TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 516.635 | Formula: C29H36N6O3
H donors: 5 H acceptors: 3 LogP: 2.73 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: NC(=O)C(N(C(=O)[C@H](NC(=O)C(N)(C)C)Cc1c(C)[nH]c2c1cccc2)C)Cc1c(C)[nH]c2c1cccc2
InChi: 1S/C29H36N6O3/c1-16-20(18-10-6-8-12-22(18)32-16)14-24(34-28(38)29(3,4)31)27(37)35(5)25(26(30)36)15-21-17(2)33-23-13-9-7-11-19(21)23/h6-13,24-25,32-33H,14-15,31H2,1-5H3,(H2,30,36)(H,34,38)/t24-,25?/m1/s1
InChiKey: JSBLASUKADEFCD-IKOFQBKESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0097	0.0459	0.0458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1115	0.7386	0.7386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1006	0.6642	0.6642
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0097	0.0459	0.062
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0004	0.0002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1499	1	1
Schistosoma mansoni	biogenic amine receptor	0.003	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0306	0.1879	0.1879
Plasmodium vivax	hypothetical protein	0.0097	0.0459	1
Echinococcus granulosus	cathepsin b	0.0158	0.0873	0.0872
Brugia malayi	hypothetical protein	0.003	0.0004	0.0004
Echinococcus granulosus	serine protein kinase ATM	0.0284	0.173	0.1729
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Schistosoma mansoni	biogenic amine receptor	0.003	0.0004	0.0002
Brugia malayi	neuropeptide F receptor	0.003	0.0004	0.0004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0402	0.2537	0.2536
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0503	0.3221	0.322
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0087	0.0396	0.0394
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.003	0.0004	0.0004
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0004	0.0002
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0097	0.0459	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0148	0.0148
Echinococcus multilocularis	CD36 class B scavenger receptor	0.0051	0.0148	0.0147
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0097	0.0459	0.0459
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1115	0.7386	0.7386
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0097	0.0459	0.0458
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0004	0.0002
Onchocerca volvulus		0.003	0.0004	0.0051
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0004	0.0002
Onchocerca volvulus		0.0097	0.0459	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0097	0.0459	0.0458
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.003	0.0004	0.0004
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.003	0.0004	0.0002
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0097	0.0459	1
Schistosoma mansoni	cd36 antigen	0.0051	0.0148	0.0147
Loa Loa (eye worm)	phosphatidylinositol 3	0.0097	0.0459	0.0459
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1115	0.7386	0.7386
Echinococcus granulosus	neuropeptide receptor	0.003	0.0004	0.0002
Echinococcus granulosus	7tm_1 domain containing protein	0.003	0.0004	0.0002
Schistosoma mansoni	alpha-1 adrenergic receptor	0.003	0.0004	0.0002
Brugia malayi	hypothetical protein	0.003	0.0004	0.0004
Giardia lamblia	Hypothetical protein	0.0097	0.0459	0.0288
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0004	0.0002
Echinococcus multilocularis	lysosome membrane protein 2	0.0051	0.0148	0.0147
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.003	0.0004	0.0002
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.003	0.0004	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0219	0.1292	0.1291
Echinococcus multilocularis	somatostatin receptor	0.003	0.0004	0.0002
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.003	0.0004	0.0002
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0097	0.0459	0.0458
Echinococcus multilocularis	neuropeptides capa receptor	0.003	0.0004	0.0002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1193	0.7913	0.7913
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0097	0.0459	0.0458
Echinococcus granulosus	g protein coupled receptor	0.003	0.0004	0.0002
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0004	0.0002
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0004	0.0002
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0097	0.0459	0.0458
Echinococcus multilocularis	allatostatin A receptor	0.003	0.0004	0.0002
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0097	0.0459	0.0458
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.003	0.0004	0.0004
Brugia malayi	hypothetical protein	0.003	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0284	0.173	0.1729
Onchocerca volvulus	Matrilysin homolog	0.0053	0.0164	0.3549
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0097	0.0459	0.0458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0097	0.0459	0.0458
Leishmania major	phosphatidylinositol kinase, putative	0.0097	0.0459	0.0458
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0284	0.173	0.173
Trichomonas vaginalis	PIKK family atypical protein kinase	0.081	0.5308	0.5307
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0097	0.0459	0.0459
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0284	0.173	0.1729
Echinococcus granulosus	CD36 class B scavenger receptor	0.0051	0.0148	0.0147
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0097	0.0459	0.0458
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0097	0.0459	0.0458
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0097	0.0459	0.0458
Brugia malayi	sulfakinin receptor protein	0.003	0.0004	0.0004
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0284	0.173	0.1729
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0097	0.0459	1
Brugia malayi	Serotonin receptor	0.003	0.0004	0.0004
Echinococcus granulosus	CD36 class B scavenger receptor	0.0051	0.0148	0.0147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0808	0.53	0.5299
Schistosoma mansoni	hypothetical protein	0.003	0.0004	0.0002
Mycobacterium ulcerans	DNA polymerase IV	0.0045	0.0109	1
Onchocerca volvulus		0.003	0.0004	0.0051
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Giardia lamblia	GTOR	0.1499	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Echinococcus granulosus	CD36 class B scavenger receptor	0.0051	0.0148	0.0147
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0503	0.3221	0.322
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0004	0.0002
Mycobacterium ulcerans	DNA polymerase IV	0.0045	0.0109	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0503	0.3221	0.322
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0973	0.6422	0.6421
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0097	0.0459	0.0288
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.003	0.0004	0.0004
Echinococcus granulosus	allatostatin A receptor	0.003	0.0004	0.0002
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0503	0.3221	0.3221
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0503	0.3221	0.322
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0097	0.0459	0.0458
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0097	0.0459	0.0458
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0001	0.0001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1193	0.7913	0.7913
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0001	0.0001
Brugia malayi	G protein-coupled receptor	0.003	0.0004	0.0004
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0503	0.3221	0.322
Echinococcus granulosus	orexin receptor type 2	0.003	0.0004	0.0002
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0097	0.0459	0.0458
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0004	0.0002
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.003	0.0004	0.0002
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0097	0.0459	0.0458
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0503	0.3221	0.322
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.003	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0097	0.0459	0.0459
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Brugia malayi	hypothetical protein	0.0051	0.0148	0.0148
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1194	0.7922	0.7921
Brugia malayi	Tachykinin-like peptides receptor 99D	0.003	0.0004	0.0004
Brugia malayi	Dopamine receptor protein 2	0.003	0.0004	0.0004
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0097	0.0459	0.0458
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0097	0.0459	0.0459
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0004	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0414	0.0413
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0097	0.0459	0.0458
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0097	0.0459	0.0459
Echinococcus granulosus	CD36 class B scavenger receptor	0.0051	0.0148	0.0147
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0284	0.173	0.1729
Entamoeba histolytica	protein kinase rad3, putative	0.0284	0.173	0.1729
Schistosoma mansoni	histamine h1 receptor	0.003	0.0004	0.0002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0284	0.173	0.1729
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.003	0.0004	0.0002
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0001	0.0001
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1194	0.7922	0.7921
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.0414	0.0414
Onchocerca volvulus	Neuropeptide F receptor homolog	0.003	0.0004	0.0051
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0097	0.0459	0.062
Brugia malayi	hypothetical protein	0.003	0.0004	0.0004
Trypanosoma brucei	DNA polymerase IV, putative	0.0045	0.0109	0.0108
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0004	0.0004
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0097	0.0459	0.0458
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0097	0.0459	0.0458
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0097	0.0459	0.0458
Entamoeba histolytica	hypothetical protein	0.0097	0.0459	0.0458
Brugia malayi	Dopamine receptor protein 1	0.003	0.0004	0.0004
Brugia malayi	hypothetical protein	0.003	0.0004	0.0004
Brugia malayi	Papain family cysteine protease containing protein	0.0029	0.0001	0.0001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1499	1	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.1194	0.7922	0.7921
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.0414	0.0414
Schistosoma mansoni	opsin-like receptor	0.003	0.0004	0.0002
Schistosoma mansoni	opsin-like receptor	0.003	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Echinococcus granulosus	g protein coupled receptor	0.003	0.0004	0.0002
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0097	0.0459	1
Loa Loa (eye worm)	cysteine protease	0.0029	0.0001	0.0001
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0284	0.173	0.1729
Brugia malayi	putative neuropeptide receptor	0.003	0.0004	0.0004
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1499	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0097	0.0459	0.0458
Brugia malayi	GnHR receptor homolog	0.003	0.0004	0.0004
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0097	0.0459	0.0458
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0004	0.0002
Onchocerca volvulus		0.003	0.0004	0.0051
Echinococcus multilocularis		0.0097	0.0459	0.0458
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0004	0.0002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0004	0.0002
Brugia malayi	hypothetical protein	0.003	0.0004	0.0004
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0097	0.0459	0.0458
Brugia malayi	Matrixin family protein	0.0058	0.0196	0.0196
Echinococcus granulosus	hypothetical protein	0.003	0.0004	0.0002
Brugia malayi	polk-prov protein	0.0034	0.0034	0.0034
Brugia malayi	hypothetical protein	0.003	0.0004	0.0004
Trypanosoma brucei	unspecified product	0.0038	0.006	0.0058
Loa Loa (eye worm)	matrixin family protein	0.0053	0.0164	0.0164
Echinococcus multilocularis	neuropeptide s receptor	0.003	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Schistosoma mansoni	CD36-like class B scavenger receptor	0.0051	0.0148	0.0147
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0097	0.0459	0.0458
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1499	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0029	0.0001	0.0001
Brugia malayi	G-protein coupled receptor	0.003	0.0004	0.0004
Onchocerca volvulus		0.0097	0.0459	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0503	0.3221	0.322
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Leishmania major	hypothetical protein, conserved	0.0097	0.0459	0.0458
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0187	0.1072	0.1071
Loa Loa (eye worm)	ctsf protein	0.0029	0.0001	0.0001
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0097	0.0459	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0097	0.0459	0.0459
Toxoplasma gondii	FATC domain-containing protein	0.0284	0.173	0.2341
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.003	0.0004	0.0002
Loa Loa (eye worm)	phosphatidylinositol 3	0.0503	0.3221	0.3221
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0097	0.0459	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.003	0.0004	0.0002
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0004	0.0004
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.003	0.0004	0.0002
Echinococcus granulosus	dna polymerase kappa	0.0045	0.0109	0.0108
Entamoeba histolytica	hypothetical protein	0.0097	0.0459	0.0458
Echinococcus granulosus	neuropeptide receptor A26	0.003	0.0004	0.0002
Brugia malayi	cathepsin B-like cysteine proteinase	0.0158	0.0873	0.0873
Loa Loa (eye worm)	phosphatidylinositol 3	0.0097	0.0459	0.0459
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0004	0.0002
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0004	0.0002
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0284	0.173	0.173
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0004	0.0002
Echinococcus granulosus	sex peptide receptor	0.003	0.0004	0.0002
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.003	0.0004	0.0002
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.003	0.0004	0.0002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0004	0.0002
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0004	0.0002
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0097	0.0459	0.0458
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0097	0.0459	0.0459
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0097	0.0459	0.0458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0503	0.3221	0.322
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1499	1	1
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0004	0.0002
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0097	0.0459	0.0458
Schistosoma mansoni	biogenic amine receptor	0.003	0.0004	0.0002
Echinococcus multilocularis	neuropeptide receptor	0.003	0.0004	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Schistosoma mansoni	biogenic amine (5HT) receptor	0.003	0.0004	0.0002
Loa Loa (eye worm)	G-protein coupled receptor	0.003	0.0004	0.0004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0097	0.0459	0.0459
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0219	0.1292	0.1291
Brugia malayi	larval opioid receptor	0.003	0.0004	0.0004
Echinococcus multilocularis	G-protein coupled receptor, putative	0.003	0.0004	0.0002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0896	0.5895	0.5895
Brugia malayi	Melatonin receptor type 1A	0.003	0.0004	0.0004
Trypanosoma brucei	DNA polymerase IV, putative	0.0045	0.0109	0.0108
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0503	0.3221	0.322
Onchocerca volvulus		0.003	0.0004	0.0051
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.003	0.0004	0.0004
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0219	0.1292	0.1291
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0097	0.0459	0.0458
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Loa Loa (eye worm)	matrixin family protein	0.0058	0.0196	0.0196
Echinococcus granulosus	somatostatin receptor	0.003	0.0004	0.0002
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0284	0.173	0.1729
Echinococcus multilocularis	CD36 class B scavenger receptor	0.0051	0.0148	0.0147
Loa Loa (eye worm)	fibroinase	0.0029	0.0001	0.0001
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0623	0.4037	0.4036
Brugia malayi	CD36 family protein	0.0051	0.0148	0.0148
Echinococcus multilocularis	neuropeptide FF receptor 2	0.003	0.0004	0.0002
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0158	0.0873	0.0872
Schistosoma mansoni	hypothetical protein	0.0034	0.0033	0.0032
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.003	0.0004	0.0002
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0097	0.0459	1
Loa Loa (eye worm)	hypothetical protein	0.0219	0.1292	0.1292
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0158	0.0873	0.0872
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0097	0.0459	0.0458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.081	0.5308	0.5307
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1115	0.7386	0.7386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0887	0.5835	0.5834
Loa Loa (eye worm)	phosphatidylinositol 3	0.0097	0.0459	0.0459
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0055	0.0175	0.0174
Schistosoma mansoni	CD36-like class B scavenger receptor	0.0051	0.0148	0.0147
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0004	0.0002
Echinococcus multilocularis	cathepsin b	0.0158	0.0873	0.0872
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0097	0.0459	0.062
Echinococcus granulosus	serotonin receptor	0.003	0.0004	0.0002
Onchocerca volvulus		0.003	0.0004	0.0051
Echinococcus multilocularis	g-protein coupled receptor	0.003	0.0004	0.0002
Brugia malayi	FAT domain containing protein	0.0219	0.1292	0.1292
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0004	0.0002
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0097	0.0459	0.0459
Schistosoma mansoni	growth hormone secretagogue receptor	0.003	0.0004	0.0002
Onchocerca volvulus		0.003	0.0004	0.0051
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.003	0.0004	0.0002
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0414	0.0413
Onchocerca volvulus		0.003	0.0004	0.0051
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.003	0.0004	0.0004
Brugia malayi	AKH receptor	0.003	0.0004	0.0004
Brugia malayi	G protein-coupled receptor F59B2.13	0.003	0.0004	0.0004
Entamoeba histolytica	hypothetical protein	0.0097	0.0459	0.0458
Schistosoma mansoni	hypothetical protein	0.003	0.0004	0.0002
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0097	0.0459	0.0458
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1499	1	1
Toxoplasma gondii	cathepsin B	0.0055	0.0175	0.0236
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0158	0.0873	0.0872
Schistosoma mansoni	hypothetical protein	0.003	0.0004	0.0002
Echinococcus multilocularis	cathepsin b	0.0158	0.0873	0.0872
Schistosoma mansoni	amine GPCR	0.003	0.0004	0.0002
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0004	0.0002
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.006	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0459	0.0459
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Toxoplasma gondii	target of rapamycin (TOR), putative	0.1115	0.7386	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0414	0.0413
Trichomonas vaginalis	DNA polymerase eta, putative	0.0045	0.0109	0.0108
Echinococcus multilocularis	dna polymerase kappa	0.0045	0.0109	0.0108
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Echinococcus granulosus	CD36 class B scavenger receptor	0.0051	0.0148	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0001	0.0001
Echinococcus granulosus	neuropeptide receptor	0.003	0.0004	0.0002
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0097	0.0459	0.0458
Brugia malayi	hypothetical protein	0.003	0.0004	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0316	0.195	0.1949
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0414	0.0413
Echinococcus multilocularis	sex peptide receptor	0.003	0.0004	0.0002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.081	0.5308	0.5307
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0097	0.0459	0.0458
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0097	0.0459	0.0459
Trichomonas vaginalis	PIKK family atypical protein kinase	0.081	0.5308	0.5307
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0503	0.3221	0.322
Echinococcus multilocularis	serine protein kinase ATM	0.0284	0.173	0.1729
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0001	0.0001
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0158	0.0873	0.0872
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1115	0.7386	0.7386
Onchocerca volvulus		0.003	0.0004	0.0051
Schistosoma mansoni	neuropeptide receptor	0.003	0.0004	0.0002
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.003	0.0004	0.0002
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0097	0.0459	0.0458
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0503	0.3221	0.322
Schistosoma mansoni	neuropeptide F-like receptor	0.003	0.0004	0.0002
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1499	1	1
Schistosoma mansoni	amine GPCR	0.003	0.0004	0.0002
Mycobacterium leprae	conserved hypothetical protein	0.0097	0.0459	1
Schistosoma mansoni	hypothetical protein	0.003	0.0004	0.0002
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0097	0.0459	0.0458
Echinococcus multilocularis	CD36 class B scavenger receptor	0.0051	0.0148	0.0147
Brugia malayi	hypothetical protein	0.003	0.0004	0.0004
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.003	0.0004	0.0002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1193	0.7913	0.7913
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0097	0.0459	0.0458
Echinococcus multilocularis	neuropeptide Y receptor	0.003	0.0004	0.0002
Echinococcus granulosus	7TM GPCR rhodopsin	0.003	0.0004	0.0002
Echinococcus granulosus	fmrfamide receptor	0.003	0.0004	0.0002
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.003	0.0004	0.0002
Onchocerca volvulus	Lysosome membrane protein 2 homolog	0.0051	0.0148	0.3207
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Brugia malayi	G-protein coupled receptor	0.003	0.0004	0.0004
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1499	1	1
Schistosoma mansoni	neuropeptide receptor	0.003	0.0004	0.0002
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0097	0.0459	0.0458
Brugia malayi	neuropeptide F receptor	0.003	0.0004	0.0004
Echinococcus granulosus	G protein coupled receptor 139	0.003	0.0004	0.0002
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.003	0.0004	0.0002
Brugia malayi	Hemopexin family protein	0.0034	0.0033	0.0033
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0097	0.0459	0.0458
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0097	0.0459	0.0458
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0004	0.0002
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0175	0.0174
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0097	0.0459	0.0458
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0097	0.0459	0.0458
Brugia malayi	ORL1-like opioid receptor	0.003	0.0004	0.0004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.003	0.0004	0.0002
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0004	0.0002
Loa Loa (eye worm)	cathepsin B	0.0055	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0148	0.0148
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0097	0.0459	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1499	1	1
Schistosoma mansoni	neuropeptide receptor	0.003	0.0004	0.0002
Schistosoma mansoni	adenoreceptor	0.003	0.0004	0.0002
Echinococcus multilocularis	neuropeptide receptor A26	0.003	0.0004	0.0002
Echinococcus granulosus	tm gpcr rhodopsin	0.003	0.0004	0.0002
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0932	0.6142	0.6142
Schistosoma mansoni	hypothetical protein	0.0097	0.0459	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0034	0.0034
Loa Loa (eye worm)	phosphatidylinositol 3	0.1499	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0055	0.0175	0.0174
Echinococcus granulosus	alpha 1A adrenergic receptor	0.003	0.0004	0.0002
Echinococcus granulosus	neuropeptides capa receptor	0.003	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0034	0.0033
Leishmania major	hypothetical protein, unknown function	0.0097	0.0459	0.0458
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0148	0.0148
Brugia malayi	RE15519p	0.003	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Echinococcus granulosus	g-protein coupled receptor	0.003	0.0004	0.0002
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0097	0.0459	0.0458
Brugia malayi	putative neuropeptide receptor NPR1	0.003	0.0004	0.0004
Echinococcus multilocularis	Zinc finger, PHD finger	0.0097	0.0459	0.0458
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0001	0.0001
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0097	0.0459	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1193	0.7913	0.7913
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0459	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0148	0.0148
Brugia malayi	hypothetical protein	0.0051	0.0148	0.0148
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0029	0.0001	0.0001
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0097	0.0459	0.0458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1115	0.7386	0.7386
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.003	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1499	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Echinococcus granulosus	dro:myosuppressin receptor	0.003	0.0004	0.0002
Schistosoma mansoni	neuropeptide receptor	0.003	0.0004	0.0002
Schistosoma mansoni	amine GPCR	0.003	0.0004	0.0002
Echinococcus multilocularis	CD36 class B scavenger receptor	0.0051	0.0148	0.0147
Onchocerca volvulus		0.003	0.0004	0.0051
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0004	0.0002
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.003	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0097	0.0459	0.0458
Echinococcus multilocularis	orexin receptor type 2	0.003	0.0004	0.0002
Echinococcus granulosus	peptide allatostatin:somatostatin	0.003	0.0004	0.0002
Brugia malayi	hypothetical protein	0.003	0.0004	0.0004
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0053	0.0164	0.3549
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.003	0.0004	0.0004
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.003	0.0004	0.0002
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0284	0.173	0.1729
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.003	0.0004	0.0004
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0187	0.1072	0.1071
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0709	0.4624	0.4624
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0097	0.0459	0.0458
Echinococcus granulosus	neuropeptide Y receptor	0.003	0.0004	0.0002
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0808	0.53	0.5299
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0932	0.6142	0.6142
Schistosoma mansoni	neuropeptide f receptor 76f	0.003	0.0004	0.0002
Echinococcus multilocularis	G protein coupled receptor 139	0.003	0.0004	0.0002
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.003	0.0004	0.0002
Onchocerca volvulus		0.003	0.0004	0.0051
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0097	0.0459	0.0458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1499	1	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0503	0.3221	0.322
Trichomonas vaginalis	conserved hypothetical protein	0.0187	0.1072	0.1071
Echinococcus granulosus	biogenic amine 5HT receptor	0.003	0.0004	0.0002
Echinococcus granulosus	g protein coupled receptor	0.003	0.0004	0.0002
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0097	0.0459	0.0458
Echinococcus multilocularis	CD36 class B scavenger receptor	0.0051	0.0148	0.0147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0808	0.53	0.5299
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Loa Loa (eye worm)	TYRA-2 protein	0.003	0.0004	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0004	0.0002
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.003	0.0004	0.0002
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0097	0.0459	0.0288
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Echinococcus granulosus	neuropeptide s receptor	0.003	0.0004	0.0002
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1499	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.003	0.0004	0.0002
Echinococcus multilocularis	serotonin receptor	0.003	0.0004	0.0002
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.003	0.0004	0.0002
Schistosoma mansoni	amine GPCR	0.003	0.0004	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0097	0.0459	0.0458
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Echinococcus multilocularis	fmrfamide receptor	0.003	0.0004	0.0002
Loa Loa (eye worm)	phosphatidylinositol 3	0.0097	0.0459	0.0459
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0097	0.0459	0.0458
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Echinococcus multilocularis	dro:myosuppressin receptor	0.003	0.0004	0.0002
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0097	0.0459	0.062
Onchocerca volvulus		0.003	0.0004	0.0051
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0097	0.0459	0.0458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1193	0.7913	0.7913
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0887	0.5835	0.5834
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1115	0.7386	0.7386
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1072	0.1072
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0284	0.173	0.1729
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0097	0.0459	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0158	0.0873	0.0873
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0097	0.0459	0.0458
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0097	0.0459	0.0458
Onchocerca volvulus		0.003	0.0004	0.0051
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.0414	0.0413
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.128	0.8509	0.8508
Brugia malayi	Dopamine receptor	0.003	0.0004	0.0004
Echinococcus multilocularis	serotonin receptor	0.003	0.0004	0.0002
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0097	0.0459	0.0458
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0034	0.0033
Echinococcus multilocularis	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Entamoeba histolytica	hypothetical protein	0.0284	0.173	0.1729
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Onchocerca volvulus		0.003	0.0004	0.0051
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0097	0.0459	0.0458
Echinococcus granulosus	cathepsin b	0.0158	0.0873	0.0872
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0316	0.195	0.2639
Loa Loa (eye worm)	melatonin receptor type 1A	0.003	0.0004	0.0004
Echinococcus granulosus	lysosome membrane protein 2	0.0051	0.0148	0.0147
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0109	0.0108
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0097	0.0459	0.0458
Onchocerca volvulus		0.0034	0.0033	0.069
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.003	0.0004	0.0051
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0097	0.0459	0.0458
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0045	0.0109	0.0108
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0284	0.173	0.1729
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0503	0.3221	0.322
Loa Loa (eye worm)	hypothetical protein	0.0284	0.173	0.173
Onchocerca volvulus		0.003	0.0004	0.0051
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1499	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0503	0.3221	0.322
Schistosoma mansoni	amine GPCR	0.003	0.0004	0.0002
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0087	0.0396	0.0394
Echinococcus multilocularis	g protein coupled receptor	0.003	0.0004	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.003	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0316	0.195	0.195
Onchocerca volvulus		0.003	0.0004	0.0051
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0097	0.0459	0.0458
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0097	0.0459	0.0458
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0097	0.0459	0.0458
Schistosoma mansoni	scavenger receptor class B type-2 (sr-B2)	0.0051	0.0148	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0148	0.0148
Echinococcus granulosus	neuropeptide FF receptor 2	0.003	0.0004	0.0002
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0055	0.0175	0.0174
Onchocerca volvulus		0.003	0.0004	0.0051
Brugia malayi	follicle stimulating hormone receptor	0.003	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0219	0.1292	0.1291
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0896	0.5895	0.5895
Onchocerca volvulus		0.003	0.0004	0.0051
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.0414	0.0413
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0097	0.0459	0.0458
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.0414	0.0413
Entamoeba histolytica	hypothetical protein	0.0097	0.0459	0.0458
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0896	0.5895	0.5895
Schistosoma mansoni	myosin xvIII	0.003	0.0004	0.0002
Brugia malayi	Serotonin receptor	0.003	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0097	0.0459	0.0458
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1499	1	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0055	0.0175	0.0174
Loa Loa (eye worm)	neuropeptide F receptor	0.003	0.0004	0.0004
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0097	0.0459	0.062
Loa Loa (eye worm)	hypothetical protein	0.003	0.0004	0.0004
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0158	0.0873	0.0872
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0284	0.173	0.1729
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0148	0.0148
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.003	0.0004	0.0002
Schistosoma mansoni	opsin-like receptor	0.003	0.0004	0.0002
Plasmodium vivax	hypothetical protein, conserved	0.0097	0.0459	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Concentration (functional)	= 200 ng ml-1	Compound was measured for elevated levels of GH release in infant rats after administration of the compound subcutaneously at 300 microg/kg	ChEMBL.	9703459

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 175095