Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aspartyl protease ASP1 | 0.0342 | 0.0467 | 1 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0107 | 0.0033 | 0.0053 |
Brugia malayi | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Plasmodium vivax | plasmepsin V, putative | 0.0342 | 0.0467 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1757 | 0.3078 | 1 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0176 | 0.0161 | 0.042 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Brugia malayi | Choline O-acetyltransferase | 0.0431 | 0.0632 | 0.1021 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.3442 | 0.6187 | 1 |
Plasmodium falciparum | plasmepsin VII | 0.0342 | 0.0467 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0342 | 0.0467 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0431 | 0.0632 | 0.4271 |
Brugia malayi | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Plasmodium falciparum | plasmepsin III | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1757 | 0.3078 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.0033 | 0.0033 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0867 | 0.1435 | 0.2319 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0867 | 0.1435 | 0.4603 |
Plasmodium falciparum | plasmepsin V | 0.0342 | 0.0467 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3442 | 0.6187 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1757 | 0.3078 | 1 |
Plasmodium vivax | aspartyl protease, putative | 0.0342 | 0.0467 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0342 | 0.0467 | 1 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0342 | 0.0467 | 0.0755 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0107 | 0.0033 | 0.0107 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Schistosoma mansoni | choline o-acyltransferase | 0.0431 | 0.0632 | 0.0632 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0867 | 0.1435 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.0632 | 0.1021 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0431 | 0.0632 | 0.4271 |
Brugia malayi | Choline O-acetyltransferase | 0.0431 | 0.0632 | 0.1021 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0867 | 0.1435 | 0.4661 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0107 | 0.0033 | 0.0107 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0431 | 0.0632 | 0.1021 |
Plasmodium vivax | plasmepsin IV, putative | 0.0342 | 0.0467 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0107 | 0.0033 | 0.0107 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0342 | 0.0467 | 0.5 |
Plasmodium falciparum | plasmepsin II | 0.0342 | 0.0467 | 0.5 |
Plasmodium falciparum | plasmepsin VI | 0.0342 | 0.0467 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0091 | 0.0003 | 0.001 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Brugia malayi | Pepsin A precursor | 0.0342 | 0.0467 | 0.0755 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Brugia malayi | MAP kinase sur-1 | 0.0107 | 0.0033 | 0.0053 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1757 | 0.3078 | 1 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0176 | 0.0161 | 0.026 |
Plasmodium falciparum | plasmepsin X | 0.0342 | 0.0467 | 0.5 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0431 | 0.0632 | 0.1021 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0205 | 0.0214 | 0.0346 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Plasmodium falciparum | plasmepsin IX | 0.0342 | 0.0467 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0342 | 0.0467 | 0.5 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0342 | 0.0467 | 0.0755 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Schistosoma mansoni | choline o-acyltransferase | 0.0431 | 0.0632 | 0.0632 |
Plasmodium falciparum | plasmepsin IV | 0.0342 | 0.0467 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0342 | 0.0467 | 0.5 |
Echinococcus granulosus | choline O acetyltransferase | 0.0431 | 0.0632 | 0.2052 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0431 | 0.0632 | 0.1021 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0205 | 0.0214 | 0.0214 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0342 | 0.0467 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0342 | 0.0467 | 0.0755 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0342 | 0.0467 | 0.1518 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1757 | 0.3078 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0089 | 0 | 0.5 |
Giardia lamblia | Kinase, AGC AKT | 0.0176 | 0.0161 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0867 | 0.1435 | 0.4661 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0431 | 0.0632 | 0.2052 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Plasmodium falciparum | plasmepsin I | 0.0342 | 0.0467 | 0.5 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0205 | 0.0214 | 0.0696 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0867 | 0.1435 | 0.4603 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0342 | 0.0467 | 0.0755 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.4271 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0205 | 0.0214 | 0.0696 |
Toxoplasma gondii | aspartyl protease | 0.0342 | 0.0467 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0107 | 0.0033 | 0.0107 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0342 | 0.0467 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0342 | 0.0467 | 0.1518 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Onchocerca volvulus | 0.0342 | 0.0467 | 0.7396 | |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0342 | 0.0467 | 0.0755 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0431 | 0.0632 | 0.4271 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Onchocerca volvulus | 0.0342 | 0.0467 | 0.7396 | |
Plasmodium vivax | aspartyl protease, putative | 0.0342 | 0.0467 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0342 | 0.0467 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0342 | 0.0467 | 0.0755 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0867 | 0.1435 | 0.2319 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.