TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 380.48 | Formula: C23H28N2O3
H donors: 1 H acceptors: 2 LogP: 2.99 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COCCNC(=O)C1(C)CCCN(C1)C(=O)c1ccc(cc1)c1ccccc1
InChi: 1S/C23H28N2O3/c1-23(22(27)24-14-16-28-2)13-6-15-25(17-23)21(26)20-11-9-19(10-12-20)18-7-4-3-5-8-18/h3-5,7-12H,6,13-17H2,1-2H3,(H,24,27)
InChiKey: PCDFXQRZYCGJQR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.037	0.037
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0137	0.1813	0.2004
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0028	0.0277	0.0306
Echinococcus multilocularis	neuropeptide receptor A26	0.0019	0.0147	0.0162
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0147	0.0162
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0147	0.0162
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.002	0.0164	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0503	0.0503
Brugia malayi	hypothetical protein	0.0019	0.0147	0.0147
Brugia malayi	G-protein coupled receptor	0.0019	0.0147	0.0147
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0012	0.005	0.134
Echinococcus multilocularis	protein arginine N methyltransferase 7	0.0012	0.005	0.0055
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0647	0.9046	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus multilocularis	dnaJ subfamily B	0.0421	0.5838	0.6453
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0147	0.0162
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.002	0.0164	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.037	1
Echinococcus multilocularis	allatostatin A receptor	0.0019	0.0147	0.0162
Brugia malayi	G protein-coupled receptor	0.0019	0.0147	0.0147
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.037	0.1223
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0147	0.0162
Echinococcus multilocularis	G protein coupled receptor 139	0.0019	0.0147	0.0162
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0147	0.0162
Brugia malayi	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	dnaJ subfamily B	0.0421	0.5838	0.6453
Schistosoma mansoni	hypothetical protein	0.0019	0.0147	0.0162
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.037	0.037
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.002	0.0164	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Brugia malayi	Dopamine receptor protein 2	0.0019	0.0147	0.0147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0147	0.0162
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0147	0.0162
Leishmania major	hypothetical protein, conserved	0.0035	0.037	0.037
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0715	1	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.037	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.037	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0503	0.0556
Toxoplasma gondii	ABC1 family protein	0.0035	0.037	0.2061
Echinococcus multilocularis	orexin receptor type 2	0.0019	0.0147	0.0162
Echinococcus granulosus	allatostatin A receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0147	0.0162
Echinococcus multilocularis	cpg binding protein	0.0031	0.032	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Brugia malayi	Dopamine receptor protein 1	0.0019	0.0147	0.0147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0147	0.0162
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0147	0.0162
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0019	0.0147	0.0147
Echinococcus granulosus	fmrfamide receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0019	0.0147	0.0162
Brugia malayi	CXXC zinc finger family protein	0.003	0.0296	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	glutamate receptor 2	0.0012	0.0047	0.0052
Schistosoma mansoni	neuropeptide f receptor 76f	0.0019	0.0147	0.0162
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0007	0.0007
Plasmodium falciparum	phosphoethanolamine N-methyltransferase	0.0009	0	0.5
Echinococcus granulosus	vesicular acetylcholine transporter	0.0647	0.9046	1
Brugia malayi	larval opioid receptor	0.0019	0.0147	0.0147
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0035	0.037	0.037
Schistosoma mansoni	amine GPCR	0.0019	0.0147	0.0162
Brugia malayi	hypothetical protein	0.0019	0.0147	0.0147
Toxoplasma gondii	histone arginine methyltransferase PRMT4/CARM1	0.0135	0.1795	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0147	0.0162
Schistosoma mansoni	histamine h1 receptor	0.0019	0.0147	0.0162
Trypanosoma brucei	Protein arginine N-methyltransferase 1 catalytic subunit	0.0012	0.005	0.005
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0012	0.0047	0.0052
Mycobacterium ulcerans	beta-lactamase	0.0035	0.037	1
Mycobacterium tuberculosis	Conserved protein	0.0035	0.037	0.1223
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0019	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0035	0.037	0.037
Brugia malayi	follicle stimulating hormone receptor	0.0019	0.0147	0.0147
Schistosoma mansoni	amine GPCR	0.0019	0.0147	0.0162
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0503	0.0556
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Trypanosoma cruzi	arginine N-methyltransferase, type III	0.0012	0.005	0.005
Echinococcus granulosus	7tm_1 domain containing protein	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.037	0.1223
Loa Loa (eye worm)	hypothetical protein	0.0715	1	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0019	0.0147	0.0162
Brugia malayi	putative neuropeptide receptor NPR1	0.0019	0.0147	0.0147
Onchocerca volvulus		0.0035	0.037	0.0251
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0147	0.0162
Brugia malayi	G-protein coupled receptor	0.0019	0.0147	0.0147
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0147	0.0162
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0019	0.0147	0.0147
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0012	0.005	0.005
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0147	0.0162
Brugia malayi	Protein arginine N-methyltransferase	0.0012	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Brugia malayi	hypothetical protein	0.0019	0.0147	0.0147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0147	0.0162
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0019	0.0147	0.0147
Brugia malayi	neuropeptide F receptor	0.0019	0.0147	0.0147
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.067	0.3733
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0147	0.0162
Brugia malayi	Serotonin receptor	0.0019	0.0147	0.0147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0147	0.0162
Trypanosoma cruzi	arginine N-methyltransferase, putative	0.0012	0.005	0.005
Schistosoma mansoni	hypothetical protein	0.0012	0.005	0.0055
Echinococcus granulosus	methyltransferase protein 5	0.0012	0.005	0.0055
Brugia malayi	beta-lactamase	0.0035	0.037	0.037
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.037	0.0409
Schistosoma mansoni	opsin-like receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0019	0.0147	0.0147
Schistosoma mansoni	opsin-like receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0019	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0365	0.5051	0.5051
Echinococcus granulosus	dro:myosuppressin receptor	0.0019	0.0147	0.0162
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0147	0.0147
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0012	0.0047	0.0052
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0503	0.0556
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0019	0.0147	0.0162
Brugia malayi	Melatonin receptor type 1A	0.0019	0.0147	0.0147
Loa Loa (eye worm)	protein arginine N-methyltransferase	0.0012	0.005	0.005
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0296	0.0296
Plasmodium falciparum	protein arginine N-methyltransferase 1	0.0009	0	0.5
Echinococcus multilocularis	serotonin receptor	0.0137	0.1813	0.2004
Echinococcus multilocularis	nmda type glutamate receptor	0.0028	0.0277	0.0306
Echinococcus granulosus	g-protein coupled receptor	0.0019	0.0147	0.0162
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0647	0.9046	0.9046
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.002	0.0164	0.0544
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0035	0.037	0.037
Leishmania major	arginine N-methyltransferase, type I	0.0012	0.005	0.005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	protein arginine n-methyltransferase	0.0135	0.1795	0.1984
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.037	0.1223
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	neuropeptide receptor A26	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1813	0.1813
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0647	0.9046	0.9046
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0019	0.0147	0.0147
Entamoeba histolytica	arginine N-methyltransferase protein, putative	0.0012	0.005	0.5
Onchocerca volvulus		0.0123	0.1623	0.1658
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0012	0.0047	0.0052
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0019	0.0147	0.0162
Brugia malayi	hypothetical protein	0.0019	0.0147	0.0147
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0019	0.0147	0.0147
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	vesicular acetylcholine transporter	0.0647	0.9046	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0147	0.0162
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0012	0.005	0.134
Brugia malayi	Serotonin receptor	0.0463	0.6443	0.6443
Mycobacterium ulcerans	lipase LipD	0.0035	0.037	1
Entamoeba histolytica	arginine N-methyltransferase 1, putative	0.0012	0.005	0.5
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0147	0.0162
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0503	0.0503
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0012	0.0047	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0035	0.037	0.037
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0019	0.0147	0.0162
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.037	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0147	0.0162
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0019	0.0147	0.0162
Brugia malayi	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.037	0.0409
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0019	0.0147	0.0162
Echinococcus granulosus	protein arginine N methyltransferase 7	0.0012	0.005	0.0055
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0012	0.0047	0.0052
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.037	0.037
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0147	0.0162
Brugia malayi	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	cpg binding protein	0.0031	0.032	0.0353
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0147	0.0162
Brugia malayi	RE15519p	0.0019	0.0147	0.0147
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	hypothetical protein	0.0019	0.0147	0.0162
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0147	0.0162
Toxoplasma gondii	bicoid-interacting protein BIN3	0.0012	0.005	0.0276
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.037	0.1223
Toxoplasma gondii	histone arginine methyltransferase PRMT3	0.0012	0.005	0.0276
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Trypanosoma cruzi	protein arginine n-methyltransferase 7	0.0012	0.005	0.005
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	hypothetical protein	0.0019	0.0147	0.0162
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0715	1	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0012	0.0047	0.0052
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	neuropeptide s receptor	0.0019	0.0147	0.0162
Brugia malayi	G protein-coupled receptor F59B2.13	0.0019	0.0147	0.0147
Schistosoma mansoni	hypothetical protein	0.0019	0.0147	0.0162
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Loa Loa (eye worm)	beta-lactamase	0.0035	0.037	0.037
Echinococcus multilocularis	somatostatin receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Schistosoma mansoni	growth hormone secretagogue receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Schistosoma mansoni	amine GPCR	0.0019	0.0147	0.0162
Brugia malayi	beta-lactamase family protein	0.0035	0.037	0.037
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0019	0.0147	0.0147
Brugia malayi	GnHR receptor homolog	0.0019	0.0147	0.0147
Leishmania major	C-8 sterol isomerase-like protein	0.0715	1	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0019	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus multilocularis	histone arginine methyltransferase CARMER	0.0135	0.1795	0.1984
Entamoeba histolytica	hypothetical protein	0.0012	0.005	0.5
Echinococcus multilocularis	serotonin receptor	0.0137	0.1813	0.2004
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.037	0.0409
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1813	0.1813
Echinococcus multilocularis	g-protein coupled receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0035	0.037	0.037
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0019	0.0147	0.0162
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0019	0.0147	0.0147
Trypanosoma cruzi	arginine N-methyltransferase, type I	0.0012	0.005	0.005
Mycobacterium tuberculosis	Conserved protein	0.0035	0.037	0.1223
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0019	0.0147	0.0162
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	adenoreceptor	0.0019	0.0147	0.0162
Schistosoma mansoni	hypothetical protein	0.0019	0.0147	0.0162
Loa Loa (eye worm)	melatonin receptor type 1A	0.0019	0.0147	0.0147
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.037	1
Trypanosoma brucei	protein arginine n-methyltransferase 7	0.0012	0.005	0.005
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0147	0.0162
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.037	0.1223
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Brugia malayi	ORL1-like opioid receptor	0.0019	0.0147	0.0147
Loa Loa (eye worm)	TYRA-2 protein	0.0019	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Onchocerca volvulus		0.0035	0.037	0.0251
Schistosoma mansoni	cpg binding protein	0.0031	0.032	0.0353
Brugia malayi	Dopamine receptor	0.0019	0.0147	0.0147
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.037	1
Onchocerca volvulus		0.003	0.0296	0.0167
Loa Loa (eye worm)	Carm1-pending protein	0.0135	0.1795	0.1795
Brugia malayi	sulfakinin receptor protein	0.0019	0.0147	0.0147
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	orexin receptor type 2	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.037	0.1223
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0012	0.0047	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0147	0.0162
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.037	0.1223
Brugia malayi	putative neuropeptide receptor	0.0019	0.0147	0.0147
Echinococcus multilocularis	neuropeptide s receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	neuropeptide FF receptor 2	0.0019	0.0147	0.0162
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.002	0.0164	0.4447
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.037	1
Schistosoma mansoni	cpg binding protein	0.003	0.0296	0.0327
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0147	0.0162
Leishmania major	arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490	0.0012	0.005	0.005
Brugia malayi	neuropeptide F receptor	0.0019	0.0147	0.0147
Echinococcus granulosus	histone arginine methyltransferase CARMER	0.0135	0.1795	0.1984
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0647	0.9046	1
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0012	0.0047	0.0052
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.037	0.0409
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0765	0.0845
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0147	0.0162
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.037	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Schistosoma mansoni	amine GPCR	0.0019	0.0147	0.0162
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Brugia malayi	hypothetical protein	0.0012	0.005	0.005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0147	0.0162
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0503	0.0556
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.037	0.037
Echinococcus multilocularis	dro:myosuppressin receptor	0.0019	0.0147	0.0162
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Schistosoma mansoni	myosin xvIII	0.0019	0.0147	0.0162
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0147	0.0147
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.3025	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0005	0.0005
Trichomonas vaginalis	esterase, putative	0.0035	0.037	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.0147	0.0162
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0147	0.0162
Onchocerca volvulus		0.0035	0.037	0.0251
Trichomonas vaginalis	protein arginine N-methyltransferase, putative	0.0012	0.005	0.134
Loa Loa (eye worm)	hypothetical protein	0.0035	0.037	0.037
Echinococcus multilocularis	sex peptide receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Chlamydia trachomatis	glutamine binding protein	0.002	0.0164	0.5
Schistosoma mansoni	hypothetical protein	0.0421	0.5838	0.6453
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0503	0.0556
Brugia malayi	Carm1-pending protein	0.0135	0.1795	0.1795
Echinococcus granulosus	sex peptide receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	neuropeptide F receptor	0.0019	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0503	0.0556
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0019	0.0147	0.0162
Mycobacterium leprae	Probable lipase LipE	0.0035	0.037	1
Brugia malayi	hypothetical protein	0.0019	0.0147	0.0147
Trypanosoma cruzi	arginine N-methyltransferase, type I	0.0012	0.005	0.005
Schistosoma mansoni	glutamate receptor NMDA	0.0012	0.0047	0.0052
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0019	0.0147	0.0162
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0503	0.0556
Brugia malayi	hypothetical protein	0.0019	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0147	0.0162
Schistosoma mansoni	cpg binding protein	0.0031	0.032	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	somatostatin receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	biogenic amine 5HT receptor	0.0137	0.1813	0.2004
Schistosoma mansoni	amine GPCR	0.0192	0.2591	0.2864
Schistosoma mansoni	opsin-like receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	G-protein coupled receptor	0.0019	0.0147	0.0147
Echinococcus multilocularis	glutamate receptor 2	0.0012	0.0047	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0012	0.005	0.005
Echinococcus granulosus	serotonin receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0147	0.0162
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0147	0.0162
Mycobacterium tuberculosis	Conserved protein	0.0035	0.037	0.1223
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0147	0.0162
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0147	0.0162
Brugia malayi	AKH receptor	0.0019	0.0147	0.0147
Echinococcus granulosus	nmda type glutamate receptor	0.0028	0.0277	0.0306
Brugia malayi	beta-lactamase family protein	0.0035	0.037	0.037
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0147	0.0162
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.037	0.037
Mycobacterium ulcerans	hypothetical protein	0.0035	0.037	1
Echinococcus granulosus	G protein coupled receptor 139	0.0019	0.0147	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0019	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0147	0.0147
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0147	0.0162
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.037	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0019	0.0147	0.0162
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0147	0.0162
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0147	0.0162

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2359520

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1752559