Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0354 | 1 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0336 | 0.9326 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0156 | 0.2667 | 0.0452 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0354 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.2667 | 0.1532 |
Brugia malayi | vesicle-fusing ATPase | 0.0207 | 0.4584 | 1 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0354 | 1 | 1 |
Giardia lamblia | AAA family ATPase | 0.0212 | 0.4742 | 0.5 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0336 | 0.9326 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.2667 | 0.1532 |
Echinococcus multilocularis | serotonin receptor | 0.0156 | 0.2667 | 0.0452 |
Trypanosoma brucei | Valosin-containing protein | 0.0336 | 0.9326 | 0.5 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.0212 | 0.4742 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0156 | 0.2667 | 0.0452 |
Brugia malayi | valosin containing protein | 0.0207 | 0.4584 | 1 |
Mycobacterium ulcerans | ATPase | 0.0212 | 0.4742 | 0.5 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0336 | 0.9326 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0336 | 0.9326 | 0.5 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0336 | 0.9326 | 0.5 |
Toxoplasma gondii | cell division protein CDC48AP | 0.0212 | 0.4742 | 0.0000097958 |
Loa Loa (eye worm) | hypothetical protein | 0.0207 | 0.4584 | 1 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0207 | 0.4584 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0354 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0336 | 0.9326 | 0.9122 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0354 | 1 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0336 | 0.9326 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 116.3 nM | Displacement of [3H]spiperone from dopamine D2 receptor in rat striatum after 15 mins by liquid scintillation counting analysis | ChEMBL. | 23675993 |
Ki (binding) | = 139.9 nM | Displacement of [3H]ketanserin from 5HT2A receptor in rat cerebral cortex after 15 mins by liquid scintillation counting analysis | ChEMBL. | 23675993 |
Ki (binding) | = 328.2 nM | Displacement of [3H]8-OH-DPAT from 5HT1A receptor in rat cerebral cortex after 30 mins by liquid scintillation counting analysis | ChEMBL. | 23675993 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.