Detailed information for compound 1765938

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 396.39 | Formula: C22H20O7
  • H donors: 2 H acceptors: 3 LogP: 3.03 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCc1c(COC(=O)C)cc2c(c1c1ccc(c(c1)O)OC)c1OCOc1cc2
  • InChi: 1S/C22H20O7/c1-12(24)27-10-15-7-13-4-6-19-22(29-11-28-19)21(13)20(16(15)9-23)14-3-5-18(26-2)17(25)8-14/h3-8,23,25H,9-11H2,1-2H3
  • InChiKey: FUNRWRBTAOMNKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.0547 0.0547
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0162 0.1864 1
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0599 0.3213
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.0344
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0373 0.0373
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.0547 0.0547
Schistosoma mansoni amine oxidase 0.0042 0.0321 0.0321
Echinococcus multilocularis neuropeptide s receptor 0.0452 0.5569 0.5569
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0547 0.2934
Leishmania major DNA damage repair protein, putative 0.002 0.0041 0.0219
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.013 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0348 0.1866
Plasmodium falciparum protoporphyrinogen oxidase 0.0042 0.0321 0.1538
Echinococcus granulosus neuropeptide s receptor 0.0452 0.5569 0.5569
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.0547 0.2934
Leishmania major UDP-galactopyranose mutase 0.0042 0.0321 0.1724
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0042 0.0321 0.0438
Loa Loa (eye worm) CBP-B 0.015 0.1705 0.1824
Brugia malayi Cytochrome P450 family protein 0.0061 0.0567 0.0606
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0321 0.1538
Brugia malayi Inositol-1 0.0036 0.0255 0.0273
Echinococcus granulosus neuropeptide receptor A26 0.0452 0.5569 0.5569
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0063 0.06 0.06
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0219
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0162 0.1864 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0061 0.0567 0.0606
Leishmania major DNA polymerase eta, putative 0.0063 0.0599 0.3213
Echinococcus multilocularis neuropeptide receptor A26 0.0452 0.5569 0.5569
Schistosoma mansoni dihydroorotate dehydrogenase 0.0162 0.1864 0.1864
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0041 0.0219
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.0321 0.1724
Trypanosoma cruzi UDP-galactopyranose mutase 0.0042 0.0321 0.1724
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0255 0.1369
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0063 0.06 1
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0599 0.3213
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0042 0.0321 0.1538
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.0547 0.0585
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0206 0.0303
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0063 0.06 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0041 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0321 0.0472
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0011 0.0012
Brugia malayi SWIRM domain containing protein 0.0042 0.0321 0.0344
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.0547 0.9066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1034 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0255 0.1369
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0162 0.1864 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.0344
Echinococcus granulosus dna polymerase kappa 0.0063 0.0599 0.0599
Toxoplasma gondii histone lysine-specific demethylase 0.0042 0.0321 0.1724
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0041 0.0219
Schistosoma mansoni terminal deoxycytidyl transferase 0.0063 0.0599 0.0599
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0373 0.0373
Schistosoma mansoni hypothetical protein 0.0031 0.0183 0.0183
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0243 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1034 0.1106
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0255 0.0255
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0255 0.1369
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0183 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0009 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.0344
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0063 0.0599 0.0599
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.0321 0.0321
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0507 0.0542
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0041 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0348 0.1866
Echinococcus multilocularis dnaJ subfamily B 0.0798 1 1
Schistosoma mansoni hypothetical protein 0.0031 0.0183 0.0183
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0011 0.0011
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0216 0.2548 0.2548
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0183 0.0183
Brugia malayi TAZ zinc finger family protein 0.0216 0.2548 0.2725
Loa Loa (eye worm) hypothetical protein 0.0097 0.1034 0.1106
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.06 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.06 1
Echinococcus multilocularis CREB binding protein 0.0035 0.0242 0.0242
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0547 0.0547
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.0547 0.2934
Trypanosoma brucei unspecified product 0.0044 0.0348 0.1866
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0042 0.0321 0.0321
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.0547 0.2934
Brugia malayi Cytochrome P450 family protein 0.0027 0.013 0.0139
Trypanosoma brucei unspecified product 0.0063 0.0599 0.3213
Schistosoma mansoni DNA polymerase eta 0.0063 0.0599 0.0599
Trypanosoma brucei cytochrome P450, putative 0.0027 0.013 0.0699
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0547 0.8468
Echinococcus multilocularis protoporphyrinogen oxidase 0.0042 0.0321 0.0321
Schistosoma mansoni inositol monophosphatase 0.0036 0.0255 0.0255
Echinococcus granulosus GPCR family 2 0.0031 0.0183 0.0183
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.0547 0.2934
Echinococcus granulosus CREB binding protein 0.0133 0.1491 0.1491
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0063 0.0599 0.0599
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0255 0.0348
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.0547 0.2934
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0183 0.0196
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.0547 0.2934
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0063 0.0599 0.0599
Loa Loa (eye worm) hypothetical protein 0.0063 0.0599 0.064
Echinococcus multilocularis 0.0042 0.0321 0.0321
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0041 0.0219
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0042 0.0321 0.1538
Mycobacterium tuberculosis Conserved hypothetical protein 0.0063 0.0599 0.088
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0063 0.0599 0.9981
Echinococcus multilocularis cpg binding protein 0.0059 0.0547 0.0547
Echinococcus multilocularis GPCR, family 2 0.0031 0.0183 0.0183
Brugia malayi hypothetical protein 0.0035 0.0243 0.026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.0344
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.0547 0.0547
Trypanosoma brucei unspecified product 0.0044 0.0348 0.1866
Echinococcus granulosus CREB binding protein 0.0035 0.0242 0.0242
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0255 0.1369
Brugia malayi amine oxidase, flavin-containing family protein 0.0042 0.0321 0.0344
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.064 0.0685
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0243 0.0243
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0042 0.0321 0.0321
Mycobacterium ulcerans oxidoreductase 0.0042 0.0321 0.0438
Mycobacterium tuberculosis Possible oxidoreductase 0.0042 0.0321 0.0472
Schistosoma mansoni CREB-binding protein 2 0.0216 0.2548 0.2548
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.0599 0.3213
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0547 0.8468
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0255 0.0339
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.013 0.0699
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0549 0.6808 1
Echinococcus granulosus geminin 0.0361 0.4402 0.4402
Loa Loa (eye worm) transcription factor SMAD2 0.0217 0.2559 0.2737
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1034 0.1106
Schistosoma mansoni cpg binding protein 0.0059 0.0547 0.0547
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0045 0.0365 0.1958
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0373 0.0373
Schistosoma mansoni hypothetical protein 0.0067 0.064 0.064
Echinococcus multilocularis dna polymerase kappa 0.0063 0.0599 0.0599
Echinococcus granulosus CREB binding protein 0.0035 0.0242 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0162 0.1864 1
Loa Loa (eye worm) inositol-1 0.0036 0.0255 0.0273
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0599 0.0816
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0547 0.8468
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0183 0.0196
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0063 0.06 0.06
Leishmania major DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Echinococcus multilocularis dna polymerase eta 0.0063 0.0599 0.0599
Mycobacterium ulcerans hypothetical protein 0.002 0.0041 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Echinococcus multilocularis CREB binding protein 0.0035 0.0242 0.0242
Trypanosoma brucei protein kinase, putative 0.0059 0.0547 0.2934
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0063 0.06 0.06
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0373 0.0398
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0373 0.0373
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0255 0.1369
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.013 0.0699
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0041 0.0219
Schistosoma mansoni amine oxidase 0.0042 0.0321 0.0321
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0063 0.0599 0.064
Brugia malayi MAP kinase sur-1 0.0059 0.0547 0.0585
Leishmania major DNA polymerase kappa, putative 0.002 0.0041 0.0219
Brugia malayi CXXC zinc finger family protein 0.0056 0.0507 0.0542
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0042 0.0321 0.1724
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0063 0.06 0.3217
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0162 0.1864 0.1993
Schistosoma mansoni cpg binding protein 0.0059 0.0547 0.0547
Schistosoma mansoni hypothetical protein 0.0361 0.4402 0.4402
Brugia malayi hypothetical protein 0.0042 0.0321 0.0344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0373 0.0373
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0162 0.1864 0.254
Brugia malayi Cytochrome P450 family protein 0.0027 0.013 0.0139
Onchocerca volvulus 0.0056 0.0507 1
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0041 0.0219
Mycobacterium ulcerans DNA polymerase IV 0.0063 0.0599 0.0816
Echinococcus granulosus dna polymerase eta 0.0063 0.0599 0.0599
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0599 0.3213
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.013 0.0177
Schistosoma mansoni hypothetical protein 0.0361 0.4402 0.4402
Schistosoma mansoni inositol monophosphatase 0.0036 0.0255 0.0255
Echinococcus multilocularis CREB binding protein 0.0035 0.0242 0.0242
Schistosoma mansoni microtubule-associated protein tau 0.068 0.8489 0.8489
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0067 0.064 0.0685
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0042 0.0321 0.0321
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0183 0.0183
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0063 0.06 0.06
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0599 0.064
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0373 0.0398
Leishmania major DNA polymerase eta, putative 0.002 0.0041 0.0219
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0162 0.1864 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.06 1
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0162 0.1864 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0063 0.0599 0.9982
Brugia malayi MH2 domain containing protein 0.0217 0.2559 0.2737
Echinococcus multilocularis CREB binding protein 0.0148 0.1681 0.1681
Schistosoma mansoni hypothetical protein 0.0035 0.0243 0.0243
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0373 0.0373
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.06 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.0344
Loa Loa (eye worm) hypothetical protein 0.0101 0.1085 0.116
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0183 0.0196
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0348 0.1866
Loa Loa (eye worm) MH2 domain-containing protein 0.0217 0.2559 0.2737
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0547 0.8468
Giardia lamblia DINP protein human, muc B family 0.0063 0.0599 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0063 0.0599 0.9981
Brugia malayi Zinc finger, C2H2 type family protein 0.0063 0.06 0.0641
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.013 0.0139
Echinococcus multilocularis microtubule associated protein 2 0.068 0.8489 0.8489
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0041 0.0219
Schistosoma mansoni cpg binding protein 0.0056 0.0507 0.0507
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.0599 0.088
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0162 0.1864 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0041 0.0219
Schistosoma mansoni hypothetical protein 0.0031 0.0183 0.0183
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0041 0.0219
Trypanosoma cruzi DNA polymerase eta, putative 0.0063 0.0599 0.3213
Echinococcus granulosus lysine specific histone demethylase 1A 0.0042 0.0321 0.0321
Schistosoma mansoni hypothetical protein 0.0031 0.0183 0.0183
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0162 0.1864 1
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0042 0.0321 0.1538
Mycobacterium ulcerans monoamine oxidase 0.0042 0.0321 0.0438
Leishmania major dihydroorotate dehydrogenase 0.0162 0.1864 1
Brugia malayi follicle stimulating hormone receptor 0.0748 0.9352 1
Echinococcus granulosus CREB binding protein 0.0216 0.2548 0.2548
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0162 0.1864 0.1993
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.131 0.131
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.1196 0.6417
Echinococcus granulosus microtubule associated protein 2 0.068 0.8489 0.8489
Plasmodium falciparum dihydroorotate dehydrogenase 0.0162 0.1864 1
Trypanosoma brucei DNA polymerase eta, putative 0.0063 0.0599 0.3213
Loa Loa (eye worm) hypothetical protein 0.0031 0.0183 0.0196
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.0547 0.2934
Brugia malayi polk-prov protein 0.002 0.0041 0.0044
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.059 0.7339 1
Brugia malayi ImpB/MucB/SamB family protein 0.0063 0.0599 0.064
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0041 0.0219
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.0344
Echinococcus multilocularis geminin 0.0361 0.4402 0.4402
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0041 0.0219
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.059 0.7339 1
Schistosoma mansoni hypothetical protein 0.0798 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0011 0.0011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0748 0.9352 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0019 0.0028 0.0029
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.0547 0.0547
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0321 0.1538
Echinococcus granulosus cpg binding protein 0.0059 0.0547 0.0547
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0206 0.1108
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.0041 0.0219
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0255 0.0255
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0042 0.0321 0.1538
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0041 0.0219
Leishmania major cytochrome p450-like protein 0.0027 0.013 0.0699
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0041 0.0219
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0162 0.1864 0.2738
Chlamydia trachomatis protoporphyrinogen oxidase 0.0042 0.0321 0.5
Loa Loa (eye worm) CYP4Cod1 0.0027 0.013 0.0139
Mycobacterium ulcerans dehydrogenase 0.0042 0.0321 0.0438
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0599 0.3213
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0041 0.0041
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.06 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.