Detailed information for compound 1796106

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.524 | Formula: C24H33NO2
  • H donors: 2 H acceptors: 1 LogP: 5.45 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@]1(C)OCCC(C1)(CCNCc1ccccc1O)c1ccc(cc1)C
  • InChi: 1S/C24H33NO2/c1-4-23(3)18-24(14-16-27-23,21-11-9-19(2)10-12-21)13-15-25-17-20-7-5-6-8-22(20)26/h5-12,25-26H,4,13-18H2,1-3H3/t23-,24?/m1/s1
  • InChiKey: AZZXQPIFKYDBCE-MIHMCVIASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0024 0.0199
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.004 0.0373
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0155 0.0584
Leishmania major glucose transporter, lmgt2 0.0039 0.0188 0.067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0028 0.0023
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0051 0.0149
Plasmodium falciparum plastid replication-repair enzyme 0.0034 0.0147 0.034
Entamoeba histolytica hypothetical protein 0.0036 0.0161 0.8344
Entamoeba histolytica hypothetical protein 0.0036 0.0161 0.8344
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0012 0.0044
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0188 0.067
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0051 0.0464
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0028 0.0023
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0204 0.1456 0.5477
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0051 0.0164
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0028 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0051 0.0192
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0028 0.0025
Plasmodium vivax glutathione reductase, putative 0.0047 0.0247 0.0588
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.004 0.0072
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0024 0.0141
Leishmania major hypothetical protein, conserved 0.0025 0.0081 0.0263
Schistosoma mansoni ap endonuclease 0.002 0.004 0.022
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0024 0.0017
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0052 0.0152
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0155 0.169
Brugia malayi Sugar transporter family protein 0.0018 0.0024 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0141
Trypanosoma brucei unspecified product 0.0021 0.0051 0.0192
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.004 0.0398
Toxoplasma gondii exonuclease III APE 0.002 0.004 0.0109
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0188 0.067
Echinococcus multilocularis twinkle protein, mitochondrial 0.0025 0.0079 0.01
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0028 0.0025
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Plasmodium vivax proline--tRNA ligase, putative 0.0044 0.0227 0.0538
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0188 0.067
Trypanosoma brucei glucose transporter 1E 0.0039 0.0188 0.071
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0038 0.0178 0.9582
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0024 0.0141
Leishmania major DNA polymerase eta, putative 0.0021 0.0051 0.0149
Brugia malayi Thioredoxin reductase 0.0047 0.0247 0.0325
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0104 0.119
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0799 0.4964
Brugia malayi Sugar transporter family protein 0.0018 0.0024 0.0017
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0024 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0028 0.0023
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0247 0.1482
Loa Loa (eye worm) sugar transporter 0.0018 0.0024 0.0199
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0799 1
Brugia malayi glutathione reductase 0.0047 0.0247 0.0325
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.0858 0.3546
Schistosoma mansoni hypothetical protein 0.0025 0.0079 0.0515
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0028 0.0005
Schistosoma mansoni sugar transporter 0.0018 0.0024 0.0091
Plasmodium vivax CDK-related protein kinase 6, putative 0.0536 0.4009 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0141
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0155 0.0198
Plasmodium vivax calcium-dependent protein kinase, putative 0.0039 0.0185 0.0433
Schistosoma mansoni hypothetical protein 0.0036 0.0161 0.1134
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0104 0.1089
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.004 0.0109
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0028 0.0128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0653 0.4883
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.004 0.0153
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0257
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.004 0.0373
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0051 0.0149
Trypanosoma brucei glucose transporter, putative 0.0039 0.0188 0.071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Plasmodium vivax sugar transporter, putative 0.0018 0.0024 0.003
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0024 0.0045
Onchocerca volvulus 0.0035 0.0155 0.0131
Echinococcus multilocularis geminin 0.0187 0.1326 0.1946
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0051 0.0149
Giardia lamblia DINP protein human, muc B family 0.0021 0.0051 0.0149
Brugia malayi Sugar transporter family protein 0.0126 0.0858 0.1172
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0227 0.0815
Trypanosoma brucei telomerase reverse transcriptase 0.0359 0.2649 1
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0389 0.1429
Schistosoma mansoni sugar transporter 0.0018 0.0024 0.0091
Plasmodium falciparum calcium-dependent protein kinase 2 0.0039 0.0185 0.0433
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0104 0.0386
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0155 0.0599
Brugia malayi nuclear hormone receptor 0.0018 0.0028 0.0023
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0155 0.0902
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0184 0.0256
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0039 0.0184 0.0724
Brugia malayi hypothetical protein 0.0018 0.0024 0.0017
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0051 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0141
Echinococcus multilocularis solute carrier family 22 0.0018 0.0024 0.0018
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0104 0.119
Entamoeba histolytica hypothetical protein 0.0036 0.0161 0.8344
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0024 0.0155
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0028 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0178 0.1269
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0028 0.0023
Plasmodium falciparum calcium-dependent protein kinase 5 0.0039 0.0185 0.0433
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0188 0.2086
Leishmania major glucose transporter, lmgt1 0.0039 0.0188 0.067
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0051 0.0192
Leishmania major mitochondrial DNA polymerase I protein A, putative 0.0034 0.0147 0.0515
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.004 0.0182
Schistosoma mansoni coup transcription factor 0.0018 0.0028 0.0128
Mycobacterium ulcerans hypothetical protein 0.0035 0.0155 0.1847
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0104 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0051 0.0192
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0034 0.0147 0.0556
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0024 0.0141
Trypanosoma brucei mitochondrial DNA polymerase I protein A, putative 0.0034 0.0147 0.0556
Loa Loa (eye worm) twinkle helicase 0.0025 0.0079 0.0853
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0024 0.0155
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0104 0.0392
Chlamydia trachomatis DNA polymerase I 0.0117 0.0786 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0227 0.0815
Leishmania major DNA polymerase kappa, putative 0.0021 0.0051 0.0149
Trypanosoma brucei glucose transporter, putative 0.0039 0.0188 0.071
Schistosoma mansoni sugar transporter 0.0018 0.0024 0.0091
Echinococcus multilocularis dna polymerase eta 0.0021 0.0051 0.0058
Echinococcus granulosus dna polymerase eta 0.0021 0.0051 0.0164
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0028 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0028 0.0257
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0024 0.0018
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.0858 0.1254
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0257
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0257
Echinococcus multilocularis solute carrier family 22 0.0018 0.0024 0.0018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0155 0.1089
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0188 0.071
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0184 0.0256
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.1375
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.004 0.0373
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0028 0.0025
Trypanosoma brucei trypanothione reductase 0.0047 0.0247 0.0931
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.0858 0.3546
Toxoplasma gondii protein kinase, putative 0.0357 0.2631 0.9931
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0247 0.2817
Schistosoma mansoni protein kinase 0.0039 0.0184 0.1315
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0104 0.035
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.1739
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0155 0.1847
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0038 0.0178 0.0247
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.0858 0.1254
Plasmodium vivax plastid replication-repair enzyme, putative 0.0034 0.0147 0.034
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0799 0.4964
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0247 0.0984
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0083 0.0526 0.1287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0653 0.4883
Plasmodium falciparum glutathione reductase 0.0047 0.0247 0.0588
Entamoeba histolytica protein kinase, putative 0.0039 0.0184 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.004 0.0043
Brugia malayi ecdysteroid receptor 0.0018 0.0028 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0653 0.2687
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0081 0.0173
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0104 0.035
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.1739
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.004 0.0121
Trypanosoma brucei sugar transporter, putative 0.0018 0.0024 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0028 0.0023
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0104 0.0449
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0051 0.0192
Schistosoma mansoni glucose transport protein 0.0126 0.0858 0.6443
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.1739
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0204 0.1456 0.3614
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0039 0.0184 0.0696
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Schistosoma mansoni protein kinase 0.0039 0.0184 0.1315
Mycobacterium tuberculosis Conserved protein 0.0035 0.0155 0.0902
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0188 0.2086
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0257
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0039 0.0185 0.0656
Toxoplasma gondii DNA polymerase I domain-containing protein 0.0034 0.0147 0.0515
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0051 0.0149
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0257
Brugia malayi hypothetical protein 0.0025 0.0081 0.0096
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0894 0.6763 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0051 0.0149
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.1739
Brugia malayi Telomerase reverse transcriptase 0.0955 0.7238 1
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0028 0.0128
Trypanosoma brucei glucose transporter, putative 0.0039 0.0188 0.071
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0028 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0155 0.169
Giardia lamblia Hexose transporter 0.0018 0.0024 0.0045
Mycobacterium leprae Probable lipase LipE 0.0035 0.0155 0.1149
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0051 0.0299
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0104 0.035
Schistosoma mansoni glucose transport protein 0.0126 0.0858 0.6443
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Schistosoma mansoni protein kinase 0.0039 0.0184 0.1315
Brugia malayi major facilitator superfamily protein 0.0018 0.0024 0.0017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0081 0.0872
Trichomonas vaginalis DNA polymerase I, putative 0.0034 0.0147 0.1604
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0141
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0227 0.0856
Echinococcus granulosus solute carrier family 22 0.0018 0.0024 0.005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0257
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0081 0.0263
Echinococcus multilocularis solute carrier family 22 0.0018 0.0024 0.0018
Loa Loa (eye worm) beta-lactamase 0.0035 0.0155 0.1739
Plasmodium falciparum proline--tRNA ligase 0.0044 0.0227 0.0538
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0104 0.0128
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0155 0.1149
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0044 0.0227 0.0815
Mycobacterium ulcerans sugar transporter 0.0018 0.0024 0.0155
Plasmodium falciparum calcium-dependent protein kinase 1 0.0039 0.0185 0.0433
Schistosoma mansoni hypothetical protein 0.0187 0.1326 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0077 0.0773
Giardia lamblia Sugar-proton symporter 0.0018 0.0024 0.0045
Leishmania major glucose transporter, lmgt3 0.0039 0.0188 0.067
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0184 0.1315
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0034 0.0147 0.0515
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.004 0.0109
Echinococcus granulosus twinkle protein mitochondrial 0.0025 0.0079 0.0284
Toxoplasma gondii RNA-directed DNA polymerase 0.0359 0.2649 1
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0051 0.0192
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0083 0.0526 0.195
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0024 0.003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0028 0.0025
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0051 0.0507
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.0858 0.321
Trypanosoma cruzi hexose transporter 0.0039 0.0188 0.067
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0028 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0028 0.0023
Mycobacterium ulcerans DNA polymerase I 0.0117 0.0786 1
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0024 0.0045
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0028 0.0071
Toxoplasma gondii sugar transporter ST1 0.0018 0.0024 0.0045
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0155 0.0212
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0028 0.0071
Trypanosoma cruzi mitochondrial DNA polymerase I protein A, putative 0.0034 0.0147 0.0515
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0155 0.0902
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0653 0.4883
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0155 0.1739
Loa Loa (eye worm) hypothetical protein 0.0038 0.0178 0.2017
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0038 0.0178 0.1474
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.052
Plasmodium falciparum calcium-dependent protein kinase 3 0.0039 0.0185 0.0433
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0051 0.0299
Mycobacterium tuberculosis Conserved protein 0.0035 0.0155 0.0902
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0188 0.2086
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0051 0.0192
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0051 0.0507
Schistosoma mansoni sugar transporter 0.0018 0.0024 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0028 0.0023
Leishmania major telomerase reverse transcriptase, putative 0.0359 0.2649 1
Giardia lamblia Telomerase catalytic subunit 0.0359 0.2649 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0155 0.0902
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0184 0.0256
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0653 0.7593
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0024 0.005
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0188 0.071
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0051 0.0192
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0039 0.0184 0.0239
Schistosoma mansoni hypothetical protein 0.0025 0.0079 0.0515
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0024 0.005
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0028 0.0128
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0081 0.0173
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0707 0.4387
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.0858 0.3546
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0653 0.095
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0028 0.0025
Onchocerca volvulus 0.0048 0.0255 0.0232
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.004 0.004
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Echinococcus granulosus dna polymerase kappa 0.0021 0.0051 0.0164
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0028 0.0071
Leishmania major hypothetical protein, conserved 0.0035 0.0155 0.0542
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Onchocerca volvulus 0.0035 0.0155 0.0131
Leishmania major protein kinase, putative 0.0039 0.0184 0.0655
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0117 0.0786 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0161 0.0624
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0028 0.0071
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0188 0.067
Onchocerca volvulus 0.0035 0.0155 0.0131
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0039 0.0185 0.0433
Echinococcus granulosus solute carrier family 22 0.0018 0.0024 0.005
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0155 0.0358
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.0858 0.1254
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0024 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0188 0.2086
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.0858 0.1254
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0155 0.0542
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.0858 1
Brugia malayi hypothetical protein 0.0016 0.0012 0.0001
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0104 0.0231
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0051 0.0054
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0188 0.071
Echinococcus multilocularis solute carrier family 22 0.0018 0.0024 0.0018
Trypanosoma brucei glucose transporter, putative 0.0039 0.0188 0.071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0028 0.0257
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0028 0.0071
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.1653
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0389 0.1429
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0051 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0028 0.0023
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0051 0.0248
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0389 0.4866
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0707 0.4387
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0024 0.0017
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0038 0.0178 0.0231
Plasmodium falciparum mitogen-activated protein kinase 2 0.0204 0.1456 0.3614
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0051 0.0192
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0028 0.0128
Entamoeba histolytica hypothetical protein 0.0028 0.0104 0.4399
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.0858 0.3546
Giardia lamblia Prolyl-tRNA synthetase 0.0038 0.0178 0.0632
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0188 0.2086
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0051 0.0464
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0359 0.2649 1
Schistosoma mansoni DNA polymerase I 0.0034 0.0147 0.1034
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0039 0.0184 0.0256
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0028 0.0128
Schistosoma mansoni hypothetical protein 0.0187 0.1326 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0024 0.0091
Brugia malayi beta-lactamase 0.0035 0.0155 0.0198
Mycobacterium ulcerans lipase LipD 0.0035 0.0155 0.1847
Trichomonas vaginalis CAMK family protein kinase 0.0039 0.0184 0.2041
Echinococcus multilocularis tumor protein p63 0.0326 0.2399 0.3536
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0028 0.0257
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.1739
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0028 0.0128
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0389 0.0558
Echinococcus granulosus solute carrier family 22 0.0018 0.0024 0.005
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0039 0.0184 0.2088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.004 0.0072
Toxoplasma gondii helicase, putative 0.0034 0.0147 0.0515
Trypanosoma brucei glucose transporter, putative 0.0039 0.0188 0.071
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0028 0.0071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.004 0.0109
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0081 0.0305
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0024 0.0045
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0117 0.0786 0.4887
Leishmania major hypothetical protein, conserved 0.0018 0.0024 0.0045
Echinococcus granulosus solute carrier family 22 0.0018 0.0024 0.005
Plasmodium vivax hexose transporter 0.0126 0.0858 0.2118
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0389 0.2378
Toxoplasma gondii 5'-3' exonuclease, N-terminal resolvase family domain-containing protein 0.0041 0.02 0.0714
Schistosoma mansoni DNA polymerase eta 0.0021 0.0051 0.0299
Plasmodium falciparum protein kinase 7 0.0357 0.2631 0.6553
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0188 0.2086
Brugia malayi steroid hormone receptor 0.0018 0.0028 0.0023
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0028 0.0128
Onchocerca volvulus 0.0018 0.0028 0.0005
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0024 0.0155
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0012 0.0044
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0038 0.0178 0.1269
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0039 0.0185 0.0433
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.1141
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0028 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0028 0.0257
Echinococcus granulosus calcium dependent protein kinase 0.0036 0.0166 0.0647
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0104 0.035
Entamoeba histolytica hypothetical protein 0.0036 0.0161 0.8344
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0024 0.0071 0.0375
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0051 0.0149
Trypanosoma brucei glucose transporter, putative 0.0039 0.0188 0.071
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0799 0.4964
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0161 0.0221
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0028 0.0025
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0083 0.0526 0.1287
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0024 0.0076
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0044 0.0227 0.0815
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0024 0.0071 0.0375
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Plasmodium falciparum thioredoxin reductase 0.0047 0.0247 0.0588
Toxoplasma gondii sugar transporter ST2 0.0018 0.0024 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0028 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0051 0.0192
Plasmodium falciparum protein kinase 6 0.0536 0.4009 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.004 0.0341
Toxoplasma gondii sugar transporter ST3 0.0018 0.0024 0.0045
Entamoeba histolytica DNA-directed DNA polymerase, putative 0.0034 0.0147 0.743
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0051 0.0192
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0038 0.0178 0.0231
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0081 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0028 0.0257
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0257
Brugia malayi hypothetical protein 0.0036 0.0161 0.0206
Schistosoma mansoni glucose transport protein 0.0126 0.0858 0.6443
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0044 0.0227 0.0815
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0653 0.0888
Echinococcus granulosus General substrate transporter 0.0108 0.0722 0.2974
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0028 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0024 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0051 0.0192
Trypanosoma brucei glucose transporter, putative 0.0039 0.0188 0.071
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.004 0.0109
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0255 0.185
Echinococcus multilocularis calcium dependent protein kinase 0.0036 0.0166 0.0229
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Loa Loa (eye worm) sugar transporter 0.0126 0.0858 1
Echinococcus multilocularis General substrate transporter 0.0108 0.0722 0.1052
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0104 0.0702
Trichomonas vaginalis esterase, putative 0.0035 0.0155 0.169
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0083 0.0526 0.195
Brugia malayi Cam kinase protein 1 0.0039 0.0184 0.0239
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0081 0.0263
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0028 0.0128
Schistosoma mansoni ap endonuclease 0.002 0.004 0.022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0155 0.0902
Leishmania major trypanothione reductase 0.0047 0.0247 0.0891
Trichomonas vaginalis ap endonuclease, putative 0.002 0.004 0.0341
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0155 0.169
Brugia malayi beta-lactamase family protein 0.0035 0.0155 0.0198
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0083 0.0526 0.195
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0155 0.0902
Brugia malayi nuclear receptor NHR-88 0.0018 0.0028 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0051 0.0192
Loa Loa (eye worm) hypothetical protein 0.0038 0.0178 0.2017
Plasmodium falciparum hexose transporter 0.0126 0.0858 0.2118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0155 0.1089
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0051 0.0054
Loa Loa (eye worm) hypothetical protein 0.0018 0.0028 0.0257
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0389 0.4866
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0024 0.0199
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0707 0.4387
Schistosoma mansoni glucose transporter 0.0018 0.0024 0.0091
Entamoeba histolytica protein kinase, putative 0.0039 0.0184 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0161 0.1134
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0028 0.0023
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0024 0.0076
Chlamydia trachomatis lysine--tRNA ligase 0.0028 0.0104 0.119
Plasmodium falciparum calcium-dependent protein kinase 4 0.0039 0.0185 0.0433
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0024 0.0045
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0039 0.0185 0.0433
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0184 0.0724
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0028 0.0025
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0104 0.0231
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0024 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0083 0.0526 0.1985
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0389 0.2869
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0038 0.0178 0.197
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0155 0.0902
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0247 0.0891
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0389 0.4866
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0028 0.0025
Treponema pallidum DNA polymerase I (polA) 0.0117 0.0786 1
Toxoplasma gondii thioredoxin reductase 0.0047 0.0247 0.0891
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0188 0.2086
Mycobacterium tuberculosis Probable reductase 0.0107 0.0707 0.4387
Brugia malayi DNA polymerase I family protein 0.0034 0.0147 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0028 0.0023
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0359 0.2649 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0028 0.0071
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0028 0.0128
Schistosoma mansoni hypothetical protein 0.0126 0.0858 0.6443
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0081 0.0263
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0155 0.169
Echinococcus granulosus tumor protein p63 0.0326 0.2399 1
Brugia malayi hypothetical protein 0.0018 0.0024 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0653 0.2687
Trypanosoma brucei glucose transporter 2A 0.0039 0.0188 0.071
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0028 0.0071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0039 0.0184 0.2088
Mycobacterium ulcerans 5'-3' exonuclease 0.0083 0.0526 0.6639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0028 0.0257
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0024 0.0018
Brugia malayi major facilitator superfamily protein 0.0018 0.0024 0.0017
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0039 0.0185 0.0656
Onchocerca volvulus Twinkle protein, mitochondrial homolog 0.0025 0.0079 0.0056
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0155 0.1847
Mycobacterium ulcerans beta-lactamase 0.0035 0.0155 0.1847
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0653 0.095
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0051 0.0058
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0389 0.2869
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.1739
Loa Loa (eye worm) hypothetical protein 0.0048 0.0255 0.2913
Plasmodium falciparum telomerase reverse transcriptase 0.0359 0.2649 0.6599
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0028 0.0257
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0117 0.0786 0.9832
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0028 0.0128
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0247 0.0348
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0707 0.8742
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0051 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0155 0.0542
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0051 0.0722
Loa Loa (eye worm) glutathione reductase 0.0047 0.0247 0.2817
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0012 0.0044
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0024 0.0141
Trypanosoma brucei glucose transporter, putative 0.0039 0.0188 0.071
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0389 0.1579
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0083 0.0526 0.3244
Brugia malayi beta-lactamase family protein 0.0035 0.0155 0.0198
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1597 1
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0038 0.0178 0.0699
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0028 0.0005
Toxoplasma gondii ABC1 family protein 0.0035 0.0155 0.0542
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0039 0.0185 0.0656
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0051 0.052
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0028 0.0023
Plasmodium vivax telomerase reverse transcriptase, putative 0.0359 0.2649 0.6599
Brugia malayi hypothetical protein 0.0018 0.0024 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0155 0.169
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0028 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0028 0.0023
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0012 0.0044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0707 0.4387
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0104 0.0702
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0051 0.0192
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0247 0.0588
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0184 0.0724
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0039 0.0184 0.0724
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0199
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0024 0.0155
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0707 0.4387
Loa Loa (eye worm) hypothetical protein 0.0039 0.0184 0.2088
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0155 0.0902
Echinococcus granulosus geminin 0.0187 0.1326 0.5504
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0028 0.0257
Mycobacterium tuberculosis Conserved protein 0.0035 0.0155 0.0902

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 5.7 Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as beta-arrestin recruitment by chemiluminescence assay ChEMBL. 24063433
EC50 (functional) = 6.3 Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescence assay ChEMBL. 24063433
Efficacy (binding) = 32 % Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as beta-arrestin recruitment by chemiluminescence assay relative to morphine ChEMBL. 24063433
Efficacy (functional) = 74 % Agonist activity at human mu opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation by fluorescence assay relative to morphine ChEMBL. 24063433

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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