
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0308 0.5954 0.5954
Brugia malayi Receptor family ligand binding region containing protein 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0262 0.1181
Brugia malayi beta-lactamase family protein 0.0038 0.0606 0.1018
Brugia malayi Furin-like cysteine rich region family protein 0.0119 0.2221 0.3731
Echinococcus multilocularis SH2 motif 0.0189 0.3597 0.3597
Trichomonas vaginalis STE family protein kinase 0.0119 0.2221 1
Schistosoma mansoni tyrosine kinase 0.0308 0.5954 0.7178
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.057 0.1609
Leishmania major phosphatidylinositol 3-kinase, putative 0.0036 0.057 0.1609
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0119 0.2221 0.3731
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0606 0.1018
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0119 0.2221 1
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Echinococcus granulosus tyrosine protein kinase Lyn 0.0308 0.5954 0.5954
Onchocerca volvulus 0.0119 0.2221 0.3731
Brugia malayi Variant SH3 domain containing protein 0.0189 0.3597 0.6041
Plasmodium falciparum protein kinase, putative 0.0119 0.2221 1
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.2221 0.2678
Trichomonas vaginalis protein tyrosine kinase, putative 0.0119 0.2221 1
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Mycobacterium tuberculosis Conserved protein 0.0038 0.0606 0.1316
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.8295 0.8295
Loa Loa (eye worm) hypothetical protein 0.0119 0.2221 0.3731
Schistosoma mansoni serine/threonine protein kinase 0.0119 0.2221 0.2678
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Entamoeba histolytica hypothetical protein, conserved 0.0119 0.2221 0.3731
Echinococcus multilocularis serine protein kinase ATM 0.002 0.0262 0.0262
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Echinococcus granulosus tensin 0.0189 0.3597 0.3597
Onchocerca volvulus 0.0038 0.0606 0.1018
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.5954 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0189 0.3597 0.6041
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0308 0.5954 0.5954
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0119 0.2221 0.2221
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0119 0.2221 0.2221
Entamoeba histolytica protein kinase, putative 0.0119 0.2221 0.3731
Echinococcus multilocularis protein kinase 0.0119 0.2221 0.2221
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0036 0.057 0.057
Echinococcus multilocularis tyrosine protein kinase csk 0.0119 0.2221 0.2221
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.4605 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0189 0.3597 0.6041
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.5954 1
Schistosoma mansoni tyrosine kinase 0.0308 0.5954 0.7178
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0606 0.5
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Brugia malayi Sex muscle abnormal protein 5 0.0189 0.3597 0.6041
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Plasmodium falciparum protein kinase, putative 0.0119 0.2221 1
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Entamoeba histolytica protein kinase rad3, putative 0.002 0.0262 0.0441
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0606 0.1316
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Echinococcus multilocularis SH2 domain containing protein 7 0.0189 0.3597 0.3597
Echinococcus multilocularis tyrosine protein kinase 0.0119 0.2221 0.2221
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0119 0.2221 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0119 0.2221 0.3731
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Onchocerca volvulus 0.0119 0.2221 0.3731
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0189 0.3597 0.4336
Echinococcus granulosus tyrosine protein kinase Src42A 0.0189 0.3597 0.3597
Echinococcus multilocularis receptor type guanylyl cyclase 0.0119 0.2221 0.2221
Echinococcus granulosus raf serine:threonine protein kinase 0.0119 0.2221 0.2221
Echinococcus granulosus SHC transforming protein 3 0.0189 0.3597 0.3597
Entamoeba histolytica serine/threonine kinase, putative 0.0119 0.2221 0.3731
Loa Loa (eye worm) TK/FER protein kinase 0.0119 0.2221 0.3731
Mycobacterium tuberculosis Conserved protein 0.0038 0.0606 0.1316
Echinococcus granulosus integrin linked protein kinase 0.0119 0.2221 0.2221
Entamoeba histolytica tyrosin kinase, putative 0.0119 0.2221 0.3731
Plasmodium falciparum tyrosine kinase-like protein 0.0119 0.2221 1
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Loa Loa (eye worm) TK protein kinase 0.0119 0.2221 0.3731
Schistosoma mansoni vav2 0.0189 0.3597 0.4336
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0308 0.5954 0.5954
Loa Loa (eye worm) TK/FER protein kinase 0.0119 0.2221 0.3731
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Toxoplasma gondii protein kinase 0.0119 0.2221 1
Echinococcus granulosus tyrosine protein kinase csk 0.0119 0.2221 0.2221
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0308 0.5954 0.5954
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0119 0.2221 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.3597 0.6041
Loa Loa (eye worm) SRC-1 0.0308 0.5954 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Schistosoma mansoni SH2A 0.0189 0.3597 0.4336
Brugia malayi SH2 domain containing protein 0.0189 0.3597 0.6041
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0036 0.057 0.0958
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0119 0.2221 1
Loa Loa (eye worm) TK protein kinase 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0119 0.2221 0.3731
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0189 0.3597 0.3597
Schistosoma mansoni nck2/grb4 0.0189 0.3597 0.4336
Echinococcus multilocularis tyrosine protein kinase Blk 0.0308 0.5954 0.5954
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0189 0.3597 0.6041
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.2221 1
Entamoeba histolytica SH2 domain containing protein 0.0189 0.3597 0.6041
Echinococcus multilocularis tyrosine protein kinase csk 0.0119 0.2221 0.2221
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0119 0.2221 0.2221
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0606 0.1778
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0119 0.2221 0.2221
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0308 0.5954 0.5954
Schistosoma mansoni hypothetical protein 0.0189 0.3597 0.4336
Leishmania major hypothetical protein, conserved 0.0038 0.0606 0.171
Schistosoma mansoni hypothetical protein 0.0189 0.3597 0.4336
Onchocerca volvulus 0.0189 0.3597 0.6041
Brugia malayi Raf kinase 0.0119 0.2221 0.3731
Loa Loa (eye worm) hypothetical protein 0.0038 0.0606 0.1018
Loa Loa (eye worm) hypothetical protein 0.0013 0.0127 0.0213
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Giardia lamblia GTOR 0.0036 0.057 0.2567
Brugia malayi Protein kinase domain containing protein 0.0119 0.2221 0.3731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.057 0.2567
Loa Loa (eye worm) TK protein kinase 0.0119 0.2221 0.3731
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0189 0.3597 0.3597
Schistosoma mansoni tyrosine kinase 0.0119 0.2221 0.2678
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0308 0.5954 0.5954
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0606 0.2729
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0189 0.3597 0.6041
Echinococcus multilocularis 0.0189 0.3597 0.3597
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0606 0.1778
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.002 0.0262 0.0262
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0119 0.2221 0.3731
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.2221 0.3731
Entamoeba histolytica hypothetical protein 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Loa Loa (eye worm) TK/FER protein kinase 0.0308 0.5954 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.2221 0.3731
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0127 0.057
Onchocerca volvulus 0.0119 0.2221 0.3731
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Onchocerca volvulus 0.0189 0.3597 0.6041
Brugia malayi C-terminal src kinase protein 1 0.0119 0.2221 0.3731
Echinococcus multilocularis ephrin type A receptor 4 A 0.0119 0.2221 0.2221
Schistosoma mansoni protein kinase 0.0119 0.2221 0.2678
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0119 0.2221 1
Echinococcus granulosus expressed conserved protein 0.0189 0.3597 0.3597
Echinococcus granulosus tyrosine protein kinase Fyn 0.0308 0.5954 0.5954
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0308 0.5954 0.5954
Trichomonas vaginalis TKL family protein kinase 0.0119 0.2221 1
Onchocerca volvulus 0.003 0.0456 0.0766
Echinococcus granulosus suppressor of cytokine signaling 6 0.0189 0.3597 0.3597
Brugia malayi SH2 domain containing protein 0.0189 0.3597 0.6041
Entamoeba histolytica tyrosine kinase, putative 0.0119 0.2221 0.3731
Echinococcus multilocularis tyrosine protein kinase HCK 0.0119 0.2221 0.2221
Leishmania major hypothetical protein, conserved 0.0119 0.2221 0.6266
Brugia malayi beta-lactamase 0.0038 0.0606 0.1018
Plasmodium falciparum protein kinase, putative 0.0119 0.2221 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 14 % The concentration to inhibit cell proliferation of PC3 human tumour cell lines using the sulforhodamine B assay ChEMBL. 9341910
Inhibition (functional) = 18 % The concentration to inhibit cell proliferation of MDA-MB-231 human tumour cell lines using the sulforhodamine B assay ChEMBL. 9341910
Inhibition (functional) = 19 % The concentration to inhibit colony formation of PC3 human tumour cell lines ChEMBL. 9341910
Inhibition (functional) = 19 % The concentration to inhibit cell proliferation of MCF-7 human tumour cell lines using the sulforhodamine B assay ChEMBL. 9341910
Inhibition (functional) = 21 % The concentration to inhibit colony formation of Ishikawa human tumour cell lines ChEMBL. 9341910
Inhibition (functional) = 42 % The concentration to inhibit colony formation of MCF-7 human tumour cell lines ChEMBL. 9341910
Inhibition (functional) = 42 % The concentration to inhibit colony formation of MDA-MB-231 human tumour cell lines ChEMBL. 9341910

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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