Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Kappa opioid receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | ribokinase, putative | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | ribokinase | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.08 | 1 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | pseudouridine metabolizing bifunctional protein | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0031 | 0 | 0.5 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0031 | 0 | 0.5 |
Mycobacterium ulcerans | fructokinase, PfkB | 0.0031 | 0 | 0.5 |
Mycobacterium ulcerans | carbohydrate kinase CbhK | 0.0031 | 0 | 0.5 |
Leishmania major | adenosine kinase-like protein | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | ribokinase, putative | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | ribokinase | 0.0031 | 0 | 0.5 |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0031 | 0 | 0.5 |
Entamoeba histolytica | kinase, PfkB family | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | adenosine kinase | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | adenosine kinase | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | pseudouridine metabolizing bifunctional protein | 0.0031 | 0 | 0.5 |
Entamoeba histolytica | fructokinase, putative | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | Ribokinase RbsK | 0.0031 | 0 | 0.5 |
Mycobacterium leprae | Probable adenosine kinase adk | 0.0031 | 0 | 0.5 |
Leishmania major | adenosine kinase, putative | 0.0031 | 0 | 0.5 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0031 | 0 | 0.5 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.08 | 1 | 1 | |
Trichomonas vaginalis | ribokinase, putative | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | ribokinase, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | ribokinase, putative | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | ribokinase, putative | 0.0031 | 0 | 0.5 |
Leishmania major | putative PfkB family sugar kinase | 0.0031 | 0 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0031 | 0 | 0.5 |
Giardia lamblia | Ribokinase | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | Adenosine kinase | 0.0031 | 0 | 0.5 |
Leishmania major | ribokinase, putative | 0.0031 | 0 | 0.5 |
Leishmania major | tagatose-6-phosphate kinase-like protein | 0.0031 | 0 | 0.5 |
Entamoeba histolytica | ribokinase, putative | 0.0031 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0031 | 0 | 0.5 |
Leishmania major | tagatose-6-phosphate kinase-like protein | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | ribokinase | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.0031 | 0 | 0.5 |
Leishmania major | adenosine kinase-like protein | 0.0031 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Antinociceptive activity in acetic acid induced abdominal constriction assay after sc administration and abolished by naloxone administered at 3 mg/kg sc in mice; NT-Not Tested | ChEMBL. | 1659636 |
ED50 (functional) | = 0.71 mg kg-1 | Sedative activity after sc administration in female mice (Alderley Park strain) | ChEMBL. | 1659636 |
ED50 (functional) | = 0.71 mg kg-1 | Sedative activity after sc administration in female mice (Alderley Park strain) | ChEMBL. | 1659636 |
IC50 (binding) | = 8.2 nM | Binding affinity against opioid receptor kappa in guinea pig brain membrane using [3H]-bremazocine as the radioligand | ChEMBL. | 1659636 |
IC50 (binding) | = 8.2 nM | Binding affinity against opioid receptor kappa in guinea pig brain membrane using [3H]-bremazocine as the radioligand | ChEMBL. | 1659636 |
Ke (functional) | = 11.8 nM | In vitro efficacy in field stimulated mouse vas deferens assay expressed as Ke for naloxone versus compound | ChEMBL. | 1659636 |
Ke (functional) | = 11.8 nM | In vitro efficacy in field stimulated mouse vas deferens assay expressed as Ke for naloxone versus compound | ChEMBL. | 1659636 |
Potency ratio (functional) | = 10.3 | Agonistic activity on field stimulated mouse vas deferens preparation expressed as molar potency ratio of the compound relative to standard agonist EKC | ChEMBL. | 1659636 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.