Detailed information for compound 177004

Basic information

Technical information
  • TDR Targets ID: 177004
  • Name: N-[9-[4-(methanesulfonamido)-2-methoxyanilino ]acridin-3-yl]methanesulfonamide
  • MW: 486.564 | Formula: C22H22N4O5S2
  • H donors: 3 H acceptors: 5 LogP: 2.66 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1Nc1c2ccccc2nc2c1ccc(c2)NS(=O)(=O)C)NS(=O)(=O)C
  • InChi: 1S/C22H22N4O5S2/c1-31-21-13-15(26-33(3,29)30)9-11-19(21)24-22-16-6-4-5-7-18(16)23-20-12-14(8-10-17(20)22)25-32(2,27)28/h4-13,25-26H,1-3H3,(H,23,24)
  • InChiKey: IASYDGLWRGAEQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[9-[4-(methanesulfonamido)-2-methoxy-anilino]acridin-3-yl]methanesulfonamide
  • N-[9-[4-(methanesulfonamido)-2-methoxyanilino]-3-acridinyl]methanesulfonamide
  • N-[9-[[2-methoxy-4-(methylsulfonylamino)phenyl]amino]acridin-3-yl]methanesulfonamide
  • N-[9-[(4-methanesulfonamido-2-methoxyphenyl)amino]acridin-3-yl]methanesulfonamide
  • N-[9-[(4-methanesulfonamido-2-methoxy-phenyl)amino]acridin-3-yl]methanesulfonamide
  • N-[9-[(4-methanesulfonamido-2-methoxyphenyl)amino]-3-acridinyl]methanesulfonamide
  • 97869-50-6
  • Methanesulfonamide, N-(3-methoxy-4-((3-((methylsulfonyl)amino)-9-acridinyl)amino)phenyl)-
  • N-(3-Methoxy-4-((3-((methylsulfonyl)amino)-9-acridinyl)amino)phenyl)methanesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.2374 0.5214 0.5198
Trichomonas vaginalis PIKK family atypical protein kinase 0.3255 0.7334 0.7325
Loa Loa (eye worm) hypothetical protein 0.0552 0.0827 0.0827
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.031 0.0246 0.0335
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0349 0.0339 0.0339
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0291 0.02 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.4362 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0291 0.02 0.02
Schistosoma mansoni phosphatidylinositol 4-kinase 0.031 0.0246 0.0246
Entamoeba histolytica protein kinase rad3, putative 0.0843 0.1528 0.1355
Echinococcus granulosus serine protein kinase ATM 0.0843 0.1528 0.1528
Trichomonas vaginalis PIKK family atypical protein kinase 0.3478 0.7871 0.7864
Trichomonas vaginalis PIKK family atypical protein kinase 0.2374 0.5214 0.5198
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.031 0.0246 0.0212
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0349 0.0339 0.0142
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0647 0.1057 0.1057
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0233 0.0059 0.0059
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.15 0.3111 0.3111
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0843 0.1528 0.1528
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.02 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.3715 0.8442 0.8437
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0223 0.0035 0.0035
Mycobacterium tuberculosis Conserved hypothetical protein 0.0291 0.02 0.5
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.031 0.0246 0.0212
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.031 0.0246 0.0246
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.031 0.0246 0.0246
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4362 1 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.15 0.3111 0.3111
Echinococcus multilocularis Zinc finger, PHD finger 0.031 0.0246 0.0246
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0476 0.0644 0.0644
Trichomonas vaginalis PIKK family atypical protein kinase 0.0291 0.02 0.0166
Loa Loa (eye worm) hypothetical protein 0.0409 0.0483 0.0483
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.031 0.0245 0.0245
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2056 0.4448 0.4448
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.031 0.0246 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.3478 0.7871 0.7864
Trichomonas vaginalis PIKK family atypical protein kinase 0.4362 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0843 0.1528 0.1528
Loa Loa (eye worm) phosphatidylinositol 3 0.15 0.3111 0.3111
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0349 0.0339 0.0339
Loa Loa (eye worm) phosphatidylinositol 3 0.4362 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.033 0.0293 0.0095
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0223 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.1172 0.232 0.2293
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.031 0.0246 0.0246
Trichomonas vaginalis PIKK family atypical protein kinase 0.2597 0.5751 0.5737
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0291 0.02 0.02
Schistosoma mansoni voltage-gated potassium channel 0.0233 0.0059 0.0059
Leishmania major phosphatidylinositol 3-kinase, putative 0.149 0.3086 0.3086
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0416 0.0501 0.0468
Leishmania major phosphatidylinositol kinase related protein, putative 0.0291 0.02 0.02
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.031 0.0246 0.0246
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0223 0.0035 0.0035
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0552 0.0827 0.0827
Loa Loa (eye worm) hypothetical protein 0.0881 0.1619 0.1619
Trichomonas vaginalis PIKK family atypical protein kinase 0.2831 0.6313 0.6301
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0643 0.1048 0.1048
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1539 0.3203 0.3203
Mycobacterium leprae conserved hypothetical protein 0.0291 0.02 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0843 0.1528 0.1498
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4362 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.149 0.3086 0.3062
Echinococcus granulosus potassium voltage gated channel subfamily H 0.031 0.0245 0.0245
Entamoeba histolytica hypothetical protein 0.0843 0.1528 0.1355
Trichomonas vaginalis PIKK family atypical protein kinase 0.3478 0.7871 0.7864
Brugia malayi FAT domain containing protein 0.0647 0.1057 0.1057
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1539 0.3203 0.3203
Plasmodium falciparum phosphatidylinositol 3-kinase 0.031 0.0246 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1539 0.3203 0.3203
Loa Loa (eye worm) phosphatidylinositol 3 0.0291 0.02 0.02
Leishmania major hypothetical protein, conserved 0.0379 0.0412 0.0412
Trichomonas vaginalis conserved hypothetical protein 0.0938 0.1758 0.1729
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4362 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0233 0.0059 0.0059
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0409 0.0483 0.0483
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0223 0.0035 0.0035
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.037 0.0389 0.0193
Loa Loa (eye worm) hypothetical protein 0.0296 0.021 0.021
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0349 0.0339 0.0306
Schistosoma mansoni fkbp-rapamycin associated protein 0.0843 0.1528 0.1528
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0349 0.0339 0.0306
Giardia lamblia GTOR 0.4362 1 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0223 0.0035 0.0035
Schistosoma mansoni 60S ribosomal protein L21 0.0218 0.0024 0.0024
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1539 0.3203 0.3203
Trichomonas vaginalis PIKK family atypical protein kinase 0.2608 0.5776 0.5762
Trichomonas vaginalis PIKK family atypical protein kinase 0.149 0.3086 0.3062
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1539 0.3203 0.3203
Trichomonas vaginalis PIKK family atypical protein kinase 0.2371 0.5206 0.5189
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0233 0.0059 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0552 0.0827 0.0795
Entamoeba histolytica hypothetical protein 0.0437 0.0551 0.0358
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0223 0.0035 0.0035
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0349 0.0339 0.0339
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0223 0.0035 0.0035
Echinococcus granulosus hyperpolarization activated cyclic 0.0223 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.2597 0.5751 0.5737
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.02 0.02
Loa Loa (eye worm) phosphatidylinositol kinase 0.0291 0.02 0.02
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0476 0.0644 0.0644
Trypanosoma cruzi target of rapamycin kinase 3 0.3481 0.788 0.788
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.031 0.0245 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.2608 0.5776 0.5762
Loa Loa (eye worm) hypothetical protein 0.0647 0.1057 0.1057
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0643 0.1048 0.1048
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.031 0.0246 0.0212
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0349 0.0339 0.0339
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0843 0.1528 0.1528
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0476 0.0644 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.3478 0.7871 0.7864
Loa Loa (eye worm) phosphatidylinositol 3 0.0291 0.02 0.02
Echinococcus multilocularis 0.0291 0.02 0.02
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0843 0.1528 0.1528
Loa Loa (eye worm) phosphatidylinositol 3 0.0291 0.02 0.02
Leishmania major phosphatidylinositol 4-kinase, putative 0.0291 0.02 0.02
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.031 0.0246 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3255 0.7334 0.7325
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0437 0.0551 0.0358
Schistosoma mansoni voltage-gated potassium channel 0.0233 0.0059 0.0059
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0223 0.0035 0.0035
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4362 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0843 0.1528 0.1528
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.054 0.0799 0.0799
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0291 0.02 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.2374 0.5214 0.5198
Echinococcus multilocularis voltage gated potassium channel 0.0233 0.0059 0.0059
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0291 0.02 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.3255 0.7334 0.7325
Trichomonas vaginalis PIKK family atypical protein kinase 0.3255 0.7334 0.7325
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0291 0.02 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.2926 0.6544 0.6532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0843 0.1528 0.1498
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0223 0.0035 0.0035
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0223 0.0035 0.0035
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3481 0.788 0.788
Trichomonas vaginalis conserved hypothetical protein 0.0647 0.1057 0.1026
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0291 0.02 0.0272
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0291 0.02 0.02
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0476 0.0644 0.0612
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0291 0.02 0.02
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0853 0.1553 0.138
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0223 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0938 0.1758 0.1758
Trichomonas vaginalis PIKK family atypical protein kinase 0.4362 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0291 0.02 0.0272
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0647 0.1057 0.1057
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4362 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4362 1 1
Onchocerca volvulus 0.0291 0.02 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0349 0.0339 0.0306
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.031 0.0246 0.0246
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0223 0.0035 0.0035
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0409 0.0483 0.0483
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0476 0.0644 0.0644
Loa Loa (eye worm) hypothetical protein 0.0233 0.0059 0.0059
Loa Loa (eye worm) phosphatidylinositol 3 0.0291 0.02 0.02
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0643 0.1048 0.1048
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0476 0.0644 0.0612
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0291 0.02 0.02
Echinococcus multilocularis serine protein kinase ATM 0.0843 0.1528 0.1528
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4362 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3481 0.788 0.788
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0938 0.1758 0.2397
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0223 0.0035 0.0035
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0223 0.0035 0.0035
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0291 0.02 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.3255 0.7334 0.7325
Trichomonas vaginalis PIKK family atypical protein kinase 0.3255 0.7334 0.7325
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0291 0.02 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.2608 0.5776 0.5762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0291 0.02 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.2371 0.5206 0.5189
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.031 0.0246 0.0246
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0291 0.02 0.02
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4362 1 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.031 0.0246 0.0047
Loa Loa (eye worm) hypothetical protein 0.0843 0.1528 0.1528
Trichomonas vaginalis PIKK family atypical protein kinase 0.3255 0.7334 0.7325
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1539 0.3203 0.3203
Schistosoma mansoni voltage-gated potassium channel 0.032 0.0269 0.0269
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.031 0.0246 0.0246
Leishmania major phosphatidylinositol 3-kinase, putative 0.031 0.0246 0.0246
Onchocerca volvulus 0.0291 0.02 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.149 0.3086 0.3086
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4362 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0291 0.02 0.02
Schistosoma mansoni voltage-gated potassium channel 0.032 0.0269 0.0269
Loa Loa (eye worm) phosphatidylinositol 3 0.0605 0.0954 0.0954
Schistosoma mansoni voltage-gated potassium channel 0.0218 0.0024 0.0024
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0291 0.02 0.02
Loa Loa (eye worm) hypothetical protein 0.0223 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0853 0.1553 0.1523
Trichomonas vaginalis PIKK family atypical protein kinase 0.149 0.3086 0.3062
Schistosoma mansoni hypothetical protein 0.0647 0.1057 0.1057
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.031 0.0246 0.0246
Echinococcus granulosus hyperpolarization activated cyclic 0.0223 0.0035 0.0035
Leishmania major phosphatidylinositol kinase, putative 0.0291 0.02 0.02
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0416 0.0501 0.0468
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1823 0.3886 0.3886
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4362 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.031 0.0246 0.0246
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0349 0.0339 0.0142
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.031 0.0246 0.0047
Toxoplasma gondii FATC domain-containing protein 0.0843 0.1528 0.2083
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0291 0.02 0.02
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0291 0.02 0.02
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0843 0.1528 0.1528
Trichomonas vaginalis PIKK family atypical protein kinase 0.15 0.3111 0.3087
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0291 0.02 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.149 0.3086 0.3062
Trichomonas vaginalis conserved hypothetical protein 0.0552 0.0827 0.0795
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0291 0.02 0.02
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0223 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.2374 0.5214 0.5198
Schistosoma mansoni hypothetical protein 0.0291 0.02 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.3478 0.7871 0.7864
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4362 1 1
Leishmania major hypothetical protein, unknown function 0.0291 0.02 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.2371 0.5206 0.5189
Loa Loa (eye worm) hypothetical protein 0.0291 0.02 0.02
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0409 0.0483 0.0483
Brugia malayi Cyclic-nucleotide gated cation channel 0.0223 0.0035 0.0035
Schistosoma mansoni voltage-gated potassium channel 0.0223 0.0035 0.0035
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0291 0.02 0.02
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0377 0.0407 0.0212
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0476 0.0644 0.0454
Echinococcus granulosus voltage gated potassium channel 0.0233 0.0059 0.0059
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0843 0.1528 0.1528
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.054 0.0799 0.0799
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.031 0.0245 0.0245
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.031 0.0246 0.0335
Echinococcus multilocularis hyperpolarization activated cyclic 0.0223 0.0035 0.0035
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0843 0.1528 0.1528
Toxoplasma gondii target of rapamycin (TOR), putative 0.3255 0.7334 1

Activities

Activity type Activity value Assay description Source Reference
Log 1/D50 (functional) = 2.95 Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice. ChEMBL. 7069706
Log 1/LD10 (ADMET) = 2.85 Compound concentration in mole/kg/day lethal to 10% of mice ChEMBL. 7069706

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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