Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0342 | 0.0467 | 0.7396 | |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0205 | 0.0214 | 0.0696 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1757 | 0.3078 | 1 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.0176 | 0.0161 | 0.026 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0431 | 0.0632 | 0.1021 |
Giardia lamblia | Kinase, AGC AKT | 0.0176 | 0.0161 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0342 | 0.0467 | 0.1518 |
Brugia malayi | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0107 | 0.0033 | 0.0107 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Plasmodium falciparum | plasmepsin VI | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0342 | 0.0467 | 0.0755 |
Plasmodium falciparum | plasmepsin IV | 0.0342 | 0.0467 | 0.5 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0342 | 0.0467 | 1 |
Echinococcus granulosus | choline O acetyltransferase | 0.0431 | 0.0632 | 0.2052 |
Brugia malayi | MAP kinase sur-1 | 0.0107 | 0.0033 | 0.0053 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0867 | 0.1435 | 0.4661 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0431 | 0.0632 | 0.4271 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0342 | 0.0467 | 0.0755 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0107 | 0.0033 | 0.0107 |
Plasmodium vivax | aspartyl protease, putative | 0.0342 | 0.0467 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1757 | 0.3078 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0431 | 0.0632 | 0.4271 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0342 | 0.0467 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0107 | 0.0033 | 0.0107 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Plasmodium falciparum | plasmepsin X | 0.0342 | 0.0467 | 0.5 |
Plasmodium falciparum | plasmepsin V | 0.0342 | 0.0467 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.4271 |
Brugia malayi | Choline O-acetyltransferase | 0.0431 | 0.0632 | 0.1021 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1757 | 0.3078 | 1 |
Plasmodium vivax | plasmepsin V, putative | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Brugia malayi | Pepsin A precursor | 0.0342 | 0.0467 | 0.0755 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0342 | 0.0467 | 0.1518 |
Brugia malayi | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1757 | 0.3078 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0342 | 0.0467 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3442 | 0.6187 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0342 | 0.0467 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0867 | 0.1435 | 0.4603 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0431 | 0.0632 | 0.2052 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0091 | 0.0003 | 0.001 |
Schistosoma mansoni | choline o-acyltransferase | 0.0431 | 0.0632 | 0.0632 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0107 | 0.0033 | 0.0033 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0867 | 0.1435 | 0.4603 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0176 | 0.0161 | 0.042 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0431 | 0.0632 | 0.1021 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0867 | 0.1435 | 0.2319 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0205 | 0.0214 | 0.0346 |
Plasmodium falciparum | plasmepsin VII | 0.0342 | 0.0467 | 0.5 |
Plasmodium falciparum | plasmepsin IX | 0.0342 | 0.0467 | 0.5 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0431 | 0.0632 | 0.4271 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0867 | 0.1435 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0342 | 0.0467 | 1 |
Plasmodium vivax | plasmepsin IV, putative | 0.0342 | 0.0467 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0107 | 0.0033 | 0.0107 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0342 | 0.0467 | 0.0755 |
Loa Loa (eye worm) | hypothetical protein | 0.0342 | 0.0467 | 0.0755 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0205 | 0.0214 | 0.0214 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0342 | 0.0467 | 0.5 |
Onchocerca volvulus | 0.0431 | 0.0632 | 1 | |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0107 | 0.0033 | 0.0053 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0342 | 0.0467 | 0.0467 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0867 | 0.1435 | 0.2319 |
Loa Loa (eye worm) | hypothetical protein | 0.0431 | 0.0632 | 0.1021 |
Toxoplasma gondii | aspartyl protease | 0.0342 | 0.0467 | 1 |
Plasmodium falciparum | plasmepsin III | 0.0342 | 0.0467 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0431 | 0.0632 | 0.0632 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0431 | 0.0632 | 0.1966 |
Brugia malayi | Choline O-acetyltransferase | 0.0431 | 0.0632 | 0.1021 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0431 | 0.0632 | 0.1021 |
Plasmodium falciparum | plasmepsin I | 0.0342 | 0.0467 | 0.5 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0342 | 0.0467 | 1 |
Onchocerca volvulus | 0.0342 | 0.0467 | 0.7396 | |
Plasmodium vivax | aspartyl protease, putative | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.3442 | 0.6187 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0089 | 0 | 0.5 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0342 | 0.0467 | 0.0755 |
Plasmodium vivax | aspartyl protease, putative | 0.0342 | 0.0467 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1757 | 0.3078 | 1 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0205 | 0.0214 | 0.0696 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0431 | 0.0632 | 0.1966 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0342 | 0.0467 | 0.0755 |
Plasmodium falciparum | plasmepsin II | 0.0342 | 0.0467 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0342 | 0.0467 | 0.0755 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0342 | 0.0467 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0867 | 0.1435 | 0.4661 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.