Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % | |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % | |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0109 | 0.0043 | 0.5 |
Loa Loa (eye worm) | solute carrier family 8 | 0.5822 | 0.3978 | 0.3978 |
Plasmodium falciparum | cation/H+ antiporter | 0.0147 | 0.007 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.0025 | 0.0063 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0109 | 0.0043 | 0.0043 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.0025 | 0.0025 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger 6 | 0.0147 | 0.007 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.007 | 0.007 |
Plasmodium vivax | cation/H+ antiporter, putative | 0.0147 | 0.007 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.0043 | 0.0492 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0109 | 0.0043 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0236 | 0.0131 | 0.0329 |
Echinococcus multilocularis | sodium:potassium:calcium exchanger | 0.0147 | 0.007 | 0.0176 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.0043 | 0.0492 |
Echinococcus granulosus | sodium:potassium:calcium exchanger 6 | 0.0147 | 0.007 | 0.0176 |
Toxoplasma gondii | manganese resistance 1 protein, putative | 0.0147 | 0.007 | 0.5 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0147 | 0.007 | 0.0176 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0109 | 0.0043 | 0.0109 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.0025 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.007 | 0.007 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0002 | 0.0004 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.0043 | 0.0492 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.0025 | 0.0063 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0236 | 0.0131 | 0.0329 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0109 | 0.0043 | 0.0043 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0109 | 0.0043 | 0.0109 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.0025 | 0.0025 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.0025 | 0.0063 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.0043 | 0.0492 |
Echinococcus multilocularis | sodium calcium exchanger | 0.5822 | 0.3978 | 1 |
Schistosoma mansoni | kinase | 0.0062 | 0.0012 | 0.0029 |
Brugia malayi | Na/Ca eXchangers family member (ncx-4) | 0.0147 | 0.007 | 0.007 |
Schistosoma mansoni | sodium/calcium exchanger | 0.5822 | 0.3978 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0109 | 0.0043 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0147 | 0.007 | 0.0888 |
Onchocerca volvulus | 1.4567 | 1 | 1 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.0043 | 0.0492 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0147 | 0.007 | 0.0888 |
Brugia malayi | Sodium/calcium exchanger protein | 0.2329 | 0.1573 | 0.1573 |
Schistosoma mansoni | potassium-dependent sodium-calcium exchanger 3 4 | 0.0147 | 0.007 | 0.0176 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.0043 | 0.0492 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0002 | 0.0002 |
Giardia lamblia | Kinase, PLK | 0.0109 | 0.0043 | 0.5 |
Trypanosoma brucei | polo-like protein kinase | 0.0109 | 0.0043 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1027 | 0.0676 | 1 |
Treponema pallidum | hypothetical protein | 0.0147 | 0.007 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.1027 | 0.0676 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0002 | 0.0004 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0109 | 0.0043 | 0.0492 |
Echinococcus granulosus | sodium calcium exchanger | 0.5822 | 0.3978 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0109 | 0.0043 | 0.0042 |
Mycobacterium leprae | Probable ionic transporter integral membrane protein ChaA | 0.0147 | 0.007 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0025 | 0.0025 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.0025 | 0.0063 |
Echinococcus granulosus | sodium:potassium:calcium exchanger | 0.0147 | 0.007 | 0.0176 |
Onchocerca volvulus | Sodium\/potassium\/calcium exchanger | 0.0147 | 0.007 | 0.0068 |
Loa Loa (eye worm) | Na/Ca eXchangers family member | 0.0147 | 0.007 | 0.007 |
Entamoeba histolytica | sodium/calcium exchanger protein, putative | 0.0147 | 0.007 | 1 |
Mycobacterium tuberculosis | Probable ionic transporter integral membrane protein ChaA | 0.0147 | 0.007 | 0.5 |
Brugia malayi | K+-dependent Na+/Ca+ exchanger related-protein | 0.0147 | 0.007 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.0131 | 0.0131 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0147 | 0.007 | 0.0888 |
Loa Loa (eye worm) | hypothetical protein | 0.2329 | 0.1573 | 0.1573 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.0025 | 0.0063 |
Schistosoma mansoni | na/ca exchanger | 0.0147 | 0.007 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.007 | 0.007 |
Brugia malayi | hypothetical protein | 0.0236 | 0.0131 | 0.0131 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.007 | 0.0176 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.0025 | 0.0025 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.0025 | 0.0063 |
Loa Loa (eye worm) | IKK protein kinase | 1.4567 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0109 | 0.0043 | 0.0109 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.