TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1024.22 | Formula: C46H65N13O10S2
H donors: 11 H acceptors: 10 LogP: -1.53 Rotable bonds: 20
Rule of 5 violations (Lipinski): 3
SMILES: NC(=O)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccccc1)Cc1ccccc1)C(C)C
InChi: 1S/C46H65N13O10S2/c1-26(2)38-44(68)56-32(23-35(47)60)41(65)57-33(45(69)59-19-10-16-34(59)43(67)54-29(15-9-18-51-46(49)50)39(63)52-24-36(48)61)25-71-70-20-17-37(62)53-30(21-27-11-5-3-6-12-27)40(64)55-31(42(66)58-38)22-28-13-7-4-8-14-28/h3-8,11-14,26,29-34,38H,9-10,15-25H2,1-2H3,(H2,47,60)(H2,48,61)(H,52,63)(H,53,62)(H,54,67)(H,55,64)(H,56,68)(H,57,65)(H,58,66)(H4,49,50,51)/t29-,30-,31-,32-,33-,34-,38-/m0/s1
InChiKey: YDDZJUBSHQSGST-CDKUOFBKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Vasopressin V2 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	neuropeptide receptor	Vasopressin V2 receptor	370 aa	303 aa	24.1 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Vasopressin V2 receptor	370 aa	311 aa	21.2 %
Brugia malayi	GnHR receptor homolog	Vasopressin V2 receptor	370 aa	304 aa	23.0 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Vasopressin V2 receptor	370 aa	340 aa	20.9 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Vasopressin V2 receptor	370 aa	313 aa	20.1 %
Echinococcus granulosus	allatostatin A receptor	Vasopressin V2 receptor	370 aa	319 aa	23.2 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Vasopressin V2 receptor	370 aa	304 aa	24.0 %
Onchocerca volvulus		Vasopressin V2 receptor	370 aa	343 aa	22.7 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Vasopressin V2 receptor	370 aa	361 aa	22.2 %
Echinococcus multilocularis	allatostatin A receptor	Vasopressin V2 receptor	370 aa	321 aa	22.7 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Vasopressin V2 receptor	370 aa	329 aa	23.7 %
Schistosoma mansoni	adenoreceptor	Vasopressin V2 receptor	370 aa	314 aa	24.2 %
Echinococcus multilocularis	neuropeptide receptor	Vasopressin V2 receptor	370 aa	303 aa	23.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tubulin beta 1 chain	0.0132	0.7288	0.7093
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.0635	0.0871
Leishmania major	cytochrome p450-like protein	0.0089	0.4254	0.544
Trypanosoma cruzi	cytochrome P450, putative	0.0089	0.4254	0.544
Leishmania major	beta tubulin	0.0132	0.7288	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0052	0.1578	0.2166
Leishmania major	beta tubulin	0.0132	0.7288	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0052	0.1578	0.0973
Leishmania major	alpha tubulin	0.0052	0.1578	0.1418
Plasmodium vivax	tubulin alpha chain, putative	0.0052	0.1578	0.1418
Brugia malayi	beta-tubulin, identical	0.0132	0.7288	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0062	0.2344	0.2569
Loa Loa (eye worm)	tubulin alpha chain	0.0052	0.1578	0.2166
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0062	0.2344	0.4135
Giardia lamblia	Beta tubulin	0.0132	0.7288	1
Echinococcus multilocularis	tubulin alpha chain	0.0052	0.1578	0.0973
Schistosoma mansoni	tubulin subunit beta	0.0132	0.7288	0.678
Trypanosoma cruzi	alpha tubulin, putative	0.0052	0.1578	0.1418
Echinococcus granulosus	tubulin alpha chain	0.0052	0.1578	0.0973
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0132	0.7288	1
Leishmania major	alpha tubulin	0.0052	0.1578	0.1418
Plasmodium falciparum	tubulin beta chain	0.0132	0.7288	1
Echinococcus granulosus	tubulin alpha chain	0.0052	0.1578	0.0973
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1578	0.2166
Leishmania major	alpha tubulin	0.0052	0.1578	0.1418
Echinococcus multilocularis	tubulin epsilon chain	0.0052	0.1578	0.0973
Trypanosoma cruzi	epsilon tubulin, putative	0.0052	0.1578	0.1418
Plasmodium falciparum	tubulin gamma chain	0.0052	0.1578	0.1418
Trichomonas vaginalis	tubulin, putative	0.0132	0.7288	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0052	0.1578	0.2166
Trypanosoma brucei	tubulin gamma chain	0.0052	0.1578	0.2166
Echinococcus granulosus	Tubulin beta 2C chain	0.0132	0.7288	0.7093
Leishmania major	beta tubulin	0.0132	0.7288	1
Loa Loa (eye worm)	alpha-tubulin	0.0052	0.1578	0.2166
Loa Loa (eye worm)	BEN-1 protein	0.0132	0.7288	1
Loa Loa (eye worm)	glutathione reductase	0.0038	0.0635	0.0871
Plasmodium falciparum	alpha tubulin 1	0.0052	0.1578	0.1418
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0052	0.1578	0.1418
Plasmodium vivax	tubulin alpha chain, putative	0.0052	0.1578	0.1418
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0118	0.6288	0.6021
Toxoplasma gondii	beta-1 tubulin, putative	0.0132	0.7288	1
Leishmania major	beta tubulin	0.0132	0.7288	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0118	0.6288	0.6021
Trichomonas vaginalis	tubulin beta chain, putative	0.0052	0.1578	0.2166
Echinococcus multilocularis	Tubulin beta 2C chain	0.0132	0.7288	0.7093
Loa Loa (eye worm)	hypothetical protein	0.0064	0.2438	0.3345
Echinococcus multilocularis	peroxisome assembly protein 26	0.0052	0.1578	0.0973
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0052	0.1578	0.0973
Leishmania major	beta tubulin	0.0132	0.7288	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0132	0.7288	0.7093
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0097	0.4768	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0087	0.4083	0.8342
Leishmania major	beta tubulin	0.0132	0.7288	1
Trypanosoma brucei	alpha tubulin	0.0052	0.1578	0.2166
Brugia malayi	alpha-tubulin	0.0052	0.1578	0.2166
Trichomonas vaginalis	tubulin beta chain, putative	0.0052	0.1578	0.2166
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0062	0.2344	0.1793
Echinococcus multilocularis	tubulin alpha 1C chain	0.0052	0.1578	0.0973
Loa Loa (eye worm)	tubulin beta-2A chain	0.0132	0.7288	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0052	0.1578	0.0973
Loa Loa (eye worm)	cytochrome P450 family protein	0.0089	0.4254	0.5837
Echinococcus multilocularis	tubulin alpha 3 chain	0.0052	0.1578	0.0973
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0062	0.2344	0.1793
Trypanosoma cruzi	tubulin gamma chain	0.0052	0.1578	0.1418
Loa Loa (eye worm)	cytochrome P450 family protein	0.0089	0.4254	0.5837
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0087	0.4083	0.8342
Trichomonas vaginalis	tubulin beta chain, putative	0.0052	0.1578	0.2166
Giardia lamblia	Beta tubulin	0.0132	0.7288	1
Trypanosoma brucei	beta tubulin	0.0052	0.1578	0.2166
Trichomonas vaginalis	tubulin beta chain, putative	0.0132	0.7288	1
Leishmania major	beta tubulin	0.0132	0.7288	1
Schistosoma mansoni	tubulin subunit beta	0.0132	0.7288	0.678
Schistosoma mansoni	hypothetical protein	0.0171	1	1
Echinococcus granulosus	beta tubulin	0.0132	0.7288	0.7093
Trypanosoma brucei	epsilon tubulin	0.0052	0.1578	0.2166
Echinococcus granulosus	tubulin alpha 1C chain	0.0052	0.1578	0.0973
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0132	0.7288	0.7093
Echinococcus granulosus	tubulin gamma 1 chain	0.0052	0.1578	0.0973
Schistosoma mansoni	tubulin subunit beta	0.0132	0.7288	0.678
Loa Loa (eye worm)	tubulin beta-4 chain	0.0132	0.7288	1
Brugia malayi	Cytochrome P450 family protein	0.0089	0.4254	0.5837
Schistosoma mansoni	lipoxygenase	0.0118	0.6288	0.5593
Loa Loa (eye worm)	tubulin gamma chain	0.0052	0.1578	0.2166
Entamoeba histolytica	tubulin family protein	0.0132	0.7288	1
Trypanosoma brucei	cytochrome P450, putative	0.0089	0.4254	0.5837
Echinococcus multilocularis	tubulin alpha 3 chain	0.0052	0.1578	0.0973
Echinococcus multilocularis	tubulin gamma 1 chain	0.0052	0.1578	0.0973
Echinococcus granulosus	peroxisome assembly protein 26	0.0052	0.1578	0.0973
Toxoplasma gondii	alpha-tubulin I, putative	0.0052	0.1578	0.1418
Leishmania major	alpha tubulin	0.0052	0.1578	0.1418
Leishmania major	alpha tubulin	0.0052	0.1578	0.1418
Echinococcus granulosus	Tubulin alpha 1 chain	0.0052	0.1578	0.0973
Echinococcus multilocularis	beta tubulin	0.0132	0.7288	0.7093
Plasmodium vivax	tubulin beta chain, putative	0.0132	0.7288	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0052	0.1578	0.1418
Trypanosoma brucei	beta tubulin	0.0132	0.7288	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0052	0.1578	0.2166
Leishmania major	beta tubulin	0.0132	0.7288	1
Leishmania major	alpha tubulin	0.0052	0.1578	0.1418
Plasmodium vivax	tubulin epsilon chain, putative	0.0052	0.1578	0.1418
Leishmania major	alpha tubulin	0.0052	0.1578	0.1418
Loa Loa (eye worm)	CYP4Cod1	0.0089	0.4254	0.5837
Echinococcus multilocularis	tubulin alpha	0.0052	0.1578	0.0973
Loa Loa (eye worm)	BEN-1 protein	0.0132	0.7288	1
Trypanosoma cruzi	cytochrome P450, putative	0.0089	0.4254	0.544
Brugia malayi	Tubulin beta-1 chain	0.0132	0.7288	1
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0052	0.1578	0.2166
Toxoplasma gondii	aldehyde dehydrogenase	0.0062	0.2344	0.2569
Echinococcus multilocularis	Tubulin beta 2C chain	0.0132	0.7288	0.7093
Echinococcus granulosus	alpha tubulin	0.0052	0.1578	0.0973
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0097	0.4768	1
Leishmania major	beta tubulin	0.0132	0.7288	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0132	0.7288	0.7093
Brugia malayi	Cytochrome P450 family protein	0.0089	0.4254	0.5837
Schistosoma mansoni	tubulin subunit beta	0.0132	0.7288	0.678
Echinococcus granulosus	Tubulin beta 2C chain	0.0132	0.7288	0.7093
Mycobacterium tuberculosis	Probable reductase	0.0087	0.4083	0.8342
Trichomonas vaginalis	tubulin beta chain, putative	0.0052	0.1578	0.2166
Trypanosoma brucei	epsilon tubulin	0.0052	0.1578	0.2166
Echinococcus multilocularis	hypothetical protein	0.0052	0.1578	0.0973
Plasmodium falciparum	alpha tubulin 2	0.0052	0.1578	0.1418
Loa Loa (eye worm)	beta-tubulin	0.0132	0.7288	1
Echinococcus multilocularis	tubulin subunit beta	0.0132	0.7288	0.7093
Echinococcus multilocularis	geminin	0.0171	1	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0052	0.1578	0.1418
Trichomonas vaginalis	tubulin gamma chain, putative	0.0052	0.1578	0.2166
Echinococcus multilocularis	Tubulin beta 2C chain	0.0132	0.7288	0.7093
Schistosoma mansoni	tubulin subunit beta	0.0132	0.7288	0.678
Leishmania major	beta tubulin	0.0132	0.7288	1
Echinococcus multilocularis	tubulin alpha chain	0.0052	0.1578	0.0973
Echinococcus granulosus	Tubulin beta 2C chain	0.0132	0.7288	0.7093
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0052	0.1578	0.0973
Leishmania major	beta tubulin	0.0132	0.7288	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0087	0.4083	0.8342
Echinococcus multilocularis	tubulin subunit TubB	0.0052	0.1578	0.0973
Leishmania major	beta tubulin	0.0132	0.7288	1
Trypanosoma brucei	alpha tubulin	0.0052	0.1578	0.2166
Brugia malayi	glutathione reductase	0.0038	0.0635	0.0871
Giardia lamblia	Beta tubulin	0.0132	0.7288	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.0132	0.7288	0.7093
Brugia malayi	Tubulin gamma chain	0.0052	0.1578	0.2166
Echinococcus granulosus	tubulin alpha chain	0.0052	0.1578	0.0973
Echinococcus multilocularis	tubulin alpha chain	0.0052	0.1578	0.0973
Brugia malayi	Tubulin alpha chain	0.0052	0.1578	0.2166
Echinococcus granulosus	tubulin alpha 3 chain	0.0052	0.1578	0.0973
Loa Loa (eye worm)	tubulin alpha chain	0.0052	0.1578	0.2166
Trichomonas vaginalis	tubulin gamma chain, putative	0.0132	0.7288	1
Leishmania major	epsilon tubulin, putative	0.0052	0.1578	0.1418
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0097	0.4768	1
Leishmania major	beta tubulin	0.0132	0.7288	1
Trypanosoma brucei	epsilon tubulin	0.0052	0.1578	0.2166
Schistosoma mansoni	hypothetical protein	0.0171	1	1
Onchocerca volvulus		0.0029	0	0.5
Brugia malayi	Tubulin alpha-2 chain	0.0052	0.1578	0.2166
Plasmodium falciparum	tubulin epsilon chain, putative	0.0052	0.1578	0.1418
Echinococcus granulosus	tubulin alpha 1C chain	0.0052	0.1578	0.0973
Echinococcus multilocularis	tubulin alpha chain	0.0052	0.1578	0.0973
Trypanosoma brucei	beta tubulin	0.0132	0.7288	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0087	0.4083	0.8342
Toxoplasma gondii	beta-tubulin, putative	0.0132	0.7288	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0132	0.7288	0.7093
Brugia malayi	tubulin alpha chain - mouse	0.0052	0.1578	0.2166
Echinococcus multilocularis	beta tubulin	0.0132	0.7288	0.7093
Loa Loa (eye worm)	alpha-tubulin	0.0052	0.1578	0.2166
Echinococcus multilocularis	Tubulin beta 2C chain	0.0132	0.7288	0.7093
Leishmania major	beta tubulin	0.0132	0.7288	1
Leishmania major	alpha tubulin	0.0052	0.1578	0.1418
Toxoplasma gondii	beta tubulin	0.0132	0.7288	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0132	0.7288	1
Echinococcus granulosus	beta tubulin	0.0132	0.7288	0.7093
Trypanosoma cruzi	beta tubulin, putative	0.0132	0.7288	1
Trypanosoma brucei	beta tubulin	0.0132	0.7288	1
Trypanosoma brucei	alpha tubulin	0.0052	0.1578	0.2166
Schistosoma mansoni	lipoxygenase	0.0083	0.3777	0.2611
Echinococcus granulosus	tubulin alpha 3 chain	0.0052	0.1578	0.0973
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0089	0.4254	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0052	0.1578	0.2166
Trichomonas vaginalis	tubulin alpha chain, putative	0.0052	0.1578	0.2166
Leishmania major	alpha tubulin	0.0052	0.1578	0.1418
Echinococcus granulosus	tubulin alpha chain	0.0052	0.1578	0.0973
Echinococcus granulosus	tubulin subunit beta	0.0132	0.7288	0.7093
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0052	0.1578	0.0973
Leishmania major	alpha tubulin	0.0052	0.1578	0.1418
Echinococcus granulosus	tubulin alpha chain	0.0052	0.1578	0.0973
Leishmania major	alpha tubulin	0.0052	0.1578	0.1418
Leishmania major	beta tubulin	0.0132	0.7288	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0132	0.7288	1
Entamoeba histolytica	tubulin family protein	0.0132	0.7288	1
Echinococcus granulosus	tubulin subunit TubB	0.0052	0.1578	0.0973
Echinococcus multilocularis	tubulin alpha chain	0.0052	0.1578	0.0973
Brugia malayi	Tubulin alpha-2 chain	0.0052	0.1578	0.2166
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0087	0.4083	0.8342
Trypanosoma brucei	trypanothione reductase	0.0038	0.0635	0.0871
Trypanosoma brucei	beta tubulin	0.0132	0.7288	1
Plasmodium vivax	tubulin gamma chain, putative	0.0052	0.1578	0.1418
Leishmania major	beta tubulin	0.0132	0.7288	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0052	0.1578	0.2166
Leishmania major	beta tubulin	0.0132	0.7288	1
Loa Loa (eye worm)	tubulin beta chain	0.0132	0.7288	1
Echinococcus granulosus	tubulin alpha	0.0052	0.1578	0.0973
Leishmania major	alpha tubulin	0.0052	0.1578	0.1418
Echinococcus multilocularis	Tubulin beta 2C chain	0.0132	0.7288	0.7093
Echinococcus granulosus	Tubulin alpha 1 chain	0.0052	0.1578	0.0973
Echinococcus granulosus	tubulin epsilon chain	0.0052	0.1578	0.0973
Leishmania major	beta tubulin	0.0132	0.7288	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.2344	0.0909
Trypanosoma brucei	alpha tubulin	0.0052	0.1578	0.2166
Schistosoma mansoni	tubulin subunit beta	0.0132	0.7288	0.678
Mycobacterium tuberculosis	Probable oxidoreductase	0.0097	0.4768	1
Brugia malayi	Thioredoxin reductase	0.0038	0.0635	0.0871
Schistosoma mansoni	aldehyde dehydrogenase	0.0062	0.2344	0.0909
Brugia malayi	tubulin alpha-2 chain	0.0052	0.1578	0.2166
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0132	0.7288	1
Leishmania major	gamma-tubulin	0.0052	0.1578	0.1418
Trichomonas vaginalis	tubulin beta chain, putative	0.0052	0.1578	0.2166

Activities

Activity type	Activity value	Assay description	Source	Reference
K bind (binding)	= 0.0000001 M	Vasopressin V2 receptor binding affinity measured by competition with tritiated LVP lysine vasopressin in pig renal medullary preparation	ChEMBL.	2965243
Ki (binding)	= 0.00000001 M	Inhibition of LVP-sensitive adenylate cyclase in a pig renal medullary preparation	ChEMBL.	2965243

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2371440

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1745545