Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.005 | 0.0278 | 0.0036 |
Brugia malayi | valosin containing protein | 0.0069 | 0.106 | 0.0837 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 1 | 0.5 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0118 | 0.3013 | 1 |
Trypanosoma brucei | Valosin-containing protein | 0.0112 | 0.277 | 0.5 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0069 | 0.106 | 0.0837 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.005 | 0.0278 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0278 | 0.0036 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.007 | 0.1116 | 0.5 |
Giardia lamblia | AAA family ATPase | 0.007 | 0.1116 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0278 | 0.0036 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0112 | 0.277 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0112 | 0.277 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0278 | 0.0036 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.005 | 0.0278 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0278 | 0.0036 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.005 | 0.0278 | 0.0036 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.005 | 0.0278 | 0.0036 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.005 | 0.0278 | 0.0036 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0112 | 0.277 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.005 | 0.0278 | 0.0036 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0112 | 0.277 | 0.5 |
Onchocerca volvulus | 0.0292 | 1 | 1 | |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.005 | 0.0278 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0278 | 0.0036 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.005 | 0.0278 | 0.0036 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.005 | 0.0278 | 0.0036 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.005 | 0.0278 | 0.0036 |
Plasmodium vivax | amine transporter, putative | 0.005 | 0.0278 | 0.1003 |
Echinococcus granulosus | transitional endoplasmic reticulum atpase | 0.0118 | 0.3013 | 0.2813 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.005 | 0.0278 | 0.0036 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 1 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.005 | 0.0278 | 0.0036 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.005 | 0.0278 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.106 | 0.0837 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.005 | 0.0278 | 0.0036 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0112 | 0.277 | 0.2589 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 1 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0118 | 0.3013 | 0.2839 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.005 | 0.0278 | 0.0036 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0118 | 0.3013 | 0.2839 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 1 | 1 |
Toxoplasma gondii | transitional endoplasmic reticulum ATPase, putative | 0.007 | 0.1116 | 0.3066 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0278 | 0.0036 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.005 | 0.0278 | 0.0036 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0112 | 0.277 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.005 | 0.0278 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.0069 | 0.106 | 0.0837 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0112 | 0.277 | 0.5 |
Mycobacterium ulcerans | ATPase | 0.007 | 0.1116 | 0.5 |
Brugia malayi | hypothetical protein | 0.005 | 0.0278 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0278 | 0.0036 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.005 | 0.0278 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.005 | 0.0278 | 0.0036 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.005 | 0.0278 | 0.0036 |
Toxoplasma gondii | cell division protein CDC48AP | 0.007 | 0.1116 | 0.3066 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0118 | 0.3013 | 0.2813 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.005 | 0.0278 | 0.0036 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0118 | 0.3013 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.005 | 0.0278 | 0.1003 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.005 | 0.0278 | 0.0036 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 441 nM | Inhibition of high affinity uptake of [3H]-NE by norepinephrine transporter in nerve endings obtained from rat brain. | ChEMBL. | 12109901 |
Ki (binding) | = 441 nM | Inhibition of high affinity uptake of [3H]-NE by norepinephrine transporter in nerve endings obtained from rat brain. | ChEMBL. | 12109901 |
Ki (binding) | = 3150 nM | Inhibition of high affinity uptake of [3H]-DA by dopamine transporter in nerve endings obtained from rat brain. | ChEMBL. | 12109901 |
Ki (binding) | = 3150 nM | Inhibition of high affinity uptake of [3H]-DA by dopamine transporter in nerve endings obtained from rat brain. | ChEMBL. | 12109901 |
Ki (binding) | > 10000 nM | Inhibition of high affinity uptake of [3H]-5-HT by serotonin transporter in nerve endings obtained from rat brain. | ChEMBL. | 12109901 |
Ki (binding) | > 10000 nM | Inhibition of high affinity uptake of [3H]-5-HT by serotonin transporter in nerve endings obtained from rat brain. | ChEMBL. | 12109901 |
Ratio (binding) | < 0.04 | Ratio of Ki at norepinephrine transporter and Ki at 5-HT transporter. | ChEMBL. | 12109901 |
Ratio (binding) | = 0.14 | Ratio of Ki at norepinephrine transporter and Ki at dopamine transporter. | ChEMBL. | 12109901 |
Ratio (binding) | > 3.17 | Ratio of Ki at 5-HT transporter and Ki at dopamine transporter. | ChEMBL. | 12109901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.