Detailed information for compound 175743

Basic information

Technical information
  • TDR Targets ID: 175743
  • Name: 5-hydroxy-N,2-dimethyl-3-oxo-4-(1-phenylethyl )furan-2-carboxamide
  • MW: 275.3 | Formula: C15H17NO4
  • H donors: 2 H acceptors: 3 LogP: 2.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)C1(C)OC(=C(C1=O)C(c1ccccc1)C)O
  • InChi: 1S/C15H17NO4/c1-9(10-7-5-4-6-8-10)11-12(17)15(2,14(19)16-3)20-13(11)18/h4-9,18H,1-3H3,(H,16,19)
  • InChiKey: WYTWHVFMOQVWHE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-hydroxy-N,2-dimethyl-3-oxo-4-(1-phenylethyl)-2-furancarboxamide
  • 5-hydroxy-3-keto-N,2-dimethyl-4-(1-phenylethyl)-2-furamide
  • 2-Furancarboxamide, 2,5-dihydro-3-hydroxy-N,2-dimethyl-5-oxo-4-(1-phenylethyl)-
  • AIDS-210550
  • AIDS210550

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis musashi 0.0021 0.0027 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.007 0.0071
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.022 0.0506 0.3722
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0051 0.0336
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0011 0.0004 0.0004
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.0777 0.0777
Schistosoma mansoni survival motor neuron protein 0.0038 0.0067 0.0061
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.0575 0.1152
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.022 0.0506 0.0503
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0037 0.001
Mycobacterium tuberculosis Conserved protein 0.0039 0.007 0.0129
Echinococcus multilocularis lamin 0.0021 0.0027 0.014
Schistosoma mansoni ran 0.0023 0.0032 0.0025
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.022 0.0506 0.0872
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.022 0.0506 0.3722
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.022 0.0506 0.3722
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0036 0.0085
Schistosoma mansoni hypothetical protein 0.0028 0.0044 0.0038
Schistosoma mansoni importin beta-1 0.0031 0.0051 0.0045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0095 0.0503
Schistosoma mansoni hypothetical protein 0.0038 0.0067 0.0061
Onchocerca volvulus 0.0119 0.0262 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0012 0.0006 0.0028
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.007 0.0129
Toxoplasma gondii ABC1 family protein 0.0039 0.007 0.0475
Schistosoma mansoni lamin 0.0021 0.0027 0.0021
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0789 0.1879 0.3396
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.022 0.0506 0.1403
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.007 0.0071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0039 0.0071 0.0067
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.022 0.0506 0.05
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0006 0.0028
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.171 0.4098 0.7476
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0032 0.0163
Leishmania major cytochrome p450-like protein 0.0025 0.0036 0.0085
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.022 0.0506 0.269
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0028 0.0044 0.0231
Echinococcus granulosus lamin 0.0021 0.0027 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.007 0.0179
Mycobacterium leprae conserved hypothetical protein 0.057 0.1349 1
Plasmodium vivax importin-beta 2, putative 0.0031 0.0051 0.0336
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.228 0.5471 1
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.206 0.4941 1
Plasmodium vivax hypothetical protein, conserved 0.0039 0.007 0.0475
Loa Loa (eye worm) hypothetical protein 0.4159 1 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0024 0.005
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.228 0.5471 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0789 0.1879 0.3396
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0789 0.1879 0.3396
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0789 0.1879 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.022 0.0506 0.0503
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0012 0.0006 0.0028
Loa Loa (eye worm) hypothetical protein 0.0039 0.007 0.007
Brugia malayi Muscleblind-like protein 0.0278 0.0647 0.0644
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0789 0.1879 0.3396
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0789 0.1879 0.1874
Trichomonas vaginalis conserved hypothetical protein 0.228 0.5471 1
Brugia malayi hypothetical protein 0.0013 0.0007 0.0003
Brugia malayi hypothetical protein 0.0185 0.0423 0.042
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.022 0.0506 0.05
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0021 0.0027 0.0027
Plasmodium vivax phosphodiesterase gamma, putative 0.022 0.0506 0.3722
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0789 0.1879 1
Mycobacterium ulcerans beta-lactamase 0.0039 0.007 0.0069
Echinococcus granulosus importin subunit beta 1 0.0031 0.0051 0.0268
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0037 0.0087
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.022 0.0506 0.05
Brugia malayi beta-lactamase family protein 0.0039 0.007 0.0066
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.007 0.0179
Plasmodium falciparum GAF domain-related protein, putative 0.057 0.1349 1
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1349 0.2422
Toxoplasma gondii hypothetical protein 0.057 0.1349 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.022 0.0506 1
Trypanosoma brucei hypothetical protein, conserved 0.022 0.0506 0.1403
Brugia malayi beta-lactamase family protein 0.0039 0.007 0.0066
Loa Loa (eye worm) hypothetical protein 0.0039 0.007 0.007
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.228 0.5471 1
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0024 0.005
Entamoeba histolytica hypothetical protein 0.0025 0.0037 0.4387
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.007 0.0129
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0789 0.1879 0.5256
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Loa Loa (eye worm) hypothetical protein 0.057 0.1349 0.1349
Leishmania major GTP-binding protein, putative 0.0023 0.0032 0.0071
Brugia malayi latrophilin 2 splice variant baaae 0.0027 0.0041 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1349 0.2422
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.022 0.0506 0.1403
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0028 0.0044 0.0231
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.007 0.0069
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Leishmania major cAMP-specific phosphodiesterase, putative 0.022 0.0506 0.1403
Toxoplasma gondii GAF domain-containing protein 0.057 0.1349 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0223 0.0514 0.3779
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0006
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0032 0.0189
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.022 0.0506 0.05
Schistosoma mansoni hypothetical protein 0.0316 0.0737 0.0732
Brugia malayi Cytochrome P450 family protein 0.0025 0.0036 0.0033
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Loa Loa (eye worm) isocitrate dehydrogenase 0.0012 0.0006 0.0006
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0051 0.0127
Schistosoma mansoni intermediate filament proteins 0.0021 0.0027 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.007 0.0071
Echinococcus granulosus microtubule associated protein 2 0.0541 0.1281 0.6815
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0051 0.0127
Giardia lamblia hypothetical protein 0.022 0.0506 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0789 0.1879 0.3396
Brugia malayi beta-lactamase 0.0039 0.007 0.0066
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0789 0.1879 0.5256
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.007 0.0069
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.007 0.007
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.007 0.0129
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.206 0.4941 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0095 0.0089
Brugia malayi hypothetical protein 0.0119 0.0262 0.0258
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.149 0.3568 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.022 0.0506 0.0503
Brugia malayi Cytochrome P450 family protein 0.0025 0.0036 0.0033
Loa Loa (eye worm) intermediate filament protein 0.0021 0.0027 0.0027
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Loa Loa (eye worm) hypothetical protein 0.0185 0.0423 0.0423
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.022 0.0506 0.1403
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.007 0.0071
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.022 0.0506 0.269
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.057 0.1349 0.2721
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Leishmania major hypothetical protein, conserved 0.002 0.0024 0.005
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0223 0.0514 0.3779
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.022 0.0506 0.1403
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0032 0.0032
Brugia malayi follicle stimulating hormone receptor 0.0433 0.1021 0.1017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0026
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.007 0.0064
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.0051
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.022 0.0506 0.1403
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0039 0.0071 0.0071
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.0024 0.005
Echinococcus multilocularis muscleblind protein 0.0278 0.0647 0.3442
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.007 0.0368
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.022 0.0506 0.269
Echinococcus multilocularis geminin 0.0316 0.0737 0.3922
Schistosoma mansoni lamin 0.0021 0.0027 0.0021
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.022 0.0506 0.269
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0012 0.0006 0.0003
Mycobacterium tuberculosis Conserved protein 0.0039 0.007 0.0129
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0012 0.0006 0.0028
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.022 0.0506 0.269
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.007 0.0129
Echinococcus granulosus muscleblind protein 0.0278 0.0647 0.3442
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0789 0.1879 0.3396
Echinococcus multilocularis snurportin 1 0.0332 0.0777 0.4133
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0012 0.0006 0.0028
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0789 0.1879 0.5256
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.007 0.0179
Echinococcus multilocularis muscleblind protein 1 0.0278 0.0647 0.3442
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Leishmania major hypothetical protein, conserved 0.022 0.0506 0.1403
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.022 0.0506 0.0872
Brugia malayi isocitrate dehydrogenase 0.0012 0.0006 0.0003
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0032 0.0189
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.022 0.0506 0.269
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0012 0.0006 0.0028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0095 0.0503
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.171 0.4098 0.7476
Loa Loa (eye worm) hypothetical protein 0.0039 0.007 0.007
Leishmania major hypothetical protein, conserved 0.022 0.0506 0.1403
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0095 0.0089
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0789 0.1879 0.1876
Echinococcus granulosus intermediate filament protein 0.0021 0.0027 0.014
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.022 0.0506 0.269
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0024 0.0132
Entamoeba histolytica hypothetical protein 0.0028 0.0044 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0789 0.1879 0.5256
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.022 0.0506 0.05
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0095 0.0089
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.007 0.0129
Brugia malayi Isocitrate dehydrogenase 0.0012 0.0006 0.0003
Entamoeba histolytica hypothetical protein 0.0028 0.0044 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.022 0.0506 0.269
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0789 0.1879 0.3396
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0024 0.0132
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.0289 0.0289
Onchocerca volvulus 0.0039 0.007 0.1819
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0789 0.1879 0.3396
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.022 0.0506 0.1403
Trypanosoma cruzi hypothetical protein, conserved 0.022 0.0506 0.1403
Leishmania major importin beta-1 subunit, putative 0.0025 0.0037 0.0087
Entamoeba histolytica hypothetical protein 0.0028 0.0044 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.007 0.0129
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0012 0.0006 0.0028
Brugia malayi hypothetical protein 0.0028 0.0044 0.0041
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.022 0.0506 0.0872
Trypanosoma cruzi hypothetical protein, conserved 0.022 0.0506 0.1403
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0506 0.0872
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0037 0.001
Onchocerca volvulus 0.0039 0.007 0.1819
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.022 0.0506 0.0503
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0032 0.0028
Echinococcus granulosus GPCR family 2 0.0012 0.0006 0.0028
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0038 0.0067 0.0064
Loa Loa (eye worm) hypothetical protein 0.0278 0.0647 0.0647
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Loa Loa (eye worm) hypothetical protein 0.0278 0.0647 0.0647
Mycobacterium ulcerans putative regulatory protein 0.057 0.1349 0.2676
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.022 0.0506 0.05
Toxoplasma gondii hypothetical protein 0.057 0.1349 1
Echinococcus multilocularis survival motor neuron protein 1 0.0185 0.0423 0.2249
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0006 0.0028
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0433 0.1021 0.1021
Schistosoma mansoni ran 0.0023 0.0032 0.0025
Brugia malayi RNA, U transporter 1 0.0088 0.019 0.0186
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0037 0.001
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Loa Loa (eye worm) hypothetical protein 0.0021 0.0027 0.0027
Echinococcus granulosus geminin 0.0316 0.0737 0.3922
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.022 0.0506 0.0872
Loa Loa (eye worm) hypothetical protein 0.0039 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.022 0.0506 0.0506
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.022 0.0506 0.0872
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0039 0.007 0.0179
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0095 0.0092
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.022 0.0506 0.0872
Giardia lamblia Hypothetical protein 0.022 0.0506 1
Trypanosoma cruzi hypothetical protein, conserved 0.022 0.0506 0.1403
Echinococcus granulosus snurportin 1 0.0332 0.0777 0.4133
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1349 0.2422
Loa Loa (eye worm) hypothetical protein 0.0039 0.007 0.007
Mycobacterium ulcerans hypothetical protein 0.0039 0.007 0.0069
Trichomonas vaginalis esterase, putative 0.0039 0.007 0.0071
Echinococcus granulosus lamin dm0 0.0021 0.0027 0.014
Trichomonas vaginalis conserved hypothetical protein 0.057 0.1349 0.2422
Plasmodium falciparum phosphodiesterase delta, putative 0.022 0.0506 0.3722
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0036 0.0036
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0036 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.022 0.0506 0.1403
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.022 0.0506 0.0872
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.022 0.0506 0.0872
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Echinococcus multilocularis lamin dm0 0.0021 0.0027 0.014
Mycobacterium ulcerans lipase LipD 0.0039 0.007 0.0069
Schistosoma mansoni transcription factor LCR-F1 0.0028 0.0044 0.0038
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.022 0.0506 0.1403
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.4159 1 1
Onchocerca volvulus 0.0038 0.0067 0.1713
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0789 0.1879 0.3396
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0789 0.1879 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0006 0.0028
Plasmodium vivax hypothetical protein, conserved 0.057 0.1349 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0041
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.007 0.0368
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.022 0.0506 0.1403
Echinococcus multilocularis GPCR, family 2 0.0012 0.0006 0.0028
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Schistosoma mansoni microtubule-associated protein tau 0.0541 0.1281 0.1275
Loa Loa (eye worm) hypothetical protein 0.0119 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0039 0.0071 0.0071
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0789 0.1879 0.5256
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0095 0.0503
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.007 0.0129
Schistosoma mansoni hypothetical protein 0.0316 0.0737 0.0732
Mycobacterium tuberculosis Conserved protein 0.0039 0.007 0.0129
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0019
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.022 0.0506 0.269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0012 0.0006 0.0006
Entamoeba histolytica hypothetical protein 0.0028 0.0044 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.007 0.007
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.022 0.0506 0.05
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0032 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0095 0.0503
Plasmodium falciparum cGMP-specific phosphodiesterase 0.022 0.0506 0.3722
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.022 0.0506 0.05
Loa Loa (eye worm) hypothetical protein 0.022 0.0506 0.0506
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0789 0.1879 1
Echinococcus multilocularis microtubule associated protein 2 0.0541 0.1281 0.6815
Brugia malayi Latrophilin receptor protein 2 0.0012 0.0006 0.0003
Plasmodium falciparum phosphodiesterase gamma, putative 0.022 0.0506 0.3722
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.007 0.0064
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0636 0.1509 0.8032
Schistosoma mansoni hypothetical protein 0.0332 0.0777 0.0771
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.007 0.0071
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.022 0.0506 0.269
Onchocerca volvulus 0.0039 0.007 0.1819
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.0024 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.022 0.0506 0.1403
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0024 0.0132
Plasmodium falciparum importin beta, putative 0.0031 0.0051 0.0336
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.022 0.0506 0.3722
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0032 0.0071
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0036 0.0036
Toxoplasma gondii hypothetical protein 0.057 0.1349 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Loa Loa (eye worm) beta-lactamase 0.0039 0.007 0.007
Brugia malayi Calcitonin receptor-like protein seb-1 0.0039 0.0071 0.0067
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0032 0.0071
Echinococcus multilocularis isocitrate dehydrogenase 0.0012 0.0006 0.0028
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.0289 0.0289
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.022 0.0506 0.0506
Brugia malayi hypothetical protein 0.002 0.0024 0.002
Brugia malayi intermediate filament protein 0.0021 0.0027 0.0024
Brugia malayi Importin beta-1 subunit 0.0031 0.0051 0.0048
Mycobacterium ulcerans putative regulatory protein 0.057 0.1349 0.2676
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.149 0.3568 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.022 0.0506 0.05
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0095 0.0095
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.022 0.0506 0.269
Brugia malayi Intermediate filament tail domain containing protein 0.0021 0.0027 0.0024
Mycobacterium tuberculosis Conserved hypothetical protein 0.149 0.3568 0.7219
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0032 0.0189
Trypanosoma cruzi hypothetical protein, conserved 0.022 0.0506 0.1403
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Loa Loa (eye worm) PDE1B protein 0.022 0.0506 0.0506
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0789 0.1879 0.3396
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Leishmania major hypothetical protein, conserved 0.149 0.3568 1
Loa Loa (eye worm) hypothetical protein 0.022 0.0506 0.0506
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.022 0.0506 0.3722
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0032 0.0163
Brugia malayi MH2 domain containing protein 0.013 0.0289 0.0286
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0012 0.0006 0.0000048796
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0027 0.0041 0.0035
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.022 0.0506 0.0872
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.022 0.0506 0.3722
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0036 0.0085
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.022 0.0506 0.1403
Plasmodium falciparum cGMP-specific phosphodiesterase 0.022 0.0506 0.3722
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0789 0.1879 0.3396
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.022 0.0506 0.0872
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.007 0.0066
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.022 0.0506 0.1403
Trichomonas vaginalis conserved hypothetical protein 0.022 0.0506 0.0872
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.149 0.3568 1
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0051 0.0268
Echinococcus granulosus survival motor neuron protein 1 0.0185 0.0423 0.2249
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.022 0.0506 0.269

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 244 uM Inhibitory concentration of the compound against Protease ChEMBL. 15149657
IC50 (binding) = 244 uM Inhibitory concentration of the compound against Protease ChEMBL. 15149657

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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