Detailed information for compound 1782243

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 466.452 | Formula: C26H21F3N2O3
  • H donors: 1 H acceptors: 3 LogP: 4.91 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1c2ccc(cc2N(C(=O)C2(C1=O)CCc1c2ccc(c1)O)c1ccccc1)C(F)(F)F
  • InChi: 1S/C26H21F3N2O3/c1-2-30-21-11-8-17(26(27,28)29)15-22(21)31(18-6-4-3-5-7-18)24(34)25(23(30)33)13-12-16-14-19(32)9-10-20(16)25/h3-11,14-15,32H,2,12-13H2,1H3
  • InChiKey: SFSAADWACSNSGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.1042 0.1042
Schistosoma mansoni polycystin 1-related 0.002 0.0305 0.0305
Onchocerca volvulus 0.0029 0.0619 0.0587
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0016 0.015 0.1218
Schistosoma mansoni hypothetical protein 0.0041 0.1042 0.1042
Chlamydia trachomatis glutamine binding protein 0.0023 0.0419 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Schistosoma mansoni aldehyde dehydrogenase 0.005 0.136 0.136
Brugia malayi Pre-SET motif family protein 0.0022 0.0362 0.0391
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.1042 0.1042
Echinococcus granulosus neuropeptide receptor 0.0041 0.1042 0.1042
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0032 0.0714 0.5251
Brugia malayi hypothetical protein 0.0041 0.1042 0.1123
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0305 0.0305
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0016 0.015 0.0162
Schistosoma mansoni alpha-1 adrenergic receptor 0.0041 0.1042 0.1042
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.1042 0.1042
Echinococcus granulosus somatostatin receptor 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0014 0.008 0.0132
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0305 0.0305
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0041 0.1042 0.1042
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.1042 0.1042
Echinococcus multilocularis g protein coupled receptor 0.0041 0.1042 0.1042
Echinococcus multilocularis neuropeptide s receptor 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0041 0.1042 0.1042
Schistosoma mansoni biogenic amine (5HT) receptor 0.0226 0.7555 0.7555
Loa Loa (eye worm) intermediate filament protein 0.0049 0.1329 0.1432
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0871 0.0871
Brugia malayi hypothetical protein 0.0131 0.4225 0.4554
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.136 0.1913
Trypanosoma cruzi squalene synthase, putative 0.0183 0.6051 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0041 0.1042 0.1042
Echinococcus granulosus inositol monophosphatase 1 0.003 0.067 0.067
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0024 0.0434 0.0434
Echinococcus multilocularis geminin 0.0295 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni histamine h1 receptor 0.0041 0.1042 0.1042
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Brugia malayi ORL1-like opioid receptor 0.0041 0.1042 0.1123
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0023 0.0419 0.2215
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni hypothetical protein 0.0041 0.1042 0.1042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0362 0.0362
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0016 0.015 0.0248
Echinococcus granulosus RUN 0.002 0.0305 0.0305
Onchocerca volvulus 0.0049 0.1329 0.191
Brugia malayi hypothetical protein 0.0046 0.1232 0.1328
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.1042 0.1042
Schistosoma mansoni rab6-interacting 0.002 0.0305 0.0305
Schistosoma mansoni neuropeptide f receptor 76f 0.0041 0.1042 0.1042
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.005 0.136 0.2247
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1042 0.1042
Echinococcus granulosus nmda type glutamate receptor 0.0129 0.4135 0.4135
Trichomonas vaginalis DNA helicase recq, putative 0.0016 0.015 0.008
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0016 0.015 0.015
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0014 0.0083 0.0083
Plasmodium vivax SET domain protein, putative 0.0022 0.0362 0.294
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.1042 0.1123
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.1103 0.1103
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni opsin-like receptor 0.0041 0.1042 0.1042
Brugia malayi hypothetical protein 0.002 0.0305 0.0329
Onchocerca volvulus 0.0022 0.0362 0.0107
Echinococcus multilocularis transfer RNA-Lys 0.0029 0.0619 0.0619
Brugia malayi G protein-coupled receptor 0.0041 0.1042 0.1123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Trichomonas vaginalis myo inositol monophosphatase, putative 0.003 0.067 0.0673
Echinococcus granulosus neuropeptide s receptor 0.0041 0.1042 0.1042
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.015 0.1104
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0041 0.1042 0.1042
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0014 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus granulosus alpha 1A adrenergic receptor 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1042 0.1042
Trypanosoma cruzi phytoene synthase, putative 0.0057 0.161 0.2661
Echinococcus granulosus orexin receptor type 2 0.0041 0.1042 0.1042
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.003 0.067 0.1107
Brugia malayi hypothetical protein 0.0041 0.1042 0.1123
Brugia malayi Tachykinin-like peptides receptor 99D 0.0041 0.1042 0.1123
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.1042 0.1042
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0014 0.008 0.008
Brugia malayi neuropeptide F receptor 0.0041 0.1042 0.1123
Schistosoma mansoni single-minded 0.0039 0.0978 0.0978
Onchocerca volvulus 0.0041 0.1042 0.1376
Loa Loa (eye worm) glutaminase 0.0204 0.6771 0.7297
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1042 0.1042
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0041 0.1042 0.1123
Brugia malayi Pre-SET motif family protein 0.0151 0.4922 0.5304
Echinococcus multilocularis lamin dm0 0.0049 0.1329 0.1329
Echinococcus granulosus tar DNA binding protein 0.0052 0.1436 0.1436
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.8846 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0023 0.0419 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.1232 0.2037
Schistosoma mansoni amine GPCR 0.0041 0.1042 0.1042
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.1042 0.1042
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0041 0.1042 0.1123
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Giardia lamblia Histone acetyltransferase GCN5 0.0029 0.0621 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Brugia malayi hypothetical protein 0.0041 0.1042 0.1123
Brugia malayi hypothetical protein 0.003 0.0653 0.0704
Schistosoma mansoni ap endonuclease 0.0014 0.008 0.008
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0023 0.0419 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.5666 0.6373
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0016 0.015 0.0162
Loa Loa (eye worm) hypothetical protein 0.0016 0.015 0.0162
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0041 0.1042 0.1042
Echinococcus granulosus neuropeptide FF receptor 2 0.0041 0.1042 0.1042
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0362 0.0362
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.003 0.067 0.0882
Onchocerca volvulus 0.0041 0.1042 0.1376
Schistosoma mansoni opsin-like receptor 0.0041 0.1042 0.1042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1042 0.1042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.1042 0.1042
Schistosoma mansoni loxhd1 0.002 0.0305 0.0305
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0041 0.1042 0.1042
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0032 0.0739 0.0739
Brugia malayi Serotonin receptor 0.0041 0.1042 0.1123
Echinococcus multilocularis nmda type glutamate receptor 0.0129 0.4135 0.4135
Schistosoma mansoni opsin-like receptor 0.0041 0.1042 0.1042
Schistosoma mansoni lamin 0.0049 0.1329 0.1329
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0041 0.1042 0.1042
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.5666 0.6373
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0131 0.4225 0.4554
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.136 0.1913
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0057 0.161 1
Echinococcus granulosus glutamate receptor NMDA 0.0096 0.2995 0.2995
Echinococcus multilocularis musashi 0.0049 0.1329 0.1329
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0036 0.0871 0.0939
Plasmodium vivax ataxin-2 like protein, putative 0.0046 0.1232 1
Schistosoma mansoni rab6-interacting 0.002 0.0305 0.0305
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0041 0.1042 0.1123
Entamoeba histolytica recQ family helicase, putative 0.0016 0.015 0.1191
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0057 0.161 0.2434
Schistosoma mansoni neuropeptide receptor 0.0041 0.1042 0.1042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1042 0.1042
Onchocerca volvulus 0.0041 0.1042 0.1376
Echinococcus granulosus allatostatin A receptor 0.0041 0.1042 0.1042
Schistosoma mansoni amine GPCR 0.0041 0.1042 0.1042
Onchocerca volvulus 0.0041 0.1042 0.1376
Echinococcus multilocularis inositol monophosphatase 1 0.003 0.067 0.067
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.1232 1
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.1103 0.1103
Echinococcus multilocularis g protein coupled receptor 0.0041 0.1042 0.1042
Brugia malayi Dopamine receptor 0.0041 0.1042 0.1123
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.015 0.1104
Loa Loa (eye worm) hypothetical protein 0.0023 0.0402 0.0433
Brugia malayi Intermediate filament tail domain containing protein 0.0049 0.1329 0.1432
Loa Loa (eye worm) hypothetical protein 0.002 0.0305 0.0329
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.5666 0.6373
Echinococcus granulosus biogenic amine 5HT receptor 0.0226 0.7555 0.7555
Schistosoma mansoni aldehyde dehydrogenase 0.005 0.136 0.136
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus multilocularis somatostatin receptor 0.0041 0.1042 0.1042
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.1042 0.1042
Loa Loa (eye worm) doublecortin family protein 0.002 0.0305 0.0329
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0871 0.0871
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Brugia malayi G protein-coupled receptor F59B2.13 0.0041 0.1042 0.1123
Schistosoma mansoni DNA helicase recq5 0.0016 0.015 0.015
Brugia malayi Serotonin receptor 0.0041 0.1042 0.1123
Schistosoma mansoni hypothetical protein 0.0295 1 1
Brugia malayi putative neuropeptide receptor 0.0041 0.1042 0.1123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Schistosoma mansoni hypothetical protein 0.0295 1 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0029 0.0621 0.9172
Echinococcus granulosus neuropeptide receptor A26 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0305 0.0305
Echinococcus granulosus serotonin receptor 0.0041 0.1042 0.1042
Trypanosoma cruzi squalene synthase, putative 0.0183 0.6051 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Loa Loa (eye worm) hypothetical protein 0.0226 0.7555 0.8142
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0041 0.1042 0.1123
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0016 0.015 0.015
Schistosoma mansoni jumonji domain containing protein 0.0043 0.1103 0.1103
Echinococcus granulosus 7TM GPCR rhodopsin 0.0041 0.1042 0.1042
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.1042 0.1042
Brugia malayi exodeoxyribonuclease III family protein 0.0014 0.008 0.0086
Brugia malayi cytoplasmic intermediate filament protein 0.0026 0.0526 0.0567
Echinococcus multilocularis neuropeptide receptor 0.0041 0.1042 0.1042
Echinococcus granulosus lamin 0.0049 0.1329 0.1329
Schistosoma mansoni amine GPCR 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus granulosus g protein coupled receptor 0.0041 0.1042 0.1042
Echinococcus granulosus intermediate filament protein 0.0049 0.1329 0.1329
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni glutaminase 0.0204 0.6771 0.6771
Brugia malayi hypothetical protein 0.0041 0.1042 0.1123
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0022 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus multilocularis fmrfamide receptor 0.0041 0.1042 0.1042
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0305 0.2474
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Brugia malayi hypothetical protein 0.0041 0.1042 0.1123
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0014 0.008 0.008
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.1042 0.1042
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.5666 0.6373
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0016 0.015 0.015
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.1042 0.1042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Schistosoma mansoni lipoxygenase 0.002 0.0305 0.0305
Schistosoma mansoni intermediate filament proteins 0.0049 0.1329 0.1329
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Onchocerca volvulus 0.0041 0.1042 0.1376
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.1042 0.1042
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0041 0.1042 0.1042
Brugia malayi sulfakinin receptor protein 0.0041 0.1042 0.1123
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.1042 0.1042
Echinococcus granulosus peptide allatostatin:somatostatin 0.0041 0.1042 0.1042
Schistosoma mansoni inositol monophosphatase 0.003 0.067 0.067
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0014 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.8846 1
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.8846 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Brugia malayi jmjC domain containing protein 0.0043 0.1103 0.1189
Echinococcus multilocularis glutamate receptor NMDA 0.0096 0.2995 0.2995
Brugia malayi hypothetical protein 0.0041 0.1042 0.1123
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0041 0.1042 0.1123
Brugia malayi hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni myosin xvIII 0.0041 0.1042 0.1042
Trypanosoma brucei PAB1-binding protein , putative 0.0046 0.1232 0.2037
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.8846 1
Echinococcus granulosus dro:myosuppressin receptor 0.0041 0.1042 0.1042
Brugia malayi hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni neuropeptide receptor 0.0041 0.1042 0.1042
Schistosoma mansoni tar DNA-binding protein 0.0052 0.1436 0.1436
Brugia malayi PAS domain containing protein 0.0039 0.0978 0.1054
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0024 0.0434 0.0434
Echinococcus granulosus g-protein coupled receptor 0.0041 0.1042 0.1042
Leishmania major squalene synthase, putative 0.0183 0.6051 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0041 0.1042 0.1042
Schistosoma mansoni inositol monophosphatase 0.003 0.067 0.067
Schistosoma mansoni glutamate receptor NMDA 0.011 0.3479 0.3479
Brugia malayi Dopamine receptor protein 2 0.0041 0.1042 0.1123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0362 0.0362
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0036 0.0871 0.0871
Echinococcus multilocularis neuropeptide receptor 0.0041 0.1042 0.1042
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0016 0.015 0.0248
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.1042 0.1123
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.1042 0.1123
Echinococcus granulosus neuropeptide receptor 0.0041 0.1042 0.1042
Schistosoma mansoni hypothetical protein 0.0057 0.161 0.161
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0871 0.0871
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Onchocerca volvulus 0.0041 0.1042 0.1376
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0043 0.1103 0.1103
Echinococcus granulosus histone acetyltransferase KAT2B 0.0032 0.0714 0.0714
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.5666 0.6373
Schistosoma mansoni hypothetical protein 0.0039 0.0956 0.0956
Trypanosoma cruzi PAB1-binding protein , putative 0.0046 0.1232 0.2037
Trypanosoma brucei squalene synthase, putative 0.0183 0.6051 1
Onchocerca volvulus 0.0041 0.1042 0.1376
Echinococcus multilocularis RUN 0.002 0.0305 0.0305
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0032 0.0714 0.0724
Echinococcus granulosus histone lysine methyltransferase setb 0.0022 0.0362 0.0362
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.1042 0.1042
Brugia malayi hypothetical protein 0.0101 0.3152 0.3397
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.5993 0.6745
Leishmania major hypothetical protein, conserved 0.0057 0.161 0.2661
Mycobacterium ulcerans putative regulatory protein 0.0029 0.0619 0.0806
Brugia malayi RNA binding protein 0.0052 0.1436 0.1548
Brugia malayi hypothetical protein 0.0041 0.1042 0.1123
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0021 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.002 0.0305 0.0329
Echinococcus granulosus fmrfamide receptor 0.0041 0.1042 0.1042
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.1042 0.1042
Echinococcus multilocularis g protein coupled receptor 0.0041 0.1042 0.1042
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0016 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Leishmania major hypothetical protein, conserved 0.0046 0.1232 0.2037
Brugia malayi acetyltransferase, GNAT family protein 0.0108 0.3391 0.3655
Echinococcus multilocularis G-protein coupled receptor, putative 0.0041 0.1042 0.1042
Trichomonas vaginalis glutaminase, putative 0.0204 0.6771 0.7633
Schistosoma mansoni neuropeptide receptor 0.0041 0.1042 0.1042
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0022 0.0362 0.2665
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.1042 0.1042
Onchocerca volvulus 0.0172 0.5657 0.9983
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0048 0.1297 0.1398
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.1042 0.1042
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0275 0.9279 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.1103 0.1103
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.1042 0.1042
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.003 0.067 0.4927
Loa Loa (eye worm) glutaminase 2 0.0204 0.6771 0.7297
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0023 0.0419 1
Onchocerca volvulus 0.0041 0.1042 0.1376
Onchocerca volvulus 0.0041 0.1042 0.1376
Toxoplasma gondii LsmAD domain-containing protein 0.0046 0.1232 0.9063
Echinococcus multilocularis serotonin receptor 0.0226 0.7555 0.7555
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.5666 1
Schistosoma mansoni adenoreceptor 0.0041 0.1042 0.1042
Brugia malayi hypothetical protein 0.002 0.0305 0.0329
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0041 0.1042 0.1042
Plasmodium falciparum histone acetyltransferase GCN5 0.0029 0.0621 0.504
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0014 0.0083 0.0083
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0026 0.0526 0.0567
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.1042 0.1042
Loa Loa (eye worm) RNA binding protein 0.0052 0.1436 0.1548
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1042 0.1042
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0016 0.015 0.0248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1042 0.1042
Brugia malayi RNA recognition motif domain containing protein 0.0052 0.1436 0.1548
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0022 0.0362 0.0362
Echinococcus granulosus nmda type glutamate receptor 0.0101 0.3159 0.3159
Echinococcus multilocularis orexin receptor type 2 0.0041 0.1042 0.1042
Echinococcus granulosus lamin dm0 0.0049 0.1329 0.1329
Schistosoma mansoni tar DNA-binding protein 0.0052 0.1436 0.1436
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.8846 1
Brugia malayi G-protein coupled receptor 0.0041 0.1042 0.1123
Echinococcus multilocularis G protein coupled receptor 139 0.0041 0.1042 0.1042
Echinococcus multilocularis bloom syndrome protein 0.0016 0.015 0.015
Echinococcus granulosus single minded 2 0.0029 0.0619 0.0619
Brugia malayi Inositol-1 0.003 0.067 0.0722
Brugia malayi larval opioid receptor 0.0041 0.1042 0.1123
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0041 0.1042 0.1042
Schistosoma mansoni hypothetical protein 0.002 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0046 0.1232 0.1328
Echinococcus granulosus sex peptide receptor 0.0041 0.1042 0.1042
Onchocerca volvulus 0.0041 0.1042 0.1376
Trichomonas vaginalis myo inositol monophosphatase, putative 0.003 0.067 0.0673
Schistosoma mansoni tar DNA-binding protein 0.0052 0.1436 0.1436
Echinococcus granulosus tachykinin peptides receptor 99D 0.0041 0.1042 0.1042
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.1042 0.1123
Brugia malayi G-protein coupled receptor 0.0041 0.1042 0.1123
Echinococcus multilocularis allatostatin A receptor 0.0041 0.1042 0.1042
Echinococcus granulosus G protein coupled receptor 139 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0024 0.0434 0.0468
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Schistosoma mansoni neuropeptide receptor 0.0041 0.1042 0.1042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0871 0.0871
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0032 0.0714 0.5251
Loa Loa (eye worm) acetyltransferase 0.0108 0.3391 0.3655
Brugia malayi GnHR receptor homolog 0.0041 0.1042 0.1123
Trichomonas vaginalis bromodomain-containing protein, putative 0.0032 0.0714 0.0724
Brugia malayi glutaminase DH11.1 0.0204 0.6771 0.7297
Loa Loa (eye worm) hypothetical protein 0.0049 0.1329 0.1432
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0032 0.0714 0.5794
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0014 0.008 0.0132
Brugia malayi neuropeptide F receptor 0.0041 0.1042 0.1123
Brugia malayi follicle stimulating hormone receptor 0.0275 0.9279 1
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.1042 0.1042
Brugia malayi hypothetical protein 0.0041 0.1042 0.1123
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0041 0.1042 0.1042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0014 0.008 0.0132
Schistosoma mansoni hypothetical protein 0.0041 0.1042 0.1042
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0014 0.0083 0.0083
Trichomonas vaginalis DNA helicase recq, putative 0.0016 0.015 0.008
Echinococcus multilocularis glutamate receptor 2 0.0014 0.0083 0.0083
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.1042 0.1042
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0305 0.0305
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.1042 0.1042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0041 0.1042 0.1042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1042 0.1042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0151 0.4922 0.5304
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Echinococcus multilocularis neuropeptide FF receptor 2 0.0041 0.1042 0.1042
Loa Loa (eye worm) inositol-1 0.003 0.067 0.0722
Loa Loa (eye worm) hypothetical protein 0.0057 0.161 0.1735
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.003 0.067 1
Brugia malayi intermediate filament protein 0.0049 0.1329 0.1432
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0041 0.1042 0.1042
Schistosoma mansoni hypothetical protein 0.0041 0.1042 0.1042
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.005 0.136 0.136
Onchocerca volvulus 0.0041 0.1042 0.1376
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.5666 0.6373
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0108 0.3391 0.3391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.1042 0.1042
Onchocerca volvulus 0.0041 0.1042 0.1376
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.1576 0.1576
Plasmodium falciparum ataxin-2 like protein, putative 0.0046 0.1232 1
Brugia malayi putative neuropeptide receptor NPR1 0.0041 0.1042 0.1123
Entamoeba histolytica myo-inositol monophosphatase, putative 0.003 0.067 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0041 0.1042 0.1123
Onchocerca volvulus 0.0041 0.1042 0.1376
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus multilocularis lamin 0.0049 0.1329 0.1329
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0052 0.1436 0.1548
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.008 0.0648
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.1042 0.1042
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0021 0.0332 0.0332
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.1042 0.1042
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.5993 0.6745
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Brugia malayi Bloom's syndrome protein homolog 0.0016 0.015 0.0162
Echinococcus multilocularis sex peptide receptor 0.0041 0.1042 0.1042
Brugia malayi AKH receptor 0.0041 0.1042 0.1123
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0014 0.0083 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0036 0.0871 0.0871
Echinococcus multilocularis neuropeptide receptor A26 0.0041 0.1042 0.1042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0049 0.1329 0.1432
Trichomonas vaginalis set domain proteins, putative 0.0172 0.5657 0.6362
Brugia malayi Doublecortin family protein 0.002 0.0305 0.0329
Echinococcus multilocularis Squalene phytoene synthase 0.0057 0.161 0.161
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0108 0.3391 0.3391
Trichomonas vaginalis DNA helicase recq1, putative 0.0016 0.015 0.008
Echinococcus granulosus bloom syndrome protein 0.0016 0.015 0.015
Brugia malayi RE15519p 0.0041 0.1042 0.1123
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0041 0.1042 0.1123
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.1042 0.1042
Schistosoma mansoni hypothetical protein 0.0021 0.0332 0.0332
Schistosoma mansoni growth hormone secretagogue receptor 0.0041 0.1042 0.1042
Echinococcus granulosus hypothetical protein 0.0041 0.1042 0.1042
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0305 0.0305
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0041 0.1042 0.1042
Echinococcus granulosus g protein coupled receptor 0.0041 0.1042 0.1042
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.1103 0.1103
Trichomonas vaginalis inositol monophosphatase, putative 0.003 0.067 0.0673
Echinococcus granulosus 7tm_1 domain containing protein 0.0041 0.1042 0.1042
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0022 0.0362 0.0362
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0016 0.015 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0036 0.0871 0.0871
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.1576 0.1576
Echinococcus multilocularis tar DNA binding protein 0.0052 0.1436 0.1436
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0305 0.0305
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Onchocerca volvulus 0.0041 0.1042 0.1376
Schistosoma mansoni biogenic amine receptor 0.0041 0.1042 0.1042
Schistosoma mansoni aryl hydrocarbon receptor 0.0039 0.0978 0.0978
Schistosoma mansoni tar DNA-binding protein 0.0052 0.1436 0.1436
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0014 0.0083 0.0083
Onchocerca volvulus Huntingtin homolog 0.0101 0.3152 0.531
Brugia malayi bHLH-PAS transcription factor 0.0029 0.0619 0.0668
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0041 0.1042 0.1042
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0305 0.2474
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.003 0.067 0.1107
Schistosoma mansoni lipoxygenase 0.0056 0.1576 0.1576
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0036 0.0871 0.0939
Loa Loa (eye worm) hypothetical protein 0.0022 0.0362 0.0391
Giardia lamblia Sgs1 DNA helicase, putative 0.0016 0.015 0.1298
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.1103 0.1189
Schistosoma mansoni amine GPCR 0.0041 0.1042 0.1042
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Echinococcus granulosus Squalene phytoene synthase 0.0057 0.161 0.161
Schistosoma mansoni amine GPCR 0.0041 0.1042 0.1042
Schistosoma mansoni tar DNA-binding protein 0.0052 0.1436 0.1436
Onchocerca volvulus 0.0041 0.1042 0.1376
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.005 0.136 0.8366
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.8846 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.008 0.0648
Brugia malayi hypoxia-induced factor 1 0.0121 0.3867 0.4167
Onchocerca volvulus 0.0041 0.1042 0.1376
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0016 0.015 0.1218
Schistosoma mansoni lamin 0.0049 0.1329 0.1329
Brugia malayi TAR-binding protein 0.0052 0.1436 0.1548
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0027 0.0558 0.3124
Loa Loa (eye worm) hypoxia-induced factor 1 0.0121 0.3867 0.4167
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Toxoplasma gondii aldehyde dehydrogenase 0.005 0.136 1
Echinococcus multilocularis fmrfamide receptor 0.0041 0.1042 0.1042
Echinococcus multilocularis nmda type glutamate receptor 0.0101 0.3159 0.3159
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0014 0.0083 0.0083
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0027 0.0558 0.5
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.8846 0.9534
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.003 0.067 0.1107
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.5666 0.6373
Brugia malayi Melatonin receptor type 1A 0.0041 0.1042 0.1123
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0041 0.1042 0.1376
Echinococcus multilocularis serotonin receptor 0.0226 0.7555 0.7555
Schistosoma mansoni DNA helicase recq1 0.0016 0.015 0.015
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0043 0.1103 0.1103
Onchocerca volvulus Huntingtin homolog 0.0101 0.3152 0.531
Echinococcus granulosus g protein coupled receptor 0.0041 0.1042 0.1042
Echinococcus granulosus glutamate receptor 2 0.0014 0.0083 0.0083
Loa Loa (eye worm) melatonin receptor type 1A 0.0041 0.1042 0.1123
Loa Loa (eye worm) RecQ helicase 0.0016 0.015 0.0162
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.8846 0.9534
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0041 0.1042 0.1123
Brugia malayi Dopamine receptor protein 1 0.0041 0.1042 0.1123
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0014 0.008 0.0086
Loa Loa (eye worm) hypothetical protein 0.0101 0.3152 0.3397
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni biogenic amine receptor 0.0041 0.1042 0.1042
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.005 0.136 0.136
Brugia malayi jmjC domain containing protein 0.0043 0.1103 0.1189
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni ap endonuclease 0.0014 0.008 0.008
Toxoplasma gondii exonuclease III APE 0.0014 0.008 0.0587
Loa Loa (eye worm) hypothetical protein 0.0101 0.3152 0.3397
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.1042 0.1042
Echinococcus multilocularis dro:myosuppressin receptor 0.0041 0.1042 0.1042
Mycobacterium ulcerans glutaminase 0.0204 0.6771 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0014 0.008 0.0132
Loa Loa (eye worm) TYRA-2 protein 0.0041 0.1042 0.1123
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0021 0.0332 0.0332
Loa Loa (eye worm) hypothetical protein 0.0023 0.0402 0.0433
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0023 0.0419 0.0506
Onchocerca volvulus 0.0049 0.1329 0.191
Echinococcus granulosus histone acetyltransferase KAT2B 0.0105 0.3285 0.3285
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0041 0.1042 0.1042
Onchocerca volvulus 0.0041 0.1042 0.1376
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0041 0.1042 0.1123
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.136 0.1913
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0041 0.1042 0.1042
Loa Loa (eye worm) TAR-binding protein 0.0052 0.1436 0.1548
Mycobacterium ulcerans phytoene synthase, CrtB 0.0057 0.161 0.2287
Onchocerca volvulus Neuropeptide F receptor homolog 0.0041 0.1042 0.1376
Loa Loa (eye worm) hypothetical protein 0.0226 0.7555 0.8142
Echinococcus multilocularis g-protein coupled receptor 0.0041 0.1042 0.1042
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.003 0.067 0.1107
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Loa Loa (eye worm) hypothetical protein 0.0041 0.1042 0.1123
Schistosoma mansoni biogenic amine receptor 0.0041 0.1042 0.1042

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 32 uM Cytotoxicity against human C8166 cells ChEMBL. 23583513

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.