Detailed information for compound 1782057

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1078.47 | Formula: C53H63Cl3N8O10
  • H donors: 6 H acceptors: 8 LogP: 5.9 Rotable bonds: 25
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C(COCC(=O)N1CCC(CC1)NC(=O)c1nn(c(c1C)c1ccc(cc1)Cl)c1ccc(cc1Cl)Cl)NCCCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2([C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)C)ccc1O)O
  • InChi: 1S/C53H63Cl3N8O10/c1-31-47(61-64(39-13-12-35(55)26-37(39)56)48(31)32-7-10-34(54)11-8-32)51(70)59-36-16-22-63(23-17-36)45(69)30-73-28-43(67)58-21-6-4-3-5-20-57-42(66)27-72-29-44(68)60-38-15-18-53(71)41-25-33-9-14-40(65)49-46(33)52(53,50(38)74-49)19-24-62(41)2/h7-14,26,36,38,41,50,65,71H,3-6,15-25,27-30H2,1-2H3,(H,57,66)(H,58,67)(H,59,70)(H,60,68)/t38-,41+,50-,52-,53+/m0/s1
  • InChiKey: JYJRMYBSYRNJPJ-UTAPOLOESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Schistosoma mansoni hypothetical protein 0.0185 0.3031 0.3031
Schistosoma mansoni notch 0.0185 0.3031 0.3031
Echinococcus multilocularis chromobox protein 1 0.005 0.06 0.0575
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Echinococcus multilocularis short transient receptor potential channel 6 0.0046 0.053 0.0504
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Onchocerca volvulus 0.0574 1 1
Schistosoma mansoni amine GPCR 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus granulosus GPCR family 2 0.0037 0.0377 0.0351
Echinococcus granulosus delta-like protein 1 0.0185 0.3031 0.3012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0222 0.3698 0.614
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Schistosoma mansoni biogenic amine receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0377 0.0351
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Echinococcus granulosus protein jagged 1 0.0185 0.3031 0.3012
Onchocerca volvulus 0.0185 0.3031 0.3012
Loa Loa (eye worm) hypothetical protein 0.0081 0.1156 0.1156
Schistosoma mansoni transient receptor potential channel 0.0069 0.0952 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0207 0.0247
Loa Loa (eye worm) hypothetical protein 0.0022 0.0098 0.0098
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0026 0.0175 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0027 0.0027
Schistosoma mansoni cell polarity protein 0.0185 0.3031 0.3031
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0109 0.1655 0.5
Brugia malayi Calcium binding EGF domain containing protein 0.0185 0.3031 0.3012
Schistosoma mansoni hypothetical protein 0.0185 0.3031 0.3031
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi Delta serrate ligand family protein 0.0185 0.3031 0.3012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0026 0.0175 0.0148
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) notch protein 0.0185 0.3031 0.3031
Loa Loa (eye worm) transcription factor SMAD2 0.0091 0.1336 0.1336
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1765 0.1743
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi Bromodomain containing protein 0.0022 0.0103 0.0077
Schistosoma mansoni hypothetical protein 0.0037 0.0377 0.0377
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0377 0.0377
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0943 0.0943
Loa Loa (eye worm) hypothetical protein 0.0044 0.0488 0.0488
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi EGF-like domain containing protein 0.0185 0.3031 0.3012
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Echinococcus granulosus metabotropic glutamate receptor 5 0.002 0.007 0.0044
Loa Loa (eye worm) hypothetical protein 0.0049 0.0589 0.0589
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0026 0.0175 1
Schistosoma mansoni histamine h1 receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Onchocerca volvulus 0.035 0.5984 0.5973
Echinococcus multilocularis fibropellin Ia 0.0185 0.3031 0.3012
Echinococcus granulosus neurogenic locus notch protein 4 0.0185 0.3031 0.3012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0222 0.3698 0.614
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Brugia malayi Blistered cuticle protein 3 0.0574 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0027 0.0027
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0035 0.0008
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0042 0.0467 0.0442
Echinococcus multilocularis protein jagged 1 0.0185 0.3031 0.3012
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0028 0.0207 0.018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus granulosus notch 0.0185 0.3031 0.3012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0377 0.0351
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0027 0.0027
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0027 0.0027
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0026 0.0175 1
Schistosoma mansoni hypothetical protein 0.0185 0.3031 0.3031
Loa Loa (eye worm) hypothetical protein 0.0024 0.0127 0.0127
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0027 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0069 0.0943 0.0943
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Trichomonas vaginalis set domain proteins, putative 0.035 0.5984 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0026 0.0169 0.0142
Loa Loa (eye worm) animal heme peroxidase 0.0574 1 1
Schistosoma mansoni chromobox protein 0.005 0.06 0.06
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0222 0.3698 0.614
Echinococcus multilocularis slit 2 protein 0.0185 0.3031 0.3012
Echinococcus multilocularis geminin 0.0281 0.4742 0.4728
Schistosoma mansoni hypothetical protein 0.0185 0.3031 0.3031
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0044 0.0496 0.0471
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0103 0.0228
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0185 0.3031 0.3012
Echinococcus multilocularis protein jagged 2 0.0185 0.3031 0.3012
Schistosoma mansoni slit 0.0185 0.3031 0.3031
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0109 0.1655 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0027 0.0027
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0222 0.3698 0.5
Echinococcus granulosus neurogenic locus protein delta 0.0185 0.3031 0.3012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0026 0.0175 1
Schistosoma mansoni notch 0.0185 0.3031 0.3031
Loa Loa (eye worm) animal heme peroxidase 0.0574 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0044 0.0496 0.0471
Schistosoma mansoni hypothetical protein 0.0037 0.0377 0.0377
Echinococcus granulosus transient receptor potential ion channel A 0.0067 0.091 0.0886
Onchocerca volvulus Heterochromatin protein 1 homolog 0.003 0.0245 0.0219
Loa Loa (eye worm) hypothetical protein 0.0026 0.0169 0.0169
Schistosoma mansoni septate junction protein 0.0185 0.3031 0.3031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Onchocerca volvulus Slit protein homolog 0.0185 0.3031 0.3012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Echinococcus granulosus protein jagged 2 0.0185 0.3031 0.3012
Echinococcus multilocularis notch 0.0185 0.3031 0.3012
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0027 0.0027
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0035 0.0035
Schistosoma mansoni myosin xvIII 0.0018 0.0027 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0222 0.3698 0.614
Loa Loa (eye worm) hypothetical protein 0.0044 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Schistosoma mansoni hypothetical protein 0.0018 0.0027 0.0027
Schistosoma mansoni amine GPCR 0.0018 0.0027 0.0027
Brugia malayi Cadherin domain containing protein 0.0185 0.3031 0.3012
Onchocerca volvulus 0.0574 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus granulosus lysine specific demethylase 5A 0.0069 0.0943 0.0918
Brugia malayi Animal haem peroxidase family protein 0.0574 1 1
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0377 0.0351
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0222 0.3698 0.614
Brugia malayi Cadherin domain containing protein 0.0185 0.3031 0.3012
Brugia malayi notch-like transmembrane receptor 0.0185 0.3031 0.3012
Schistosoma mansoni notch 0.0185 0.3031 0.3031
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0026 0.0175 1
Onchocerca volvulus 0.0185 0.3031 0.3012
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0035 0.0035
Onchocerca volvulus Peroxidase homolog 0.0574 1 1
Schistosoma mansoni hypothetical protein 0.0037 0.0377 0.0377
Echinococcus multilocularis neurogenic locus notch protein 4 0.0185 0.3031 0.3012
Schistosoma mansoni amine GPCR 0.0018 0.0027 0.0027
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0027 0.0027
Schistosoma mansoni transient receptor potential channel 4 0.0069 0.0952 0.0952
Loa Loa (eye worm) blistered cuticle protein 3 0.0574 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0377 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0207 0.0247
Onchocerca volvulus 0.0052 0.0643 0.0618
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0027 0.0027
Brugia malayi MH2 domain containing protein 0.0091 0.1336 0.1313
Schistosoma mansoni hypothetical protein 0.0018 0.0027 0.0027
Trichomonas vaginalis chromobox protein, putative 0.003 0.0245 0.0312
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0222 0.3698 0.614
Echinococcus granulosus peregrin 0.0022 0.0103 0.0077
Brugia malayi Calcitonin receptor-like protein seb-1 0.0118 0.1827 0.1805
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0035 0.0008
Brugia malayi jmjC domain containing protein 0.0018 0.0035 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi EGF-like domain containing protein 0.0185 0.3031 0.3012
Brugia malayi Animal haem peroxidase family protein 0.0574 1 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Brugia malayi Muscle positioning protein 4 0.0185 0.3031 0.3012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Onchocerca volvulus 0.0185 0.3031 0.3012
Schistosoma mansoni notch 0.0185 0.3031 0.3031
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.007
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0026 0.0175 1
Schistosoma mansoni metabotropic glutamate receptor 0.0137 0.2158 0.2158
Onchocerca volvulus Neurogenic locus notch homolog 0.0185 0.3031 0.3012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0496 0.0496
Echinococcus multilocularis neurogenic locus protein delta 0.0185 0.3031 0.3012
Echinococcus granulosus neurogenic locus notch protein 0.0185 0.3031 0.3012
Echinococcus multilocularis jumonji domain containing protein 0.0031 0.0259 0.0233
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0026 0.0175 0.0148
Echinococcus granulosus neural cadherin 0.0185 0.3031 0.3012
Loa Loa (eye worm) MH2 domain-containing protein 0.0091 0.1336 0.1336
Treponema pallidum fructose-bisphosphate aldolase 0.0222 0.3698 0.5
Onchocerca volvulus Dual oxidase homolog 0.0574 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Toxoplasma gondii PHD-finger domain-containing protein 0.0022 0.0103 0.0228
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.002 0.007 0.0044
Brugia malayi Animal haem peroxidase family protein 0.0574 1 1
Onchocerca volvulus Chorion peroxidase homolog 0.0574 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0044 0.0496 0.0471
Echinococcus granulosus neurogenic locus notch protein 0.0185 0.3031 0.3012
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.007 0.0044
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0109 0.1655 0.5
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Echinococcus granulosus transient receptor potential gamma protein 0.0069 0.0952 0.0928
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0222 0.3698 0.5
Brugia malayi Isocitrate dehydrogenase 0.0026 0.0175 0.0148
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0185 0.3031 0.3031
Brugia malayi Pre-SET motif family protein 0.0044 0.0496 0.0471
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0027 0.0027
Echinococcus multilocularis fat cadherin tumor suppressor 0.0185 0.3031 0.3012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi EGF-like domain containing protein 0.0185 0.3031 0.3012
Brugia malayi PHD-finger family protein 0.0022 0.0103 0.0077
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0035 0.0008
Loa Loa (eye worm) hypothetical protein 0.0028 0.0207 0.0207
Echinococcus granulosus jumonji domain containing protein 0.0031 0.0259 0.0233
Onchocerca volvulus Putative cubilin 0.0185 0.3031 0.3012
Schistosoma mansoni hypothetical protein 0.0037 0.0377 0.0377
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0943 0.0918
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0035 0.0035
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0027 0.0027
Echinococcus multilocularis neurogenic locus notch protein 0.0185 0.3031 0.3012
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Schistosoma mansoni opsin-like receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Brugia malayi GCC2 and GCC3 family protein 0.0185 0.3031 0.3012
Loa Loa (eye worm) hypothetical protein 0.0069 0.0952 0.0952
Echinococcus multilocularis transient receptor potential ion channel A 0.0067 0.091 0.0886
Echinococcus granulosus protein jagged 2 0.0185 0.3031 0.3012
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Echinococcus multilocularis peregrin 0.0022 0.0103 0.0077
Brugia malayi jmjC domain containing protein 0.0018 0.0035 0.0008
Schistosoma mansoni hypothetical protein 0.0281 0.4742 0.4742
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0103 0.1479
Loa Loa (eye worm) animal heme peroxidase 0.0574 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0027 0.0027
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0027 0.0027
Brugia malayi jmjC domain containing protein 0.0115 0.1765 0.1743
Loa Loa (eye worm) hypothetical protein 0.0118 0.1827 0.1827
Schistosoma mansoni jumonji domain containing protein 0.01 0.1497 0.1497
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0035 0.0035
Giardia lamblia High cysteine protein 0.0185 0.3031 0.8146
Echinococcus granulosus TRP transient receptor potential channel 0.0026 0.0169 0.0142
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Onchocerca volvulus Peroxidasin homolog 0.0574 1 1
Echinococcus granulosus short transient receptor potential channel 6 0.0046 0.053 0.0504
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0377 0.0351
Toxoplasma gondii EGF family domain-containing protein 0.0185 0.3031 1
Plasmodium falciparum phd finger protein, putative 0.0022 0.0103 0.4887
Trichomonas vaginalis chromobox protein, putative 0.005 0.06 0.0911
Echinococcus granulosus phd:f box containing protein 0.0018 0.0035 0.0008
Echinococcus multilocularis neurogenic locus notch protein 0.0185 0.3031 0.3012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0044 0.0496 0.154
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Echinococcus multilocularis protein jagged 1 0.0185 0.3031 0.3012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Onchocerca volvulus 0.0574 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0027 0.0027
Onchocerca volvulus Peroxidasin homolog 0.0574 1 1
Echinococcus granulosus geminin 0.0281 0.4742 0.4728
Echinococcus multilocularis neural cadherin 0.0185 0.3031 0.3012
Echinococcus multilocularis PHD finger protein rhinoceros 0.0022 0.0103 0.0077
Echinococcus granulosus peroxidasin 0.0574 1 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0035 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0943 0.0943
Onchocerca volvulus 0.0185 0.3031 0.3012
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi Animal haem peroxidase family protein 0.0574 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0026 0.0175 0.0148
Brugia malayi Calcium binding EGF domain containing protein 0.0185 0.3031 0.3012
Echinococcus multilocularis peroxidasin 0.0574 1 1
Schistosoma mansoni neuropeptide receptor 0.0018 0.0027 0.0027
Brugia malayi Heterochromatin protein 1 0.005 0.06 0.0575
Echinococcus multilocularis chromobox protein 1 0.005 0.06 0.0575
Echinococcus multilocularis isocitrate dehydrogenase 0.0026 0.0175 0.0148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0118 0.1827 0.1805
Echinococcus multilocularis GPCR, family 2 0.0037 0.0377 0.0351
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) animal heme peroxidase 0.0574 1 1
Trichomonas vaginalis chromobox protein, putative 0.005 0.06 0.0911
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0222 0.3698 0.614
Schistosoma mansoni hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0035 0.0008
Brugia malayi latrophilin 2 splice variant baaae 0.0081 0.1156 0.1132
Loa Loa (eye worm) hypothetical protein 0.0037 0.0377 0.0377
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0222 0.3698 0.614
Schistosoma mansoni peroxidasin 0.0574 1 1
Schistosoma mansoni hypothetical protein 0.0185 0.3031 0.3031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0027 0.0027
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0026 0.0175 0.0148
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0018 0.0027 0.0027
Echinococcus granulosus PHD finger protein rhinoceros 0.0022 0.0103 0.0077
Trichomonas vaginalis chromobox protein, putative 0.003 0.0245 0.0312
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0035 0.0035
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0027 0.0027
Brugia malayi Animal haem peroxidase family protein 0.0574 1 1
Brugia malayi chromobox protein homolog 3 0.0028 0.0207 0.018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Onchocerca volvulus Peroxidase homolog 0.0574 1 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus granulosus short transient receptor potential channel 6 0.0046 0.053 0.0504
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0027 0.0027
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0035 0.0035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0118 0.1827 0.1827
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus multilocularis short transient receptor potential channel 6 0.0046 0.053 0.0504
Schistosoma mansoni notch 0.0185 0.3031 0.3031
Onchocerca volvulus Alhambra homolog 0.0022 0.0103 0.0077
Echinococcus granulosus chromobox protein 1 0.005 0.06 0.0575
Toxoplasma gondii isocitrate dehydrogenase 0.0026 0.0175 0.0466
Onchocerca volvulus 0.0022 0.0098 0.0072
Schistosoma mansoni hypothetical protein 0.0281 0.4742 0.4742
Schistosoma mansoni adenoreceptor 0.0018 0.0027 0.0027
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0035 0.0008
Brugia malayi EGF-like domain containing protein 0.0185 0.3031 0.3012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0307 0.5222 0.5222
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0185 0.3031 0.3012
Schistosoma mansoni hypothetical protein 0.0185 0.3031 0.3031
Schistosoma mansoni biogenic amine receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus granulosus chromobox protein 1 0.005 0.06 0.0575
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi jmjC domain containing protein 0.0018 0.0035 0.0008
Loa Loa (eye worm) Notch2 0.0185 0.3031 0.3031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0027 0.0027
Toxoplasma gondii isocitrate dehydrogenase 0.0026 0.0175 0.0466
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Schistosoma mansoni transient receptor potential channel 0.0046 0.053 0.053
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0026 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0026 0.0175 0.0148
Loa Loa (eye worm) heterochromatin protein 1 0.005 0.06 0.06
Schistosoma mansoni amine GPCR 0.0018 0.0027 0.0027
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0026 0.0175 0.3026
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0027 0.0027
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0027 0.0027
Brugia malayi EGF-like domain containing protein 0.0185 0.3031 0.3012
Schistosoma mansoni biogenic amine receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0027 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0027 0.0027
Brugia malayi Peroxidasin 0.0574 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi Calcium binding EGF domain containing protein 0.0185 0.3031 0.3012
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0035 0.0035
Brugia malayi isocitrate dehydrogenase 0.0026 0.0175 0.0148
Plasmodium vivax SET domain protein, putative 0.0044 0.0496 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0027 0.0027
Schistosoma mansoni neuropeptide receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0035 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Brugia malayi Pre-SET motif family protein 0.0307 0.5222 0.5209
Giardia lamblia Fructose-bisphosphate aldolase 0.0222 0.3698 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Schistosoma mansoni peroxidasin 0.0574 1 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0026 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0185 0.3031 0.3031
Schistosoma mansoni hypothetical protein 0.0022 0.0103 0.0103
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0027 0.0027
Echinococcus granulosus fibropellin Ia 0.0185 0.3031 0.3012
Schistosoma mansoni transient receptor potential channel 0.0046 0.053 0.053
Schistosoma mansoni neuropeptide receptor 0.0018 0.0027 0.0027
Echinococcus granulosus slit 2 protein 0.0185 0.3031 0.3012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Schistosoma mansoni opsin-like receptor 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0027
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0185 0.3031 0.3031
Schistosoma mansoni laminin gamma-3 chain 0.0185 0.3031 0.3031
Schistosoma mansoni neuropeptide receptor 0.0018 0.0027 0.0027
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0035 0.0008
Schistosoma mansoni chromobox protein 0.005 0.06 0.06
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0052 0.0643 0.0643
Brugia malayi Transient-receptor-potential like protein 0.0026 0.0169 0.0142
Schistosoma mansoni opsin-like receptor 0.0018 0.0027 0.0027
Brugia malayi jmjC domain containing protein 0.0018 0.0035 0.0008
Echinococcus multilocularis transient receptor potential gamma protein 0.0069 0.0952 0.0928
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1765 0.1743
Echinococcus multilocularis neurogenic locus protein delta 0.0185 0.3031 0.3012
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0022 0.0103 0.0103
Brugia malayi EGF-like domain containing protein 0.0185 0.3031 0.3012
Schistosoma mansoni hypothetical protein 0.0081 0.1156 0.1156
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0035 0.0008
Onchocerca volvulus 0.0185 0.3031 0.3012
Echinococcus granulosus protein jagged 1 0.0185 0.3031 0.3012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0377 0.0351
Brugia malayi EGF-like domain containing protein 0.0185 0.3031 0.3012
Schistosoma mansoni notch 0.0185 0.3031 0.3031
Schistosoma mansoni amine GPCR 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0574 1 1
Brugia malayi jmjC domain containing protein 0.0069 0.0943 0.0918
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0027 0.0027

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Induction of human MOPR/CB1receptor internalization transiently expressed in HEK293 cells at 1 uM after 30 mins by immunofluorescence assay ChEMBL. 23734559
Activity (functional) = 79.58 % Reduction in tolerance acquisition in ICR-CD1 mouse assessed as compound antinociception effect at 125 to 2500 pmol intrathecally administered on day 1 and repeated on day 2 measured on day 2 by radiant heat tail flick test ChEMBL. 23734559

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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