TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.213 | Formula: C16H13Cl2N5O
H donors: 2 H acceptors: 3 LogP: 4.34 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)Cl)NC(=O)c1nnn(c1N)c1ccccc1C
InChi: 1S/C16H13Cl2N5O/c1-9-4-2-3-5-13(9)23-15(19)14(21-22-23)16(24)20-12-7-6-10(17)8-11(12)18/h2-8H,19H2,1H3,(H,20,24)
InChiKey: GYGFOHPIPQIPRL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0127	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0032
Trichomonas vaginalis	replication factor C large subunit, putative	0.0011	0.00000034704	0.0000013322
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0127	0.0458
Loa Loa (eye worm)	glycosyl hydrolase family 2	0.0231	0.2479	0.8978
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0127	0.0458
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0127	0.0168
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0127	0.0168
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.0123	0.0163
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0127	0.0168
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0127	0.0458
Brugia malayi	manba-prov protein	0.0079	0.0762	0.2759
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0127	0.0127
Entamoeba histolytica	hypothetical protein	0.004	0.0326	0.1896
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0011	0.0000044167	0.0000044167
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0127	0.09
Entamoeba histolytica	hypothetical protein	0.0088	0.0869	0.505
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0127	0.0168
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0127	0.09
Schistosoma mansoni	lipoxygenase	0.0022	0.0123	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0127	0.0458
Onchocerca volvulus		0.0022	0.0123	0.0876
Plasmodium falciparum	multidrug resistance protein 1	0.0011	0.0000044167	0.0003
Brugia malayi	Beta-glucuronidase precursor	0.0225	0.2405	0.8711
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0127	0.0168
Brugia malayi	hypothetical protein	0.0012	0.0009	0.0032
Echinococcus granulosus	Polycystic kidney disease protein	0.0022	0.0123	0.0163
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0061	0.0566	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0446
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0088	0.0869	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0127	0.0458
Schistosoma mansoni	multidrug resistance protein	0.0011	0.0000044167	0.0000058538
Loa Loa (eye worm)	beta-glucuronidase	0.0225	0.2405	0.8711
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0446
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0088	0.0869	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0127	0.0458
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0127	0.0458
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.0009	0.0012
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.00000034704	0.0000013322
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0127	0.0127
Onchocerca volvulus		0.0022	0.0127	0.09
Brugia malayi	Glycosyl hydrolases family 2, sugar binding domain containing protein	0.0231	0.2479	0.8978
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0127	0.0458
Entamoeba histolytica	hypothetical protein	0.004	0.0326	0.1896
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0127	0.0458
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0127	0.0458
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0011	0.0000044167	0.5
Schistosoma mansoni	multidrug resistance protein	0.0011	0.0000044167	0.0000058538
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0032
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.004	0.0328	0.3776
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.0009	0.0009
Echinococcus granulosus	multidrug resistance protein 1	0.0011	0.0000044167	0.0000058538
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.0009	0.0012
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0127	0.0168
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.004	0.0328	0.1907
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0127	0.0168
Plasmodium falciparum	LCCL domain-containing protein	0.0022	0.0123	1
Brugia malayi	nuclear receptor RXR	0.0012	0.0009	0.0032
Schistosoma mansoni	hypothetical protein	0.0085	0.0836	0.1107
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.004	0.0328	0.3776
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0127	0.0458
Schistosoma mansoni	loxhd1	0.0022	0.0123	0.0163
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0011	0.0000044167	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0127	0.0127
Brugia malayi	hypothetical protein	0.0012	0.0009	0.0032
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0127	0.0458
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0127	0.0127
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.004	0.0328	1
Schistosoma mansoni	rab6-interacting	0.0022	0.0123	0.0163
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.0009	0.0032
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.004	0.0328	0.3776
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0127	0.0458
Entamoeba histolytica	hypothetical protein	0.004	0.0326	0.1896
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0127	0.0458
Entamoeba histolytica	beta-galactosidase, putative	0.0164	0.172	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0011	0.0000044167	0.0000044167
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0127	0.0127
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0011	0.0000044167	0.0000058538
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0032
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0088	0.0869	0.3147
Brugia malayi	hypothetical protein	0.0136	0.1406	0.5094
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0011	0.0000044167	0.0000058538
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0127	0.0458
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0011	0.0000044167	0.0000044167
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0127	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0256	0.2761	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0032
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.004	0.0328	0.0435
Plasmodium vivax	multidomain scavenger receptor, putative	0.0022	0.0123	1
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0088	0.0869	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0127	0.0168
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0127	0.0168
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0011	0.0000044167	0.0000058538
Toxoplasma gondii	ATPase, AAA family protein	0.0011	0.00000034704	0.0786
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0127	0.0458
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0127	0.0127
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0326	0.0432
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0326	0.0432
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.00000034704	0.0000013322
Echinococcus granulosus	ubiquitin specific protease 41	0.004	0.0328	0.0435
Echinococcus granulosus	multidrug resistance protein 1	0.0011	0.0000044167	0.0000058538
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.004	0.0328	0.0435
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0011	0	0.5
Schistosoma mansoni	beta-mannosidase	0.0079	0.0762	0.101
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0127	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0127	0.0458
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0127	0.0127
Schistosoma mansoni	hypothetical protein	0.0022	0.0123	0.0163
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.0123	0.0123
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0127	0.0168
Echinococcus multilocularis	ubiquitin specific protease 41	0.004	0.0328	0.0328
Entamoeba histolytica	protein kinase domain containing protein	0.0088	0.0869	0.505
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.004	0.0328	0.0328
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0465	0.1685
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0465	0.0617
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0127	0.0458
Onchocerca volvulus	Huntingtin homolog	0.0136	0.1406	1
Echinococcus granulosus	RUN	0.0022	0.0123	0.0163
Plasmodium vivax	multidrug resistance protein 1, putative	0.0011	0.0000044167	0.0003
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0328	0.1259
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0127	0.0168
Echinococcus multilocularis	microtubule associated protein 2	0.0682	0.7545	0.7545
Trichomonas vaginalis	beta-mannosidase, putative	0.0079	0.0762	0.2924
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.004	0.0328	0.1188
Onchocerca volvulus	Huntingtin homolog	0.0136	0.1406	1
Schistosoma mansoni	lipoxygenase	0.0061	0.0566	0.0751
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0011	0	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0127	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0864	0.3128
Brugia malayi	hypothetical protein	0.0022	0.0123	0.0446
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0127	0.0168
Brugia malayi	hypothetical protein	0.0256	0.2761	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0127	0.0458
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0127	0.0458
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0009	0.0032
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0127	0.0168
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0326	0.0326
Entamoeba histolytica	hypothetical protein	0.004	0.0326	0.1896
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.004	0.0328	0.0328
Echinococcus multilocularis	replication factor c subunit 1	0.0011	0.00000034704	0.00000034704
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.004	0.0328	0.1259
Brugia malayi	hypothetical protein	0.004	0.0326	0.1182
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0127	0.0127
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0127	0.0168
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0127	0.0168
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0011	0.00000034704	0.0000020173
Schistosoma mansoni	rab6-interacting	0.0022	0.0123	0.0163
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0127	0.0458
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0127	0.0168
Echinococcus multilocularis	dual specificity	0.0088	0.0869	0.0869
Brugia malayi	hypothetical protein	0.0022	0.0123	0.0446
Entamoeba histolytica	protein kinase, putative	0.0088	0.0869	0.505
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0009	0.0032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0127	0.0458
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0127	0.0127
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0061	0.0566	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0127	0.0458
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.004	0.0328	0.3776
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0011	0.0000044167	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0011	0.0000044167	0.0000058538
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.0869	0.1151
Onchocerca volvulus		0.0052	0.0465	0.3308
Echinococcus granulosus	survival motor neuron protein 1	0.0256	0.2761	0.3659
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.0123	0.0163
Echinococcus granulosus	multidrug resistance protein 1	0.0011	0.0000044167	0.0000058538
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0127	0.0458
Schistosoma mansoni	hypothetical protein	0.004	0.0326	0.0432
Loa Loa (eye worm)	hypothetical protein	0.004	0.0328	0.1188
Echinococcus multilocularis	Polycystic kidney disease protein	0.0022	0.0123	0.0123
Entamoeba histolytica	protein kinase, putative	0.0088	0.0869	0.505
Brugia malayi	Doublecortin family protein	0.0022	0.0123	0.0446
Echinococcus multilocularis	RUN	0.0022	0.0123	0.0123
Schistosoma mansoni	microtubule-associated protein tau	0.0682	0.7545	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0864	0.3128
Onchocerca volvulus		0.0022	0.0123	0.0876
Echinococcus granulosus	dual specificity	0.0088	0.0869	0.1151
Schistosoma mansoni	hypothetical protein	0.0052	0.0465	0.0617
Trichomonas vaginalis	beta-galactosidase, putative	0.0243	0.2605	1
Echinococcus granulosus	microtubule associated protein 2	0.0682	0.7545	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.004	0.0328	0.0435
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0011	0.0000044167	0.0000044167
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0127	0.0458
Echinococcus multilocularis	survival motor neuron protein 1	0.0256	0.2761	0.2761
Schistosoma mansoni	multidrug resistance protein	0.0011	0.0000044167	0.0000058538
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0127	0.0168
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0127	0.0168
Brugia malayi	steroid hormone receptor	0.0022	0.0127	0.0458
Brugia malayi	nuclear hormone receptor	0.0022	0.0127	0.0458
Loa Loa (eye worm)	doublecortin family protein	0.0022	0.0123	0.0446
Trichomonas vaginalis	conserved hypothetical protein	0.0243	0.2605	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.152	0.5506
Schistosoma mansoni	smdr2	0.0011	0.0000044167	0.0000058538
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0127	0.0168
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0011	0	0.5
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.004	0.0328	0.0435
Schistosoma mansoni	coup transcription factor	0.0022	0.0127	0.0168
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0127	0.0458
Brugia malayi	Protein kinase domain containing protein	0.0088	0.0869	0.3147
Echinococcus multilocularis	multidrug resistance protein 1	0.0011	0.0000044167	0.0000044167
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0127	0.0458
Echinococcus multilocularis	multidrug resistance protein 1	0.0011	0.0000044167	0.0000044167
Echinococcus granulosus	replication factor c subunit 1	0.0011	0.00000034704	0.00000045996
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0011	0.0000044167	0.0000044167
Schistosoma mansoni	chromosome transmission fidelity factor	0.0011	0.00000034704	0.00000045996
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0009	0.0032
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0127	0.0168
Schistosoma mansoni	polycystin 1-related	0.0022	0.0123	0.0163
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0009	0.0012
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0011	0.0000044167	1
Brugia malayi	ecdysteroid receptor	0.0022	0.0127	0.0458
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0127	0.09
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1406	0.5094
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.0123	0.0123
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.004	0.0328	0.1259
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0127	0.0458
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0127	0.0458
Treponema pallidum	DNA ligase (lig)	0.0011	0	0.5
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0088	0.0869	1
Trichomonas vaginalis	glycoside hydrolase, putative	0.0243	0.2605	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0127	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1406	0.5094

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 60.87 %	Cytotoxicity against human T47D cells assessed as cell growth at 10'-5 M after 48 hrs by SRB assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2425306

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1783043