Detailed information for compound 1775047

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 377.479 | Formula: C23H27N3O2
  • H donors: 0 H acceptors: 2 LogP: 3.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)N1CCN(CC1)CN1C(=O)CC(C1=O)(C)c1ccccc1
  • InChi: 1S/C23H27N3O2/c1-18-7-6-10-20(15-18)25-13-11-24(12-14-25)17-26-21(27)16-23(2,22(26)28)19-8-4-3-5-9-19/h3-10,15H,11-14,16-17H2,1-2H3
  • InChiKey: VLORGZLMIJFDTQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.053 0.0526
Loa Loa (eye worm) hypothetical protein 0.0129 0.0484 0.048
Schistosoma mansoni transient receptor potential channel 4 0.0212 0.0826 0.0822
Mycobacterium ulcerans hypothetical protein 0.0024 0.005 1
Echinococcus granulosus cpg binding protein 0.0032 0.0081 0.0077
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0196 0.0192
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0082 0.0077
Echinococcus granulosus sodium channel protein 0.0104 0.0381 0.0377
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.005 1
Echinococcus granulosus expressed protein 0.0047 0.0143 0.0138
Schistosoma mansoni hypothetical protein 0.0065 0.0217 0.0213
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0036 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0036 0.0032
Echinococcus multilocularis transient receptor potential ion channel A 0.0199 0.0772 0.0768
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0036 0.0032
Echinococcus granulosus geminin 0.0503 0.2032 0.2028
Echinococcus multilocularis calcium activated potassium channel 0.0019 0.003 0.0026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.005 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0112 0.0108
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0058 0.0054
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0119 0.0115
Trypanosoma cruzi ISWI complex protein 0.0017 0.0019 0.8671
Loa Loa (eye worm) hypothetical protein 0.0212 0.0826 0.0822
Echinococcus granulosus short transient receptor potential channel 6 0.0142 0.0538 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0036 0.0032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0036 0.0032
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.0794 0.079
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0036 0.4113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0029 0.0025
Echinococcus granulosus calcium activated potassium channel 0.0019 0.003 0.0026
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0217 0.0213
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0021 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0036 0.0032
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0036 0.0032
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0044 0.0134 0.013
Onchocerca volvulus Alhambra homolog 0.0032 0.0082 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0021 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0036 0.0032
Schistosoma mansoni zinc finger protein 0.0023 0.0045 0.0041
Brugia malayi Transient-receptor-potential like protein 0.0083 0.0292 0.0288
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0008 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0036 0.0032
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0217 0.0213
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0032
Echinococcus multilocularis geminin 0.0503 0.2032 0.2028
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0021 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.005 0.1224
Echinococcus multilocularis expressed protein 0.0047 0.0143 0.0138
Leishmania major hypothetical protein, conserved 0.0017 0.0019 0.0392
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0104 0.0381 0.0377
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.005 1
Echinococcus granulosus expressed conserved protein 0.009 0.0321 0.0317
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0082 0.4396
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0027 0.0023
Brugia malayi Bromodomain containing protein 0.0034 0.0092 0.0088
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.2429 1 1
Trypanosoma cruzi ISWI complex protein 0.0017 0.0019 0.8671
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0066 0.0062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0021
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0047 0.0143 0.0138
Brugia malayi Bromodomain containing protein 0.0084 0.0295 0.0291
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0036 0.0032
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0021 0.0017
Echinococcus granulosus transient receptor potential gamma protein 0.0212 0.0826 0.0822
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0077
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0021 0.0017
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0021 0.1491
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0036 0.0032
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.005 0.5
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0293 0.0289
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0021 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.053 0.0526
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0036 0.0032
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0021 0.0139
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0036 0.0032
Echinococcus multilocularis protein dispatched 1 0.0047 0.0143 0.0139
Schistosoma mansoni bromodomain containing protein 0.0071 0.0242 0.0238
Toxoplasma gondii TIM10 family protein, putative 0.0047 0.0143 0.7863
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0036 0.0032
Trypanosoma brucei ISWI complex protein 0.0017 0.0019 0.8671
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0119 0.0115
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0021 0.0017
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0222 0.0218
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0021 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0022 0.0017
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0082 0.0077
Schistosoma mansoni hypothetical protein 0.0503 0.2032 0.2028
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0082 0.4396
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0345 1
Giardia lamblia PHD finger protein 15 0.0032 0.0082 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.0794 0.079
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0036 0.4113
Brugia malayi nuclear receptor NHR-88 0.0021 0.0036 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0082 0.5723
Brugia malayi CXXC zinc finger family protein 0.0028 0.0066 0.0062
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0058 0.0054
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0125 0.012
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.005 0.1224
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0226 0.0222
Brugia malayi PHD-finger family protein 0.0014 0.0008 0.0004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.053 0.0526
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0143 0.7863
Echinococcus granulosus short transient receptor potential channel 6 0.0142 0.0538 0.0534
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.018 1
Brugia malayi PHD-finger family protein 0.0029 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0163 0.0625 0.0621
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0036 0.0032
Echinococcus multilocularis zinc finger protein 0.0023 0.0045 0.0041
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0112 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0036 0.0032
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0125 0.012
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0029 0.0025
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0036 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0036 0.0032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0217 0.0213
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.0527 0.0523
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0133 0.0129
Schistosoma mansoni transient receptor potential channel 0.0142 0.0538 0.0534
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0036 0.0032
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.0794 0.079
Echinococcus multilocularis peregrin 0.0034 0.0092 0.0088
Brugia malayi nuclear hormone receptor 0.0021 0.0036 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.005 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.053 0.0526
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0514 0.051
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0036 0.0032
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0143 1
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0119 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0036 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.053 0.0526
Loa Loa (eye worm) hypothetical protein 0.0048 0.0149 0.0145
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0058 0.0054
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0047 0.0143 0.0138
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0021 0.0017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0125 0.012
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0021
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0036 0.0032
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0109 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0024 0.005 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0029 0.0025
Loa Loa (eye worm) hypothetical protein 0.0077 0.0269 0.0265
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0037 0.0033
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0104 0.0381 1
Echinococcus multilocularis expressed conserved protein 0.009 0.0321 0.0317
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0032
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0217 0.0213
Echinococcus granulosus MAP kinase activated protein kinase 2 0.2429 1 1
Brugia malayi steroid hormone receptor 0.0021 0.0036 0.0032
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0217 0.0213
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0036 0.4113
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.0381 0.0377
Echinococcus multilocularis GPCR, family 2 0.0065 0.0217 0.0213
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0021 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.005 1
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0047 0.0143 1
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0015
Echinococcus multilocularis short transient receptor potential channel 6 0.0142 0.0538 0.0534
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0027 0.0023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0036 0.0032
Echinococcus granulosus zinc finger protein 0.0023 0.0045 0.0041
Echinococcus multilocularis short transient receptor potential channel 6 0.0142 0.0538 0.0534
Onchocerca volvulus 0.0028 0.0066 0.7957
Schistosoma mansoni cpg binding protein 0.0032 0.0081 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0036 0.0032
Schistosoma mansoni zinc finger protein 0.0017 0.0019 0.0015
Echinococcus granulosus muscleblind protein 0.0163 0.0625 0.0621
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.005 1
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.003 0.0025
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0036 0.0032
Brugia malayi jmjC domain containing protein 0.0042 0.0125 0.012
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0042 0.0123 0.0119
Brugia malayi ecdysteroid receptor 0.0021 0.0036 0.0032
Schistosoma mansoni coup transcription factor 0.0021 0.0036 0.0032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0036 0.0032
Schistosoma mansoni transient receptor potential channel 0.0212 0.0826 0.0822
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0083 0.0292 0.0288
Echinococcus granulosus TRP transient receptor potential channel 0.0083 0.0292 0.0288
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0021 1
Onchocerca volvulus 0.0021 0.0036 0.4113
Loa Loa (eye worm) hypothetical protein 0.0055 0.0176 0.0172
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0046
Brugia malayi Bromodomain containing protein 0.0042 0.0123 0.0119
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0043 0.0039
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0226 0.0222
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0036 0.0032
Echinococcus multilocularis transient receptor potential gamma protein 0.0212 0.0826 0.0822
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.005 0.0157 0.0153
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.053 0.0526
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.053 0.0526
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0036 0.0032
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0217 0.0213
Schistosoma mansoni patched 1 0.0041 0.0119 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0036 0.0032
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0119 0.0115
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0065 0.0217 0.0213
Schistosoma mansoni transient receptor potential channel 0.0142 0.0538 0.0534
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0133 0.0129
Echinococcus multilocularis cpg binding protein 0.0032 0.0081 0.0077
Echinococcus granulosus GPCR family 2 0.0065 0.0217 0.0213
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0345 0.0341
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.005 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0514 0.051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0036 0.0032
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0032
Brugia malayi isocitrate dehydrogenase 0.0017 0.0021 0.0017
Schistosoma mansoni hypothetical protein 0.0139 0.0527 0.0523
Brugia malayi Muscleblind-like protein 0.0163 0.0625 0.0621
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0036 0.0032
Echinococcus multilocularis protein patched 0.0041 0.0119 0.0115
Loa Loa (eye worm) hypothetical protein 0.007 0.0238 0.0234
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0047 0.0143 0.0138
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.005 0.5
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0008 0.0003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0036 0.0032
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0036 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0024 0.005 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0036 0.0032
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0021 1
Plasmodium falciparum phd finger protein, putative 0.0032 0.0082 0.5723
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0036 0.0032
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.005 0.1224
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0036 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0032
Schistosoma mansoni cpg binding protein 0.0028 0.0066 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.053 0.0526
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0021 0.0967
Loa Loa (eye worm) hypothetical protein 0.0095 0.0345 0.0341
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0025 0.175
Schistosoma mansoni hypothetical protein 0.0039 0.0113 0.0109
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0345 0.0341
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0036 0.0032
Schistosoma mansoni hypothetical protein 0.0503 0.2032 0.2028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0021
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.2429 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0036 0.0032
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0025 0.139
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0082 0.0077
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.0381 0.0377
Echinococcus multilocularis muscleblind protein 1 0.0163 0.0625 0.0621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0036 0.0032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0036 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0119 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.005 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.005 1
Schistosoma mansoni hypothetical protein 0.0065 0.0217 0.0213
Schistosoma mansoni hypothetical protein 0.0032 0.0082 0.0077
Schistosoma mansoni hypothetical protein 0.0039 0.0113 0.0109
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.3202 0.3199
Brugia malayi AMP-binding enzyme family protein 0.0024 0.005 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0025 0.0021
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0345 0.0341
Schistosoma mansoni hypothetical protein 0.0065 0.0217 0.0213
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0036 0.0032
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0021 0.0452
Echinococcus granulosus peregrin 0.0034 0.0092 0.0088
Loa Loa (eye worm) hypothetical protein 0.0139 0.0527 0.0523
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0217 0.0213
Loa Loa (eye worm) hypothetical protein 0.0024 0.005 0.0046
Schistosoma mansoni hypothetical protein 0.0065 0.0217 0.0213
Loa Loa (eye worm) hypothetical protein 0.0163 0.0625 0.0621
Schistosoma mansoni hypothetical protein 0.0023 0.0043 0.0039
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0027 0.0023
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0036 0.0032
Schistosoma mansoni cpg binding protein 0.0032 0.0081 0.0077
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0125 0.012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0036 0.0032
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0025 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0036 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0036 0.0032
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0021 0.0967
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0082 0.0077
Loa Loa (eye worm) hypothetical protein 0.0019 0.0029 0.0025
Echinococcus granulosus transient receptor potential ion channel A 0.0199 0.0772 0.0768
Brugia malayi CHE-14 protein 0.0041 0.0119 0.0115
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0021 0.0017
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0029 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0036 0.0032
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0021 0.1491
Schistosoma mansoni serine/threonine protein kinase 0.2429 1 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0036 0.0032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0036 0.0032
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.053 0.0526
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0351 0.0347
Schistosoma mansoni hypothetical protein 0.0039 0.0113 0.0109
Loa Loa (eye worm) hypothetical protein 0.0204 0.0794 0.079
Schistosoma mansoni hypothetical protein 0.0039 0.0113 0.0109
Loa Loa (eye worm) hypothetical protein 0.0083 0.0292 0.0288
Onchocerca volvulus 0.0024 0.005 0.596
Echinococcus multilocularis muscleblind protein 0.0163 0.0625 0.0621
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0027 0.0023
Brugia malayi PHD-finger family protein 0.0032 0.0082 0.0077
Loa Loa (eye worm) hypothetical protein 0.0041 0.0119 0.0115
Brugia malayi jmjC domain containing protein 0.0104 0.0381 0.0377
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0036 0.0032
Echinococcus multilocularis sodium channel protein 0.0104 0.0381 0.0377
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0025 0.175

Activities

Activity type Activity value Assay description Source Reference
TD50 (ADMET) = 300 mg kg-1 Neurotoxicity in ip dosed CF-1 albino mouse after 4 hrs by rotarod test ChEMBL. 23777899

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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