Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | aspartyl protease, putative | 0.0342 | 0.0467 | 0.5 |
Onchocerca volvulus | 0.0342 | 0.0467 | 0.7396 | |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0342 | 0.0467 | 1 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Plasmodium falciparum | plasmepsin I | 0.0342 | 0.0467 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0431 | 0.0632 | 0.0632 |
Brugia malayi | Choline O-acetyltransferase | 0.0431 | 0.0632 | 0.1021 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0431 | 0.0632 | 0.1021 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0342 | 0.0467 | 0.0755 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.3442 | 0.6187 | 1 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0089 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0107 | 0.0033 | 0.0053 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0867 | 0.1435 | 0.2319 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.0632 | 0.1021 |
Toxoplasma gondii | aspartyl protease | 0.0342 | 0.0467 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Plasmodium falciparum | plasmepsin III | 0.0342 | 0.0467 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.0342 | 0.0467 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0342 | 0.0467 | 0.0755 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0205 | 0.0214 | 0.0696 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0342 | 0.0467 | 0.0755 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0867 | 0.1435 | 0.4661 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0342 | 0.0467 | 1 |
Plasmodium vivax | aspartyl protease, putative | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1757 | 0.3078 | 1 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0431 | 0.0632 | 0.4271 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0107 | 0.0033 | 0.0107 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0342 | 0.0467 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0867 | 0.1435 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0342 | 0.0467 | 0.5 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0431 | 0.0632 | 0.1021 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0205 | 0.0214 | 0.0346 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0867 | 0.1435 | 0.2319 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0176 | 0.0161 | 0.042 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Plasmodium falciparum | plasmepsin IX | 0.0342 | 0.0467 | 0.5 |
Plasmodium falciparum | plasmepsin VII | 0.0342 | 0.0467 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0205 | 0.0214 | 0.0214 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0342 | 0.0467 | 0.0755 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0342 | 0.0467 | 0.5 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Brugia malayi | Choline O-acetyltransferase | 0.0431 | 0.0632 | 0.1021 |
Plasmodium falciparum | plasmepsin V | 0.0342 | 0.0467 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.4271 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1757 | 0.3078 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0107 | 0.0033 | 0.0107 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Plasmodium falciparum | plasmepsin X | 0.0342 | 0.0467 | 0.5 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0342 | 0.0467 | 0.1518 |
Brugia malayi | Pepsin A precursor | 0.0342 | 0.0467 | 0.0755 |
Plasmodium vivax | plasmepsin V, putative | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0342 | 0.0467 | 0.0755 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0431 | 0.0632 | 0.4271 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0107 | 0.0033 | 0.0107 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0342 | 0.0467 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0431 | 0.0632 | 0.4271 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1757 | 0.3078 | 1 |
Plasmodium vivax | aspartyl protease, putative | 0.0342 | 0.0467 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0091 | 0.0003 | 0.001 |
Schistosoma mansoni | choline o-acyltransferase | 0.0431 | 0.0632 | 0.0632 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0431 | 0.0632 | 0.2052 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.0033 | 0.0033 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0867 | 0.1435 | 0.4603 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Brugia malayi | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Loa Loa (eye worm) | hypothetical protein | 0.3442 | 0.6187 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0342 | 0.0467 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0867 | 0.1435 | 0.4603 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1757 | 0.3078 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0342 | 0.0467 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0342 | 0.0467 | 0.1518 |
Brugia malayi | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0107 | 0.0033 | 0.0107 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0205 | 0.0214 | 0.0696 |
Onchocerca volvulus | 0.0342 | 0.0467 | 0.7396 | |
Giardia lamblia | Kinase, AGC AKT | 0.0176 | 0.0161 | 1 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1757 | 0.3078 | 1 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0176 | 0.0161 | 0.026 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0431 | 0.0632 | 0.1021 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Brugia malayi | MAP kinase sur-1 | 0.0107 | 0.0033 | 0.0053 |
Echinococcus granulosus | choline O acetyltransferase | 0.0431 | 0.0632 | 0.2052 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0342 | 0.0467 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0867 | 0.1435 | 0.4661 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Plasmodium falciparum | plasmepsin VI | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Plasmodium falciparum | plasmepsin IV | 0.0342 | 0.0467 | 0.5 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0342 | 0.0467 | 0.0755 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.